All Relations between 5-ht receptor 1a and dorsal raphe

Publication Sentence Publish Date Extraction Date Species
Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. whole-cell recordings from dorsal raphe serotonin neurons revealed altered 5-ht1a receptor-dependent inhibitory postsynaptic currents (5-ht1a-ipscs) in female but not male ko neurons. 2023-10-17 2023-11-08 mouse
Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588734. fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. 2023-01-02 2023-08-14 Not clear
Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. 2021-08-06 2023-08-13 Not clear
Sophia Khom, Sarah A Wolfe, Reesha R Patel, Dean Kirson, David M Hedges, Florence P Varodayan, Michal Bajo, Marisa Robert. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32769108. the cea receives dense innervation from the dorsal raphe nucleus, the major source of 5-ht, and expresses 5-ht receptor subtypes (e.g., 5-ht2c and 5-ht1a) critically linked to alcohol use disorder. 2021-01-01 2023-08-13 rat
Mal-Soon Shin, Sang-Seo Park, Jae-Min Lee, Tae-Woon Kim, Young-Pyo Ki. Treadmill exercise improves depression-like symptoms by enhancing serotonergic function through upregulation of 5-HT Journal of exercise rehabilitation. vol 13. issue 1. 2020-10-01. PMID:28349031. serotonin receptor type 1a (5-ht1a) expression in the dorsal raphe was reduced by obx and treadmill exercise increased 5-ht1a expression in the olfactory bulbectomized rats. 2020-10-01 2023-08-13 rat
Mal-Soon Shin, Sang-Seo Park, Jae-Min Lee, Tae-Woon Kim, Young-Pyo Ki. Treadmill exercise improves depression-like symptoms by enhancing serotonergic function through upregulation of 5-HT Journal of exercise rehabilitation. vol 13. issue 1. 2020-10-01. PMID:28349031. the antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregulation of 5-ht1a expression in the dorsal raphe. 2020-10-01 2023-08-13 rat
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Li. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. Journal of exercise rehabilitation. vol 13. issue 2. 2020-09-30. PMID:28503522. 5-ht, tph, and 5-ht1a receptor expressions in the dorsal raphe were suppressed by rotenone injection and treadmill exercise increased the expressions of 5-ht, tph, and 5-ht1a receptor in the rotenone-injected rats. 2020-09-30 2023-08-13 rat
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Li. Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats. Journal of exercise rehabilitation. vol 13. issue 2. 2020-09-30. PMID:28503522. the antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregulation of 5-ht1a expression in the dorsal raphe. 2020-09-30 2023-08-13 rat
Motohiro Okada, Kouji Fukuyama, Ruri Okubo, Takashi Shiroyama, Yuto Ued. Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus. Pharmaceuticals (Basel, Switzerland). vol 12. issue 4. 2020-09-30. PMID:31590422. lurasidone sub-chronically activates serotonergic transmission via desensitization of 5-ht1a and 5-ht7 receptors in dorsal raphe nucleus. 2020-09-30 2023-08-13 Not clear
Alberto Montalbano, Boris Mlinar, Francesco Bonfiglio, Lorenzo Polenzani, Maurizio Magnani, Renato Corradett. Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism. PloS one. vol 14. issue 9. 2020-04-02. PMID:31557210. dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-ht1a receptor partial agonism and α1-adrenoceptor antagonism. 2020-04-02 2023-08-13 mouse
Alberto Montalbano, Boris Mlinar, Francesco Bonfiglio, Lorenzo Polenzani, Maurizio Magnani, Renato Corradett. Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism. PloS one. vol 14. issue 9. 2020-04-02. PMID:31557210. in this study, we used cell-attached or whole-cell patch-clamp recordings to characterize the effects of trazodone at somatodendritic 5-ht1a receptors (5-ht1aars) and α1-adrenoceptors of serotonergic neurons in rodent dorsal raphe slices. 2020-04-02 2023-08-13 mouse
