All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Eman Ali, Fakhar Latif, Yusra Mashkoor, Ayesha Sheikh, Amna Iqbal, Rabia Owais, Jawad Ahmed, Sadiq Naveed, Abdul Moeed, Irfan Ullah, Sanila Mugha. Role of adjunctive cariprazine for treatment-resistant depression in patients with major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. Asian journal of psychiatry. vol 95. 2024-03-21. PMID:38513509. cariprazine is an orally active dopamine d3-preferring d3/d2 receptor and serotonin 5-ht1a receptor partial agonist, being considered as a treatment for refractory mdd. 2024-03-21 2024-03-24 Not clear
Małgorzata Łupina, Agnieszka Wąsik, Irena Baranowska-Bosiacka, Maciej Tarnowski, Tymoteusz Słowik, Piotr Listos, Jolanta Kotlińska, Danuta Kosik-Bogacka, Izabela Gutowska, Joanna Listo. Acute and Chronic Exposure to Linagliptin, a Selective Inhibitor of Dipeptidyl Peptidase-4 (DPP-4), Has an Effect on Dopamine, Serotonin and Noradrenaline Level in the Striatum and Hippocampus of Rats. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474255. acute linagliptin exposure increases the serotonin level in both areas, while after chronic linagliptin administration a tendency for the mrna expression of serotoninergic receptors (5-ht1a and 5-ht2a) to increase was observed. 2024-03-13 2024-03-15 rat
Jie Zhou, Jiao-Wen Wu, Bai-Lin Song, Yi Jiang, Qiu-Hong Niu, Lai-Fu Li, Ying-Juan Li. 5-HT1A receptors within the intermediate lateral septum modulate stress vulnerability in male mice. Progress in neuro-psychopharmacology & biological psychiatry. 2024-02-14. PMID:38354893. these stress-susceptible mice also exhibited elevated neuronal activity in the ls as evidenced by greater c-fos expression, greater activity of 5-ht neurons in both the dorsal and median raphe nucleus, and downregulated expression of the 5-ht1a receptor in the intermediate ls (lsi). 2024-02-14 2024-02-17 mouse
Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys. PLoS biology. vol 22. issue 1. 2024-01-01. PMID:38163325. these results suggest that 5-ht deficiency disrupts 2 processes, the subjective valuation of costs and rewards, via 5-ht1a and 5-ht1b receptors, thus leading to reduced motivation. 2024-01-01 2024-01-05 monkey
Manas R Biswal, Ryan J Paulson, Riddhi Vichare, Alfred S Lewi. Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136248. the purpose of our study was to determine if buspirone, a partial serotonin 1a (5-ht1a) receptor agonist, protected against oxidative stress-induced changes in the rpe. 2023-12-23 2023-12-25 mouse
Polona Rus Prelog, Anja Kokalj Palandaci. Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report. BMC psychiatry. vol 23. issue 1. 2023-12-11. PMID:38082232. it functions as a partial agonist with high affinity for dopamine d2 and d3 and serotonin 5-ht1a receptors, an antagonist for 5-ht2a (moderate affinity) and 5-ht2b (high affinity) receptors. 2023-12-11 2023-12-17 Not clear
Hamed Alizadeh Pahlavan. Possible role of exercise therapy on depression: effector neurotransmitters as key players. Behavioural brain research. 2023-12-04. PMID:38048912. swimming exercise has antidepressant effects by increasing the sensitivity of serotonin 5-ht2 receptors and postsynaptic 5-ht1a receptors, increasing 5-ht and 5hiaa levels, increasing tph and serotonin, and decreasing inflammatory levels of ifn-γ and tnf-α. 2023-12-04 2023-12-10 Not clear
Emerson F Harkin, Georges Nasrallah, Brice Le François, Paul R Alber. Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958600. serotonin 1a (5-ht1a) autoreceptors located on serotonin neurons inhibit their activity, and their upregulation has been implicated in depression, suicide and resistance to antidepressant treatment. 2023-11-14 2023-11-20 human
Iman Touati, Mohnad Abdalla, Yassir Boulaamane, Nawal Al-Hoshani, Abdulaziz Alouffi, Mohammed Reda Britel, Amal Maurad. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors. Journal of biomolecular structure & dynamics. 2023-10-18. PMID:37850444. identification of novel dual acting ligands targeting the adenosine a2a and serotonin 5-ht1a receptors. 2023-10-18 2023-11-08 Not clear
Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. whole-cell recordings from dorsal raphe serotonin neurons revealed altered 5-ht1a receptor-dependent inhibitory postsynaptic currents (5-ht1a-ipscs) in female but not male ko neurons. 2023-10-17 2023-11-08 mouse
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. vilazodone, a selective serotonin reuptake inhibitor with diminished impact on methylphenidate-induced gene regulation in the striatum: role of 5-ht1a receptor. 2023-10-08 2023-10-15 rat
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. vilazodone differs from prototypical ssris in that, in addition to blocking serotonin reuptake, it acts as a partial agonist at the 5-ht1a serotonin receptor subtype. 2023-10-08 2023-10-15 rat
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. studies showed that stimulation of the 5-ht1a receptor tempers serotonin input to the striatum. 2023-10-08 2023-10-15 rat
Neha Munawar, Milad S Bitar, Willias Masoch. Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762636. using qrt-pcr, western blotting, immunohistochemistry, and hplc-based techniques, we also measured in the central nervous system and peripheral nervous system of diabetic animals the expression and localization of 5-ht1a receptors (5-ht1ar), levels of key enzymes involved in the synthesis and degradation of tryptophan and 5-ht, including tryptophan hydroxylase-2 (tph-2), tryptophan 2,3-dioxygenase (tdo), indoleamine 2,3-dioxygenase 1 (ido1) and ido2. 2023-09-28 2023-10-07 rat
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. using cultured drosophila serotonergic neurons, we found that exogenous serotonin reduced axon length and branching only in those expressing 5-ht1a. 2023-09-15 2023-10-07 drosophila_melanogaster
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. pharmacological activation of 5-ht1a led to reduced axon length and branching, whereas the disruption of 5-ht1a rescued outgrowth in the presence of exogenous serotonin. 2023-09-15 2023-10-07 drosophila_melanogaster
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. altogether this suggests that 5-ht1a is a serotonin autoreceptor in a subpopulation of serotonergic neurons and initiates signaling pathways that regulate axon outgrowth and branching during drosophila development. 2023-09-15 2023-10-07 drosophila_melanogaster
Michael Frazure, In Morimoto, Nathan Fielder, Nicholas Mellen, Kimberly Iceman, Teresa Pitt. Serotonin therapies for opioid-induced dysphagia and respiratory depression: sex differences in a rat electromyography model. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662371. we also evaluated utility of serotonin 5-ht1a agonists (8-oh-dpat and buspirone) to improve swallowing and breathing outcomes following buprenorphine administration. 2023-09-04 2023-09-07 rat
Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C Hopkins, Antony Loebel, Rebecca Elliott, Catherine J Harmer, Bill Deakin, Kenneth S Kobla. Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-08-07. PMID:37550314. ulotaront, a trace amine-associated receptor 1 (taar1) and serotonin 5-ht1a receptor agonist without antagonist activity at dopamine d 2023-08-07 2023-08-14 human
Che-Se Tung, You-Wei Lin, Chen-Cheng Lin, Yia-Ping Li. Time-Dependent Effects of Buspirone versus Desipramine on the 5-Choice Serial Reaction Time Task in Rats Reared in Social Isolation: Implication of Early Life Experience and Motoric Impulsivity. Journal of integrative neuroscience. vol 22. issue 4. 2023-07-31. PMID:37519173. however, most of the evidence has been obtained from acute 5-ht manipulation, whereas, the present study aimed to investigate the effects of subchronic regimen targeting of 5-ht1a receptors on motoric waiting impulsivity in socially isolated rats. 2023-07-31 2023-08-14 rat