All Relations between 5-ht receptor 1a and dorsal raphe

Publication Sentence Publish Date Extraction Date Species
M A Cooper, M S Grober, C R Nicholas, K L Huhma. Aggressive encounters alter the activation of serotonergic neurons and the expression of 5-HT1A mRNA in the hamster dorsal raphe nucleus. Neuroscience. vol 161. issue 3. 2009-08-24. PMID:19362123. aggressive encounters alter the activation of serotonergic neurons and the expression of 5-ht1a mrna in the hamster dorsal raphe nucleus. 2009-08-24 2023-08-12 Not clear
Jacqueline Borg, Susanne Henningsson, Tomoyuki Saijo, Makoto Inoue, Jessica Bah, Lars Westberg, Johan Lundberg, Hristina Jovanovic, Bengt Andrée, Anna-Lena Nordstrom, Christer Halldin, Elias Eriksson, Lars Fard. Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans. The international journal of neuropsychopharmacology. vol 12. issue 6. 2009-08-18. PMID:19126263. regional binding potential (bp) of [11c]way 100635 to 5-ht1a receptor was calculated for the dorsal raphe nuclei, the hippocampus, the anterior cingulate, the insula, the temporal cortex and the frontal cortex. 2009-08-18 2023-08-12 human
Marie-Bernadette Assié, Ouissame Mnie-Filali, Véronique Ravailhe, Christelle Benas, Marc Marien, Cécile Bétry, Luc Zimmer, Nasser Haddjeri, Adrian Newman-Tancred. F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: influence on neuronal firing and neurotransmitter release. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19326477. in the dorsal raphe, both ligands suppressed firing activity, consistent with agonism at 5-ht1a autoreceptors, although ssr181507 (25-75 microg/kg, i.v.) 2009-07-07 2023-08-12 rat
Xavier López-Gil, Francesc Artigas, Albert Adel. Role of different monoamine receptors controlling MK-801-induced release of serotonin and glutamate in the medial prefrontal cortex: relevance for antipsychotic action. The international journal of neuropsychopharmacology. vol 12. issue 4. 2009-06-26. PMID:18752722. on the other hand, atypical antipsychotic drugs might further act upon 5-ht2a, 5-ht1a and alpha1-adrenoceptors present in pyramidal cells (including those projecting to the dorsal raphe nucleus), which would directly inhibit an excessive excitability of these cells. 2009-06-26 2023-08-12 Not clear
Francis Rodriguez Bambico, Nhu-Tram Nguyen, Gabriella Gobb. Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 3. 2009-05-20. PMID:19147333. these were associated with a decrease in the spontaneous firing activity (35.4%) as well as in the number of spontaneously active 5-ht neurons, and a desensitization of somatodendritic 5-ht1a autoreceptors in the dorsal raphe. 2009-05-20 2023-08-12 rat
Elena Castro, Alvaro Díaz, Antonio Rodriguez-Gaztelumendi, Elena Del Olmo, Angel Pazo. WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality. Neuropharmacology. vol 55. issue 8. 2009-04-15. PMID:18809415. however, the net stimulation of [35s]gtpgammas binding induced by the 5-ht1a agonist 8-oh-dpat was significantly attenuated in dorsal raphe nucleus (drn), but not in hippocampus, after chronic fluoxetine. 2009-04-15 2023-08-12 rat
F Pain, M Dhenain, H Gurden, A L Routier, F Lefebvre, R Mastrippolito, P Lanièc. A method based on Monte Carlo simulations and voxelized anatomical atlases to evaluate and correct uncertainties on radiotracer accumulation quantitation in beta microprobe studies in the rat brain. Physics in medicine and biology. vol 53. issue 19. 2008-12-10. PMID:18765889. finally, since stereotaxic accuracy is crucial for quantification in most microprobe studies, the influence of stereotaxic positioning error was studied for several realistic experiments in favorable and unfavorable experimental situations (binding of (11)c-raclopride to d2 dopaminergic receptors in the striatum; binding of (18)f-mppf to 5ht1a receptors in the dorsal raphe nucleus). 2008-12-10 2023-08-12 rat
Matthew A Cooper, Kathleen E McIntyre, Kim L Huhma. Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat. Psychoneuroendocrinology. vol 33. issue 9. 2008-11-25. PMID:18692968. activation of 5-ht1a autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat. 2008-11-25 2023-08-12 Not clear
E Fiske, C M Portas, J Grønli, E Sørensen, B Bjorvatn, A A Bjørkum, R Ursi. Increased extracellular 5-HT but no change in sleep after perfusion of a 5-HT1A antagonist into the dorsal raphe nucleus of rats. Acta physiologica (Oxford, England). vol 193. issue 1. 2008-08-01. PMID:18081887. increased extracellular 5-ht but no change in sleep after perfusion of a 5-ht1a antagonist into the dorsal raphe nucleus of rats. 2008-08-01 2023-08-12 rat
Maura Boldrini, Mark D Underwood, J John Mann, Victoria Arang. Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. Journal of psychiatric research. vol 42. issue 6. 2008-06-24. PMID:17574270. brainstem 5-ht1a somatodendritic autoreceptors regulate serotonin neuron firing but studies of autoreceptor binding in the dorsal raphe nucleus (drn) in depressed suicides report conflicting results. 2008-06-24 2023-08-12 Not clear
