| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Chilmonczyk, A Szelejewska-Wozniakowska, J Cybulski, M Cybulski, A E Koziol, M Gdanie. Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore. Archiv der Pharmazie. vol 330. issue 5. 1997-08-14. PMID:9237427. |
preparation and affinity to 5-ht1a and 5-ht2a receptors of new buspirone analogues 7-17 are reported. |
1997-08-14 |
2023-08-12 |
Not clear |
| Z Chilmonczyk, A Szelejewska-Wozniakowska, J Cybulski, M Cybulski, A E Koziol, M Gdanie. Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore. Archiv der Pharmazie. vol 330. issue 5. 1997-08-14. PMID:9237427. |
for low affinity ligand (15) of 5-ht1a receptor conformational analysis was performed and compared with similar analyses performed for know high (buspirone 1) and very high (wy-48,723 2) affinity ligands of the receptor. |
1997-08-14 |
2023-08-12 |
Not clear |
| R A Gillespie, J Eriksen, H L Hao, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 3. 1997-08-07. PMID:9161605. |
because fetal 5-ht is an essential trophic factor, this laboratory previously investigated the hypotheses that the early ethanol-associated 5-ht deficit contributed to subsequent development abnormalities in the serotonergic system and that the effects of the fetal 5-ht deficit could be prevented by maternal treatment with buspirone, a 5-ht1a receptor agonist. |
1997-08-07 |
2023-08-12 |
rat |
| M J Millan, S Hjorth, R Samanin, R Schreiber, R Jaffard, B De Ladonchamps, S Veiga, B Goument, J L Peglion, M Spedding, M Brocc. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223550. |
in these studies, we characterized the influence of the novel benzodioxopiperazine serotonin (5-ht)1a ligand, s 15535, on the release of 5-ht in rat hippocampus and compared its potential anxiolytic properties with those of the 5-ht1a receptor partial agonist, buspirone, the 5-ht1a antagonist, way 100,635 and the benzodiazepine, diazepam (dzm). |
1997-08-07 |
2023-08-12 |
mouse |
| P Trouillas, J Xie, P Adelein. Buspirone, a serotonergic 5-HT1A agonist, is active in cerebellar ataxia. A new fact in favor of the serotonergic theory of ataxia. Progress in brain research. vol 114. 1997-08-06. PMID:9193169. |
buspirone, a serotonergic 5-ht1a agonist, is active in cerebellar ataxia. |
1997-08-06 |
2023-08-12 |
human |
| P Trouillas, J Xie, P Adelein. Buspirone, a serotonergic 5-HT1A agonist, is active in cerebellar ataxia. A new fact in favor of the serotonergic theory of ataxia. Progress in brain research. vol 114. 1997-08-06. PMID:9193169. |
to test further the serotonergic hypothesis of cerebellar ataxia, we administered buspirone, a 5-ht1a agonist usable in human medicine, in a randomized double blind drug placebo trial for 4 months. |
1997-08-06 |
2023-08-12 |
human |
| J Mos, A Van Hest, M Van Drimmelen, A H Herremans, B Olivie. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. European journal of pharmacology. vol 325. issue 2-3. 1997-08-04. PMID:9163561. |
tests for generalization and antagonism showed that compounds with agonistic action at the 5-ht1a receptor, such as 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin), buspirone and ipsapirone all substituted for the flesinoxan cue. |
1997-08-04 |
2023-08-12 |
Not clear |
| P M Callahan, K A Cunningha. Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists. Neuropharmacology. vol 36. issue 3. 1997-07-24. PMID:9175616. |
in substitution tests, the 5-ht1a receptor partial agonists buspirone and gepirone, the 5-ht1a/b receptor agonist ru 24969 and the 5-ht1b/2c receptor agonist m-trifluoromethyl-phenylpiperazine (tfmpp) failed to substitute for the cocaine stimulus, although ru 24969 did engender a maximum of 72% cocaine-lever responding. |
1997-07-24 |
2023-08-12 |
rat |
| P M Callahan, K A Cunningha. Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists. Neuropharmacology. vol 36. issue 3. 1997-07-24. PMID:9175616. |
the ability of buspirone, but not gepirone, to attenuate the cocaine stimulus probably reflects its dopamine (da) d2 receptor antagonist properties and not its efficacy at 5-ht1a receptors. |
1997-07-24 |
2023-08-12 |
rat |
| R Kavoussi, P Armstead, E Coccar. The neurobiology of impulsive aggression. The Psychiatric clinics of North America. vol 20. issue 2. 1997-07-23. PMID:9196921. |
