| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E File, N Andrew. Benzodiazepine withdrawal: behavioural pharmacology and neurochemical changes. Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910743. |
other treatments that reversed the anxiogenic response were the gabab agonist baclofen, the 5-ht1a receptor agonist buspirone, and the 5-ht3 receptor antagonist (r,s)-zacopride (gaba = gamma-aminobutyric acid; 5-ht = 5-hydroxytryptamine). |
1994-06-23 |
2023-08-12 |
rat |
| A A Alhaider, A M Ageel, O T Ginaw. The quipazine- and TFMPP-increased conditioned avoidance response in rats: role of 5HT1C/5-HT2 receptors. Neuropharmacology. vol 32. issue 12. 1994-05-10. PMID:8152532. |
the 5-ht1a agonist, buspirone, significantly decreased acquisition of conditioned avoidance. |
1994-05-10 |
2023-08-12 |
rat |
| M F Piercey, A H Tang, R A Lahti, P F VonVoigtlander, P J Schreur, R B McCall, J T Lum-Ragan, W E Hoffmann, S R Franklin, R A Cod. Pharmacology of a mixed 5-hydroxytryptamine1A/dopamine agonist. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:7908053. |
in behavioral tests designed to measure anxiolytic activities, u-67413b was a slightly more effective anxiolytic than standard 5-ht1a anxiolytics (buspirone, gepirone and ipsapirone). |
1994-04-25 |
2023-08-12 |
mouse |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
the 5-ht1a receptor agonists buspirone, 8-hydroxy-n,n-dipropyl-2-aminotetralin, gepirone and ipsapirone were evaluated for their receptor binding profiles and their effects on firing rates of 5-ht, dopamine (da) and noradrenaline (na) neurons in the dorsal raphe, substantia nigra pars compacta and the locus ceruleus, respectively. |
1994-04-25 |
2023-08-12 |
Not clear |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
all agents also bound to dopamine d2 receptors but, with the exception of buspirone, affinities were usually much lower than for 5-ht1a receptors. |
1994-04-25 |
2023-08-12 |
Not clear |
| M Asberg, B Mårtensso. Serotonin selective antidepressant drugs: past, present, future. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131153. |
the availability of drugs that selectively affect the different 5-ht receptors, such as the partial 5-ht1a agonist gepirone, will presumably be helpful for modern studies of the "anatomy of melancholy." |
1994-04-21 |
2023-08-12 |
Not clear |
| A S Eison, M S Eiso. Serotonergic mechanisms in anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 1. 1994-03-31. PMID:8115673. |
the azapirones represent a new class of agent which possesses affinity for 5-ht1a receptors (partial agonists) and is active in anxiolytic animal models as well as in the clinic (buspirone) 4. |
1994-03-31 |
2023-08-12 |
Not clear |
| J Strosznajder, M Samochocki, M Dura. Aging diminishes serotonin-stimulated arachidonic acid uptake and cholinergic receptor-activated arachidonic acid release in rat brain cortex membrane. Journal of neurochemistry. vol 62. issue 3. 1994-03-28. PMID:8113791. |
serotonin (5-ht), at 10 microm to 1 mm in the presence of pargyline and the agonist of the 5-ht1a receptor, buspirone, stimulated aa uptake into membrane lipids, mainly into phosphatidylinositol, by about 40% exclusively in adult brain synaptoneurosomes. |
1994-03-28 |
2023-08-12 |
rat |
| H A Futuro-Neto, J G Pires, M P Gilbey, A G Ramag. Evidence for the ability of central 5-HT1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways of anesthetized rabbits with smoke. Brain research. vol 629. issue 2. 1994-03-25. PMID:8111640. |
cigarette smoke passed through the nasal cavity of atenolol pre-treated anesthetized spontaneously breathing rabbits caused a bradycardia which was significantly modified by intracisternal application of the 5-ht1a receptor ligands 8-oh-dpat (50 micrograms.kg-1) and buspirone (200 micrograms.kg-1). |
1994-03-25 |
2023-08-12 |
Not clear |
| M C Boadle-Biber, V B Singh, K C Corley, T H Phan, R P Dilt. Evidence that corticotropin-releasing factor within the extended amygdala mediates the activation of tryptophan hydroxylase produced by sound stress in the rat. Brain research. vol 628. issue 1-2. 1994-03-23. PMID:7508808. |
additionally, the 5-ht1a agonist, gepirone, given either systemically (10 mg/kg) or intracerebrally into the region of the dorsal raphe (14 micrograms), blocked the tryptophan hydroxylase response to crf. |
1994-03-23 |
2023-08-12 |
rat |
| F P Zemlan, A Z Murphy, M M Behbehan. 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons. Pharmacology. vol 48. issue 1. 1994-03-14. PMID:8309982. |
this hypothesis predicts that nociceptive dorsal horn units inhibited by nrm stimulation or iontophoretic 5-ht application would also be inhibited by iontophoresis of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone. |
1994-03-14 |
2023-08-12 |
rat |
| J G Pires, A G Ramage, S R Silva, H A Futuro-Net. Effects of the 5-HT receptor antagonists cyanopindolol, ICI 169,369, cisapride and granisetron on neuroleptic-induced catalepsy in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 26. issue 8. 1994-03-07. PMID:8298521. |
buspirone, a 5-ht1a partial antagonist, cisapride, a 5-ht3/5-ht4 ligand and clomipramine, a 5-ht neuronal uptake blocker, were also employed. |
1994-03-07 |
2023-08-12 |
mouse |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
neuronal circuits involved in the anxiolytic effects of the 5-ht1a receptor agonists 8-oh-dpat ipsapirone and buspirone in the rat. |
1994-02-24 |
2023-08-12 |
rat |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
in rats, the 5-ht1a receptor full agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the 5-ht1a receptor partial agonists ipsapirone and buspirone dose dependently and completely inhibited shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus, a brain region rich in somatodendritic 5-ht1a receptors. |
1994-02-24 |
2023-08-12 |
rat |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
or dorsal raphe nucleus) and 8-oh-dpat (dorsal raphe nucleus) retained their ability to inhibit ultrasonic vocalization and, in non-lesioned rats, bilateral injection of ipsapirone, buspirone and 8-oh-dpat into the dorsal hippocampus and the amygdala - two brain regions rich in postsynaptic 5-ht1a receptors - also inhibited ultrasonic vocalization. |
1994-02-24 |
2023-08-12 |
rat |
| R Schreiber, J De Vr. Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904566. |
it is suggested that both presynaptic and (possibly to a lesser extent) postsynaptic 5-ht1a receptors are involved in the anxiolytic effects of ipsapirone, buspirone, and 8-oh-dpat. |
1994-02-24 |
2023-08-12 |
rat |
| M I Damaj, R A Glennon, B R Marti. Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice. Brain research bulletin. vol 33. issue 2. 1994-02-10. PMID:8275340. |
in addition, 8-oh-dpat and buspirone, 5-ht1a agonists, had no significant effects on nicotine-induced hypomotility. |
1994-02-10 |
2023-08-12 |
mouse |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
acute administration of the 5-ht1a receptor agonists buspirone (0.1-5 mg/kg s.c.) and ipsapirone (0.03-3 mg/kg s.c.) caused a dose-dependent decrease in 5-ht output in ventral hippocampus of the chloral hydrate anaesthetized rat. |
1994-02-04 |
2023-08-12 |
rat |
| J G Pires, S R Silva, A G Ramage, H A Futuro-Net. Influence of median raphe nucleus lesions on neuroleptic-induced catalepsy and on the anticataleptic effect of buspirone. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 26. issue 3. 1994-01-19. PMID:7903058. |
for example, buspirone (bus) and other central 5-ht1a receptor ligands reduce neuroleptic-induced catalepsy (nic). |
1994-01-19 |
2023-08-12 |
rat |
| M Davi. Pharmacological analysis of fear-potentiated startle. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 26. issue 3. 1994-01-19. PMID:8257926. |
although the 5-ht1a agonist buspirone is especially effective in blocking fear-potentiated startle, more selective 5-ht1a agonists have been less consistently effective. |
1994-01-19 |
2023-08-12 |
rat |