All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
T R Norman, M Apostolopoulos, G D Burrows, F K Jud. Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder. International clinical psychopharmacology. vol 9. issue 2. 1994-09-15. PMID:8056999. the limitations of buspirone as a specific agonist challenge of the 5-ht1a receptor are discussed. 1994-09-15 2023-08-12 Not clear
H Kuribar. Effects of SUN 8399, a potent and selective 5-HT1A agonist, on conflict behavior and ambulatory activity in mice: comparison with those of buspirone, tandospirone and diazepam. Japanese journal of pharmacology. vol 64. issue 4. 1994-09-14. PMID:8057528. effects of sun 8399, a potent and selective 5-ht1a agonist, on conflict behavior and ambulatory activity in mice: comparison with those of buspirone, tandospirone and diazepam. 1994-09-14 2023-08-12 mouse
H Kuribar. Effects of SUN 8399, a potent and selective 5-HT1A agonist, on conflict behavior and ambulatory activity in mice: comparison with those of buspirone, tandospirone and diazepam. Japanese journal of pharmacology. vol 64. issue 4. 1994-09-14. PMID:8057528. administration of sun 8399, a selective 5-ht1a agonist, on the operant behavior under a mult vi 1.5 min/fr 5-punishment schedule of food reinforcement and on the ambulatory activity were evaluated in mice, and the characteristics were compared with those of other 5-ht1a agonists, buspirone and tandospirone, and the benzodiazepine diazepam. 1994-09-14 2023-08-12 mouse
Y Mizuki, M Suetsugi, I Ushijima, M Yamad. Characteristics of the anxiolytic effects of buspirone in high- and low-anxious normal humans assessed by frontal midline theta activity. Methods and findings in experimental and clinical pharmacology. vol 16. issue 4. 1994-09-02. PMID:7519702. these results suggest that anxiety in the fmtheta group is mainly correlated with 5-ht1a receptor function, and that buspirone may have anxiolytic effects in patients with reactive anxiety but not those with endogenous anxiety. 1994-09-02 2023-08-12 human
J M Johns, M J Means, E W Bass, L W Means, L I Zimmerman, B A McMille. Prenatal exposure to cocaine: effects on aggression in Sprague-Dawley rats. Developmental psychobiology. vol 27. issue 4. 1994-08-16. PMID:7913451. subjects received a s.c. saline injection before session 1 and 2.0 mg/kg of gepirone, a 5ht1a partial agonist, prior to session 2. 1994-08-16 2023-08-12 human
P A Scott, J M Chou, H Tang, A Fraze. Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:8035316. the effects of three chemically dissimilar 5-ht1a agonists administered s.c. [8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), gepirone, and (+)4-[n-5-(methoxychroman-3-yl)n-propylamino]butyl-8-azaspiro++ +[4,5] decane-7,adione ((+) s-20499)] on both of these responses were studied. 1994-08-15 2023-08-12 rat
C A Naranjo, K E Bremne. Serotonin-altering medications and desire, consumption and effects of alcohol-treatment implications. EXS. vol 71. 1994-08-12. PMID:8032152. for example, buspirone, a 5-ht1a receptor partial agonist, reduced anxiety and alcohol craving, but not ac; a 5-ht partial agonist, m-cpp, increased craving in abstinent alcoholics; modest reductions in ac were observed with a 5-ht3 antagonist, ondansetron (0.5 mg/day, but not 4 mg/day). 1994-08-12 2023-08-12 human
D Charrier, L Dangoumau, M Hamon, A J Puech, M H Thiébo. Effects of 5-HT1A receptor ligands on a safety signal withdrawal procedure of conflict in the rat. Pharmacology, biochemistry, and behavior. vol 48. issue 1. 1994-08-10. PMID:7913228. the 5-ht1a receptor partial agonists buspirone (0.125-0.5 mg/kg) and 8-(2-[2,3-dihydro-1,4-benzodioxin-2-yl- methylamino]ethyl)-8-azaspiro[4,5]decane-7,9-dione methyl sulfonate (mdl 73005ef; 0.5-2 mg/kg) and the full agonist (+)-4-[n-(5-methoxy-chroman-3-yl)-n-propylamino]-butyl-8- azaspiro[4,5]decane-7,9-dione (s 20499; 0.125-1 mg/kg) produced a robust and dose-related release of pressing during the saf.cs-/pun.cs- period. 1994-08-10 2023-08-12 rat
D Charrier, L Dangoumau, M Hamon, A J Puech, M H Thiébo. Effects of 5-HT1A receptor ligands on a safety signal withdrawal procedure of conflict in the rat. Pharmacology, biochemistry, and behavior. vol 48. issue 1. 1994-08-10. PMID:7913228. the specific 5-ht1a antagonist (+)-n-tert-butyl-3-4-(2-methoxyphenyl)piperazin-1-yl-2-phenylpr opa namide [(+)-way 100135; 0.25-8 mg/kg] and the beta-adrenoceptor/5-ht1a antagonist (-)-tertatolol (2-8 mg/kg) did not modify the behavioral blockade, nor did (+)-way 100135 (2-4 mg/kg) reduce the ability of buspirone (0.25 mg/kg) to enhance responding during the saf.cs-/pun.cs- period. 1994-08-10 2023-08-12 rat
