| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
since 5-ht1a receptors in the mpfc provide a key feedback regulation of the dorsal raphe nucleus (drn), we used a disinhibition strategy to examined endogenous feedback control of 5-ht neurons. |
2015-07-24 |
2023-08-13 |
mouse |
| Hélio Zangrossi, Frederico G Graef. Serotonin in anxiety and panic: contributions of the elevated T-maze. Neuroscience and biobehavioral reviews. vol 46 Pt 3. 2015-07-17. PMID:24657635. |
the evidence so far reported with the etm supports the above hypothesis and indicates that: (1) whereas 5-ht neurons located at the dorsal raphe nucleus are involved in the regulation of both inhibitory avoidance and escape, those of the median raphe nucleus are primarily implicated in the former task; (2) facilitation of 5-ht1a- and 5-ht2a-mediated neurotransmission in the dorsal periaqueductal gray (dpag) is likely to mediate the panicolytic drug action; (3) stimulation of 5-ht2c receptors in the basolateral amygdala increases anxiety and is implicated in the anxiogenesis caused by short-term administration of antidepressant drugs, and (4) 5-ht1a and the μ-opioid receptors work together in the dpag to modulate escape or panic attacks. |
2015-07-17 |
2023-08-12 |
rat |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25225185. |
in addition, the effects on 5-ht1a autoreceptors in the dorsal raphe nucleus (drn) and d2 autoreceptors in the ventral tegmental area (vta) were compared with those of aripiprazole, an agent in wide clinical use. |
2015-02-17 |
2023-08-13 |
Not clear |
| Ofelia Limón-Morales, Cesar Soria-Fregozo, Marcela Arteaga-Silva, Gonzalo Vázquez-Palacios, Herlinda Bonilla-Jaim. Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine. Physiology & behavior. vol 124. 2014-12-10. PMID:24211235. |
also measured were levels of the mrna expression of 5-ht1a receptors in the dorsal raphe (dr), the hypothalamus and the hippocampus. |
2014-12-10 |
2023-08-12 |
rat |
| Ofelia Limón-Morales, Cesar Soria-Fregozo, Marcela Arteaga-Silva, Gonzalo Vázquez-Palacios, Herlinda Bonilla-Jaim. Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine. Physiology & behavior. vol 124. 2014-12-10. PMID:24211235. |
the expression of the mrna of the 5-ht1a receptors was examined in the dorsal raphe nucleus, the hypothalamus and the hippocampus using the semi-quantitative rt-pcr method. |
2014-12-10 |
2023-08-12 |
rat |
| M V Fogaça, F M C V Reis, A C Campos, F S Guimarãe. Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 3. 2014-11-25. PMID:24321837. |
moreover, restraint stress increased 5ht1a receptors expression in the dorsal raphe nucleus, an effect that was attenuated by injection of metyrapone before the restraint procedure. |
2014-11-25 |
2023-08-12 |
Not clear |
| V Michopoulos, M Perez Diaz, M Embree, K Reding, J R Votaw, J Mun, R J Voll, M M Goodman, M Wilson, M Sanchez, D Toufexi. Oestradiol alters central 5-HT1A receptor binding potential differences related to psychosocial stress but not differences related to 5-HTTLPR genotype in female rhesus monkeys. Journal of neuroendocrinology. vol 26. issue 2. 2014-10-15. PMID:24382202. |
additionally, e(2) reduced 5-ht1a bp(nd) in the dorsal raphe of all females irrespective of psychosocial stress or 5-httlpr genotype. |
2014-10-15 |
2023-08-12 |
monkey |
| Erica S Levitt, Barbara J Hunnicutt, Sharon J Knopp, John T Williams, John M Bissonnett. A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome. Journal of applied physiology (Bethesda, Md. : 1985). vol 115. issue 11. 2014-08-25. PMID:24092697. |
in whole cell voltage-clamp recordings from dorsal raphe neurons, f15599 potently induced an outward current, which was blocked by barium, reversed at the potassium equilibrium potential, and was antagonized by the 5-ht1a antagonist way100135. |
2014-08-25 |
2023-08-12 |
mouse |
| Olivia A Masseck, Katharina Spoida, Deniz Dalkara, Takashi Maejima, Johanna M Rubelowski, Lutz Wallhorn, Evan S Deneris, Stefan Herlitz. Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry. Neuron. vol 81. issue 6. 2014-05-21. PMID:24656249. |
we also show repetitive control of gi/o pathway activation in 5-ht1a receptor domains in the dorsal raphe nucleus (drn) in brain slices and in vivo, which is sufficient to modulate anxiety behavior in mice. |
2014-05-21 |
2023-08-12 |
mouse |
