| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C W Mathes, E R Smith, B R Popa, J M Davidso. Effects of intrathecal and systemic administration of buspirone on genital reflexes and mating behavior in male rats. Pharmacology, biochemistry, and behavior. vol 36. issue 1. 1990-07-11. PMID:2349270. |
we conclude that buspirone affects sexual behavior very much like dpat or other 5-ht1a drugs, to the extent known. |
1990-07-11 |
2023-08-11 |
rat |
| F Chaouloff, V Baudrie, D Laud. Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. European journal of pharmacology. vol 177. issue 1-2. 1990-06-28. PMID:2340854. |
evidence that the 5-ht1a receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. |
1990-06-28 |
2023-08-11 |
rat |
| F Chaouloff, V Baudrie, D Laud. Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. European journal of pharmacology. vol 177. issue 1-2. 1990-06-28. PMID:2340854. |
the aim of this study was to investigate the effects of the 5-ht1a receptor agonists buspirone and ipsapirone (1-10 mg/kg) on plasma adrenaline (a) levels and on glycemia in the conscious rat. |
1990-06-28 |
2023-08-11 |
rat |
| P C Moser, M D Tricklebank, D N Middlemiss, A K Mir, M F Hibert, J R Fozar. Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:1970269. |
characterization of mdl 73005ef as a 5-ht1a selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-oh-dpat and diazepam. |
1990-05-30 |
2023-08-11 |
rat |
| P C Moser, M D Tricklebank, D N Middlemiss, A K Mir, M F Hibert, J R Fozar. Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam. British journal of pharmacology. vol 99. issue 2. 1990-05-30. PMID:1970269. |
the anti-conflict effects of mdl 73005ef were reversed by low doses of the 5-ht1a receptor agonist, 8-oh-dpat; those of buspirone were neither antagonised nor mimicked by 8-oh-dpat. |
1990-05-30 |
2023-08-11 |
rat |
| M J Millan, F C Colpaer. Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat. Neuropharmacology. vol 29. issue 3. 1990-05-24. PMID:2139188. |
the 5-ht1a partial agonists, buspirone, ipsapirone and gepirone did not affect the latency to respond in the tail flick test to heat. |
1990-05-24 |
2023-08-11 |
mouse |
| J Gonzalez-Heydrich, S J Peroutk. Serotonin receptor and reuptake sites: pharmacologic significance. The Journal of clinical psychiatry. vol 51 Suppl. 1990-05-11. PMID:2157701. |
the putative novel anxiolytic effects of 5-ht1a partial agonists such as buspirone, the unique and potent antiemetic effects of 5-ht3 antagonists in cancer chemotherapy, and the antidepressant effects of selective 5-ht uptake blockers such as fluoxetine are excellent examples of the clinical relevance of selective 5-ht receptor agents. |
1990-05-11 |
2023-08-11 |
human |
| I M Anderson, P J Cowen, D G Grahame-Smit. The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology. vol 100. issue 4. 1990-04-30. PMID:2157231. |
the effects of the selective 5-ht1a receptor agonist gepirone (10 and 20 mg orally) on neuroendocrine function and temperature were assessed using a single-blind cross-over design in 12 healthy male volunteers. |
1990-04-30 |
2023-08-11 |
human |
| I M Anderson, P J Cowen, D G Grahame-Smit. The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology. vol 100. issue 4. 1990-04-30. PMID:2157231. |
further investigations are needed to determine if the neuroendocrine and temperature effects of gepirone in humans are mediated by 5-ht1a receptors. |
1990-04-30 |
2023-08-11 |
human |
| A Hirose, R Tsuji, H Shimizu, T Tatsuno, H Tanaka, Y Kumasaka, M Nakamur. Inhibition by 8-hydroxy-2-(di-n-propylamino) tetralin and SM-3997, a novel anxiolytic drug, of the hippocampal rhythmical slow activity mediated by 5-hydroxytryptamine1A receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 341. issue 1-2. 1990-04-26. PMID:1969119. |
rsa was also inhibited by 5-ht1a related anxiolytics such as buspirone, gepirone, and ipsapirone. |
1990-04-26 |
2023-08-11 |
Not clear |
| E Meller, M Goldstein, K Bohmake. Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. Molecular pharmacology. vol 37. issue 2. 1990-03-21. PMID:1968223. |
