All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
P C Mose. An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2528779. this paper examines some of the possible reasons for this and the role that buspirone's agonist activity at 5-ht1a receptors plays in this effect. 1989-10-25 2023-08-11 human
P C Mose. An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2528779. a variety of 5-ht1a receptor agonists (p-aminophenylethyl-m-trifluromethylphenyl piperazine, (+)- and (-)-mdl 72832) showed similar activity to buspirone, as did the related compound ipsapirone. 1989-10-25 2023-08-11 human
P C Mose. An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. Psychopharmacology. vol 99. issue 1. 1989-10-25. PMID:2528779. these results suggest that an agonist action at postsynaptic 5-ht1a receptors mediates the anxiogenic-like effects of buspirone in the elevated plus-maze test and that this test may either be insensitive to certain classes of anxiolytics or is measuring something unrelated to human anxiety states. 1989-10-25 2023-08-11 human
S Gleeson, S T Ahlers, R S Mansbach, J M Foust, J E Barret. Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes. The Journal of pharmacology and experimental therapeutics. vol 250. issue 3. 1989-10-17. PMID:2476547. the greatest increases in punished responding were produced by the buspirone analogs bmy 7378 and ipsapirone, which act at the 5-ht1a receptor. 1989-10-17 2023-08-11 Not clear
A B Tobin, N N Osborn. Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body. Journal of neurochemistry. vol 53. issue 3. 1989-09-18. PMID:2547897. the 5-ht1a [5-hydroxytryptamine (serotonin) type 1a] receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone mimic the serotonin response in reducing the forskolin-stimulated cyclic amp levels, as do the indole derivatives 5-methoxytryptamine, 5-hydroxtryptophan, and tryptamine. 1989-09-18 2023-08-11 rabbit
J Arn. Characterization of the discriminative stimulus properties induced by 5-HT1 and 5-HT2 agonists in rats. Pharmacology & toxicology. vol 64. issue 2. 1989-09-05. PMID:2526950. the 8-ohdpat cue was mimicked by the 5-ht1a agonists ipsapirone, buspirone, gepirone and partially by 5-methoxy-n,n-dimethyltryptamine and d-lsd. 1989-09-05 2023-08-11 rat
H C Jackson, I Kitche. Behavioural profiles of putative 5-hydroxytryptamine receptor agonists and antagonists in developing rats. Neuropharmacology. vol 28. issue 6. 1989-08-29. PMID:2526930. in contrast, locomotion was not affected by buspirone (5-ht1a); mcpp (1-(3-chlorophenyl)piperazine; 5-ht1b/5-ht1c) and doi (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane; 5-ht2) though buspirone produced a small increase in head-weaving at 5- and 20-days. 1989-08-29 2023-08-11 rat
G Curzo. 5-Hydroxytryptamine and corticosterone in an animal model of depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 13. issue 3-4. 1989-08-21. PMID:2748869. single injections of 5-ht1a agonists (8-oh-dpat, buspirone, ipsapirone, gepirone) but not of benzodiazepine anxiolytics have similar effects. 1989-08-21 2023-08-11 rat
C S Aulakh, J L Hill, D L Murph. A comparison of feeding and locomotion responses to serotonin agonists in three rat strains. Pharmacology, biochemistry, and behavior. vol 31. issue 3. 1989-07-18. PMID:2977992. the hyperphagic effects of two selective 5-ht1a agonists (8-ohdpat and buspirone) in a free feeding paradigm and the locomotor suppressant effect of the serotonin agonist, m-chlorophenylpiperazine (m-cpp) were compared in three different rat strains: wistar, sprague-dawley (sd), and fawn-hooded (fh) rats. 1989-07-18 2023-08-11 rat
H Berthold, J R Fozard, G Enge. 5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice. European journal of pharmacology. vol 162. issue 1. 1989-07-06. PMID:2566495. the actions of 8-oh-dpat and buspirone, but not of ru 24969 and idazoxan, were blocked by the 5-ht1a receptor antagonist, spiroperidol. 1989-07-06 2023-08-11 mouse