| Sawako Tabuchi, Tomomi Tsunematsu, Thomas S Kilduff, Shouta Sugio, Ming Xu, Kenji F Tanaka, Satoru Takahashi, Makoto Tominaga, Akihiro Yamanak. Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. Sleep. vol 36. issue 9. 2014-04-25. PMID:23997373. |
serotonergic (5ht) neurons of the dorsal raphe nuclei receive excitatory input from hypothalamic orexin (hypocretin) neurons and reciprocally inhibit orexin neurons through the 5ht1a receptor. |
2014-04-25 |
2023-08-12 |
Not clear |
| Yukio Ago, Ryota Araki, Tatsunori Tanaka, Asuka Sasaga, Saki Nishiyama, Kazuhiro Takuma, Toshio Matsud. Role of social encounter-induced activation of prefrontal serotonergic systems in the abnormal behaviors of isolation-reared mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23426384. |
a 5-ht1a receptor agonist, a metabotropic glutamate 2/3 receptor agonist, and a gamma-aminobutyric acid a receptor agonist attenuated isolation-induced aggressive behaviors and encounter-induced hyperactivity, c-fos expression in the prefrontal cortex and dorsal raphe nucleus, and increases in prefrontal 5-ht levels. |
2014-02-13 |
2023-08-12 |
mouse |
| G Quesseveur, D J David, M C Gaillard, P Pla, M V Wu, H T Nguyen, V Nicolas, G Auregan, I David, A Dranovsky, P Hantraye, R Hen, A M Gardier, N Déglon, B P Guiar. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Translational psychiatry. vol 3. 2013-12-23. PMID:23632457. |
the sustained administration of ssris increases the serotonergic neurotransmission in response to a functional desensitization of the inhibitory 5-ht1a autoreceptor in the dorsal raphe. |
2013-12-23 |
2023-08-12 |
mouse |
| Cynthia L Bethea, Kenny Phu, Arubala P Reddy, Judy L Camero. The effect of short-term stress on serotonin gene expression in high and low resilient macaques. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23357537. |
tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor mrnas expression were determined at 4 morphological levels of the dorsal raphe nucleus with in situ hybridization (ish) using digoxigenin-incorporated riboprobes. |
2013-12-18 |
2023-08-12 |
monkey |
| Vicky Katsidoni, Ilektra Anagnostou, George Panagi. Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus. Addiction biology. vol 18. issue 2. 2013-09-18. PMID:22862835. |
cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-ht1a receptors in the dorsal raphe nucleus. |
2013-09-18 |
2023-08-12 |
rat |
| Vicky Katsidoni, Ilektra Anagnostou, George Panagi. Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus. Addiction biology. vol 18. issue 2. 2013-09-18. PMID:22862835. |
these effects were mediated by activation of 5-ht1a receptors in the dorsal raphe. |
2013-09-18 |
2023-08-12 |
rat |
| Laura Saenz del Burgo, Roser Cortés, Guadalupe Mengod, Mario Montaña, Gontzal García del Caño, Joan Sallé. Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 3. 2013-08-19. PMID:22591911. |
under these conditions, 5-ht1a receptor mrna expression decreased in dorsal raphe nucleus and dentate gyrus. |
2013-08-19 |
2023-08-12 |
rat |
| Laura Saenz del Burgo, Roser Cortés, Guadalupe Mengod, Mario Montaña, Gontzal García del Caño, Joan Sallé. Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 3. 2013-08-19. PMID:22591911. |
it is noteworthy that chronic treatment with fluoxetine reversed the alterations on 5-ht1a receptor mrna levels only in dorsal raphe. |
2013-08-19 |
2023-08-12 |
rat |
| Naozumi Araragi, Boris Mlinar, Gilda Baccini, Lise Gutknecht, Klaus-Peter Lesch, Renato Corradett. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis. Frontiers in pharmacology. vol 4. 2013-08-12. PMID:23935583. |
firing activity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn) is controlled by inhibitory somatodendritic 5-ht1a autoreceptors. |
2013-08-12 |
2023-08-12 |
mouse |
| Kathleen Scullion, Jeffery A Boychuk, Glenn R Yamakawa, Justin T G Rodych, Stan T Nakanishi, Angela Seto, Victoria M Smith, Ryan W McCarthy, Patrick J Whelan, Michael C Antle, Quentin J Pittman, G Campbell Teske. Serotonin 1A receptors alter expression of movement representations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486969. |
in rats, electrical stimulation of the dorsal raphe lowered movement thresholds and this effect could be blocked by direct cortical application of the 5-ht1a antagonist way-100135, indicating that serotonin is primarily acting through the 5-ht1a receptor. |
2013-05-06 |
2023-08-12 |
mouse |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |