| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
5-ht, 8-oh-dpat, buspirone and sr 57746a, a new selective 5-ht1a receptor agonist, displaced [3h]-8-oh-dpat from specific binding sites in rat hippocampus membranes (ki, nm; 1.8, 1.2, 15, 3.1 respectively) and stimulated rat defaecation dose-dependently. |
1995-09-26 |
2023-08-12 |
rat |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
the putative 5-ht1a receptor antagonist, pindolol, injected s.c. or i.c.v., significantly reduced the defaecation induced by systemically administered 8-oh-dpat, buspirone or sr 57746a, but not 5-ht. |
1995-09-26 |
2023-08-12 |
rat |
| M Suzuki, T Matsuda, P Somboonthum, S Asano, K Takuma, H Nogi, A Bab. Effects of serotonin1A agonists on anoxia-induced impairment of protein synthesis in rat brain slices. Japanese journal of pharmacology. vol 67. issue 4. 1995-09-26. PMID:7650876. |
the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino) tetralin (10-100 microm) and buspirone (50 microm) attenuated the anoxia-induced decrease in protein synthesis in the slices. |
1995-09-26 |
2023-08-12 |
rat |
| J G Pires, S R Silva, H A Futuro-Net. 5-HT2 receptor blockade by ICI 170,809 does not affect the inhibitory effect of the 5-HT1A receptor ligand gepirone on neuroleptic-induced catalepsy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 27. issue 10. 1995-09-21. PMID:7640635. |
5-ht2 receptor blockade by ici 170,809 does not affect the inhibitory effect of the 5-ht1a receptor ligand gepirone on neuroleptic-induced catalepsy. |
1995-09-21 |
2023-08-12 |
rat |
| I Berlin, S Chalon, C Payan, G Schöllnhammer, F Cesselin, O Varoquaux, A J Puec. Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine. British journal of clinical pharmacology. vol 39. issue 3. 1995-08-28. PMID:7619663. |
because the 5-ht1a agonist anxiolytic azapirones have a common alpha 2-adrenoceptor antagonist metabolite, 1-(2-pyrimidinyl)-piperazine (1pp), we measured central and peripheral alpha 2-adrenoceptor dependent responses before and after intravenous administration of 0.15 mg clonidine when healthy subjects were taking buspirone (30 mg day-1 for 4 days and 10 mg on day 5), ipsapirone (15 mg day-1 for 4 days and 5 mg on day 5) or placebo. |
1995-08-28 |
2023-08-12 |
human |
| Y Wada, J Shiraishi, M Nakamura, H Hasegaw. Prolonged but not acute fluoxetine administration produces its inhibitory effect on hippocampal seizures in rats. Psychopharmacology. vol 118. issue 3. 1995-08-23. PMID:7617823. |
the fluoxetine effect on hip seizures was also assessed following long-term treatment with gepirone, a 5-ht1a receptor agonist. |
1995-08-23 |
2023-08-12 |
rat |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
1-(2-methoxyphenyl)-4-[(phthalimido)butyl] piperazine (nan-190) and 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5] decane-7,9-dione (buspirone) are 5-ht1a receptor partial agonists which decrease 5-hydroxytryptamine (5-ht) release in vivo. |
1995-08-10 |
2023-08-12 |
Not clear |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
these data demonstrate that buspirone is an agonist at the somatodendritic 5-ht1a receptor but that the inhibitory effects of nan-190 on 5-ht release may be mediated via a mechanism other than, or in addition to, 5-ht1a receptor agonism. |
1995-08-10 |
2023-08-12 |
Not clear |
| L Pan, F Gilber. Activation of 5-HT1A receptor subtype in the paraventricular nuclei of the hypothalamus induces CRH and ACTH release in the rat. Neuroendocrinology. vol 56. issue 6. 1995-07-20. PMID:1369587. |
similar responses were observed when two other 5-ht1a agonists, busipirone and gepirone, were used. |
1995-07-20 |
2023-08-11 |
rat |
| I S Ebenezer, J Brooma. Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats. Methods and findings in experimental and clinical pharmacology. vol 16. issue 8. 1995-06-26. PMID:7760584. |
pretreatment with the 5-ht1a receptor agonists 8-oh-dpat or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (cck) on food intake in rats. |
1995-06-26 |
2023-08-12 |
rat |
| I S Ebenezer, J Brooma. Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats. Methods and findings in experimental and clinical pharmacology. vol 16. issue 8. 1995-06-26. PMID:7760584. |
in order to investigate whether the inhibitory effect of systemically administered cholecystokinin (cck) on food intake is dependent on an interaction with central 5-hydroxytryptamine (5-ht) processes, we examined the effects of pretreating rats that were deprived of food for various periods of time (22 h in experiments 1 and 3, 3 h in experiment 2, and 1 h in experiment 4) with the 5-ht1a receptor agonists, 8-oh-dpat or gepirone, on the suppression of feeding induced by intraperitoneal cck. |
