All Relations between 5-ht receptor 1a and dorsal raphe

Publication Sentence Publish Date Extraction Date Species
Sven Ove Ogren, Eugenia Kuteeva, Tomas Hökfelt, Jan Keh. Galanin receptor antagonists : a potential novel pharmacological treatment for mood disorders. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863269. moreover, intracerebroventricular galanin alters the gene expression of serotonin 5-ht1a autoreceptors in the dorsal raphe and also changes their functional activity. 2006-09-19 2023-08-12 mouse
Jeanne Lanoir, Gerard Hilaire, Isabelle Sei. Reduced density of functional 5-HT1A receptors in the brain, medulla and spinal cord of monoamine oxidase-A knockout mouse neonates. The Journal of comparative neurology. vol 495. issue 5. 2006-06-26. PMID:16498683. abnormally high brain 5-ht levels in monoamine oxidase-a knockout (mao-a ko) mouse neonates raise the question of whether the distribution and density of the 5-ht1a receptors (5-ht1ar) expressed in the brain by postnatal day p7 are affected and, if so, whether the 5-ht1a autoreceptors in the dorsal raphe are modified in the same way as the postsynaptic 5-ht1ar present in raphe target structures. 2006-06-26 2023-08-12 mouse
Alexis Evrard, Nicolas Barden, Michel Hamon, Joëlle Adrie. Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice. Sleep. vol 29. issue 1. 2006-04-14. PMID:16453979. in animals, sleep deprivation and pharmacologic treatment with antidepressants exert similar effects on 5-ht neurotransmission, notably functional desensitization of 5-ht1a autoreceptors located on 5-ht neurons in the dorsal raphe nucleus (drn). 2006-04-14 2023-08-12 mouse
B E Leonar. The HPA and immune axes in stress: the involvement of the serotonergic system. European psychiatry : the journal of the Association of European Psychiatrists. vol 20 Suppl 3. 2006-03-21. PMID:16459240. the mechanism whereby chronic stress, via the crf induced activation of the dorsal raphe nucleus, can induce a change in the serotonergic system, involves an increase in the 5ht2a and a decrease in the 5ht1a receptor mediated function. 2006-03-21 2023-08-12 Not clear
Bruno P Guiard, Laurence Lanfumey, Alain M Gardie. Microdialysis approach to study serotonin outflow in mice following selective serotonin reuptake inhibitors and substance P (neurokinin 1) receptor antagonist administration: a review. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475960. preclinical electrophysiological and neurochemical studies demonstrated that the putative new class of antidepressants, substance p (neurokinin 1) nk1 receptor antagonists, enhance brain monoaminergic neurotransmissions by reducing the sensitivity of 5-ht1a autoreceptors in the dorsal raphe nucleus, and possibly alpha2 autoreceptors in the locus coeruleus. 2006-03-10 2023-08-12 mouse
Minoru Narita, Kazuya Miyagawa, Michiko Narita, Keisuke Mizuo, Mayumi Miyatake, Suzuki Tsutom. [The functional change in the 5-HT1A receptor induced by stress and the role of the 5-HT1A receptor in neuroprotection]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 25. issue 2. 2005-12-07. PMID:16220659. under this condition, a remarkable decrease in [35s]gtpgammas binding to membranes from the prefrontal cortex, amygdala and hypothalamus of restrained-stress mice stimulated by the selective 5-ht1a receptor agonist 5-carboxamidotriptamine (5-ct) was clearly observed, whereas a significant increase in [35s]gtpgammas binding stimulated by the 5-ht1a receptor agonist was clearly observed in the dorsal raphe nuclei (drn) of restrained-stress mice. 2005-12-07 2023-08-12 mouse
Renato Corradetti, Boris Mlinar, Chiara Falsini, Anna Maria Pugliese, Antonio Cilia, Carla Destefani, Rodolfo Test. Differential effects of the 5-hydroxytryptamine (5-HT)1A receptor inverse agonists Rec 27/0224 and Rec 27/0074 on electrophysiological responses to 5-HT1A receptor activation in rat dorsal raphe nucleus and hippocampus in vitro. The Journal of pharmacology and experimental therapeutics. vol 315. issue 1. 2005-11-28. PMID:15951403. differential effects of the 5-hydroxytryptamine (5-ht)1a receptor inverse agonists rec 27/0224 and rec 27/0074 on electrophysiological responses to 5-ht1a receptor activation in rat dorsal raphe nucleus and hippocampus in vitro. 2005-11-28 2023-08-12 human
