All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
S S Grewal, J K Shepherd, D J Bill, A Fletcher, C T Douris. Behavioural and pharmacological characterisation of the canopy stretched attend posture test as a model of anxiety in mice and rats. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335077. in the mouse sap test, the benzodiazepine receptor agonists, diazepam (0.5 mg/kg s.c.) and chlordiazepoxide (2 mg/kg s.c.), and the 5-ht1a receptor agonists, buspirone (1 and 3 mg/kg s.c.), ipsapirone (3 mg/kg s.c.) and 8-oh-dpat (0.2 mg/kg s.c.), all significantly decreased the frequency of sap without impairing motor activity. 1997-11-14 2023-08-12 mouse
V Jagannathan, J Venit. Pharmacokinetics and CNS pharmacodynamics of the 5-HT1A agonist buspirone in humans following acute L-tryptophan depletion challenge. Methods and findings in experimental and clinical pharmacology. vol 19. issue 5. 1997-11-12. PMID:9379784. pharmacokinetics and cns pharmacodynamics of the 5-ht1a agonist buspirone in humans following acute l-tryptophan depletion challenge. 1997-11-12 2023-08-12 human
P Sargent, D J Williamson, G Pearson, J Odontiadis, P J Cowe. Effect of paroxetine and nefazodone on 5-HT1A receptor sensitivity. Psychopharmacology. vol 132. issue 3. 1997-10-23. PMID:9292630. we used the endocrine and hypothermic responses to the 5-ht1a receptor agonist, gepirone (20 mg orally), to assess 5-ht1a receptor sensitivity in 37 healthy male volunteers who were studied before and following random double-blind, allocation to treatment with paroxetine, nefazodone or placebo for 17 days. 1997-10-23 2023-08-12 human
M A Da-Rocha, A J Puech, M H Thiébo. Influence of anxiolytic drugs on the effects of specific serotonin reuptake inhibitors in the forced swimming test in mice. Journal of psychopharmacology (Oxford, England). vol 11. issue 3. 1997-10-22. PMID:9305412. and the 5-ht1a receptor partial agonist, buspirone (0.5 mg/kg, s.c.). 1997-10-22 2023-08-12 mouse
N Collinson, G R Dawso. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272757. on the elevated plus-maze the anxiolytic-like effects of the 5-ht(1a) agonist, 8-oh-dpat, but not the anxiogenic-like effects of the 5-ht(1a) partial agonist, buspirone, are blocked by the 5-ht1a antagonist, way 100635. 1997-10-20 2023-08-12 Not clear
G Griebel, R J Rodgers, G Perrault, D J Sange. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacology, biochemistry, and behavior. vol 57. issue 4. 1997-10-16. PMID:9259011. the drugs used were 5-ht1a receptor partial (buspirone and ipsapirone) and full (8-oh-dpat and flesinoxan) agonists, mixed 5-ht2a/2c receptor antagonists (ritanserin, ketanserin, mianserin, and pirenperone), selective 5-ht3 receptor antagonists (ics 205-930, mdl 72222, ondansetron, and (rs)-zacopride), and selective (fluoxetine, fluvoxamine, and zimelidine) and nonselective (imipramine) 5-ht reuptake inhibitors. 1997-10-16 2023-08-12 rat
N Galeotti, C Ghelardini, A Bartolin. 5-HT1A agonists induce central cholinergic antinociception. Pharmacology, biochemistry, and behavior. vol 57. issue 4. 1997-10-16. PMID:9259013. the antinociceptive effects of the 5-ht1a agonists buspirone [3 mg/kg intraperitoneally (i.p. 1997-10-16 2023-08-12 mouse
H Lilienthal, A Weinand-Härer, H Winterhoff, G Winnek. Effects of maternal exposure to 3,3',4,4'-tetrachlorobiphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicology and applied pharmacology. vol 146. issue 1. 1997-10-15. PMID:9299608. differences between controls and groups exposed to pcb 77 or ptu were detected in a blocking test using the mixed serotonin 5-ht1a agonist and partial d2 antagonist buspirone. 1997-10-15 2023-08-12 rat
P Schoeffter, I Bobirnac, E Boddeke, D Hoye. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225266. it is shown that 5-ht, 8-oh-dpat, buspirone, mdl 73005 behaved as full (or nearly full) and potent agonists, whereas sdz 216-525, nan-190 and way-100135 displayed a limited (and similar) degree of intrinsic activity at human 5-ht1a receptors; on the other hand pindolol, propranolol and way 100635 behaved as "silent" antagonists. 1997-09-15 2023-08-12 human
M el Mansari, P Blie. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225283. the inhibitory effect of gepirone, which is a 5-ht1a receptor agonist but devoid of affinity for 5-ht7 receptors, was also not antagonized by way100635. 1997-09-15 2023-08-12 Not clear
