Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
F Lejeune, M J Milla. Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. Synapse (New York, N.Y.). vol 30. issue 2. 1998-11-16. PMID:9723787. |
this study examined the influence of the highly selective 5-ht1a receptor ligands, flesinoxan, s 15535, and way 100,635, upon the electrical activity of dopaminergic neurons in the ventral tegmental area (vta), as compared to serotonergic neurons in the dorsal raphe nucleus (drn) of anesthetized rats. |
1998-11-16 |
2023-08-12 |
rat |
R M Sibug, J C Compaan, O C Meijer, J Van der Gugten, B Olivier, E R De Kloe. Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels. European journal of pharmacology. vol 353. issue 2-3. 1998-11-13. PMID:9726650. |
flesinoxan administration resulted in a significant, dose-dependent downregulation of 5-ht1a receptor mrna in the dentate gyrus and dorsal raphe nucleus. |
1998-11-13 |
2023-08-12 |
rat |
H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
alterations in the activity of the central 5-ht system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-ht1a receptor, 5-ht1b receptor, and 5-ht transporter mrna in the dorsal raphe nucleus and the hippocampus. |
1998-11-04 |
2023-08-12 |
rat |
H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
the expression of 5-ht transporter, 5-ht1a receptor, and 5-ht1b receptor mrna was examined in the dorsal raphe nucleus and in the ca1 of the hippocampus by means of quantitative in situ hybridisation histochemistry. |
1998-11-04 |
2023-08-12 |
rat |
J Dong, C de Montigny, P Blie. Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. The Journal of pharmacology and experimental therapeutics. vol 286. issue 3. 1998-10-08. PMID:9732384. |
full agonistic properties of bay x 3702 on presynaptic and postsynaptic 5-ht1a receptors electrophysiological studies in the rat hippocampus and dorsal raphe. |
1998-10-08 |
2023-08-12 |
rat |
J Dong, C de Montigny, P Blie. Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. The Journal of pharmacology and experimental therapeutics. vol 286. issue 3. 1998-10-08. PMID:9732384. |
the present studies evaluated the effects of acute and long-term administration of the 5-ht1a agonist bay x 3702 on the responsiveness of dorsal raphe 5-ht neurons and of dorsal hippocampus ca3 pyramidal neurons. |
1998-10-08 |
2023-08-12 |
rat |
M Carli, P Bonalumi, R Samani. Stimulation of 5-HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753130. |
stimulation of 5-ht1a receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. |
1998-10-08 |
2023-08-12 |
rat |
M Carli, P Bonalumi, R Samani. Stimulation of 5-HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753130. |
this study investigated the effect of stimulating 5-ht1a receptors in the dorsal raphe on the impairment of learning caused by 4 microg/microl scopolamine injected in the ca1 region of the dorsal hippocampus in rats performing a two-platform spatial discrimination task. |
1998-10-08 |
2023-08-12 |
rat |
M Carli, P Bonalumi, R Samani. Stimulation of 5-HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753130. |
at 1 (but not 0.2) microg/0.5 microl administered in the dorsal raphe on each acquisition training day 5 min before bilateral intrahippocampal injection of 4 microg/microl scopolamine, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), a 5-ht1a receptor agonist, had no effect on choice accuracy and latency or errors of omission but completely antagonized the impairment of choice accuracy by intrahippocampal scopolamine. |
1998-10-08 |
2023-08-12 |
rat |
M Carli, P Bonalumi, R Samani. Stimulation of 5-HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753130. |
administered into the dorsal raphe at 0.2 and 1 microg/0.5 microl, way 100635, a 5-ht1a receptor antagonist, had no effect on rats' performance or on the impairment caused by intrahippocampal scopolamine but dose-dependently antagonized the effect of 1 microg/0.5 microl 8-oh-dpat on the scopolamine-induced deficit. |
1998-10-08 |
2023-08-12 |
rat |
M Carli, P Bonalumi, R Samani. Stimulation of 5-HT1A receptors in the dorsal raphe reverses the impairment of spatial learning caused by intrahippocampal scopolamine in rats. The European journal of neuroscience. vol 10. issue 1. 1998-10-08. PMID:9753130. |
