| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology vol 13 issue 2023 36588734 |
fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. |
2023-01-02 |
2023-01-05 |
Not clear |
| Jo\\xc3\\xa3o P F Kurita, Anderson H F F Le\\xc3\\xa3o, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, D\\xc3\\xa9bora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience vol issue 2022 36548050 |
the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. |
2022-12-22 |
2022-12-28 |
Not clear |
| Martin Kubitschke, Monika M\\xc3\\xbcller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Gro\\xc3\\x9f, Pascal Gnei\\xc3\\x9fe, Niklas Meyer, J Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Massec. Next generation genetically encoded fluorescent sensors for serotonin. Nature communications vol 13 issue 1 2022 36473867 |
we developed a family of genetically encoded serotonin (5-ht) sensors (sdarken) on the basis of the native 5-ht1a receptor and circularly permuted gfp. |
2022-12-06 |
2022-12-15 |
Not clear |
| Carla V Arga\\xc3\\xb1araz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England) vol issue 2022 36458556 |
this refinement of drn inputs is not accompanied by changes in 5-ht1a receptor-mediated inhibition over 5-ht neurons. |
2022-12-02 |
2022-12-08 |
Not clear |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.) vol issue 2022 36333646 |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-\xce\xb2, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2022-11-08 |
Not clear |
| Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E Bartlet. Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice. Molecular psychiatry vol issue 2022 36195637 |
we have previously shown using the "drinking-in-the-dark" model in mice that the stimulation of the serotonin receptor 1a (5-ht |
2022-10-04 |
2022-10-10 |
Not clear |
| Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Li. Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. Molecular neurobiology vol issue 2022 36168076 |
several 5-ht receptor subtypes have been confirmed to be associated with nociception in the spinal cord, such as 5-ht1a receptor, 5-ht1b receptor, 5-ht2 receptor, 5-ht3 receptor, and 5-ht7 receptor. |
2022-09-28 |
2022-09-29 |
Not clear |
| Bernardo Lopez-Torres, Irma Ares, Marta Mart\\xc3\\xadnez, Jorge-Enrique Maximiliano, Mar\\xc3\\xada-Rosa Mart\\xc3\\xadnez-Larra\\xc3\\xb1aga, Arturo Anad\\xc3\\xb3n, Mar\\xc3\\xada-Ar\\xc3\\xa1nzazu Mart\\xc3\\xadne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association vol 169 issue 2022 36126889 |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-27 |
2022-09-29 |
Not clear |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine vol issue 2022 35844021 |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2022-07-19 |
Not clear |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR vol 15 issue 2022 35757086 |
to determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-ht) in the striatum, expression of serotonin-1a (5-ht1a) auto-receptor in the raphe nuclei and circulating levels of leptin and corticosterone were determined in female wistar rats kept on excessive food restriction schedule. |
2022-06-27 |
2022-07-04 |
Not clear |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR vol 15 issue 2022 35757086 |
these changes in 5-ht metabolism and 5-ht1a auto-receptor expression were more profound in dr animals as compare to trf animals. |
2022-06-27 |
2022-07-04 |
Not clear |
| Yusuf Oloruntoyin Ayipo, Waleed A Alananzeh, Sani Najib Yahayaa, Mohd Nizam Mord. Molecular Modelling and Virtual Screening to Identify New Piperazine Derivatives as Potent Human 5-HT1A Antagonists and Reuptake Inhibitors. Combinatorial chemistry & high throughput screening vol issue 2022 35611784 |
serotonin/5-ht antagonist and reuptake inhibitors (saris) ameliorate depression by increasing the terminal 5-ht through the activation of somatodendritic 5-ht1a autoreceptors. |
2022-05-25 |
2022-06-13 |
Not clear |