Yongfeng Li, Jianyu Zhu, Qiaohua Zheng, Zhaoqiang Qian, Lizi Zhang, Chunling Wei, Jing Han, Zhiqiang Liu, Wei Re. 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. Neuroreport. vol 30. issue 9. 2019-12-16. PMID:31045847. 5-ht1a autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. 2019-12-16 2023-08-13 mouse
Yongfeng Li, Jianyu Zhu, Qiaohua Zheng, Zhaoqiang Qian, Lizi Zhang, Chunling Wei, Jing Han, Zhiqiang Liu, Wei Re. 5-HT1A autoreceptor in dorsal raphe nucleus mediates sensitization of conditioned place preference to cocaine in mice experienced with chronic pain. Neuroreport. vol 30. issue 9. 2019-12-16. PMID:31045847. the conditioned place preference to cocaine and was abolished by administration of the 5-ht1a receptor antagonist into the dorsal raphe nucleus (drn). 2019-12-16 2023-08-13 mouse
Constantino Sotelo, Béatrice Cholley, Salah El Mestikawy, Henri Gozlan, Michel Hamo. Direct Immunohistochemical Evidence of the Existence of 5-HT1A Autoreceptors on Serotoninergic Neurons in the Midbrain Raphe Nuclei. The European journal of neuroscience. vol 2. issue 12. 2019-11-20. PMID:12106075. double immunohistochemical staining using the anti-5-ht1a receptor antibodies and an anti-serotonin (5-ht) antiserum showed that all the 5-ht1a receptor immunoreactive neurons in the dorsal raphe, and the vast majority of them in the median raphe, are serotoninergic neurons. 2019-11-20 2023-08-12 Not clear
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. next, to elucidate mechanisms underlying the behavioral effects, we evaluated mrna expression of the serotonin 1a (5-ht1a) receptor, brain-derived neurotrophic factor (bdnf), and gaba-a receptor subunits in the medial prefrontal cortex, amygdala, dorsal and ventral hippocampi, and dorsal raphe nucleus by quantitative rt-pcr, since these genes and brain regions have been shown to be involved in cognition and emotion. 2019-08-06 2023-08-13 mouse
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. postnatal handling up-regulated mrna expression of the 5-ht1a receptor in the dorsal raphe nucleus and down-regulated 5-ht1a receptor mrna expression in the amygdala on p15 and p71. 2019-08-06 2023-08-13 mouse
Haiyan Li, Chihiro Ishikawa, Takashi Shig. Effects of postnatal handling on adult behavior and brain mRNA expression of serotonin receptor, brain-derived neurotrophic factor and GABA-A receptor subunit. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 68. 2019-08-06. PMID:29678562. taken together, the present study suggests that postnatal handling reduced anxiety-like behavior and improved learning and memory, which were accompanied by changes in mrna expression of 5-ht1a receptor, bdnf and gaba-a receptor α2 subunit in the amygdala, 5-ht1a receptor in the dorsal raphe nucleus and bdnf in the dorsal hippocampus. 2019-08-06 2023-08-13 mouse
Danilo De Gregorio, Ryan J McLaughlin, Luca Posa, Rafael Ochoa-Sanchez, Justine Enns, Martha Lopez-Canul, Matthew Aboud, Sabatino Maione, Stefano Comai, Gabriella Gobb. Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain. vol 160. issue 1. 2019-06-26. PMID:30157131. increasing doses of cbd (0.1-1.0 mg/kg) decreased the firing rate of 5-ht neurons in the dorsal raphe nucleus, which was prevented by administration of the 5-ht1a antagonist way 100635 (0.3 mg/kg, i.v.) 2019-06-26 2023-08-13 rat
Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. it may in part reflect a failure of fgfr1 treatment to uncouple the 5-ht1a postjunctional receptors and autoreceptors from the hippocampal and dorsal raphe girk channels, respectively. 2018-10-22 2023-08-13 rat
Mustapha Riad, Antonia Kobert, Laurent Descarries, Sandra Boye, Pierre-Paul Rompré, Jean-Claude Lacaill. Chronic fluoxetine rescues changes in plasma membrane density of 5-HT1A autoreceptors and serotonin transporters in the olfactory bulbectomy rodent model of depression. Neuroscience. vol 356. 2018-04-12. PMID:28528967. the density of plasma membrane labeling of 5-ht1a auto-receptors on dendrites of dorsal raphe neurons was increased after bulbectomy, but the 5-ht1a hetero-receptor membrane labeling on dendrites of ca3 hippocampal neurons was not. 2018-04-12 2023-08-13 rat