All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
A Szabó, B L Butz, R H Alpe. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain research bulletin. vol 45. issue 6. 1998-06-08. PMID:9566502. the present studies were designed to characterize: (1) the requirement of the 5-ht1a receptor agonist r(+)-8-hydroxy-2-(di-n-propylamino) tetralin [r(+)8-oh-dpat]-induced tachycardia on the integrity of serotonergic innervation of the preoptic area, (2) the ability of the 5-ht1a receptor partial agonist buspirone to elicit cardiovascular responses when microinjected into the preoptic area, (3) the role of 5-ht2 and 5-ht3 receptors in the preoptic area in cardiovascular regulation, and (4) the site specificity of the tachycardia produced by r(+)8-oh-dpat. 1998-06-08 2023-08-12 rat
M H Otter, V Matto, R Sõukand, T Skrebuhhova, L Allikmets, J Harr. Characterization of rat exploratory behavior using the exploration box test. Methods and findings in experimental and clinical pharmacology. vol 19. issue 10. 1998-05-14. PMID:9580470. buspirone and gepirone (both 1 mg/kg), the 5-ht1a receptor agonists, had no effect. 1998-05-14 2023-08-12 rat
G J Kant, R M Wylie, K Chu, S Ghos. Effects of the serotonin agonists 8-OH-DPAT, buspirone, and DOI on water maze performance. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512079. in the present report we extended those studies by examining a second 5-ht1a agonist, buspirone, to see whether its effects paralleled those of 8-oh-dpat, and by testing the effects of the 5-ht2 agonist doi. 1998-05-05 2023-08-12 rat
G J Kant, R M Wylie, K Chu, S Ghos. Effects of the serotonin agonists 8-OH-DPAT, buspirone, and DOI on water maze performance. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512079. at doses that did not affect performance in a previously learned maze, the 5-ht1a agonists 8-oh-dpat (0.1 mg/kg) and buspirone (1 mg/kg) slowed acquisition of a new maze configuration as measured by both swim time to the exit platform and errors committed. 1998-05-05 2023-08-12 rat
M Poyurovsky, A Weizma. Serotonergic agents in the treatment of acute neuroleptic-induced akathisia: open-label study of buspirone and mianserin. International clinical psychopharmacology. vol 12. issue 5. 1998-03-19. PMID:9466160. on the basis of preclinical data, which imply that the partial 5-ht1a agonist buspirone possesses anti-5-ht activity, in the present open-label study we examined the putative antiakathitic effect of buspirone in 10 neuroleptic-treated patients with acute neuroleptic-induced akathisia. 1998-03-19 2023-08-12 Not clear
M Poyurovsky, A Weizma. Serotonergic agents in the treatment of acute neuroleptic-induced akathisia: open-label study of buspirone and mianserin. International clinical psychopharmacology. vol 12. issue 5. 1998-03-19. PMID:9466160. it seems that the 5-ht1a partial agonist buspirone is of limited value in the treatment of acute neuroleptic-induced akathisia. 1998-03-19 2023-08-12 Not clear
B Costall, R J Naylo. The influence of 5-HT2 and 5-HT4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test. British journal of pharmacology. vol 122. issue 6. 1998-02-23. PMID:9401775. ritanserin was shown to enhance the disinhibitory potency of other benzodiazepines, chlordiazepoxide (4 fold), temazepam (10 fold) and lorazepam (10 fold), the 5-ht1a receptor ligands, 8-oh-dpat (25 fold), buspirone (100 fold) and lesopitron (500 fold), the 5-ht3 receptor antagonists, ondansetron (100 fold) r(+)-zacopride (100 fold) and s(-)-zacopride (greater than a 1000 fold), the substituted benzamides, sulpiride (10 fold) and tiapride (5 to 10 fold) and the cholecystokinin (cck)a receptor antagonist, devazepide (100 fold). 1998-02-23 2023-08-12 mouse
S A Vanecek, W D Essman, D P Taylor, J H Wood. Discriminative stimulus characteristics of BMY 14802 in the pigeon. The Journal of pharmacology and experimental therapeutics. vol 284. issue 1. 1998-02-11. PMID:9435153. in contrast to sigma ligands and other reference compounds, the 5-ht1a agonists buspirone, 8-oh-dpat and spiroxatrine dose-dependently produced bmy 14802-like discriminative stimulus effects. 1998-02-11 2023-08-12 pigeon
