Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Eman Ali, Fakhar Latif, Yusra Mashkoor, Ayesha Sheikh, Amna Iqbal, Rabia Owais, Jawad Ahmed, Sadiq Naveed, Abdul Moeed, Irfan Ullah, Sanila Mugha. Role of adjunctive cariprazine for treatment-resistant depression in patients with major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. Asian journal of psychiatry. vol 95. 2024-03-21. PMID:38513509. |
cariprazine is an orally active dopamine d3-preferring d3/d2 receptor and serotonin 5-ht1a receptor partial agonist, being considered as a treatment for refractory mdd. |
2024-03-21 |
2024-03-24 |
Not clear |
Małgorzata Łupina, Agnieszka Wąsik, Irena Baranowska-Bosiacka, Maciej Tarnowski, Tymoteusz Słowik, Piotr Listos, Jolanta Kotlińska, Danuta Kosik-Bogacka, Izabela Gutowska, Joanna Listo. Acute and Chronic Exposure to Linagliptin, a Selective Inhibitor of Dipeptidyl Peptidase-4 (DPP-4), Has an Effect on Dopamine, Serotonin and Noradrenaline Level in the Striatum and Hippocampus of Rats. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474255. |
acute linagliptin exposure increases the serotonin level in both areas, while after chronic linagliptin administration a tendency for the mrna expression of serotoninergic receptors (5-ht1a and 5-ht2a) to increase was observed. |
2024-03-13 |
2024-03-15 |
rat |
Jie Zhou, Jiao-Wen Wu, Bai-Lin Song, Yi Jiang, Qiu-Hong Niu, Lai-Fu Li, Ying-Juan Li. 5-HT1A receptors within the intermediate lateral septum modulate stress vulnerability in male mice. Progress in neuro-psychopharmacology & biological psychiatry. 2024-02-14. PMID:38354893. |
these stress-susceptible mice also exhibited elevated neuronal activity in the ls as evidenced by greater c-fos expression, greater activity of 5-ht neurons in both the dorsal and median raphe nucleus, and downregulated expression of the 5-ht1a receptor in the intermediate ls (lsi). |
2024-02-14 |
2024-02-17 |
mouse |
Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimot. Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys. PLoS biology. vol 22. issue 1. 2024-01-01. PMID:38163325. |
these results suggest that 5-ht deficiency disrupts 2 processes, the subjective valuation of costs and rewards, via 5-ht1a and 5-ht1b receptors, thus leading to reduced motivation. |
2024-01-01 |
2024-01-05 |
monkey |
Manas R Biswal, Ryan J Paulson, Riddhi Vichare, Alfred S Lewi. Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136248. |
the purpose of our study was to determine if buspirone, a partial serotonin 1a (5-ht1a) receptor agonist, protected against oxidative stress-induced changes in the rpe. |
2023-12-23 |
2023-12-25 |
mouse |
Polona Rus Prelog, Anja Kokalj Palandaci. Hypersexuality during treatment with cariprazine in a patient with schizophrenia? A case report. BMC psychiatry. vol 23. issue 1. 2023-12-11. PMID:38082232. |
it functions as a partial agonist with high affinity for dopamine d2 and d3 and serotonin 5-ht1a receptors, an antagonist for 5-ht2a (moderate affinity) and 5-ht2b (high affinity) receptors. |
2023-12-11 |
2023-12-17 |
Not clear |
Hamed Alizadeh Pahlavan. Possible role of exercise therapy on depression: effector neurotransmitters as key players. Behavioural brain research. 2023-12-04. PMID:38048912. |
swimming exercise has antidepressant effects by increasing the sensitivity of serotonin 5-ht2 receptors and postsynaptic 5-ht1a receptors, increasing 5-ht and 5hiaa levels, increasing tph and serotonin, and decreasing inflammatory levels of ifn-γ and tnf-α. |
2023-12-04 |
2023-12-10 |
Not clear |
Emerson F Harkin, Georges Nasrallah, Brice Le François, Paul R Alber. Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β. International journal of molecular sciences. vol 24. issue 21. 2023-11-14. PMID:37958600. |
serotonin 1a (5-ht1a) autoreceptors located on serotonin neurons inhibit their activity, and their upregulation has been implicated in depression, suicide and resistance to antidepressant treatment. |
2023-11-14 |
2023-11-20 |
human |
Iman Touati, Mohnad Abdalla, Yassir Boulaamane, Nawal Al-Hoshani, Abdulaziz Alouffi, Mohammed Reda Britel, Amal Maurad. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors. Journal of biomolecular structure & dynamics. 2023-10-18. PMID:37850444. |
identification of novel dual acting ligands targeting the adenosine a2a and serotonin 5-ht1a receptors. |
2023-10-18 |
2023-11-08 |
Not clear |
