All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
M Maes, A Van Gastel, H Y Meltzer, P Cosyns, P Blockx, R Desnyde. Acute administration of buspirone increases the escape of hypothalamic-pituitary-adrenal-axis hormones from suppression by dexamethasone in depression. Psychoneuroendocrinology. vol 21. issue 1. 1996-09-16. PMID:8778905. to further elucidate the effects of central serotonin (5-ht) activity on the negative feedback of glucocorticoids on hypothalamic-pituitary-adrenal (hpa)-axis function in depression, this study investigates the effects of buspirone, a 5-ht1a receptor agonist, on post-dst acth and cortisol levels in 75 depressed subjects. 1996-09-16 2023-08-12 human
J L Mokrosz, A Dereń-Wesołek, E Tatarczyńska, B Duszyńska, A J Bojarski, M J Mokrosz, E Chojnacka-Wójci. 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676348. 8-[4-[2-(1,2,3,4-tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-ht1a receptor ligand with the same activity profile as buspirone. 1996-08-15 2023-08-12 Not clear
J L Mokrosz, A Dereń-Wesołek, E Tatarczyńska, B Duszyńska, A J Bojarski, M J Mokrosz, E Chojnacka-Wójci. 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676348. the obtained results permit a conclusion that the basic nitrogen atom and terminal, bulky cycloimide moiety, but not the 2-pyrimidinyl group, of buspirone are directly involved in the formation of the bioactive complex with 5-ht1a receptors. 1996-08-15 2023-08-12 Not clear
K Uvnäs-Moberg, S Ahlenius, P Alster, V Hillegaar. Effects of selective serotonin and dopamine agonists on plasma levels of glucose, insulin and glucagon in the rat. Neuroendocrinology. vol 63. issue 3. 1996-08-12. PMID:8677015. an additional group of animals was given buspirone (2.0-8.0 mg kg-1) a 5-ht1a receptor agonist and da d2 receptor antagonist. 1996-08-12 2023-08-12 rat
J P Boulenge. [Treatment of generalized anxiety: new pharmacologic approaches]. L'Encephale. vol 21. issue 6. 1996-08-09. PMID:8674471. after benzodiazepines (bzd) and 5-ht1a agonists like buspirone, several other types of new anxiolytic drugs have been developed for the treatment of gad. 1996-08-09 2023-08-12 human
W P Clarke, F D Yocca, S Maayan. Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. The Journal of pharmacology and experimental therapeutics. vol 277. issue 3. 1996-08-06. PMID:8667186. other 5-ht1a agonists, nan-190, bmy-7378, buspirone and gepirone, were also ineffective in raphe region homogenates. 1996-08-06 2023-08-12 rat
D J Bootle, J J Adcock, A G Ramag. Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled capsaicin in anaesthetized cats. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646420. of the 5-ht1a receptor ligands, 8-oh-dpat (50 micrograms kg-1), buspirone (200 micrograms kg-1), way-100635 (100 micrograms kg-1), methiothepin (200 micrograms kg-1) and (-)-pindolol (100 micrograms kg-1) and the 5-ht2 receptor antagonist, cinanserin (200 micrograms kg-1), on the reflex bronchoconstriction evoked by inhaled capsaicin aerosol in alpha-chloralose anaesthetized, neuromuscularly blocked and artificially ventilated cats. 1996-07-24 2023-08-12 Not clear
D J Bootle, J J Adcock, A G Ramag. Involvement of central 5-HT1A receptors in the reflex activation of pulmonary vagal motoneurones by inhaled capsaicin in anaesthetized cats. British journal of pharmacology. vol 117. issue 4. 1996-07-24. PMID:8646420. the 5-ht1a receptor agonist, 8-oh-dpat (50 micrograms kg-1) given i.c., potentiated the capsaicin-evoked reflex bronchoconstriction, whereas buspirone (200 micrograms kg-1) i.c. 1996-07-24 2023-08-12 Not clear
I Luck. Serotonin receptor specificity in anxiety disorders. The Journal of clinical psychiatry. vol 57 Suppl 6. 1996-07-19. PMID:8647798. buspirone is a selective agonist at a subtype of serotonin receptor termed 5-ht1a, whereas fluoxetine is a selective inhibitor of the reuptake of 5-ht. 1996-07-19 2023-08-12 Not clear
M S Kleven, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. The Journal of pharmacology and experimental therapeutics. vol 276. issue 2. 1996-07-03. PMID:8632301. a conflict procedure in pigeons was used to characterize the antipunishment effects of the putative mixed 5-hydroxytryptamine (5-ht)1a agonist/5-ht2a/2c antagonists wy 50,324, cgs 18102a, lek 8804 and fg 5974 and to further investigate interactions between the antipunishment effects of the 5-ht1a agonists buspirone and 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] administered in combination with the mixed 5-ht2a/2c antagonist ritanserin and the alpha 1 antagonist prazosin. 1996-07-03 2023-08-12 pigeon
M S Kleven, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. The Journal of pharmacology and experimental therapeutics. vol 276. issue 2. 1996-07-03. PMID:8632301. the 5-ht1a agonists, buspirone and 8-oh-dpat, which lack affinity for 5-ht2a/2c receptors, produced dose-related increases in punished responding. 1996-07-03 2023-08-12 pigeon
J A Terrón, E Ramírez-San Juan, E Hong, C M Villaló. Role of alpha1-adrenoceptors in the reduction of external carotid blood flow induced by buspirone and ipsapirone in the dog. Life sciences. vol 58. issue 1. 1996-06-24. PMID:8628112. the effects of the 5-ht1a receptor agonist with anxiolytic properties, buspirone and ipsapirone, in the external carotid bed of anaesthetized dogs were analyzed. 1996-06-24 2023-08-12 dog
C Castillo, R A Bobadilla, M Ibarra, E F Castillo, E Hon. A comparative study of the effects of some 5-HT1A receptor agonists on the blood pressure of pithed rats. Archives of medical research. vol 26. issue 3. 1996-03-20. PMID:8580676. the effects of indorenate were compared with those of buspirone and ipsapirone (all selective 5-ht1a agonists) on the blood pressure of pithed rats. 1996-03-20 2023-08-12 rat
F Borsini, E Giraldo, E Monferini, G Antonini, M Parenti, G Bietti, A Donett. BIMT 17, a 5-HT2A receptor antagonist and 5-HT1A receptor full agonist in rat cerebral cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 3. 1996-03-15. PMID:8584042. buspirone, 8-oh-dpat and s 14671 (1-[2-(2-thenoylamino)ethyl]- 4[1-(7-methoxynaphtyl)]-piperazine), claimed to be 5-ht1a receptor agonists, did not reduce forskolin-stimulated camp formation in the cerebral cortex. 1996-03-15 2023-08-12 rat
F Borsini, A Ceci, G Bietti, A Donett. BIMT 17, a 5-HT1A receptor agonist/5-HT2A receptor antagonist, directly activates postsynaptic 5-HT inhibitory responses in the rat cerebral cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 352. issue 3. 1996-03-15. PMID:8584043. bimt 17 (1-[2-[4-(3-trifluoromethyl phenyl) piperazin-1-yl] ethyl] benzimidazol- [1h]-2-one), a 5-ht1a receptor agonist/5-ht2a receptor antagonist (see borsini et al., accompanying paper), in a dose range of 1-10 mg/kg i.v., dose-dependently inhibited the electrical activity of rat medial prefronto-cortical neurons, whereas buspirone, in a dose range of 0.1-1000 micrograms/kg, increased it. 1996-03-15 2023-08-12 rat
J M Monti, H Jantos, R Silveira, M Reyes-Parada, C Scorz. Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Pharmacology, biochemistry, and behavior. vol 52. issue 2. 1996-03-11. PMID:8577795. the effects of partial 5-ht1a receptor agonists buspirone (0.010-4.0 mg/kg), ipsapirone (0.010-6.0 mg/kg), and gepirone (0.025-4.0 mg/kg) on sleep and waking were studied in vehicle-treated and 5,7-dihydroxytryptamine (5,7-dht)-injected rats. 1996-03-11 2023-08-12 rat
J M Monti, H Jantos, R Silveira, M Reyes-Parada, C Scorz. Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Pharmacology, biochemistry, and behavior. vol 52. issue 2. 1996-03-11. PMID:8577795. (-)-pindolol failed to reverse the effects of ipsapirone on sleep and w. the present results tend to indicate that increased w after acute administration of buspirone, ipsapirone, or gepirone depends upon the activation of postsynaptic 5-ht1a receptors. 1996-03-11 2023-08-12 rat
C Torres, A Morales, A Cándido, A Maldonad. Differential effect of buspirone and diazepam on negative contrast in one-way avoidance learning. European journal of pharmacology. vol 280. issue 3. 1996-03-07. PMID:8566095. the main aim of the present work was to investigate the effect of buspirone, a 5-ht1a receptor agonist, on successive negative contrast in one-way avoidance learning. 1996-03-07 2023-08-12 rat
E Przegaliński, E Moryl, M Pap. The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570028. antidepressant properties of 5-ht1a receptor ligands (the full agonist 8-oh-dpat, the partial agonists ipsapirone and buspirone, and the selective antagonist way 100135) were studied in a chronic mild stress model of depression. 1996-03-04 2023-08-12 rat
R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. in contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-oh-dpat, 5-ht1a agonist), buspirone hydrochloride (5-ht1a agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (cgs 12066b, 5-ht1b agonist), ketanserin tartrate (5-ht2 antagonist), methysergide maleate (5-ht2 antagonist), fluoxetine (5-ht uptake blocker), and saline (vehicle). 1996-02-20 2023-08-12 rat