as noted previously, aggressive personality-disordered patients show a blunted prolactin response to the 5-ht1a agonist buspirone. |
1997-07-23 |
2023-08-12 |
human |
| P Trouillas, J Xie, P Adeleine, D Michel, A Vighetto, J Honnorat, R Dumas, N Nighoghossian, B Lauren. Buspirone, a 5-hydroxytryptamine1A agonist, is active in cerebellar ataxia. Results of a double-blind drug placebo study in patients with cerebellar cortical atrophy. Archives of neurology. vol 54. issue 6. 1997-07-10. PMID:9193210. |
to establish the antiataxic effect of buspirone hydrochloride, a serotonergic 5-hydroxytryptamine1a (5-ht1a) agonist, in a homogenous group of patients characterized by the same well-defined single condition, cerebellar cortical atrophy. |
1997-07-10 |
2023-08-12 |
Not clear |
| N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. |
to clarify the serotonergic mechanisms involved in the protection against ischemic neuronal damage, zd-211 (citalopram hbr), a serotonin (5-hydroxytryptamine; 5-ht) re-uptake inhibitor, or buspirone, a 5-ht1a agonist, was locally administered into the hippocampus of gerbils. |
1997-07-09 |
2023-08-12 |
Not clear |
| N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. |
pretreatment with nan-190, a 5-ht1a antagonist, completely abolished the protective effect of zd-211 or buspirone. |
1997-07-09 |
2023-08-12 |
Not clear |
| N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. |
these effects of zd-211 and buspirone were mediated through the 5-ht1a receptor in the hippocampus. |
1997-07-09 |
2023-08-12 |
Not clear |
| A Canto de Souza, R L Nunes de Souza, I R Péla, F G Graef. High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors. Pharmacology, biochemistry, and behavior. vol 56. issue 3. 1997-07-03. PMID:9077586. |
however, this attack-induced analgesia was reduced after ip administration of the 5-ht1a agonists, gepirone (0.3 and 3.0 mg/kg) and bay r 1531 (0.01 mg/kg). |
1997-07-03 |
2023-08-12 |
mouse |
| J T Weber, K Hayataka, M F O'Connor, K K Parke. Rabbit cerebral cortex 5HT1a receptors. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 117. issue 1. 1997-07-01. PMID:9185324. |
the only rank order anomalies were with methiothepin in rabbit cerebral cortex, where a comparatively high ki was observed and with buspirone in cloned human 5ht1a receptor, where a low ki was determined; these anomalies bear further study in light of the comparative pharmacology of 5ht1a receptors. |
1997-07-01 |
2023-08-12 |
human |
| P Blier, R Bergeron, C de Montign. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 5. 1997-06-27. PMID:9109104. |
the administration of the selective 5-ht1a agonist buspirone (20 mg/day for 1 week and 30 mg/day thereafter) with pindolol (2.5 mg tid) was used to activate selectively postsynaptic 5-ht1a receptors. |
1997-06-27 |
2023-08-12 |
Not clear |
| M E Tancer, T W Uhd. Role of serotonin drugs in the treatment of social phobia. The Journal of clinical psychiatry. vol 58 Suppl 5. 1997-06-19. PMID:9184626. |
these include the serotonin selective reuptake inhibitors (ssris), the partial 5-ht1a agonist buspirone, and the 5-ht3 antagonist ondansetron. |
1997-06-19 |
2023-08-12 |
Not clear |
| M Filip, E Przegalińsk. Effects of MP-3022 on the 8-OH-DPAT-induced discriminative stimulus in rats. Polish journal of pharmacology. vol 48. issue 4. 1997-06-16. PMID:9112679. |
substitution studies showed that the 8-oh-dpat cue was mimicked in a dose-dependent manner by buspirone and ipsapirone, the 5-ht1a receptor partial agonists, but not by 1-(3-chlorophenyl)piperazine (m-cpp), a nonselective 5-ht agonist. |
1997-06-16 |
2023-08-12 |
rat |
| O Stücker, E Laemmel, B Teisseire, E Vicau. Specific response of mouse tumor-feeding arterioles to stimulation by 5-HT1 agonists. International journal of radiation oncology, biology, physics. vol 37. issue 5. 1997-06-13. PMID:9169822. |
topical administration of the general 5-ht1 agonist 5-carboxamidotryptamine maleate (10(-6) to 10(-4) m) or the 5-ht1a agonist buspirone (2 x 10(-6) to 2 x 10(-4) m) induced vasoconstriction that was dramatically higher in tfa than in tia or control arterioles (p < 0.0001 in both cases). |
1997-06-13 |
2023-08-12 |
mouse |