| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Schreiber, M Brocco, V Audinot, A Gobert, S Veiga, M J Milla. (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. The Journal of pharmacology and experimental therapeutics. vol 273. issue 1. 1995-05-17. PMID:7714755. |
the 5-ht1a agonists, s 14671, s 14506, 8-hydroxy-2-(di-n-propylamino)tetralin, buspirone, ipsapirone and (+)-flesinoxan, abolished htw. |
1995-05-17 |
2023-08-12 |
rat |
| S P Hume, S Ashworth, J Opacka-Juffry, R G Ahier, A A Lammertsma, V W Pike, I A Cliffe, A Fletcher, A C Whit. Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain. European journal of pharmacology. vol 271. issue 2-3. 1995-05-09. PMID:7705452. |
substantial (77%) blockade of [3h]way-100635 binding was achieved with the 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), and the partial agonists, ipsapirone and buspirone. |
1995-05-09 |
2023-08-12 |
rat |
| J Turło, T Zawadowski, S Rump, I Jakowicz, T Gidyńska, E Gałeck. Synthesis and pharmacological screening of some N,N'-bis-[4-(4-aryl-1-piperazinyl)butyl]-substituted derivatives of 1,8-dimethylbicyclo-[2.2.2]oct-7-ene-2,3,5,6-tetracarboxydiimide. Polish journal of pharmacology. vol 46. issue 5. 1995-04-24. PMID:7894533. |
the 5-ht1a receptor affinities of tested compounds are comparable with that of buspirone. |
1995-04-24 |
2023-08-12 |
Not clear |
| C Sánchez, J Arnt, J Hyttel, E K Moltze. The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870899. |
5-ht1a agonists (bay r 1531, 8-ohdpat, flesinoxan, gepirone, 5meo dmt, buspirone, ipsapirone, bmy 14802) completely inhibit the aggressive behaviour irrespective of their intrinsic activities. |
1995-03-29 |
2023-08-12 |
mouse |
| H J Rijnders, J L Slange. The discriminative stimulus properties of buspirone involve dopamine-2 receptor antagonist activity. Psychopharmacology. vol 111. issue 1. 1995-03-29. PMID:7870934. |
mediation of the buspirone cue by 5-ht1a receptor activation seemed predominant. |
1995-03-29 |
2023-08-12 |
rat |
| H J Rijnders, J L Slange. The discriminative stimulus properties of buspirone involve dopamine-2 receptor antagonist activity. Psychopharmacology. vol 111. issue 1. 1995-03-29. PMID:7870934. |
a model was proposed suggesting a compound discriminative stimulus complex of buspirone with a dominant 5-ht1a component that overshadows a less pronounced d2 component. |
1995-03-29 |
2023-08-12 |
rat |
| M E Bronson, Y P Lin, K Burchett, M J Picker, L A Dykstr. Serotonin involvement in the discriminative stimulus effects of kappa opioids in pigeons. Psychopharmacology. vol 111. issue 1. 1995-03-29. PMID:7870936. |
buspirone (0.01-10 mg/kg), a 5ht1a partial agonist, also attenuated the discriminative stimulus effects of the training dose of u50,488 but ipsapirone, another 5ht1a partial agonist, did not. |
1995-03-29 |
2023-08-12 |
Not clear |
| N Andrews, S E Fil. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871006. |
other drugs that reduce 5-ht function (tianeptine which increases 5-ht uptake; buspirone, a 5-ht1a receptor agonist/partial agonist; zacopride, a 5-ht3 receptor antagonist) also reversed this anxiogenic response. |
1995-03-29 |
2023-08-12 |
rat |
| K Ensler, C N Ryan, J L Evende. Effects of repeated treatment with 5-HT1A agonists on active avoidance responding in the rat. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871009. |
buspirone, the 5-ht1a partial agonist/dopamine d2 antagonist, markedly decreased activity, and thus avoidance of the shocks, in a manner similar to the antipsychotic drug, haloperidol. |
1995-03-29 |
2023-08-12 |
rat |
| K Ensler, C N Ryan, J L Evende. Effects of repeated treatment with 5-HT1A agonists on active avoidance responding in the rat. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871009. |
with the exception of buspirone, the effectiveness of these compounds in increasing activity in the car test appears to be related to their agonist efficacy at the 5-ht1a receptor. |
1995-03-29 |
2023-08-12 |
rat |
| C N Ryan, J L Evenden, M Petterso. Effects of buspirone and ipsapirone on schedule induced polydipsia: comparison with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and raclopride. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871008. |