T Klint, G Andersso. Ultrasound vocalization is not related to corticosterone response in isolated rat pups. Pharmacology, biochemistry, and behavior. vol 47. issue 4. 1994-08-08. PMID:8029267. we suggest that the seemingly paradoxical effects of buspirone and 8-oh-dpat, that is, the decrease in usv and the concomitant increase in plasma cort, are due to the fact that these two drugs act as full agonists at both pre- and postsynaptic 5-ht1a receptors. 1994-08-08 2023-08-12 rat
H Y Meltzer, M Mae. Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects. Biological psychiatry. vol 35. issue 5. 1994-07-22. PMID:8011800. buspirone is another 5-ht1a agonist that increases cortisol secretion in man. 1994-07-22 2023-08-12 human
I S Ebenezer, R Tit. Sex difference in the feeding responses of non-deprived rats to the 5-HT1A agonists 8-OH-DPAT and gepirone. Methods and findings in experimental and clinical pharmacology. vol 16. issue 2. 1994-07-21. PMID:8007747. sex difference in the feeding responses of non-deprived rats to the 5-ht1a agonists 8-oh-dpat and gepirone. 1994-07-21 2023-08-12 rat
I S Ebenezer, R Tit. Sex difference in the feeding responses of non-deprived rats to the 5-HT1A agonists 8-OH-DPAT and gepirone. Methods and findings in experimental and clinical pharmacology. vol 16. issue 2. 1994-07-21. PMID:8007747. the aim of this study was to determine whether there was any difference in the feeding responses of male and female rats to the 5-ht1a agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) and gepirone. 1994-07-21 2023-08-12 rat
O Blomqvist, B Söderpalm, J A Enge. 5-HT1A receptor agonists reduce ethanol-induced locomotor activity in mice. Alcohol (Fayetteville, N.Y.). vol 11. issue 2. 1994-07-08. PMID:8204202. in the present study on mice, the 5-ht1a receptor agonists (8-oh-dpat), ipsapirone, and buspirone all antagonized the locomotor activity (lma) stimulatory effect of ethanol (2.5 g/kg). 1994-07-08 2023-08-12 mouse
P J Cowen, A C Power, C J Ware, I M Anderso. 5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. The British journal of psychiatry : the journal of mental science. vol 164. issue 3. 1994-07-07. PMID:8199791. the hypothermic, growth hormone and corticotrophin (acth) responses to the 5-ht1a receptor agonist buspirone (30 mg orally) were measured in 20 unmedicated patients with major depression and 20 healthy controls. 1994-07-07 2023-08-12 Not clear
P J Cowen, A C Power, C J Ware, I M Anderso. 5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. The British journal of psychiatry : the journal of mental science. vol 164. issue 3. 1994-07-07. PMID:8199791. within the limitations that attend the use of buspirone as a 5-ht1a probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-ht1a receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-ht1a receptors. 1994-07-07 2023-08-12 Not clear
J D Glass, M Selim, M A Re. Modulation of light-induced C-Fos expression in the suprachiasmatic nuclei by 5-HT1A receptor agonists. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199864. injection of the 5-ht1a receptor agonists, 8-oh-dpat or buspirone, 30 min before the light pulse significantly inhibited the photic expression of fos-li (maximal suppression 45.7 +/- 8.1 and 43.0 +/- 1.3%, respectively, both p < 0.01 vs. vehicle controls). 1994-07-07 2023-08-12 Not clear
Y Kitamura, T Nagatani, T Watanab. Buspirone enhances head twitch behavior in mice. European journal of pharmacology. vol 253. issue 3. 1994-07-05. PMID:8200425. we studied the effects of buspirone, a 5-ht1a receptor agonist, on head twitch behavior induced by 5-hydroxy-l-tryptophan (5-htp) administered together with pargyline in mice. 1994-07-05 2023-08-12 mouse
Y Kitamura, T Nagatani, T Watanab. Buspirone enhances head twitch behavior in mice. European journal of pharmacology. vol 253. issue 3. 1994-07-05. PMID:8200425. these findings suggest that the enhancing effect of buspirone on head twitch behavior may be exerted through the activation of post-synaptic 5-ht1a receptors. 1994-07-05 2023-08-12 mouse
S E File, N Andrew. Benzodiazepine withdrawal: behavioural pharmacology and neurochemical changes. Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910743. other treatments that reversed the anxiogenic response were the gabab agonist baclofen, the 5-ht1a receptor agonist buspirone, and the 5-ht3 receptor antagonist (r,s)-zacopride (gaba = gamma-aminobutyric acid; 5-ht = 5-hydroxytryptamine). 1994-06-23 2023-08-12 rat