B Olivier, J Mos, J van der Heyden, J Harto. Serotonergic modulation of social interactions in isolated male mice. Psychopharmacology. vol 97. issue 2. 1989-07-03. PMID:2498921. several 5-ht1a agonists (8-oh-dpat, ipsapirone, buspirone, 5-me-odmt) and a 5-ht uptake blocker (fluvoxamine) also reduced aggression. 1989-07-03 2023-08-11 mouse
C L Broekkamp, H H Berendsen, F Jenck, A M Van Delf. Animal models for anxiety and response to serotonergic drugs. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2567038. the 5-ht1a receptor is implicated in anxiety by the compounds buspirone and 8-hydroxy-2-(di-n-propyl-aminotetraline) (ohdpat). 1989-07-03 2023-08-11 Not clear
J P Feighner, W F Boye. Serotonin-1A anxiolytics: an overview. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2567039. the selective 5-hydroxytryptamine-1a (5-ht1a) anxiolytics buspirone, gepirone, ipsapirone, and sm-3997 have several important new and unique features that will be reviewed in this paper. 1989-07-03 2023-08-11 Not clear
D S Robinson, D R Alms, R C Shrotriya, M Messina, P Wickramaratn. Serotonergic anxiolytics and treatment of depression. Psychopathology. vol 22 Suppl 1. 1989-07-03. PMID:2657837. the serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor agonists buspirone and gepirone have effects on serotonergic systems, including presynaptic and postsynaptic receptors, that predict both anxiolytic and antidepressant activity. 1989-07-03 2023-08-11 Not clear
J M Liebman, S C Gerhardt, R Gerbe. Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology. vol 97. issue 4. 1989-06-27. PMID:2524857. gepirone, a 5-ht1a agonist with less marked dopamine antagonist properties, induced dyskinesias in only one of six monkeys at 30 mg/kg and did not block haloperidol-induced dyskinesias. 1989-06-27 2023-08-11 monkey
G D Tollefson, M Godes, J Montague-Clouse, S P Lancaster, M J Garve. Buspirone: effects on prolactin and growth hormone as a function of drug level in generalized anxiety. Journal of clinical psychopharmacology. vol 9. issue 2. 1989-06-27. PMID:2723131. certain evidence suggests that buspirone, a novel nonbenzodiazepine anxiolytic, may be a 5-ht1a serotonergic agonist and may antagonize postsynaptic dopaminergic receptors. 1989-06-27 2023-08-11 human
J E Barrett, S M Hoffmann, S N Olmstead, M J Foust, C Harrod, B A Weissma. Behavioral and neurochemical effects of the serotonin (5-HT)1A receptor ligand spiroxatrine. Psychopharmacology. vol 97. issue 3. 1989-06-15. PMID:2524083. when administered alone, buspirone, a compound believed to produce its anxiolytic effects through 5-ht1a agonist actions, produced effects similar to those of spiroxatrine; in combination, the two drugs produced greater effects than when either was administered alone. 1989-06-15 2023-08-11 pigeon
J E Barrett, S M Hoffmann, S N Olmstead, M J Foust, C Harrod, B A Weissma. Behavioral and neurochemical effects of the serotonin (5-HT)1A receptor ligand spiroxatrine. Psychopharmacology. vol 97. issue 3. 1989-06-15. PMID:2524083. as with 5-ht1a agonists such as buspirone and 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) in the pigeon, spiroxatrine (0.01-1.0 mg/kg) increased punished responding. 1989-06-15 2023-08-11 pigeon
D C Blanchard, R J Rodgers, C A Hendrie, K Hor. 'Taming' of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 31. issue 2. 1989-06-06. PMID:3244704. 'taming' of wild rats (rattus rattus) by 5ht1a agonists buspirone and gepirone. 1989-06-06 2023-08-11 human
D C Blanchard, R J Rodgers, C A Hendrie, K Hor. 'Taming' of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 31. issue 2. 1989-06-06. PMID:3244704. a battery of tests designed to elicit reactions to a variety of nonpainful threat stimuli was used to study the effects of the 5ht1a agonists buspirone (5-20 mg/kg), and gepirone (5-20 mg/kg) on the defensive repertoire of wild rattus rattus. 1989-06-06 2023-08-11 human