| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Charles K Perry, Rajender Vemula, Raymond G Boot. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:26011730. |
for example, preclinical studies indicate that 5-ht7 receptor activation corrects deficits in mouse models of fragile x and rett syndromes, and clinical trials for autism are underway with buspirone, a 5-ht1a partial agonist with relevant affinity at 5-ht7 receptors. |
2016-04-19 |
2023-08-13 |
mouse |
| Kim van Rooij, Saskia Poels, Petra Worst, Jos Bloemers, Hans Koppeschaar, Andrew Goldstein, Berend Olivier, Adriaan Tuite. Efficacy of testosterone combined with a PDE5 inhibitor and testosterone combined with a serotonin (1A) receptor agonist in women with SSRI-induced sexual dysfunction. A preliminary study. European journal of pharmacology. vol 753. 2016-03-14. PMID:25460030. |
21 pre- and postmenopausal women with ssri-induced sexual dysfunction participated and underwent the following interventions: a combination of testosterone (0.5 mg) sublingually and the pde5-i sildenafil (50 mg) and a combination of testosterone (0.5 mg) sublingually and the 5-ht1a receptor agonist buspirone (10 mg). |
2016-03-14 |
2023-08-13 |
Not clear |
| Denis Boulay, Sophie Ho-Van, Olivier Bergis, Patrick Avenet, Guy Griebe. Phencyclidine decreases tickling-induced 50-kHz ultrasound vocalizations in juvenile rats: a putative model of the negative symptoms of schizophrenia? Behavioural pharmacology. vol 24. issue 7. 2016-03-03. PMID:23928693. |
the 5-ht1a receptor partial agonist, buspirone (0.3 and 1 mg/kg, intraperitoneally), the dual d2/5-ht1a receptor ligand, ssr181507 (0.5-0.75 mg/kg, intraperitoneally), but not the atypical antipsychotic, aripiprazole (0.1-1 mg/kg, intraperitoneally), the 5-ht2a receptor antagonist, eplivanserin (0.3-3 mg/kg, intraperitoneally), and the glyt1 inhibitor, ssr103800 (0.3-3 mg/kg, intraperitoneally) significantly attenuated the effects of pcp on 50-khz calls. |
2016-03-03 |
2023-08-12 |
human |
| Ryuki Tsutsui, Kazuaki Shinomiya, Toshiaki Sendo, Yoshihisa Kitamura, Chiaki Kame. Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. Biological & pharmaceutical bulletin. vol 38. issue 6. 2016-02-21. PMID:26027828. |
the effect of tandospirone on sleep patterns was antagonized by the 5-ht1a receptor antagonist way-100635. |
2016-02-21 |
2023-08-13 |
rat |
| Ryuki Tsutsui, Kazuaki Shinomiya, Toshiaki Sendo, Yoshihisa Kitamura, Chiaki Kame. Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. Biological & pharmaceutical bulletin. vol 38. issue 6. 2016-02-21. PMID:26027828. |
these results clearly indicate that long-term administration of acth causes sleep disturbance, and stimulating the 5-ht1a receptor by tandospirone may be efficacious for improving sleep in cases in which benzodiazepine hypnotics are ineffective. |
2016-02-21 |
2023-08-13 |
rat |
| Elisabetta Tronci, Camino Fidalgo, Manolo Cart. Foetal Cell Transplantation for Parkinson's Disease: Focus on Graft-Induced Dyskinesia. Parkinson's disease. vol 2015. 2016-02-16. PMID:26881178. |
in agreement, clinical investigations have shown that grafted tissue may contain a large number of serotonin neurons, in the order of half of the da cells; moreover, the serotonin 5-ht1a receptor agonist buspirone has been found to produce significant dampening of gid in grafted patients. |
2016-02-16 |
2023-08-13 |
Not clear |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
previous pilot clinical studies have shown that the serotonin 5-ht1a receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. |
2016-01-19 |
2023-08-13 |
Not clear |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
the results of this study also indicate that the putative mechanism of action of tandospirone might be related to enhancement of dopamine neurotransmission via activation of the 5-ht1a receptor. |
2016-01-19 |
2023-08-13 |
Not clear |
| Fosco Bernasconi, Michael Kometer, Thomas Pokorny, Erich Seifritz, Franz X Vollenweide. The electrophysiological effects of the serotonin 1A receptor agonist buspirone in emotional face processing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25637265. |
here we investigated the spatiotemporal brain mechanisms underpinning the modulation of emotional face processing induced by buspirone, a partial 5-ht1a receptor agonist. |
2016-01-11 |
2023-08-13 |
Not clear |
| Nausheen Alam, Rahila Najam, Saira Saeed Kha. Attenuation of methylphenidate-induced tolerance on cognition by buspirone co-administration. Pakistan journal of pharmaceutical sciences. vol 28. issue 5. 2015-12-15. PMID:26408868. |
repeated buspirone administration attenuates 5-ht1a soma to dendritic receptors effectiveness. |
2015-12-15 |
2023-08-13 |
rat |
