All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
Mei Huang, John J Panos, Sunoh Kwon, Yoshihiro Oyamada, Lakshmi Rajagopal, Herbert Y Meltze. Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism. Journal of neurochemistry. vol 128. issue 6. 2014-05-14. PMID:24164459. using microdialysis and ultra performance liquid chromatography-mass spectrometry/mass spectrometry, we compared the abilities of the typical apd, haloperidol, three aapds, blonanserin, lurasidone, and olanzapine, and a selective 5-ht1a partial agonist, tandospirone, and all, except haloperidol, were found to ameliorate the cognitive deficits produced by the n-methyl-d-aspartate antagonist, phencyclidine, altering the efflux of neurotransmitters and metabolites in the rat cortex and nucleus accumbens. 2014-05-14 2023-08-12 rat
Tomiki Sumiyoshi, Yuko Higuchi, Takashi Uehar. Neural basis for the ability of atypical antipsychotic drugs to improve cognition in schizophrenia. Frontiers in behavioral neuroscience. vol 7. 2014-03-10. PMID:24137114. in particular, our data indicate chronic treatment with tandospirone, a partial 5-ht1a agonist, recover stress-induced lactate production in the prefrontal cortex of a rat model of schizophrenia. 2014-03-10 2023-08-12 rat
Chao-Lin Lu, Yu-Chi Ku, Shih-Mao Lo, Chia-Ho Peng, Che-Se Tung, You-Wei Lin, Yia-Ping Li. Acute and subchronic effects of buspirone on attention and impulsivity in the five-choice serial reaction time task in rats. Neuroscience letters. vol 556. 2014-02-10. PMID:24135334. the present study demonstrated acute and subchronic effects of a 5-ht1a receptor partial agonist, buspirone, on the performance of rats in response control indexed by the attentional accuracy and impulsive reactivity in the five-choice serial reaction time task (5-csrtt). 2014-02-10 2023-08-12 rat
Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Masabumi Minami, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. Journal of pharmacological sciences. vol 122. issue 2. 2014-01-09. PMID:23707971. tandospirone suppresses impulsive action by possible blockade of the 5-ht1a receptor. 2014-01-09 2023-08-12 rat
Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Masabumi Minami, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. Journal of pharmacological sciences. vol 122. issue 2. 2014-01-09. PMID:23707971. in the present study, we examined whether (3ar,4s,7r,7as)-rel-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1h-isoindole-1,3(2h)-dione hydrochloride (tandospirone), an anxiolytic and a partial agonist of the 5-ht1a receptor, could affect impulsive action in the 3-choice serial reaction time task. 2014-01-09 2023-08-12 rat
Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Masabumi Minami, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshiok. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. Journal of pharmacological sciences. vol 122. issue 2. 2014-01-09. PMID:23707971. n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide maleate salt (way100635; 0.3 mg/kg, s.c.), a 5-ht1a receptor antagonist, did not reverse the suppressing effects of tandospirone on impulsive action. 2014-01-09 2023-08-12 rat
Irina P Butkevich, Viktor A Mikhailenko, Tat'yana R Bagaeva, Elena A Vershinina, Anna Maria Aloisi, Vladimir A Otelli. Inflammatory pain and corticosterone response in infant rats: effect of 5-HT1A agonist buspirone prior to gestational stress. Mediators of inflammation. vol 2013. 2013-12-03. PMID:23606797. inflammatory pain and corticosterone response in infant rats: effect of 5-ht1a agonist buspirone prior to gestational stress. 2013-12-03 2023-08-12 rat
Irina P Butkevich, Viktor A Mikhailenko, Tat'yana R Bagaeva, Elena A Vershinina, Anna Maria Aloisi, Vladimir A Otelli. Inflammatory pain and corticosterone response in infant rats: effect of 5-HT1A agonist buspirone prior to gestational stress. Mediators of inflammation. vol 2013. 2013-12-03. PMID:23606797. our researches have shown that gestational stress causes exacerbation of inflammatory pain in the offspring; the maternal 5-ht1a agonist buspirone before the stress prevents the adverse effect. 2013-12-03 2023-08-12 rat
Andrea Cappelli, Monica Manini, Salvatore Valenti, Federica Castriconi, Germano Giuliani, Maurizio Anzini, Simone Brogi, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Gianluca Giorgi, Laura Mennuni, Marco Lanza, Antonio Giordani, Gianfranco Caselli, Ornella Letari, Francesco Makove. Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23466604. a new class of serotonin 5-ht1a receptor ligands related to nan-190, buspirone and aripiprazole has been designed using our potent 5-ht3 receptor ligands as templates. 2013-11-27 2023-08-12 Not clear