G Marvin, A Sharma, W Aston, C Field, M J Kendall, D A Jone. The effects of buspirone on perceived exertion and time to fatigue in man. Experimental physiology. vol 82. issue 6. 1998-01-30. PMID:9413736. male subjects exercised at 80% maximal rate of o2 uptake (vo2,max) following oral administration of either placebo or the partial 5-ht1a agonist buspirone (45 mg), using a paired design. 1998-01-30 2023-08-12 human
G Marvin, A Sharma, W Aston, C Field, M J Kendall, D A Jone. The effects of buspirone on perceived exertion and time to fatigue in man. Experimental physiology. vol 82. issue 6. 1998-01-30. PMID:9413736. serum prolactin was significantly elevated following buspirone administration, indicating increased hypothalamic 5-ht1a receptor stimulation. 1998-01-30 2023-08-12 human
R Durst, G Katz, K Jabotinsky-Rubin, H Y Knoble. [Kleptomania: phenomenological, clinical and legal aspects]. Harefuah. vol 133. issue 10. 1998-01-22. PMID:9418315. the positive response to buspirone (5-ht1a) augmentation of fluvoxamine (ssri) suggested that disturbed central serotonergic neurotransmission might play an important role in the pathogenesis of kleptomania. 1998-01-22 2023-08-12 human
G K Matheson, A Knowles, D Gage, C Michel, D Guthrie, C Bauer, J Blackbourne, D Weinzapfe. Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat. Pharmacology. vol 55. issue 2. 1998-01-09. PMID:9323305. the effects of tandospirone, enciprazine, gepirone, buspirone (5-ht1a agents) and carvotroline (5-ht2) on hypothalamic-pituitary-adrenocortical activity (hpa) activity were studied. 1998-01-09 2023-08-12 rat
M C Wolff, J D Leande. Differentiation of 5-HT1A receptor ligands by drug discrimination. European journal of pharmacology. vol 333. issue 2-3. 1998-01-05. PMID:9314023. partial agonists for the 5-ht1a receptor (e.g., buspirone) were generalized fully in the low dose condition, but only partially in the high dose condition. 1998-01-05 2023-08-12 Not clear
J A Kim, R A Gillespie, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347075. effects of maternal ethanol consumption and buspirone treatment on 5-ht1a and 5-ht2a receptors in offspring. 1997-12-16 2023-08-12 rat
J A Kim, R A Gillespie, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347075. the present study extended prior work by evaluating the effects of chronic maternal ethanol consumption and maternal buspirone treatment on 5-ht1a and 5-ht2a receptors in multiple brain areas of offspring. 1997-12-16 2023-08-12 rat
J A Kim, R A Gillespie, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347075. because fetal 5-ht functions as an essential neurotrophic factor, these studies also determined whether treatment of pregnant rats with buspirone, a 5-ht1a agonist, could overcome the effects of the fetal 5-ht deficit and prevent ethanol-associated receptor abnormalities. 1997-12-16 2023-08-12 rat
J A Kim, R A Gillespie, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347075. maternal buspirone treatment prevented the ethanol-associated abnormalities in 5-ht1a receptors in the dentate gyrus, frontal cortex, and lateral septum. 1997-12-16 2023-08-12 rat
I Sylte, Z Chilmonczyk, S G Dahl, J Cybulski, O Edvardse. The ligand-binding site of buspirone analogues at the 5-HT1A receptor. The Journal of pharmacy and pharmacology. vol 49. issue 7. 1997-12-08. PMID:9255714. the ligand-binding site of buspirone analogues at the 5-ht1a receptor. 1997-12-08 2023-08-12 Not clear
I Sylte, Z Chilmonczyk, S G Dahl, J Cybulski, O Edvardse. The ligand-binding site of buspirone analogues at the 5-HT1A receptor. The Journal of pharmacy and pharmacology. vol 49. issue 7. 1997-12-08. PMID:9255714. a three-dimensional model of the 5-ht1a receptor in man was constructed by molecular-modelling techniques and used to study the molecular interactions of a series of buspirone analogues with the 5-ht1a receptor by molecular-mechanical-energy minimization and molecular-dynamics simulations. 1997-12-08 2023-08-12 Not clear
I Ali, M E Kell. Buspirone fails to affect cocaine-induced conditioned place preference in the mouse. Pharmacology, biochemistry, and behavior. vol 58. issue 2. 1997-12-01. PMID:9300585. the conditioned place preference (cpp) procedure was employed to examine the effects of the 5-hydroxytryptamine1a (5-ht1a) receptor agonist, buspirone, on cocaine reinforcement. 1997-12-01 2023-08-12 mouse