| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ailton Spiacci, Roger Luis Henschel Pobbe, Melina Matthiesen, Helio Zangross. 5-HT1A receptors of the rat dorsal raphe lateral wings and dorsomedial subnuclei differentially control anxiety- and panic-related defensive responses. Neuropharmacology. vol 107. 2017-06-19. PMID:26145183. |
5-ht1a receptors of the rat dorsal raphe lateral wings and dorsomedial subnuclei differentially control anxiety- and panic-related defensive responses. |
2017-06-19 |
2023-08-13 |
rat |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
5-ht1a autoreceptors in the dorsal raphe nucleus convey vulnerability to compulsive cocaine seeking. |
2016-12-14 |
2023-08-13 |
mouse |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
finally, using a rat model of compulsive-like cocaine self-administration, we found that inhibition of dorsal raphe 5-ht1a autoreceptors attenuates cocaine self-administration in rats with 6 h extended access, but not 1 h access to the drug. |
2016-12-14 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
mechanisms of 5-ht1a receptor-mediated transmission in dorsal raphe serotonin neurons. |
2016-11-04 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
in the dorsal raphe nucleus, it is known that serotonin release activates metabotropic 5-ht1a autoreceptors located on serotonin neurons that leads to an inhibition of firing through the activation of g-protein-coupled inwardly rectifying potassium channels. |
2016-11-04 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
these results indicate that evoked serotonin transmission in the dorsal raphe nucleus mediated by metabotropic 5-ht1a autoreceptors may occur via point-to-point synapses rather than by paracrine mechanisms. |
2016-11-04 |
2023-08-13 |
mouse |
| Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. |
following depletion of 5-ht with para-chlorophenylalanine methyl-ester hydrochloride (pcpa), vilazodone still suppressed neuronal firing of dorsal raphe nucleus (drn) 5-ht neurons to a similar extent than controls, indicating that this inhibition is via 5-ht1a receptors activation. |
2016-08-30 |
2023-08-13 |
human |
| Nerea Llamosas, Cristina Bruzos-Cidón, José Julio Rodríguez, Luisa Ugedo, Maria Torrecill. Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior. The international journal of neuropsychopharmacology. vol 18. issue 11. 2016-07-19. PMID:25956878. |
targeting dorsal raphe 5-ht1a receptors, which are coupled to g-protein inwardly rectifying potassium (girk) channels, has revealed their contribution not only to behavioral and functional aspects of depression but also to the clinical response to its treatment. |
2016-07-19 |
2023-08-13 |
Not clear |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
pharmacological characterization of 5-ht1a autoreceptor-coupled girk channels in rat dorsal raphe 5-ht neurons. |
2016-06-06 |
2023-08-13 |
rat |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
whole-cell voltage-clamp recording in brainstem slices were used to determine concentration-response relationships for the selected girk channel blockers on 5-ht1a autoreceptor-activated inwardly rectifying k+ conductance in rat dorsal raphe 5-ht neurons. |
2016-06-06 |
2023-08-13 |
rat |
| Guillaume P Dugué, Magor L Lörincz, Eran Lottem, Enrica Audero, Sara Matias, Patricia A Correia, Clément Léna, Zachary F Maine. Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice. PloS one. vol 9. issue 8. 2016-03-17. PMID:25148042. |
in vivo, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-ht1a agonist, consistent with autoreceptor inhibition of raphe neurons. |
2016-03-17 |
2023-08-13 |
mouse |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
additionally, dorsal raphe 5-ht neurons from nlgn2 null mice exhibit reduced excitability, a loss of gabaa receptor-mediated ipscs, and increased 5-ht1a autoreceptor sensitivity. |
2016-01-21 |
2023-08-13 |
mouse |
| Yann S Mineur, Emily B Einstein, Matthew P Bentham, Mattis B Wigestrand, Sam Blakeman, Sylvia A Newbold, Marina R Picciott. Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25288485. |
we therefore knocked down 5-ht1a receptors in either the dorsal raphe (presynaptic autoreceptors) or the hippocampus (a brain area with high expression of 5-ht1a heteroreceptors sensitive to cholinergic effects on affective behaviors). |
2016-01-05 |
2023-08-13 |
mouse |
| Yann S Mineur, Emily B Einstein, Matthew P Bentham, Mattis B Wigestrand, Sam Blakeman, Sylvia A Newbold, Marina R Picciott. Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25288485. |
knockdown of 5-ht1a receptors in hippocampus, but not dorsal raphe, significantly decreased the antidepressant-like effect of cytisine. |
2016-01-05 |
2023-08-13 |
mouse |
| Yan Ping Hui, Tao Wang, Ling Na Han, Li Bo Li, Yi Na Sun, Jian Liu, Hong Fei Qiao, Qiao Jun Zhan. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat. Behavioural brain research. vol 277. 2015-09-08. PMID:24906197. |
this study sought to assess whether unilateral lesions of the medial forebrain bundle (mfb) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1a (5-ht1a) receptors of the prelimbic (prl) sub-region of ventral medial prefrontal cortex in the regulation of these behaviors, the density of 5-ht neurons in the dorsal raphe nucleus (drn) and co-localization of 5-ht1a receptor and neuronal glutamate transporter eaac1-immunoreactive (eaac1-ir) cells in the prl. |
2015-09-08 |
2023-08-13 |
rat |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
given that the major serotonergic circuit in the rat brain comprises the dorsal raphe nuclei and the medial prefrontal cortex (mpfc), and because the latter structure is involved in the control of complex behaviors and expresses 1a (5-ht1a), 2a (5-ht2a), and 3 (5-ht3) receptors, the aim was to study the role of 5-ht and of these receptors in the acquisition and extinction of a reward-dependent operant conditioning task. |
2015-09-08 |
2023-08-13 |
rat |
| Stefano Puglisi-Allegra, Diego Andolin. Serotonin and stress coping. Behavioural brain research. vol 277. 2015-09-08. PMID:25108244. |
based on growing evidence pointing to a medial prefrontal cortex-amygdala system in mediating adaptive and maladaptive stress responses, we propose a brain circuit in which serotonin neurons in the dorsal raphe depending on the crf (corticotropin releasing factor) regulatory action engage a prefrontal cortical-amygdala pathway through 5-ht1a receptors, gaba and glutamate to moderate coping behavior. |
2015-09-08 |
2023-08-13 |
human |
| Darakhshan J Halee. 5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson's disease and schizophrenia. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25503261. |
activation of somatodendritic 5-ht1a receptors in the dorsal raphe nucleus has an important role in the alleviation of extrapyramidal symptoms and levodopa-induced dyskinesia induced by antipsychotic treatment. |
2015-09-03 |
2023-08-13 |
Not clear |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
enhanced 5-ht1a receptor-dependent feedback control over dorsal raphe serotonin neurons in the sert knockout mouse. |
2015-07-24 |
2023-08-13 |
mouse |