Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. |
in contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-oh-dpat, 5-ht1a agonist), buspirone hydrochloride (5-ht1a agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (cgs 12066b, 5-ht1b agonist), ketanserin tartrate (5-ht2 antagonist), methysergide maleate (5-ht2 antagonist), fluoxetine (5-ht uptake blocker), and saline (vehicle). |
1996-02-20 |
2023-08-12 |
rat |
S P Jaw, T Dang, D D Truon. Chronic treatments with 5-HT1A agonists attenuate posthypoxic myoclonus in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 3. 1996-02-14. PMID:8545477. |
single injections of 5-ht1a agonists, buspirone (5 and 10 mg/kg body wt.) |
1996-02-14 |
2023-08-12 |
rat |
M J Detke, M Rickels, I Luck. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology. vol 121. issue 1. 1996-02-07. PMID:8539342. |
the 5-ht1a receptor agonists 8-oh-dpat and gepirone also selectively increased swimming. |
1996-02-07 |
2023-08-12 |
rat |
B K Koe, L A Lebe. Effects of serotoninergic agents on downregulation of beta-adrenoceptors by the selective serotonin reuptake inhibitor sertraline. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 2. 1996-02-06. PMID:8540763. |
in a similar manner, the 5-ht1a agonists, gepirone and 8-oh-dpat, were found to facilitate the downregulation of beta-adrenoceptors induced by sertraline. |
1996-02-06 |
2023-08-12 |
rat |
C Sánche. Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box. Pharmacology & toxicology. vol 77. issue 1. 1996-01-29. PMID:8532615. |
the partial 5-ht1a receptor agonists, buspirone and ipsapirone showed anxiolytic-like effects in a limited dose interval. |
1996-01-29 |
2023-08-12 |
mouse |
H Chen, L Zhang, D R Rubinow, D M Chuan. Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus. Brain research. Molecular brain research. vol 32. issue 2. 1996-01-18. PMID:7500848. |
chronic buspirone treatment differentially regulates 5-ht1a and 5-ht2a receptor mrna and binding sites in various regions of the rat hippocampus. |
1996-01-18 |
2023-08-12 |
rat |
H Chen, L Zhang, D R Rubinow, D M Chuan. Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus. Brain research. Molecular brain research. vol 32. issue 2. 1996-01-18. PMID:7500848. |
after buspirone treatment, the 5-ht1a receptor mrna levels were significantly decreased in the ca1 and ca2 of the hippocampus, but were markedly increased in the dentate gyrus (dg), ca3 and ca4. |
1996-01-18 |
2023-08-12 |
rat |
H Chen, L Zhang, D R Rubinow, D M Chuan. Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus. Brain research. Molecular brain research. vol 32. issue 2. 1996-01-18. PMID:7500848. |
these results demonstrate that chronic buspirone treatment differentially regulates 5-ht1a and 5-ht2a receptor mrna as well as their expressed binding sites in various regions of the hippocampus. |
1996-01-18 |
2023-08-12 |
rat |
M Suzuki, T Matsuda, S Asano, P Somboonthum, K Takuma, A Bab. Increase of noradrenaline release in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine1A receptor activation. British journal of pharmacology. vol 115. issue 4. 1995-11-30. PMID:7582494. |
the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.2 mg kg-1) and buspirone (3 mg kg-1) mimicked the effect of mkc-242 in increasing na release in the hypothalamus. |
1995-11-30 |
2023-08-12 |
rat |
U Freo, P Pietrini, G Pizzolato, M Furey-Kurkjian, A Merico, S Ruggero, M Dam, L Battisti. Dose-dependent effects of buspirone on behavior and cerebral glucose metabolism in rats. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552245. |
these were the only rcmrglc effects buspirone had in common with the potent 5-ht1a agonist dpat and suggest that low dose buspirone activates preferentially 5-ht1a receptors. |
1995-11-14 |
2023-08-12 |
rat |
