| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Doherty, V M Picke. Targeting of serotonin 1A receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain. The Journal of comparative neurology. vol 433. issue 3. 2001-07-12. PMID:11298363. |
these findings suggest a reserve of cytoplasmic 5-ht1a receptors that are mobilized to functional postsynaptic sites on the plasma membrane by afferent input to distal dendrites in the vta. |
2001-07-12 |
2023-08-12 |
rat |
| M D Doherty, V M Picke. Targeting of serotonin 1A receptors to dopaminergic neurons within the parabrachial subdivision of the ventral tegmental area in rat brain. The Journal of comparative neurology. vol 433. issue 3. 2001-07-12. PMID:11298363. |
in each region, 5-ht1a immunoreactivity was mainly observed in somatodendritic profiles, but it was also present in small unmyelinated axons and in a few axon terminals and glia, suggesting a role for 5-ht1a receptors in presynaptic and glial functions, as well as postsynaptic neuronal activation, in vta. |
2001-07-12 |
2023-08-12 |
rat |
| F Lejeune, M J Milla. Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. Synapse (New York, N.Y.). vol 30. issue 2. 1998-11-16. PMID:9723787. |
this study examined the influence of the highly selective 5-ht1a receptor ligands, flesinoxan, s 15535, and way 100,635, upon the electrical activity of dopaminergic neurons in the ventral tegmental area (vta), as compared to serotonergic neurons in the dorsal raphe nucleus (drn) of anesthetized rats. |
1998-11-16 |
2023-08-12 |
rat |
| R De La Garza, P M Callahan, K A Cunningha. The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area. Psychopharmacology. vol 137. issue 1. 1998-08-06. PMID:9631950. |
microinjection of the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (dpat; 0.1-10 microg/0.5 microl/side) or the 5-ht1a antagonist way 100635 (0.01-1.0 microg/0.5 microl/side) into the vta or snr did not substitute for the systemic cocaine cue. |
1998-08-06 |
2023-08-12 |
rat |
| R De La Garza, P M Callahan, K A Cunningha. The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area. Psychopharmacology. vol 137. issue 1. 1998-08-06. PMID:9631950. |
the discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-ht1a agonist or antagonist, into the ventral tegmental area. |
1998-08-06 |
2023-08-12 |
rat |
| R De La Garza, P M Callahan, K A Cunningha. The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area. Psychopharmacology. vol 137. issue 1. 1998-08-06. PMID:9631950. |
in the present study, we investigated the role of 5-ht1a receptors in the ventral tegmental area (vta) in mediating the discriminative stimulus effects of cocaine. |
1998-08-06 |
2023-08-12 |
rat |
| R De La Garza, P M Callahan, K A Cunningha. The discriminative stimulus properties of cocaine: effects of microinfusion of cocaine, a 5-HT1A agonist or antagonist, into the ventral tegmental area. Psychopharmacology. vol 137. issue 1. 1998-08-06. PMID:9631950. |
overall, these data indicate that 5-ht1a receptors in the vta do not mediate or modulate the discriminative stimulus effects of cocaine in the rat. |
1998-08-06 |
2023-08-12 |
rat |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
neither (+)- nor (-)-7-oh-dpat show substantial selectivity for hd3 vs. 5-ht1a receptors and their inhibition of the firing of vta as compared to drn neurones is mediated by hd3/hd2 and 5-ht1a receptors, respectively. |
1997-04-11 |
2023-08-12 |
human |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
concerning 5-ht1a receptors, the (+)-isomer showed 20-fold lower affinity than at hd3 receptors and, accordingly, it inhibited drn firing at 20-fold higher doses than for inhibition of vta firing. |
1997-04-11 |
2023-08-12 |
human |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
in our study, we evaluated the influence of their (+)- and (-) isomers on the electrical activity of serotoninergic neurones of the dorsal raphe nucleus (drn), which bear 5-ht1a autoreceptors, and of dopaminergic neurones of the ventral tegmental area (vta), which possess inhibitory d3 and d2 receptors. |
1997-04-11 |
2023-08-12 |
human |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
finally, vta neurones are stimulated by (+)-8-oh-dpat via 5-ht1a receptors and inhibited by (-)-8-oh-dpat via hd3 and/or hd2 receptors. |
1997-04-11 |
2023-08-12 |
human |
| F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics. vol 280. issue 3. 1997-04-11. PMID:9067310. |
(-)-7-oh-dpat showed even less (5-fold) selectivity for hd3 vs. 5-ht1a sites and for inhibition of vta vs. drn firing. |
1997-04-11 |
2023-08-12 |
human |
| J Zhang, J A Engel, S Hjorth, L Svensso. Changes in the acoustic startle response and prepulse inhibition of acoustic startle in rats after local injection of pertussis toxin into the ventral tegmental area. Psychopharmacology. vol 119. issue 1. 1995-10-19. PMID:7675952. |
the present results suggest that local injection of ptx into the vta causes an increased sensitivity to the behavioural effects of psychostimulants on acoustic startle and may also suggest that intact midbrain 5-ht1a receptors are essential for the effect of 5-ht1a agonists on acoustic startle. |
1995-10-19 |
2023-08-12 |
rat |
| N H Chen, M E Reit. Monoamine interactions measured by microdialysis in the ventral tegmental area of rats treated systemically with (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891086. |
the effect of (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin (8-oh-dpat), a selective serotonin 5-ht1a agonist, on levels of extracellular norepinephrine (ne), dopamine (da), and 5-ht (measured simultaneously) was investigated by microdialysis in the ventral tegmental area (vta) of freely moving rats, and their behavioral activity was monitored. |
1995-04-18 |
2023-08-12 |
rat |
| L Cervo, G Grignaschi, E Nowakowska, R Samani. 1-(3-Trifluoromethylphenyl) piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: possible role of serotonin receptors. European journal of pharmacology. vol 171. issue 1. 1990-03-12. PMID:2533079. |
infusion of 5 micrograms/microliters 8-hydroxy-2-(di-n-propylamino)tetralin, a specific 5-ht1a receptor agonist, into the vta did not modify the effect of dmi. |
1990-03-12 |
2023-08-11 |
rat |
| X M Guan, W J McBrid. Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release. Brain research bulletin. vol 23. issue 6. 1990-03-08. PMID:2575444. |
the results suggest that 5-ht innervations in the vta may have an excitatory action possibly via 5-ht1b rather than 5-ht1a receptors on the mesolimbic da system projecting to the acc and that this da system may also be regulated by glutamatergic and gabaergic (via gabaa receptors) inputs. |
1990-03-08 |
2023-08-11 |
rat |