All Relations between 5-ht receptor 1a and dorsal raphe

Reference Sentence Publish Date Extraction Date Species
Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology vol 13 issue 2023 36588734 fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. 2023-01-02 2023-01-05 Not clear
Sophia Khom, Sarah A Wolfe, Reesha R Patel, Dean Kirson, David M Hedges, Florence P Varodayan, Michal Bajo, Marisa Robert. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 40 issue 36 2021 32769108 the cea receives dense innervation from the dorsal raphe nucleus, the major source of 5-ht, and expresses 5-ht receptor subtypes (e.g., 5-ht2c and 5-ht1a) critically linked to alcohol use disorder. 2021-01-01 2022-01-13 Not clear
Motohiro Okada, Kouji Fukuyama, Ruri Okubo, Takashi Shiroyama, Yuto Ued. Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus. Pharmaceuticals (Basel, Switzerland) vol 12 issue 4 2020 31590422 lurasidone sub-chronically activates serotonergic transmission via desensitization of 5-ht1a and 5-ht7 receptors in dorsal raphe nucleus. 2020-09-30 2022-01-13 Not clear
Yongfeng Li, Jianyu Zhu, Qiaohua Zheng, Zhaoqiang Qian, Lizi Zhang, Chunling Wei, Jing Han, Zhiqiang Liu, Wei Re. 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. Neuroreport vol 30 issue 9 2019 31045847 5-ht1a autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. 2019-12-16 2022-01-13 Not clear
Yongfeng Li, Jianyu Zhu, Qiaohua Zheng, Zhaoqiang Qian, Lizi Zhang, Chunling Wei, Jing Han, Zhiqiang Liu, Wei Re. 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. Neuroreport vol 30 issue 9 2019 31045847 the conditioned place preference to cocaine and was abolished by administration of the 5-ht1a receptor antagonist into the dorsal raphe nucleus (drn). 2019-12-16 2022-01-13 Not clear
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 68 issue 2019 29678562 next, to elucidate mechanisms underlying the behavioral effects, we evaluated mrna expression of the serotonin 1a (5-ht1a) receptor, brain-derived neurotrophic factor (bdnf), and gaba-a receptor subunits in the medial prefrontal cortex, amygdala, dorsal and ventral hippocampi, and dorsal raphe nucleus by quantitative rt-pcr, since these genes and brain regions have been shown to be involved in cognition and emotion. 2019-08-06 2022-01-13 Not clear
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 68 issue 2019 29678562 postnatal handling up-regulated mrna expression of the 5-ht1a receptor in the dorsal raphe nucleus and down-regulated 5-ht1a receptor mrna expression in the amygdala on p15 and p71. 2019-08-06 2022-01-13 Not clear
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol 68 issue 2019 29678562 taken together, the present study suggests that postnatal handling reduced anxiety-like behavior and improved learning and memory, which were accompanied by changes in mrna expression of 5-ht1a receptor, bdnf and gaba-a receptor \xce\xb12 subunit in the amygdala, 5-ht1a receptor in the dorsal raphe nucleus and bdnf in the dorsal hippocampus. 2019-08-06 2022-01-13 Not clear
Danilo De Gregorio, Ryan J McLaughlin, Luca Posa, Rafael Ochoa-Sanchez, Justine Enns, Martha Lopez-Canul, Matthew Aboud, Sabatino Maione, Stefano Comai, Gabriella Gobb. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain vol 160 issue 1 2019 30157131 increasing doses of cbd (0.1-1.0 mg/kg) decreased the firing rate of 5-ht neurons in the dorsal raphe nucleus, which was prevented by administration of the 5-ht1a antagonist way 100635 (0.3 mg/kg, i.v.) 2019-06-26 2022-01-13 Not clear
In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 41 issue 5 2016 26324408 5-ht1a autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking. 2016-12-14 2022-01-12 Not clear
Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology vol 594 issue 4 2016 26634643 in the dorsal raphe nucleus, it is known that serotonin release activates metabotropic 5-ht1a autoreceptors located on serotonin neurons that leads to an inhibition of firing through the activation of g-protein-coupled inwardly rectifying potassium channels. 2016-11-04 2022-01-12 Not clear
Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology vol 594 issue 4 2016 26634643 these results indicate that evoked serotonin transmission in the dorsal raphe nucleus mediated by metabotropic 5-ht1a autoreceptors may occur via point-to-point synapses rather than by paracrine mechanisms. 2016-11-04 2022-01-12 Not clear
Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology vol 99 issue 2016 26362359 following depletion of 5-ht with para-chlorophenylalanine methyl-ester hydrochloride (pcpa), vilazodone still suppressed neuronal firing of dorsal raphe nucleus (drn) 5-ht neurons to a similar extent than controls, indicating that this inhibition is via 5-ht1a receptors activation. 2016-08-30 2022-01-12 Not clear
Yan Ping Hui, Tao Wang, Ling Na Han, Li Bo Li, Yi Na Sun, Jian Liu, Hong Fei Qiao, Qiao Jun Zhan. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat. Behavioural brain research vol 277 issue 2015 24906197 this study sought to assess whether unilateral lesions of the medial forebrain bundle (mfb) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1a (5-ht1a) receptors of the prelimbic (prl) sub-region of ventral medial prefrontal cortex in the regulation of these behaviors, the density of 5-ht neurons in the dorsal raphe nucleus (drn) and co-localization of 5-ht1a receptor and neuronal glutamate transporter eaac1-immunoreactive (eaac1-ir) cells in the prl. 2015-09-08 2022-01-12 Not clear
Darakhshan J Halee. 5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson's disease and schizophrenia. Behavioural pharmacology vol 26 issue 1-2 2015 25503261 activation of somatodendritic 5-ht1a receptors in the dorsal raphe nucleus has an important role in the alleviation of extrapyramidal symptoms and levodopa-induced dyskinesia induced by antipsychotic treatment. 2015-09-03 2022-01-12 Not clear
Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology vol 89 issue 2015 25261781 since 5-ht1a receptors in the mpfc provide a key feedback regulation of the dorsal raphe nucleus (drn), we used a disinhibition strategy to examined endogenous feedback control of 5-ht neurons. 2015-07-24 2022-01-12 Not clear
H\\xc3\\xa9lio Zangrossi, Frederico G Graef. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neuroscience and biobehavioral reviews vol 46 Pt 3 issue 2015 24657635 the evidence so far reported with the etm supports the above hypothesis and indicates that: (1) whereas 5-ht neurons located at the dorsal raphe nucleus are involved in the regulation of both inhibitory avoidance and escape, those of the median raphe nucleus are primarily implicated in the former task; (2) facilitation of 5-ht1a- and 5-ht2a-mediated neurotransmission in the dorsal periaqueductal gray (dpag) is likely to mediate the panicolytic drug action; (3) stimulation of 5-ht2c receptors in the basolateral amygdala increases anxiety and is implicated in the anxiogenesis caused by short-term administration of antidepressant drugs, and (4) 5-ht1a and the \xce\xbc-opioid receptors work together in the dpag to modulate escape or panic attacks. 2015-07-17 2022-01-12 Not clear
Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics vol 351 issue 3 2015 25225185 in addition, the effects on 5-ht1a autoreceptors in the dorsal raphe nucleus (drn) and d2 autoreceptors in the ventral tegmental area (vta) were compared with those of aripiprazole, an agent in wide clinical use. 2015-02-17 2022-01-12 Not clear
Ofelia Lim\\xc3\\xb3n-Morales, Cesar Soria-Fregozo, Marcela Arteaga-Silva, Gonzalo V\\xc3\\xa1zquez-Palacios, Herlinda Bonilla-Jaim. Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine. Physiology & behavior vol 124 issue 2014 24211235 the expression of the mrna of the 5-ht1a receptors was examined in the dorsal raphe nucleus, the hypothalamus and the hippocampus using the semi-quantitative rt-pcr method. 2014-12-10 2022-01-12 Not clear
M V Foga\\xc3\\xa7a, F M C V Reis, A C Campos, F S Guimar\\xc3\\xa3e. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol 24 issue 3 2014 24321837 moreover, restraint stress increased 5ht1a receptors expression in the dorsal raphe nucleus, an effect that was attenuated by injection of metyrapone before the restraint procedure. 2014-11-25 2022-01-12 Not clear
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