1995-06-26 |
2023-08-12 |
rat |
| X O Zhu, N McNaughto. The interaction of serotonin depletion with anxiolytics and antidepressants on reticular-elicited hippocampal RSA. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7760982. |
the present experiments tested the possibility that buspirone, chlordiazepoxide and imipramine reduce rsa frequency via 5-ht1a autoreceptors. |
1995-06-26 |
2023-08-12 |
rat |
| X O Zhu, N McNaughto. The interaction of serotonin depletion with anxiolytics and antidepressants on reticular-elicited hippocampal RSA. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7760982. |
these data suggest that: (1) buspirone obtains its frequency-reducing effects via pre- or post-synaptic 5-ht1a receptors rather than 5-ht1a autoreceptors; (2) chlordiazepoxide obtains its frequency-reducing effect via benzodiazepine receptors and gaba with no direct or indirect involvement of 5-ht systems; and (3) imipramine obtains its frequency-reducing effect by increasing the availability of 5-ht at 5-ht1a receptors which are not autoreceptors. |
1995-06-26 |
2023-08-12 |
rat |
| C A Naranjo, K E Bremne. Clinical pharmacology of serotonin-altering medications for decreasing alcohol consumption. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748304. |
for example, buspirone, a 5-ht1a receptor partial agonist, reduced anxiety and alcohol craving, but not ac; a 5-ht partial agonist, m-cpp, increased alcohol craving in abstinent alcoholics; modest reductions in ac were observed with a 5-ht3 antagonist, ondansetron (0.5 mg/day, but not 4 mg/day). |
1995-06-22 |
2023-08-12 |
rat |
| S E File, N Andrews, M al-Farhan, P Y W. The role of 5-HT in the anxiogenic effects of acute ethanol withdrawal and in the long-lasting cognitive deficits. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748345. |
the anxiogenic behaviour observed 12 h after ethanol withdrawal was inhibited by the 5-ht1a partial agonist, buspirone (200 micrograms/kg s.c.), indicating that the increased 5-ht release might underlie the anxiogenic response. |
1995-06-22 |
2023-08-12 |
rat |
| I Artaiz, G Romero, A Zazpe, A Monge, J M Calderó, J Roca, B Lasheras, J Del Rí. The pharmacology of VA21B7: an atypical 5-HT3 receptor antagonist with anxiolytic-like properties in animal models. Psychopharmacology. vol 117. issue 2. 1995-06-22. PMID:7753959. |
va21b7 was compared with standard 5-ht3 receptor antagonists such as ondansetron, tropisetron and granisetron, with the 5-ht1a agent buspirone and with diazepam. |
1995-06-22 |
2023-08-12 |
mouse |
| Z Chilmonczyk, A Leś, A Woźniakowska, J Cybulski, A E Kozioł, M Gdanie. Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues. Journal of medicinal chemistry. vol 38. issue 10. 1995-06-21. PMID:7752194. |
buspirone analogues as ligands of the 5-ht1a receptor. |
1995-06-21 |
2023-08-12 |
Not clear |
| Z Chilmonczyk, A Leś, A Woźniakowska, J Cybulski, A E Kozioł, M Gdanie. Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues. Journal of medicinal chemistry. vol 38. issue 10. 1995-06-21. PMID:7752194. |
an interdisciplinary (x-ray, 1h and 13c nmr, ir, and theoretical quantum mechanical) study on the potent 5-ht1a receptor ligand buspirone (1) and its two structural analogues, mesmar (4,4-dimethyl-1-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-2,6- piperidinedione) (2) and kaspar (8-[4-[4-(2-quinolinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane - 7,9-dione) (3), has been reported. |
1995-06-21 |
2023-08-12 |
Not clear |
| H E Molewijk, A M van der Poel, J Mos, J A van der Heyden, B Olivie. Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs. Psychopharmacology. vol 117. issue 1. 1995-05-25. PMID:7724700. |
the triazolobenzodiazepine alprazolam, the 5-ht uptake inhibitors fluvoxamine and clomipramine, the mixed 5-ht/na uptake inhibitor imipramine, the full 5-ht1a receptor agonists 8-oh-dpat and flesinoxan, the partial 5-ht1a receptor agonists buspirone, ipsapirone and bmy 7378, the alpha 2-adrenoceptor agonist clonidine and the alpha 2-adrenoceptor antagonist yohimbine reduced conditioned usv. |
1995-05-25 |
2023-08-12 |
rat |
| T Shimada, K Matsumoto, M Osanai, H Matsuda, K Terasawa, H Watanab. The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs. General pharmacology. vol 26. issue 1. 1995-05-18. PMID:7713361. |
buspirone, a partial 5-ht1a receptor agonist, produced parameter changes similar to those induced by anxiolytic benzodiazepines. |
1995-05-18 |
2023-08-12 |
mouse |