the results show that stimulation of presynaptic 5-ht1a receptors in the dorsal raphe reverses the deficit caused by intrahippocampal scopolamine, probably by facilitating the transfer of facilitatory information from the entorhinal cortex to the hippocampus. |
1998-10-08 |
2023-08-12 |
rat |
L G Larsson, C Stenfors, S B Ros. Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652362. |
since previous studies by others have indicated that the reserve of somatodendritic 5-ht1a receptors is greater in dorsal raphe nucleus innervating frontal cortex and striatum than in median raphe nucleus which mainly innervates hippocampus, the observed different regional potency of the two 5-ht1a receptor antagonists may be explained by this difference in the 5-ht1a receptor reserve. |
1998-09-16 |
2023-08-12 |
rat |
R Corradetti, N Laaris, N Hanoun, A M Laporte, E Le Poul, M Hamon, L Lanfume. Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. British journal of pharmacology. vol 123. issue 3. 1998-04-13. PMID:9504386. |
studies were performed on 5-ht1a receptors located on 5-hydroxytryptaminergic neurones in the dorsal raphe nucleus (drn) and on pyramidal cells in the ca1 and ca3 regions of the hippocampus in rat brain slices. |
1998-04-13 |
2023-08-12 |
rat |
J De Vry, R Schohe-Loop, H G Heine, J M Greuel, F Mauler, B Schmidt, H Sommermeyer, T Glase. Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495870. |
in a rat brain slice preparation containing the dorsal raphe nucleus (drn), a model of somatodendritic 5-ht1a receptor function, bay x 3702 inhibited potently (1 nm) neuronal firing. |
1998-04-09 |
2023-08-12 |
human |
D S Dupuis, C Palmier, F C Colpaert, P J Pauwel. Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489749. |
[35s]gtpgammas binding was stimulated by the mixed 5-ht1a/5-ht(1b/d) agonist l694247 in brain structures enriched in 5-ht1a binding sites, i.e., hippocampus (+140 +/- 14%), dorsal raphe (+70 +/- 8%), lateral septum (+52 +/- 12%), cingulate (+36 +/- 8%), and entorhinal cortex (+34 +/- 5%). |
1998-03-12 |
2023-08-12 |
Not clear |
H Razani, P B Hedlund, A C Hansson, K Fuxe, S O Ogre. 5-HT1A receptor activation: short-term effects on the mRNA expression of the 5-HT1A receptor and galanin in the raphe nuclei. Neuroreport. vol 8. issue 16. 1998-02-26. PMID:9427327. |
8-oh-dpat increased the hybridization signal of the 5-ht1a receptor by 105% in the dorsal raphe nucleus (b7) 30 min after the injection. |
1998-02-26 |
2023-08-12 |
Not clear |
H Razani, P B Hedlund, A C Hansson, K Fuxe, S O Ogre. 5-HT1A receptor activation: short-term effects on the mRNA expression of the 5-HT1A receptor and galanin in the raphe nuclei. Neuroreport. vol 8. issue 16. 1998-02-26. PMID:9427327. |
the results also indicate a dissociation between the effects mediated by 5-ht1a receptor functions and those regulating the coexisting peptide galanin in the dorsal raphe. |
1998-02-26 |
2023-08-12 |
Not clear |
R Corradetti, A M Pugliese, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. Acta physiologica Hungarica. vol 84. issue 4. 1998-02-02. PMID:9328615. |
electrophysiological effects of way 100635, a new 5-ht1a receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and ca1 pyramidal cells in vitro. |
1998-02-02 |
2023-08-12 |
Not clear |
R Corradetti, A M Pugliese, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. Acta physiologica Hungarica. vol 84. issue 4. 1998-02-02. PMID:9328615. |
the novel 5-ht1a receptor antagonist way 100635 [(n-(2-(-4(2-metoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyc lohexane carboxamide)] has been tested on 5-ht1a receptor-mediated inhibition of firing and intracellularly recorded hyperpolarisation of serotoninergic cells of the dorsal raphe nucleus (drn) and on hyperpolarisation of hippocampal ca1 pyramidal cells. |
1998-02-02 |
2023-08-12 |
Not clear |
R Ciccocioppo, I Panocka, C Polidori, C T Dourish, M Mass. Blockade of pre- and post-synaptic 5-HT1A receptors does not modify the effect of fluoxetine or 5-hydroxytryptophan on ethanol and food intake in rats. Psychopharmacology. vol 134. issue 1. 1998-01-27. PMID:9399367. |
blockade of presynaptic 5-ht1a receptors after injection of (+)way100135, 0.1 or 1 microgram/rat, into the dorsal raphe did not significantly modify ethanol, food or total fluid intake. |
1998-01-27 |
2023-08-12 |
rat |