rats were treated with vehicle or eedq (2 or 6 mg/kg) and 24 hr later dose-response curves were constructed for inhibition of 5-hydroxytrytophan (5-htp) accumulation (after decarboxylase inhibition with nsd-1015) by the selective 5-ht1a agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) (0.01-3 mg/kg), buspirone (0.1-7.5 mg/kg), and ipsapirone (0.1-6.25 mg/kg) and the 5-ht1a agonist/antagonist bmy 7378 (0.015-5 mg/kg). |
1990-03-21 |
2023-08-11 |
rat |
| J M Cossery, J M Mienville, P A Sheehy, A M Mellow, D M Chuan. Characterization of two distinct 5-HT receptors coupled to adenylate cyclase activation and ion current generation in NCB-20 cells. Neuroscience letters. vol 108. issue 1-2. 1990-03-19. PMID:1689472. |
putative 5-ht1a agonists (8-oh-dpat, ipsapirone, and buspirone) and 5-ht1b agonists (tfmpp and m-cpp) affected neither basal nor forskolin-dependent cyclic amp accumulation. |
1990-03-19 |
2023-08-11 |
Not clear |
| M J Millan, K Bervoets, F C Colpaer. Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. Neuroscience letters. vol 107. issue 1-3. 1990-03-14. PMID:2533334. |
ipsapirone and buspirone, partial 5-ht1a agonists, acted as antagonists. |
1990-03-14 |
2023-08-11 |
rat |
| R D Clark, K K Weinhardt, J Berger, L E Fisher, C M Brown, A C MacKinnon, A T Kilpatrick, M Speddin. 1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor. Journal of medicinal chemistry. vol 33. issue 2. 1990-03-09. PMID:2153822. |
several compounds displayed 5-ht1a receptor affinity comparable to, or greater than, the known 5-ht1a ligand buspirone. |
1990-03-09 |
2023-08-11 |
Not clear |
| R W Dunn, R Corbett, S Fieldin. Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze. European journal of pharmacology. vol 169. issue 1. 1990-02-06. PMID:2574684. |
indicative of anxiolytic effects the 5-ht1a agonists, buspirone, gepirone and 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) all significantly increased social interaction time and open arm exploration time in the social interaction and elevated plus maze procedures, respectively. |
1990-02-06 |
2023-08-11 |
Not clear |
| S A Welner, C De Montigny, J Desroches, P Desjardins, B E Suranyi-Cadott. Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment. Synapse (New York, N.Y.). vol 4. issue 4. 1990-01-31. PMID:2532423. |
conversely, fluoxetine (10 mg/kg/day), a selective blocker of 5-ht reuptake, and gepirone (10 mg/kg/day), a 5-ht1a agonist, both administered for 21 days, significantly reduced [3h]8-oh-dpat binding measured by autoradiography in the nucleus raphe dorsalis without altering hippocampal binding sites. |
1990-01-31 |
2023-08-11 |
rat |
| R J Rodgers, J K Shepher. Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone. Psychopharmacology. vol 99. issue 3. 1990-01-25. PMID:2574479. |
prevention of the analgesic consequences of social defeat in male mice by 5-ht1a anxiolytics, buspirone, gepirone and ipsapirone. |
1990-01-25 |
2023-08-11 |
mouse |
| R J Rodgers, J K Shepher. Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone. Psychopharmacology. vol 99. issue 3. 1990-01-25. PMID:2574479. |
in the present study, the effects of three 5-ht1a anxiolytics (buspirone, ipsapirone and gepirone) on basal nociception and defeat analgesia were examined. |
1990-01-25 |
2023-08-11 |
mouse |
| W Kostowski, A Płaźnik, R Stefańsk. Intra-hippocampal buspirone in animal models of anxiety. European journal of pharmacology. vol 168. issue 3. 1990-01-03. PMID:2573536. |
the effect of intra-hippocampal injections of the serotonergic 5-ht1a receptor agonist, buspirone, on rat exploratory activity was evaluated in the 'open field' and 'elevated plus maze' tests. |
1990-01-03 |
2023-08-11 |
rat |
| W Kostowski, A Płaźnik, R Stefańsk. Intra-hippocampal buspirone in animal models of anxiety. European journal of pharmacology. vol 168. issue 3. 1990-01-03. PMID:2573536. |
the results indicate an anti-emotional influence of local stimulation of 5-ht1a receptors by buspirone. |
1990-01-03 |
2023-08-11 |
rat |