| Brandon L Oliver, McKenna Burdette, Alma E Pahua, Cassandra Cavazos, Cheyenne A Morales, Bryan D Alvarez, Dionisio A Amode. Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice. Behavioural brain research vol issue 2022 35367298 |
pharmacological activation of the serotonin (5-ht) 1b and 5-ht1a receptors has been shown to induce ocd-like perseverative circling and locomotor stereotypy in rodents. |
2022-04-03 |
2022-04-14 |
Not clear |
| Anurag Chaudhary, Kalpana Singh, Nishant Verma, Sachin Kumar, Deepak Kumar, Prince Prashant Sharm. Chromenes - A Novel Class of Heterocyclic Compounds: Recent Advancements and Future Directions. Mini reviews in medicinal chemistry vol issue 2022 35362382 |
structural modifications at the chromene ring, middle aliphatic portion, and terminal aromatic ring yielded more potential 5-ht1a (5-hydroxytryptamine 1a) receptor affinity and antidiabetic activity. |
2022-04-01 |
2022-04-14 |
Not clear |
| Robert W Garvey, Enza Lacivita, Mauro Niso, Beata Duszy\\xc5\\x84ska, Paul E Harris, Marcello Leopold. Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor. ChemMedChem vol issue 2022 35286016 |
among the 5-ht receptor subtype found in pancreatic islets, serotonin receptor 1a (5-ht 1a ) demonstrates a unique ability to inhibit beta-cell insulin secretion. |
2022-03-14 |
2022-04-14 |
Not clear |
| Den\\xc3\\xa9 A Voisin, Alison Wakeford, Jonathon Nye, Jiyoung Mun, Sara R Jones, Jason Locke, Kim L Huhman, Mark E Wilson, H Elliott Albers, Vasiliki Michopoulo. Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques. Pharmacology, biochemistry, and behavior vol issue 2022 35219757 |
fluoxetine, a selective serotonin (5ht) reuptake inhibitor whose actions are mediated in part by the 5ht1a receptor (5ht1ar), has sex- and social status-specific effects on socioemotional behavior and aggressive behavior. |
2022-03-06 |
2022-03-02 |
Not clear |
| Den\\xc3\\xa9 A Voisin, Alison Wakeford, Jonathon Nye, Jiyoung Mun, Sara R Jones, Jason Locke, Kim L Huhman, Mark E Wilson, H Elliott Albers, Vasiliki Michopoulo. Sex and social status modify the effects of fluoxetine on socioemotional behaviors in Syrian hamsters and rhesus macaques. Pharmacology, biochemistry, and behavior vol issue 2022 35219757 |
fluoxetine, a selective serotonin (5ht) reuptake inhibitor whose actions are mediated in part by the 5ht1a receptor (5ht1ar), has sex- and social status-specific effects on socioemotional behavior and aggressive behavior. |
2022-02-27 |
2022-03-02 |
Not clear |
| Rie Tohge, Satoshi Kaneko, Satoshi Morise, Mitsuaki Oki, Norihiro Takenouchi, Aya Murakami, Masataka Nakamura, Hirofumi Kusaka, Yusuke Yakushij. Zonisamide attenuates the severity of levodopa-induced dyskinesia via modulation of the striatal serotonergic system in a rat model of Parkinson's disease. Neuropharmacology vol 198 issue 2021 34474045 |
continuously levodopa-infused rats or intermittently zns-injected rats did not develop aims, and no differences in the expression of brain-derived neurotrophic factor, 5-ht transporter, 5ht1a, and 5ht1b mrna between the lesioned striatum and normal side were observed. |
2022-02-04 |
2022-01-14 |
Not clear |
| Lila Wollman, Andrew Hill, Brady Hasse, Christina Young, Giovanni Hernandez-De La Pena, Richard B Levine, Ralph F Fregos. Influence of developmental nicotine exposure on serotonergic control of breathing-related motor output. Developmental neurobiology vol issue 2022 35016263 |
we applied 5ht alone, or together with antagonists of 5ht1a, 5ht2a or 5ht7 receptor subtypes. |
2022-02-01 |
2022-01-13 |
Not clear |
| Colleen Synan, Carrie Bowen, David J Heal, Christelle Froger-Coll\\xc3\\xa9aux, Patrick M Beardsley, Nina Dedic, Seth C Hopkins, Una Campbell, Kenneth S Kobla. Ulotaront, a novel TAAR1 agonist with 5-HT1A agonist activity, lacks abuse liability and attenuates cocaine cue-induced relapse in rats. Drug and alcohol dependence vol 231 issue 2022 35033729 |
ulotaront (sep-363856) is a trace amine-associated receptor 1 (taar1) agonist with 5-hydroxytryptamine type 1a (5-ht1a) agonist activity that is currently in phase 3 clinical development for the treatment of schizophrenia. |
2022-01-31 |
2022-01-27 |
Not clear |