All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
K C Lian. Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215901. they received peripheral or intra-amygdala administration of buspirone or other 5-ht1a drugs either before or after training. 1999-05-26 2023-08-12 rat
K C Lian. Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215901. further results indicated that post-training intra-amygdala infusion of buspirone or the 5-ht1a agonist 8-hydroxy-di-n-propylaminotetralin (8-oh-dpat) caused a time-dependent and dose-dependent retention deficit. 1999-05-26 2023-08-12 rat
K C Lian. Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215901. post-training intra-amygdala infusion of the 5-ht1a antagonist way100635 (n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)-n-(2-pyridyl) cyclohexane carboxamine maleate) attenuated the memory-impairing effects of buspirone. 1999-05-26 2023-08-12 rat
K C Lian. Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215901. these findings suggest that buspirone may modulate memory storage processes in the inhibitory avoidance task through an action on amygdaloid 5-ht1a receptors. 1999-05-26 2023-08-12 rat
G G Kinney, J C Griffith, T J Hudzi. Antidepressant-like effects of 5-hydroxytryptamine1A receptor agonists on operant responding under a response duration differentiation schedule. Behavioural pharmacology. vol 9. issue 4. 1999-05-20. PMID:10065919. thus, the present study sought to determine the effect of the full 5-ht1a agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the partial 5-ht1a agonist, buspirone, on responding in the response duration differentiation task. 1999-05-20 2023-08-12 rat
G G Kinney, J C Griffith, T J Hudzi. Antidepressant-like effects of 5-hydroxytryptamine1A receptor agonists on operant responding under a response duration differentiation schedule. Behavioural pharmacology. vol 9. issue 4. 1999-05-20. PMID:10065919. it was found that propranolol, trazodone, and both the full (8-oh-dpat) and partial (buspirone) 5-ht1a agonists produced increases in the mean response duration, which is typical of antidepressant activity. 1999-05-20 2023-08-12 rat
D L Mendoza, H A Bravo, H H Swanso. Antiaggresive and anxiolytic effects of gepirone in mice, and their attenuation by WAY 100635. Pharmacology, biochemistry, and behavior. vol 62. issue 3. 1999-05-17. PMID:10080243. the purpose of the investigation was to ascertain whether (a) the antiaggressive effects of the 5-ht1a partial agonist, gepirone, could be mediated via its anxiolytic action; (b) the selective 5-ht1a antagonist, way 100635, reversed these effects, and (c) the modulation of "stress hyperthermia" could be attributed to direct effects of the drugs. 1999-05-17 2023-08-12 mouse
C F Wu, J Liu, S Consolo, W Li. 5-HT1A receptors mediate inhibition of ethanol-induced ascorbic acid release in rat striatum studied by microdialysis. Neuroscience letters. vol 250. issue 2. 1999-05-12. PMID:9697927. buspirone (5.0 mg/kg, s.c.), a partial agonist of 5-ht1a receptors, and 8-oh-dpat (0.5 mg/kg, s.c.), a selective agonist of 5-ht1a receptors, showed no effect on basal ascorbic acid release in striatum, but both drugs significantly antagonized the ascorbic acid release induced by ethanol in striatum. 1999-05-12 2023-08-12 rat
H Okazawa, F Yamane, P Blier, M Diksi. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217280. the effects of acute and chronic administration of buspirone, a serotonin 5-ht1a agonist, on the 5-ht synthesis rates in various rat brain structures were investigated using alpha-[14c]methyl-l-tryptophan (alpha-[14c]mtrp) and an autoradiographic method. 1999-05-06 2023-08-12 rat
J Rehman, A Kaynan, G Christ, M Valcic, S Maayani, A Melma. Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain research. vol 821. issue 2. 1999-04-13. PMID:10064829. modulation of the sexual behavior of male rats by the anxiolytic buspirone (s-20499) and its analog gepirone were compared to the effects of 8-oh-dpat (or dpat, a selective 5-ht1a reference agonist), and bmy-7378 (a selective 5-ht1a partial agonist). 1999-04-13 2023-08-12 rat