Deepali Gupta, Mahesh Radhakrishnan, Shvetank Bhatt, Yeshwant Kurh. Role of Hypothalamic-pituitary-adrenal-axis in Affective Disorders: Anti-depressant and Anxiolytic Activity of Partial 5-HT1A Agonist in Adrenalectomised Rats. Indian journal of psychological medicine. vol 35. issue 3. 2013-11-19. PMID:24249933. buspirone (bus), a partial 5-ht1a receptor agonist has shown promising anti-depressant and anxiolytic properties in various pre-clinical and clinical studies, but the molecular and cellular mechanisms are still unclear. 2013-11-19 2023-08-12 rat
Siamak Eyhani-Rad, Alireza Mohajjel Nayebi, Javad Mahmoudi, Morteza Samini, Vahab Babapou. Role of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson's Disease. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 4. 2013-11-19. PMID:24250551. we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. 2013-11-19 2023-08-12 rat
Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). 2013-10-29 2023-08-12 Not clear
M Horiguchi, H Y Meltze. Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism. Behavioural brain research. vol 247. 2013-10-21. PMID:23538066. co-administration of sub-effective doses of blonanserin (0.3 mg/kg) and the 5-ht1a partial agonist, tandospirone (0.2 mg/kg), significantly reversed the nor deficit without diminishing activity during the acquisition or retention periods. 2013-10-21 2023-08-12 rat
M Horiguchi, H Y Meltze. Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism. Behavioural brain research. vol 247. 2013-10-21. PMID:23538066. these results suggest that blonansein and risperidone, atypical apds which lack a direct action on 5-ht1a receptors require 5-ht1a receptor stimulation to reverse the subchronic pcp-induced nor deficit and provide a support for clinical trial of blonanserin in combination with tandospirone to ameliorate cognitive impairment in schizophrenia and to have fewer side effects. 2013-10-21 2023-08-12 rat
Teresa L Garrett, Kaushal Joshi, Christine M Rapp, Molly Chapleau, David R Cool, John J Schlager, James B Luco. The effects of 8-OH-DPAT on neuroinflammation after sarin exposure in mice. Toxicology. vol 310. 2013-10-17. PMID:23692952. administration of the 5-ht1a agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) decreased glial fibrillary acidic protein (gfap) staining in mice when administered 1min after cbdp and sarin while other 5-ht1a agonists buspirone and s-14506 were not effective. 2013-10-17 2023-08-12 mouse
Jack Bergman, Rebecca A Roof, Cheryse A Furman, Jennie L Conroy, Nancy K Mello, David R Sibley, Phil Skolnic. Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors. The international journal of neuropsychopharmacology. vol 16. issue 2. 2013-08-21. PMID:22827916. buspirone, a 5-ht1a partial agonist approved for the treatment of anxiety, has been reported to also bind with high affinity to d3 and d4 receptors. 2013-08-21 2023-08-12 human
Madhusudan Grover, Michael Camiller. Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases. Journal of gastroenterology. vol 48. issue 2. 2013-08-05. PMID:23254779. the effects of antidepressants on the gastrointestinal tract may contribute to their potential efficacy in functional dyspepsia and irritable bowel syndrome; buspirone, a prototype 5-ht1a agonist, enhances gastric accommodation and reduces postprandial symptoms in response to a challenge meal. 2013-08-05 2023-08-12 Not clear
Anthony E Kline, Adam S Olsen, Christopher N Sozda, Ann N Hoffman, Jeffrey P Chen. Evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-HT1A receptor agonist buspirone after experimental traumatic brain injury. Journal of neurotrauma. vol 29. issue 10. 2013-05-22. PMID:22471653. evaluation of a combined treatment paradigm consisting of environmental enrichment and the 5-ht1a receptor agonist buspirone after experimental traumatic brain injury. 2013-05-22 2023-08-12 rat
Kyoji Okita, Akihiro Shiina, Michiko Nakazato, Masaomi Iy. Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series. Annals of general psychiatry. vol 12. issue 1. 2013-03-26. PMID:23497393. tandospirone, a 5-ht1a partial agonist is effective in treating anorexia nervosa: a case series. 2013-03-26 2023-08-12 Not clear
Kyoji Okita, Akihiro Shiina, Michiko Nakazato, Masaomi Iy. Tandospirone, a 5-HT1A partial agonist is effective in treating anorexia nervosa: a case series. Annals of general psychiatry. vol 12. issue 1. 2013-03-26. PMID:23497393. a 22-year-old female patient with anr and a 23-year-old female patient with anbp were treated successfully with the 5-ht1a partial agonist tandospirone. 2013-03-26 2023-08-12 Not clear