M S Kleven, M B Assié, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262338. to characterize their in vivo 5-hydroxytryptamine (5-ht)2a antagonist properties, the ability of the putative mixed 5-ht1a agonists/5-ht(2a,2c) antagonists (n-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) ) decane-1-carboxamide (wy-50,324), (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-piperazinyl)-3-pyridinecarboxy lic acid hydrochloride (fg5974), 9,10-didehydro-n-(2-propynyl)-6-methylergoline-8b-carboxamid e (lek-8804) and trans-1,3,4,a5,10b-hexahydro10-methoxy-4-propyl-2h-(1)benzopyra nol[3,4-b]pyridine (cgs 18102a) to antagonize both head twitches and discriminative stimulus (ds) effects produced by (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi) in rats were compared with those of the 5-ht2 antagonists ketanserin and ritanserin, and the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone. 1997-09-11 2023-08-12 rat
M S Kleven, M B Assié, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262338. in contrast, way-100635 completely blocked the effects of 8-oh-dpat, buspirone and wy-50,324, and partially blocked the effects of lek-8804, demonstrating that 5-ht1a agonist properties are involved in the effects of all of the mixed compounds except cgs 18102a. 1997-09-11 2023-08-12 rat
T Hamamura, Y Lee, Y Fujiwara, S Kurod. Serotonin1A receptor agonists induce Fos protein expression in the locus coeruleus of the conscious rat. Brain research. vol 759. issue 1. 1997-09-10. PMID:9219875. these results clearly demonstrate that azapirones activate noradrenergic neurons via 5-ht1a receptors. 1997-09-10 2023-08-12 rat
M Sas. [A new approach to innovating selective anxiolytics: pharmacological profile of a novel 5-HT1A agonist (tandospirone)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 2. 1997-09-04. PMID:9201724. [a new approach to innovating selective anxiolytics: pharmacological profile of a novel 5-ht1a agonist (tandospirone)]. 1997-09-04 2023-08-12 rat
M Sas. [A new approach to innovating selective anxiolytics: pharmacological profile of a novel 5-HT1A agonist (tandospirone)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 2. 1997-09-04. PMID:9201724. tandospirone (sedil) is a newly developed anxiolytic drug that has a much higher selective affinity for 5-ht1a than dopamine d2 receptors without the binding affinities with noradrenergic, dopaminergic, cholinergic and gabaergic receptors. 1997-09-04 2023-08-12 rat
M Sas. [A new approach to innovating selective anxiolytics: pharmacological profile of a novel 5-HT1A agonist (tandospirone)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 2. 1997-09-04. PMID:9201724. these effects are probably due to the selective action of tandospirone on 5-ht1a receptors in the limbic system to eventuate anxiolytic and antidepressant effects. 1997-09-04 2023-08-12 rat
C Moret, M Brile. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203078. the selective 5-ht reuptake inhibitor, citalopram, the 5-ht1a agonists, (+/-) 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat), ipsapirone, gepirone and the 5-ht1a/b agonist, 7-trifluoromethyl-4(4-methyl-1-piperazinyl-pyrolo[1,2-a]-quinox ali ne (cgs 12066b), the 5-ht1a/b ligands and beta-adrenoceptor antagonists, (+/-) pindolol and (+/-) alprenolol, and the non-selective 5-ht ligands, m-chlorophenylpiperazine (mcpp) and metergoline, all inhibited the synthesis of 5-ht. 1997-09-03 2023-08-12 rat
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology. vol 329. issue 1. 1997-08-22. PMID:9218690. an inhibition of phosphoinositide hydrolysis in the dorsal raphe nucleus also was found with the putative 5-ht1a receptor selective ligands, flesinoxan and gepirone. 1997-08-22 2023-08-12 Not clear
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology. vol 329. issue 1. 1997-08-22. PMID:9218690. however, addition of another putative 5ht1a receptor selective ligand, buspirone, did not alter the generation of [3h]inositol phosphates, but blocked the inhibitory effect of 8-oh-dpat on phosphoinositide hydrolysis. 1997-08-22 2023-08-12 Not clear
Z Chilmonczyk, A Szelejewska-Wozniakowska, J Cybulski, M Cybulski, A E Koziol, M Gdanie. Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore. Archiv der Pharmazie. vol 330. issue 5. 1997-08-14. PMID:9237427. preparation and affinity to 5-ht1a and 5-ht2a receptors of new buspirone analogues 7-17 are reported. 1997-08-14 2023-08-12 Not clear