| Yusuke Murata, Yuki Yanagihara, Masayoshi Mori, Kazunori Mine, Munechika Enjoj. Chronic treatment with tandospirone, a serotonin 1A receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior. Journal of affective disorders. vol 180. 2015-11-11. PMID:25879718. |
we recently showed that chronic administration of tandospirone, a clinically available 5-ht1a receptor partial agonist, increased hippocampal neurogenesis dose-dependently. |
2015-11-11 |
2023-08-13 |
Not clear |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
long evans rats were trained in an operant conditioning task while receiving fluoxetine (serotonin reuptake inhibitor, 10mg/kg), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone (5-ht1a partial agonist, 10mg/kg), risperidone (5-ht2a antagonist, 1mg/kg), ondansetron (5-ht3 antagonist, 2mg/kg) or vehicle. |
2015-09-08 |
2023-08-13 |
rat |
| Christina M Monaco, Kory M Gebhardt, Sarah M Chlebowski, Kaitlyn E Shaw, Jeffrey P Cheng, Jeremy J Henchir, Margaret F Zupa, Anthony E Klin. A combined therapeutic regimen of buspirone and environmental enrichment is more efficacious than either alone in enhancing spatial learning in brain-injured pediatric rats. Journal of neurotrauma. vol 31. issue 23. 2015-07-23. PMID:25050595. |
buspirone, a 5-ht1a receptor agonist, and environmental enrichment (ee) enhance cognition and reduce histopathology after traumatic brain injury (tbi) in adult rats, but have not been fully evaluated after pediatric tbi, which is the leading cause of death in children. |
2015-07-23 |
2023-08-13 |
rat |
| Victoria M Smith, Stephanie Iannattone, Sanjay Achal, Ryan T Jeffers, Michael C Antl. The serotonergic anxiolytic buspirone attenuates circadian responses to light. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25195769. |
the anxiolytic buspirone is a 5-ht1a receptor partial agonist. |
2015-07-23 |
2023-08-13 |
mouse |
| Victoria M Smith, Stephanie Iannattone, Sanjay Achal, Ryan T Jeffers, Michael C Antl. The serotonergic anxiolytic buspirone attenuates circadian responses to light. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25195769. |
5-ht1a receptor knockout mice exhibited potentiated photic phase shifts when pretreated with buspirone. |
2015-07-23 |
2023-08-13 |
mouse |
| Victoria M Smith, Stephanie Iannattone, Sanjay Achal, Ryan T Jeffers, Michael C Antl. The serotonergic anxiolytic buspirone attenuates circadian responses to light. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25195769. |
buspirone administration at midday produced non-photic phase advances in wildtype but not 5-ht1a receptor knockout mice. |
2015-07-23 |
2023-08-13 |
mouse |
| Victoria M Smith, Stephanie Iannattone, Sanjay Achal, Ryan T Jeffers, Michael C Antl. The serotonergic anxiolytic buspirone attenuates circadian responses to light. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25195769. |
these findings suggest that buspirone affected the circadian system in a manner similar to the 5-ht1a/7 agonist (±)-8-hydroxy-2-dipropylaminotetralin hydrobromide, primarily through the 5-ht1a receptor, and suggest that therapeutic use of buspirone to manage anxiety may impact circadian function. |
2015-07-23 |
2023-08-13 |
mouse |
| Jiang-Hong Sun, Xin-Jie Ruan, Li-Na Wang, Shuang Liang, Xin-Ping L. Study on the Antinociceptive Effects of Herba Epimedium in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-07-14. PMID:26170874. |
injection, 5-ht1a receptor partial agonist buspirone, antagonist propranolol, the adrenaline β 1-receptor selective blocking agent metoprolol, and 5-ht2a receptor agonist hydrochloride doi and antagonist ketanserin were used, and, 5 min later, he was used to investigate the impacts of drugs on the analgesic effect in the same way. |
2015-07-14 |
2023-08-13 |
mouse |
| George P Karamanolis, Stylianos Panopoulos, Anastasios Karlaftis, Konstantinos Denaxas, Dimitrios Kamberoglou, Petros P Sfikakis, Spiros D Lada. Beneficial effect of the 5-HT1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study. United European gastroenterology journal. vol 3. issue 3. 2015-07-03. PMID:26137301. |
beneficial effect of the 5-ht1a receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: a pilot study. |
2015-07-03 |
2023-08-13 |
human |
| George P Karamanolis, Stylianos Panopoulos, Anastasios Karlaftis, Konstantinos Denaxas, Dimitrios Kamberoglou, Petros P Sfikakis, Spiros D Lada. Beneficial effect of the 5-HT1A receptor agonist buspirone on esophageal dysfunction associated with systemic sclerosis: A pilot study. United European gastroenterology journal. vol 3. issue 3. 2015-07-03. PMID:26137301. |
the oral 5-ht1a receptor agonist buspirone may enhance esophageal peristalsis and lower esophageal sphincter (les) function in healthy volunteers. |
2015-07-03 |
2023-08-13 |
human |