because buspirone is known to block dopamine receptors and both buspirone and ipsapirone act as agonists at the 5-ht1a receptor, their effects on polydipsia were compared to raclopride, an antagonist at d2 receptors, and 8-oh-dpat, an agonist at the 5-ht1a receptor, thus providing information about the relative importance of the serotonergic and/or dopaminergic systems for the maintenance of polydipsia. |
1995-03-29 |
2023-08-12 |
Not clear |
| K E Vanover, J E Barret. Evaluation of the discriminative stimulus effects of the novel sedative-hypnotic CL 284,846. Psychopharmacology. vol 115. issue 3. 1995-03-24. PMID:7871067. |
the 5-ht1a agonist buspirone (1.0-10.0 mg/kg) and the barbiturate pentobarbital (3.0-17.0 mg/kg) failed to substitute for cl 284,846 up to rate-decreasing doses. |
1995-03-24 |
2023-08-12 |
rat |
| H C Dringenberg, R A Kornelsen, C H Vanderwol. Food carrying in rats is blocked by the putative anxiolytic agent buspirone. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862731. |
buspirone appears to exert its effects through 5-ht1a and/or dopamine receptors, whereas diazepam interacts with benzodiazepine receptors. |
1995-03-22 |
2023-08-12 |
rat |
| A J Farré, M Colombo, I Alvarez, G B Glavi. Some novel 5-hydroxytryptamine1A (5-HT1A) receptor agonists reduce gastric acid and pepsin secretion, reduce experimental gastric mucosal injury and enhance gastric mucus in rats. The Journal of pharmacology and experimental therapeutics. vol 272. issue 2. 1995-03-15. PMID:7853201. |
the antisecretory and gastroprotective actions of e4414 and e4424 were of significantly greater magnitude than those of the reference 5-ht1a agonists, buspirone and 8-hydroxy-2-(di-n- propylamino)tetralin. |
1995-03-15 |
2023-08-12 |
rat |
| M Riad, M B Emerit, M Hamo. Neurotrophic effects of ipsapirone and other 5-HT1A receptor agonists on septal cholinergic neurons in culture. Brain research. Developmental brain research. vol 82. issue 1-2. 1995-03-09. PMID:7842512. |
repeated treatment of primary cultures of fetal rat septal neurons with 5-ht1a receptor agonists (8-oh-dpat, ipsapirone, gepirone and buspirone) increased choline acetyltransferase activity after 6-7 days in culture. |
1995-03-09 |
2023-08-12 |
rat |
| J A Vivian, W J Farrell, S B Sapperstein, K A Micze. Diazepam withdrawal: effects of diazepam and gepirone on acoustic startle-induced 22 kHz ultrasonic vocalizations. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846191. |
three experiments evaluated the association between usv and "distress" by comparing the effects of diazepam as a prototypic benzodiazepine agonist and the putative anxiolytic gepirone with affinity for 5-hydroxytryptamine (5-ht1a) receptors in naive and diazepam-withdrawn subjects. |
1995-03-08 |
2023-08-12 |
human |
| J B Richards, K E Sabol, T H Hand, D C Jolly, G J Marek, L S Seide. Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846206. |
disruption of the irt distribution by buspirone, gepirone, ipsapirone and zalospirone may result from decreased 5-ht transmission mediated by the presynaptic, somatodendritic 5-ht1a receptor. |
1995-03-08 |
2023-08-12 |
Not clear |
| E Przegaliński, E Tatarczyńska, A Kłodzińska, E Chojnacka-Wójci. The role of postsynaptic 5-HT1A receptors in the anticonflict effect of ipsapirone. Neuropharmacology. vol 33. issue 9. 1995-02-27. PMID:7838324. |
in addition, a comparison of the effect of ipsapirone with the effect of other 5-ht1a receptor ligands (busipone, gepirone and 8-oh-dpat) has been carried out. |
1995-02-27 |
2023-08-12 |
rat |
| J C Cole, R J Rodger. Ethological evaluation of the effects of acute and chronic buspirone treatment in the murine elevated plus-maze test: comparison with haloperidol. Psychopharmacology. vol 114. issue 2. 1995-02-27. PMID:7838922. |
it is suggested that the anti-anxiety and behavioural suppressant profile of buspirone may reflect combined action at 5-ht1a and d2 receptors, respectively. |
1995-02-27 |
2023-08-12 |
mouse |
| A H Young, A L Sharpley, G M Campling, R A Hockney, P J Cowe. Effects of hydrocortisone on brain 5-HT function and sleep. Journal of affective disorders. vol 32. issue 2. 1995-02-23. PMID:7829766. |
the effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-ht1a receptors in healthy volunteers were studied using a buspirone challenge paradigm. |
1995-02-23 |
2023-08-12 |
human |