Dania V Rossi, Teresa F Burke, Julie G Hensle. Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18289523. the effect of chronic citalopram or escitalopram administration on 5-ht1a receptor function in the dorsal raphe nucleus was determined by measuring [35s]gtp gamma s binding stimulated by the 5-ht1a receptor agonist (r)-(+)-8-oh-dpat (1nm-10 microm). 2008-05-27 2023-08-12 Not clear
Dania V Rossi, Teresa F Burke, Julie G Hensle. Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. European journal of pharmacology. vol 583. issue 1. 2008-05-27. PMID:18289523. as the binding and action of escitalopram is limited by the inactive enantiomer r-citalopram present in racemic citalopram, we propose that the regulation of 5-ht1a receptor function in the dorsal raphe nucleus at the level of receptor-g protein interaction may be a result of greater inhibition of the serotonin transporter by escitalopram. 2008-05-27 2023-08-12 Not clear
Tushar Advani, Julie G Hensler, Wouter Koe. Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice. The international journal of neuropsychopharmacology. vol 10. issue 5. 2008-01-17. PMID:17134528. we have evaluated in c57bl/6j mice the effect of maternal separation and post-weaning social isolation on ethanol intake, and on serotonin1a (5-ht1a) receptor function at the level of receptor-g protein interaction in the hippocampus and dorsal raphe nucleus. 2008-01-17 2023-08-12 mouse
Tushar Advani, Julie G Hensler, Wouter Koe. Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice. The international journal of neuropsychopharmacology. vol 10. issue 5. 2008-01-17. PMID:17134528. 5-ht1a receptor-stimulated [35s]gtpgammas binding in the dorsal raphe nucleus was increased in animals reared after weaning in isolation vs. in pairs, regardless of gender or pre-weaning rearing conditions. 2008-01-17 2023-08-12 mouse
Tushar Advani, Julie G Hensler, Wouter Koe. Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice. The international journal of neuropsychopharmacology. vol 10. issue 5. 2008-01-17. PMID:17134528. our data suggest that there are long-term neurochemical consequences of social isolation of adolescent mice, specifically increased 5-ht1a receptor function in the dorsal raphe nucleus. 2008-01-17 2023-08-12 mouse
Sven Ove Ogren, Haleh Razani, Elin Elvander-Tottie, Jan Keh. The neuropeptide galanin as an in vivo modulator of brain 5-HT1A receptors: possible relevance for affective disorders. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17585970. ), was demonstrated to have strong inhibitory interactions with 5-ht1a receptor functions, particularly in the dorsal raphe but also in the hippocampus. 2007-12-06 2023-08-12 rat
Sven Ove Ogren, Haleh Razani, Elin Elvander-Tottie, Jan Keh. The neuropeptide galanin as an in vivo modulator of brain 5-HT1A receptors: possible relevance for affective disorders. Physiology & behavior. vol 92. issue 1-2. 2007-12-06. PMID:17585970. since pre- and postsynaptic 5-ht1a receptors in the dorsal raphe and hippocampus are implicated in the action of antidepressant drugs and in depressive disorders, it is suggested that galanin receptors may be an important target for development of novel antidepressant drugs. 2007-12-06 2023-08-12 rat
David R Thomas, Ellen M Soffin, Claire Roberts, James N C Kew, Raul M de la Flor, Lee A Dawson, Victoria A Fry, Sara A Coggon, Stefania Faedo, Philip D Hayes, David F Corbett, Ceri H Davies, Jim J Haga. SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16846620. in guinea pig dorsal raphe slices, sb-699551-a (1 microm) did not alter neuronal firing per se but attenuated the 5-ct-induced depression in serotonergic neuronal firing in a subpopulation of cells insensitive to the 5-ht1a receptor-selective antagonist way-100635 (100 nm). 2006-12-14 2023-08-12 human
Jean-Philippe Guilloux, Denis J P David, Bruno P Guiard, Franck Chenu, Christelle Repérant, Miklos Toth, Michel Bourin, Alain M Gardie. Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16452992. basal levels of extracellular serotonin, 5-ht ([5-ht]ext) in the frontal cortex (fcx) and the dorsal raphe nucleus (drn) did not differ between the two strains of mice, suggesting a lack of tonic control of 5-ht1a autoreceptors on nerve terminal 5-ht release. 2006-11-01 2023-08-12 mouse
Baptiste Lacoste, Mustapha Riad, Laurent Descarrie. Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus. The European journal of neuroscience. vol 23. issue 11. 2006-09-28. PMID:16819984. in rodents, treatment with nk1r antagonists has been shown to increase the firing of dorsal raphe nucleus (drn) serotonin (5-hydroxytryptamine, 5-ht) neurons and to induce a desensitization of their 5-ht1a autoreceptors, suggesting local interactions between the sp and 5-ht systems. 2006-09-28 2023-08-12 mouse