| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Mendelson, D Quartermain, T Francisco, A Sheme. 5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism. European journal of pharmacology. vol 236. issue 2. 1993-08-05. PMID:8319749. |
the memory impairment by tandospirone was mimicked by the 5-ht1a receptor agonist 8-oh-dpat (8-hydroxy-dipropylaminotetralin hbr) and blocked by the 5-ht1a receptor antagonist bmy7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspirol-[4]- decane-7,9-dione). |
1993-08-05 |
2023-08-12 |
mouse |
| S D Mendelson, D Quartermain, T Francisco, A Sheme. 5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism. European journal of pharmacology. vol 236. issue 2. 1993-08-05. PMID:8319749. |
however, the anterograde amnestic effects of tandospirone and 8-oh-dpat were not affected by pcpa, and lack of interactions between pcpa and the 5-ht1a agonists revealed in the statistical analyses indicated that the effects of pcpa were not mediated by 5-ht1a receptors. |
1993-08-05 |
2023-08-12 |
mouse |
| T F Meer. Effects of various serotonergic agents on alcohol intake and alcohol preference in Wistar rats selected at two different levels of alcohol preference. Alcohol and alcoholism (Oxford, Oxfordshire). vol 28. issue 2. 1993-07-29. PMID:8517886. |
the 5-ht1a agent buspirone reduced alcohol intake and alcohol preference in the group of medium alcohol preferring rats at doses between 0.0025 and 0.63 mg/kg. |
1993-07-29 |
2023-08-12 |
rat |
| R A Rabin, J C Winte. Studies of the biochemical basis for the discriminative properties of 8-hydroxy-2-(di-n-propylamino)tetralin. European journal of pharmacology. vol 235. issue 2-3. 1993-07-13. PMID:8508905. |
although for nine compounds (flesinoxan, mdl 73005ef, gepirone, ipsapirone, buspirone, tandospirone, yohimbine, l 657,743 and rauwolscine) complete cross generalization was associated with high affinity for the 5-ht1a receptor, eltoprazine, d-lysergic acid diethylamide and bmy 7378 had pkd > 7.44, but did not show complete mimicry of 8-oh-dpat. |
1993-07-13 |
2023-08-12 |
Not clear |
| S Tokuyama, M Takahashi, H Kanet. Involvement of serotonergic receptor subtypes in the production of antinociception by psychological stress in mice. Japanese journal of pharmacology. vol 61. issue 3. 1993-06-03. PMID:8483301. |
pretreatment of mice with 2.0 to 10 mg/kg of methysergide, a 5-ht receptor antagonist, or 1.0 to 10 mg/kg of buspirone, a 5-ht1a receptor partial agonist, dose-dependently suppressed the production of psy-sia. |
1993-06-03 |
2023-08-12 |
mouse |
| D Quartermain, J Clemente, A Sheme. 5-HT1A agonists disrupt memory of fear conditioning in mice. Biological psychiatry. vol 33. issue 4. 1993-05-20. PMID:8471677. |
a series of experiments was carried out to analyze the effects of the 5-ht1a agonists tandospirone or buspirone on the retention of fear conditioning in mice. |
1993-05-20 |
2023-08-12 |
mouse |
| A A Alhaider, G L Wilco. Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:7682614. |
8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone, putative 5-ht1a agonists, m-trifluoromethylphenyl-piperazine (tfmpp) and 7-trifluoromethyl-4(4-methyl-1-piperazinyl)-pyrrolo(1,2-1a)quinoxaline (cgs 12066b), 5-ht1b agonists, and 5-carboxamidotryptamine (5-ct), a mixed 5-ht1a and 5ht1b agonist, were used. |
1993-05-18 |
2023-08-12 |
mouse |
| B S Neal-Beliveau, J N Joyce, I Luck. Serotonergic involvement in haloperidol-induced catalepsy. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8386235. |
the 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone potently and dose-dependently reversed hal-induced catalepsy. |
1993-05-18 |
2023-08-12 |
rat |
| G P Luscombe, K F Martin, L J Hutchins, J Gosden, D J Hea. Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:8467355. |
other selective 5-ht1a receptor ligands (0.3-30 mg kg-1, s.c.) either mimicked the 8-oh-dpat response (ipsapirone, at 10 and 30 mg kg-1, s.c.) or were inactive (buspirone and gepirone). |
1993-05-13 |
2023-08-12 |
mouse |
| M Gué, C Alary, C D Rio-Lacheze, J L Junien, L Buén. Comparative involvement of 5-HT1, 5-HT2 and 5-HT3 receptors in stress-induced colonic motor alterations in rats. European journal of pharmacology. vol 233. issue 2-3. 1993-05-11. PMID:8385621. |
injection of the 5-ht1a receptor agonists, buspirone (1 mg/kg) or 8-oh-dpat (8-hydroxy-2-(di-n-propylamino(tetralin) (0.05 and 0.1 mg/kg) or benzodiazepine (clonazepam, 1 mg/kg) significantly reduced or suppressed the emotional stress-induced increase of colonic spike bursts. |
1993-05-11 |
2023-08-12 |
rat |
| J C Pecknold, L Luthe, M H Scott-Fleury, S Jenkin. Gepirone and the treatment of panic disorder: an open study. Journal of clinical psychopharmacology. vol 13. issue 2. 1993-05-06. PMID:8096526. |
gepirone, an azapirone, is a potent 5-hydroxytryptamine 1a (5-ht1a) agonist. |
1993-05-06 |
2023-08-12 |
Not clear |
| M J Millan, J M Rivet, H Canton, S Le Marouille-Girardon, A Gober. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450471. |
in contrast, dih was fully mimicked by the novel 5-ht1a receptors agonists, eltoprazine, wy 48,723, mdl 72832, tandospirone, s 14671, s 14506 and wy 50,324, whereas the novel partial agonist, zalospirone, was less efficacious. |
1993-04-14 |
2023-08-12 |
rat |
| M J Millan, J M Rivet, H Canton, S Le Marouille-Girardon, A Gober. Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. The Journal of pharmacology and experimental therapeutics. vol 264. issue 3. 1993-04-14. PMID:8450471. |
at postsynaptic 5-ht1a receptors mediating hypothermia, eltoprazine, wy 48,723, mdl 72832 and tandospirone are agonists, zalospirone is a partial agonist and (-)-tertatolol, way 100,135, mdl 73005 ef and sdz 216-525 are antagonists. |
1993-04-14 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
because of the importance of fetal serotonin (5-ht) and 5-ht1a receptors for the normal development of 5-ht containing neurons, we initiated studies to determine whether administration of a 5-ht1a agonist, buspirone, to pregnant rats could overcome the adverse effects of in utero ethanol exposure on the developing serotonergic system in offspring. |
1993-04-12 |
2023-08-12 |
rat |
| J G Wettstein, E S Teeple, W H Mors. Combination of buspirone and other drugs with beta-CCE in monkeys: effects on respiration and behavior. Pharmacology, biochemistry, and behavior. vol 44. issue 3. 1993-04-12. PMID:8095725. |
the respiratory stimulant effects of beta-cce in both air and 5% co2 were enhanced by prior treatment with the 5-hydroxytryptamine1a (5-ht1a) partial agonist buspirone (0.03 and 0.3 mg/kg) and a weak bzr inverse agonist, sr 95195 (10.0 mg/kg). |
1993-04-12 |
2023-08-12 |
monkey |
| J G Wettstein, E S Teeple, W H Mors. Combination of buspirone and other drugs with beta-CCE in monkeys: effects on respiration and behavior. Pharmacology, biochemistry, and behavior. vol 44. issue 3. 1993-04-12. PMID:8095725. |
moreover, the findings suggest either that coactivation of benzodiazepine and 5-ht1a sites lead to a greater than additive effect or that beta-cce and buspirone share a common mechanism of action that is unrelated to the receptor at which bzr inverse agonists act. |
1993-04-12 |
2023-08-12 |
monkey |
| R J Blanchard, E B Yudko, D C Blanchard, H K Taukuli. High-frequency (35-70 kHz) ultrasonic vocalizations in rats confronted with anesthetized conspecifics: effects of gepirone, ethanol, and diazepam. Pharmacology, biochemistry, and behavior. vol 44. issue 2. 1993-04-07. PMID:8095340. |
in females, but not males, these calls were reduced in number by gepirone, 5-hydroxytryptamine1a (5-ht1a) agonist, at both 1.0- and 10.0-mg/kg doses and by diazepam, a benzodiazepine, at 3.0 but not 1.0 mg/kg. |
1993-04-07 |
2023-08-12 |
human |
| Y Fujiwara, H Tomita, M Hikiji, K Kashihara, S Otsuki, T Ohnuki, Y Hamagishi, T Oki, I Sora, W R Roesk. Characterization of a cloned rat serotonin 5-HT1A receptor expressed in the HeLa cell line. Life sciences. vol 52. issue 11. 1993-04-06. PMID:8095315. |
the specific binding was inhibited by selective 5-ht1a partial agonists, such as buspirone, ipsapirone, gepirone, tandospirone, zalospirone and sun8399 with ki values of 1-30nm, whereas other neurotropic drugs except for spiperone (ki = 46 nm) and nemonapride (ki = 2.3 nm) were effective only at concentrations of more than 100 microm. |
1993-04-06 |
2023-08-12 |
rat |
| W H Wang, T A Lovic. Inhibitory serotonergic effects on rostral ventrolateral medullary neurons. Pflugers Archiv : European journal of physiology. vol 422. issue 2. 1993-02-25. PMID:1336851. |
in rats anaesthetised with urethane, iontophoretic application of 5-hydroxytryptamine (5-ht) and the 5-ht1a agonists buspirone, flesinoxan and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited ongoing or amino-acid-evoked activity of neurons in the rostral ventrolateral medulla (rvlm) including barosensitive cells with spinally projecting axons. |
1993-02-25 |
2023-08-11 |
rat |
| Y Sugimoto, J Yamada, I Kimura, Y Watanabe, K Horisak. The effects of the serotonin1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats. Japanese journal of pharmacology. vol 60. issue 2. 1993-02-05. PMID:1479742. |
the effects of the serotonin1a (5-ht1a) receptor agonist buspirone on the plasma glucose and pancreatic hormones insulin and glucagon were investigated in rats. |
1993-02-05 |
2023-08-11 |
rat |