Serena B Gumusoglu, Michaela D Kiel, Aleigha Gugel, Brandon M Schickling, Kaylee R Weaver, Marisol C Lauffer, Hannah R Sullivan, Kaylie J Coulter, Brianna M Blaine, Mushroor Kamal, Yuping Zhang, Eric J Devor, Donna A Santillan, Stephanie C Gantz, Mark K Santilla. Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-10-17. PMID:37848733. |
whole-cell recordings from dorsal raphe serotonin neurons revealed altered 5-ht1a receptor-dependent inhibitory postsynaptic currents (5-ht1a-ipscs) in female but not male ko neurons. |
2023-10-17 |
2023-11-08 |
mouse |
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. |
vilazodone, a selective serotonin reuptake inhibitor with diminished impact on methylphenidate-induced gene regulation in the striatum: role of 5-ht1a receptor. |
2023-10-08 |
2023-10-15 |
rat |
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. |
vilazodone differs from prototypical ssris in that, in addition to blocking serotonin reuptake, it acts as a partial agonist at the 5-ht1a serotonin receptor subtype. |
2023-10-08 |
2023-10-15 |
rat |
Michael Hrabak, Connor Moon, Carlos A Bolaños-Guzmán, Heinz Steine. Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor. Molecular neurobiology. 2023-10-08. PMID:37807008. |
studies showed that stimulation of the 5-ht1a receptor tempers serotonin input to the striatum. |
2023-10-08 |
2023-10-15 |
rat |
Neha Munawar, Milad S Bitar, Willias Masoch. Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762636. |
using qrt-pcr, western blotting, immunohistochemistry, and hplc-based techniques, we also measured in the central nervous system and peripheral nervous system of diabetic animals the expression and localization of 5-ht1a receptors (5-ht1ar), levels of key enzymes involved in the synthesis and degradation of tryptophan and 5-ht, including tryptophan hydroxylase-2 (tph-2), tryptophan 2,3-dioxygenase (tdo), indoleamine 2,3-dioxygenase 1 (ido1) and ido2. |
2023-09-28 |
2023-10-07 |
rat |
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. |
using cultured drosophila serotonergic neurons, we found that exogenous serotonin reduced axon length and branching only in those expressing 5-ht1a. |
2023-09-15 |
2023-10-07 |
drosophila_melanogaster |
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. |
pharmacological activation of 5-ht1a led to reduced axon length and branching, whereas the disruption of 5-ht1a rescued outgrowth in the presence of exogenous serotonin. |
2023-09-15 |
2023-10-07 |
drosophila_melanogaster |
Delaney R Long, Ava Kinser, Abby Olalde-Welling, Luke Brewer, Juri Lim, Dayle Matheny, Breanna Long, Douglas H Roossie. 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons. Developmental neurobiology. 2023-09-15. PMID:37714743. |
altogether this suggests that 5-ht1a is a serotonin autoreceptor in a subpopulation of serotonergic neurons and initiates signaling pathways that regulate axon outgrowth and branching during drosophila development. |
2023-09-15 |
2023-10-07 |
drosophila_melanogaster |
Michael Frazure, In Morimoto, Nathan Fielder, Nicholas Mellen, Kimberly Iceman, Teresa Pitt. Serotonin therapies for opioid-induced dysphagia and respiratory depression: sex differences in a rat electromyography model. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662371. |
we also evaluated utility of serotonin 5-ht1a agonists (8-oh-dpat and buspirone) to improve swallowing and breathing outcomes following buprenorphine administration. |
2023-09-04 |
2023-09-07 |
rat |
Francesca Perini, Jadwiga Maria Nazimek, Shane Mckie, Liliana P Capitão, Jessica Scaife, Deepa Pal, Michael Browning, Gerard R Dawson, Hiroyuki Nishikawa, Una Campbell, Seth C Hopkins, Antony Loebel, Rebecca Elliott, Catherine J Harmer, Bill Deakin, Kenneth S Kobla. Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy. Schizophrenia (Heidelberg, Germany). vol 9. issue 1. 2023-08-07. PMID:37550314. |
ulotaront, a trace amine-associated receptor 1 (taar1) and serotonin 5-ht1a receptor agonist without antagonist activity at dopamine d |
2023-08-07 |
2023-08-14 |
human |
Che-Se Tung, You-Wei Lin, Chen-Cheng Lin, Yia-Ping Li. Time-Dependent Effects of Buspirone versus Desipramine on the 5-Choice Serial Reaction Time Task in Rats Reared in Social Isolation: Implication of Early Life Experience and Motoric Impulsivity. Journal of integrative neuroscience. vol 22. issue 4. 2023-07-31. PMID:37519173. |
however, most of the evidence has been obtained from acute 5-ht manipulation, whereas, the present study aimed to investigate the effects of subchronic regimen targeting of 5-ht1a receptors on motoric waiting impulsivity in socially isolated rats. |
2023-07-31 |
2023-08-14 |
rat |