J Rehman, A Kaynan, G Christ, M Valcic, S Maayani, A Melma. Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor. Brain research. vol 821. issue 2. 1999-04-13. PMID:10064829. if a tentative shared target site by dpat and buspirone is the 5-ht1a receptor, than the same 5-ht receptor sub-type at different locations (brain, raphe nuclei, spinal cord and autonomic ganglia) may modulate rat sexual behavior in opposing ways. 1999-04-13 2023-08-12 rat
S F de Boer, M Lesourd, E Mocaer, J M Koolhaa. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027850. the present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1a (serotonin) (5-ht1a) receptor agonist, alnespirone [s-20499, (s)-n-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-ht1a agonist 8-hydroxy-2- dipropylaminotetralin (8-oh-dpat), the partial 5-ht1a agonists ipsapirone and buspirone, and the mixed 5-ht1a/1b agonist eltoprazine. 1999-04-01 2023-08-12 rat
S F de Boer, M Lesourd, E Mocaer, J M Koolhaa. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027850. the involvement of 5-ht1a receptors in the antiaggressive actions of these drugs was confirmed by showing that the selective 5-ht1a receptor antagonist way-100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride), which was inactive alone, fully prevented the antiaggressive effects of alnespirone, 8-oh-dpat, and buspirone and partly reversed those of ipsapirone and eltoprazine. 1999-04-01 2023-08-12 rat
S F de Boer, M Lesourd, E Mocaer, J M Koolhaa. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027850. furthermore, the data provide evidence for a major involvement of these 5-ht1a receptors in the modulation of aggressive behavior by 8-oh-dpat, ipsapirone, buspirone, and eltoprazine. 1999-04-01 2023-08-12 rat
B Olivier, H E Molewijk, J A van der Heyden, R van Oorschot, E Ronken, J Mos, K A Micze. Ultrasonic vocalizations in rat pups: effects of serotonergic ligands. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884114. usv were reduced at low doses and in both temperature conditions by the full 5-ht1a receptor agonists flesinoxan and 8-oh-dpat (8-hydroxy-2-(di-n-propylamino) tetralin.hbr) and the partial 5-ht1a receptor agonists buspirone, ipsapirone and bmy 7378 (2-[4-[4-[2-pyrimidinyl]-1,2-piperazinyl]butyl]-1,2-benzi-isoth iozol-3-(2h)one-1,1-dioxide. 1999-03-29 2023-08-12 rat
F G Graeff, C F Netto, H Zangross. The elevated T-maze as an experimental model of anxiety. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884116. the anxiolytic agents diazepam (benzodiazepine), buspirone and ipsapirone (5-ht1a agonists) as well as ritanserin (5-ht2 antagonist) selectively impaired inhibitory avoidance while leaving one-way escape unchanged. 1999-03-29 2023-08-12 rat
J Dunlop, Y Zhang, D L Smith, L E Schechte. Characterization of 5-HT1A receptor functional coupling in cells expressing the human 5-HT1A receptor as assessed with the cytosensor microphysiometer. Journal of pharmacological and toxicological methods. vol 40. issue 1. 1999-03-26. PMID:9920534. concentration-dependent agonist activity was also observed in the presence of buspirone, ipsapirone, bmy7378, nan-190 and way100135, and each of these compounds behaved as partial 5-ht1a receptor agonists. 1999-03-26 2023-08-12 human
G A Kennett, B Trail, F Brigh. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. vol 37. issue 12. 1999-03-23. PMID:9886683. 1 h pre-test), but not the 5-ht2c/2b receptor agonist, m-chlorophenylpiperazine (mcpp, 0.3-3 mg/kg i.p) or the 5-ht1a receptor agonist, buspirone (5-20 mg/kg p.o. 1999-03-23 2023-08-12 rat
K Tada, K Kasamo, N Ueda, T Suzuki, T Kojima, K Ishikaw. Anxiolytic 5-hydroxytryptamine1A agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: single-unit study in unanesthetized, unrestrained rats. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918598. systemic administration of selective 5-ht1a agonists, 8-hydroxy-2-(di-n-propylamino)tetralin, buspirone, ipsapirone, and flesinoxan produced a dose-dependent inhibition of neuronal activity. 1999-02-22 2023-08-12 rat
H C Dringenberg, R A Kornelsen, R Pacelli, K Petersen, C H Vanderwol. Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821552. treatment with the 5-ht1a receptor agonist buspirone (0.1 mg/kg, s.c.) increased the time that unlesioned rats spent in the uncovered compartment (103 s), an effect that was less pronounced in hippocampus-lesioned rats and completely abolished by amygdala lesions. 1999-02-05 2023-08-12 rat