Andrea Gogos, Snezana Kusljic, Maarten van den Buus. 8-OH-DPAT-induced effects on prepulse inhibition: pre- vs. post-synaptic 5-HT1A receptor activation. Pharmacology, biochemistry, and behavior. vol 81. issue 3. 2005-09-26. PMID:15955549. it is unclear whether this effect is due to the activation of pre- or post-synaptic 5-ht1a receptors, however pre-synaptic receptors located in the dorsal raphe nucleus (drn) may play a role. 2005-09-26 2023-08-12 rat
C L Bethea, J M Streicher, S J Mirkes, R L Sanchez, A P Reddy, J L Camero. Serotonin-related gene expression in female monkeys with individual sensitivity to stress. Neuroscience. vol 132. issue 1. 2005-07-20. PMID:15780474. in situ hybridization and quantitative image analysis was used to measure mrnas coding for sert (serotonin transporter), 5ht1a autoreceptor, mao-a and mao-b (monoamine oxidases) at six levels of the dorsal raphe nucleus (drn). 2005-07-20 2023-08-12 monkey
C L Bethea, J M Streicher, S J Mirkes, R L Sanchez, A P Reddy, J L Camero. Serotonin-related gene expression in female monkeys with individual sensitivity to stress. Neuroscience. vol 132. issue 1. 2005-07-20. PMID:15780474. thus, all serotonin-related mrnas examined in the dorsal raphe to date were lower (sert, mao-a) or exhibited a lower trend (5ht1a, mao-b) in the stress sensitive animals, which probably reflects the lower number of serotonin neurons present. 2005-07-20 2023-08-12 monkey
Qian Li, Andrew Holmes, Li Ma, Louis D Van de Kar, Francisca Garcia, Dennis L Murph. Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 48. 2005-07-12. PMID:15574737. these mice also showed decreased density of 5-hydroxytryptamine (5-ht1a) receptors in the hypothalamus, amygdala, and dorsal raphe. 2005-07-12 2023-08-12 mouse
Richard McQuade, Mel M Leitch, Sarah E Gartside, Allan H Youn. Effect of chronic lithium treatment on glucocorticoid and 5-HT1A receptor messenger RNA in hippocampal and dorsal raphe nucleus regions of the rat brain. Journal of psychopharmacology (Oxford, England). vol 18. issue 4. 2005-04-12. PMID:15582915. effect of chronic lithium treatment on glucocorticoid and 5-ht1a receptor messenger rna in hippocampal and dorsal raphe nucleus regions of the rat brain. 2005-04-12 2023-08-12 rat
Jordanna E Bermack, Nasser Haddjeri, Guy Debonne. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 310. issue 2. 2005-03-28. PMID:15044555. effects of the potential antidepressant opc-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-ht1a ligand: modulation of neuronal activity in the dorsal raphe nucleus. 2005-03-28 2023-08-12 rat
Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. corticosterone strongly increases the affinity of dorsal raphe 5-ht1a receptors. 2004-09-16 2023-08-12 rat
Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. the effects of corticosterone (10 mg/kg, s.c., 6 h) on dorsal raphe 5-ht1a autoreceptors have been studied in adrenalectomized rats with or without porcine galanin modulation. 2004-09-16 2023-08-12 rat
Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. galanin (10 nm) increases dorsal raphe 5-ht1a autoreceptor density (+65%, p<0.05) and its kd value (+248%, p<0.05) only in adrenalectomized rats treated with corticosterone. 2004-09-16 2023-08-12 rat
Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. dorsal raphe glucocorticoid receptors activation by corticosterone may therefore lead to an increased signalling of 5-ht1a autoreceptors that may become counteracted by galanin receptor activation. 2004-09-16 2023-08-12 rat
Inmaculada Bellido, Anita C Hansson, Aurelio J Gómez-Luque, Beth Andbjer, Luigi F Agnati, Kjell Fux. Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors. Neuroreport. vol 15. issue 9. 2004-09-16. PMID:15194873. glucocorticoids, by enhancing dorsal raphe 5-ht1a autoreceptor function, may therefore cause reduced 5-ht neuronal activity and thus lead to a depressive state. 2004-09-16 2023-08-12 rat
Tsuguka Shiwa, Taku Amano, Hiroaki Matsubayashi, Takahiro Seki, Masashi Sasa, Norio Saka. Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HT1A receptor. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501160. perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-ht1a receptor. 2004-07-09 2023-08-12 rat
Jaime M Monti, Héctor Janto. Differential effects of the 5-HT1A receptor agonist flesinoxan given locally or systemically on REM sleep in the rat. European journal of pharmacology. vol 478. issue 2-3. 2004-06-17. PMID:14575796. direct infusion of the 5-ht1a receptor agonist (0.06 and/or 0.12 nmol) into the dorsal raphe nucleus induced a significant increment of rem sleep and augmented the number of rem periods during the second and/or third 2-h period of recording. 2004-06-17 2023-08-12 rat