U Freo, P Pietrini, G Pizzolato, M Furey-Kurkjian, A Merico, S Ruggero, M Dam, L Battisti. Dose-dependent effects of buspirone on behavior and cerebral glucose metabolism in rats. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552245. |
the topographic distribution and direction of rcmrglc changes by high doses of buspirone differ from those produced by the 5-ht1a agonist dpat. |
1995-11-14 |
2023-08-12 |
rat |
T Jaros, W Kolasiewic. Attenuation of the fentanyl-induced muscle rigidity by the selective 5HT1A agonist 8-OH-DPAT. Polish journal of pharmacology. vol 47. issue 1. 1995-11-09. PMID:7550544. |
these results seem to be clinically important in case other 5ht1a agonists, buspirone or gepirone (potent anxiolytics), also prevented fentanyl-induced muscle rigidity in humans. |
1995-11-09 |
2023-08-12 |
rat |
A B Alfieri, L X Cubedd. Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients. British journal of cancer. vol 72. issue 4. 1995-11-08. PMID:7547213. |
buspirone, an agonist of the 5-ht1a subtype of serotonin receptors, has shown antiemetic activity in animal models. |
1995-11-08 |
2023-08-12 |
Not clear |
M Freire-Garabal, M J Nů nez-Iglesias, J L Balboa, J C Fernåndez-Rial, M Rey-Mende. Effects of buspirone on the immune response to stress in mice. Pharmacology, biochemistry, and behavior. vol 51. issue 4. 1995-10-19. PMID:7675864. |
several experiments were conducted to evaluate the effects of buspirone, a selective 5-hydroxytryptamine-1a (5-ht1a) anxiolytic, on the immune system of mice exposed to a chronic auditory stressor. |
1995-10-19 |
2023-08-12 |
mouse |
M J Detke, S Wieland, I Luck. Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists. Psychopharmacology. vol 119. issue 1. 1995-10-19. PMID:7675949. |
blockade of the antidepressant-like effects of 8-oh-dpat, buspirone and desipramine in the rat forced swim test by 5ht1a receptor antagonists. |
1995-10-19 |
2023-08-12 |
rat |
M J Detke, S Wieland, I Luck. Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists. Psychopharmacology. vol 119. issue 1. 1995-10-19. PMID:7675949. |
the 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) and buspirone decreased immobility in the fst. |
1995-10-19 |
2023-08-12 |
rat |
R Schreiber, M Brocco, B L de Ladonchamps, M J Milla. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667330. |
in contrast, the arylpiperazine 5-ht1a receptor agonists, ly 165,163 and tandospirone, increased punished responding only at higher doses (med: 0.16 and 0.63 mg/kg, respectively), and also with a lesser maximal effect (2065% and 3695%, respectively). |
1995-10-11 |
2023-08-12 |
pigeon |
R Schreiber, M Brocco, B L de Ladonchamps, M J Milla. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667330. |
further, a correlation analysis across each of the above agonists, as well as 8-oh-dpat, buspirone, and (+)-flesinoxan, revealed a significant correlation for their relative potency in augmenting punished responding and their affinity for 5-ht1a receptors in vitro (r = +0.95, p < 0.001). |
1995-10-11 |
2023-08-12 |
pigeon |
G Griebel, D C Blanchard, A Jung, C K Masuda, R J Blanchar. 5-HT1A agonists modulate mouse antipredator defensive behavior differently from the 5-HT2A antagonist pirenperone. Pharmacology, biochemistry, and behavior. vol 51. issue 2-3. 1995-10-11. PMID:7667334. |
the present study evaluated the ability of 8-oh-dpat (0.05-10 mg/kg, sc, 5) and gepirone (2.5-10 mg/kg, ip, 30), a full- and a partial agonist at 5-ht1a sites, as well as pirenperone (0.25-1 mg/kg, ip, 30), a preferential 5-ht2a receptor antagonist, to exert an anxiolytic-like action in the mdtb. |
1995-10-11 |
2023-08-12 |
mouse |
T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
we investigated the acute effects of 5-hydroxytryptamine (5-ht), and of the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), buspirone and sr 57746a, on rat faecal pellet output and water content. |
1995-09-26 |
2023-08-12 |
rat |