All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
L A Dawson, H Q Nguyen, A Geige. Effects of venlafaxine on extracellular concentrations of 5-HT and noradrenaline in the rat frontal cortex: augmentation via 5-HT1A receptor antagonism. Neuropharmacology. vol 38. issue 8. 1999-10-12. PMID:10462128. combination treatment with the selective 5-ht1a antagonist way100635 produced a dose-dependent augmentation of venlafaxine-induced (3-30 mg/kg s.c) extracellular 5-ht concentrations, but had no further effect on na above that produced by venlafaxine alone. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. the optically pure enantiomers of the potential atypical antipsychotic agents 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (5-ome-bpat, 5) and 5-methoxy-2-{n-[2-(2,6-dimethoxy)benzamidoethyl]-n-n-propylamino}t etralin [5-ome-(2,6-di-ome)-bpat, 6] were synthesized and evaluated for their in vitro binding affinities at alpha1-, alpha2-, and beta-adrenergic, muscarinic, dopamine d1, d2a, and d3, and serotonin 5-ht1a and 5-ht2 receptors. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. in addition, their intrinsic efficacies at serotonin 5-ht1a receptors were established in vitro. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. (s)- and (r)-5 had high affinities for dopamine d2a, d3, and serotonin 5-ht1a receptors, moderate affinities for alpha1-adrenergic and serotonin 5-ht2 receptors, and no affinity (ki > 1000 nm) for the other receptor subtypes. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. (s)- and (r)-6 had lower affinities for the dopamine d2a and the serotonin 5-ht1a receptor, compared to (s)- and (r)-5, and hence showed some selectivity for the dopamine d3 receptor. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. the interactions with the receptors were stereospecific, since the serotonin 5-ht1a receptor preferred the (s)-enantiomers, while the dopamine d2a and d3 receptors preferred the (r)-enantiomers of 5 and 6. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. the intrinsic efficacies at the serotonin 5-ht1a receptor were established by measuring their ability to inhibit vip-induced camp production in gh4zd10 cells expressing serotonin 5-ht1a receptors. 1999-10-12 2023-08-12 rat
E J Homan, S Copinga, L Unelius, D M Jackson, H V Wikström, C J Gro. Synthesis and Pharmacology of the enantiomers of the potential atypical antipsychotic agents 5-OMe-BPAT and 5-OMe-(2,6-di-OMe)-BPAT. Bioorganic & medicinal chemistry. vol 7. issue 7. 1999-10-12. PMID:10465402. both enantiomers of 5 behaved as full serotonin 5-ht1a receptor agonists in this assay, while both enantiomers of 6 behaved as weak partial agonists. 1999-10-12 2023-08-12 rat
J Gervais, J J Soghomonian, D Richard, C Rouillar. Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391482. in a second series of experiments, the effects of a combined administration of dopamine d1 and serotonin 5-ht1a or 5-ht2a/2c agonists were studied. 1999-10-08 2023-08-12 rat
J Gervais, J J Soghomonian, D Richard, C Rouillar. Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391482. the goal of the last series of experiments was to determine the effects of a combined administration of the dopamine d2 agonist and either serotonin 5-ht1a or 5-ht2a/2c agonists. 1999-10-08 2023-08-12 rat
J Gervais, J J Soghomonian, D Richard, C Rouillar. Dopamine and serotonin interactions in the modulation of the expression of the immediate-early transcription factor, nerve growth factor-inducible B, in the striatum. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391482. our results show that: (i) striatal nerve growth factor-inducible b messenger rna expression exhibited a lateral-medial gradient in drug-naive rats, (ii) quinpirole and 8-hydroxy-2-(di-n-propylaminotetralin) administered alone induced a significant decrease in striatal nerve growth factor-inducible b messenger rna expression while 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane significantly increased it, (iii) complex interactions were found when dopamine d1 and serotonin 5-ht1a or 5-ht2a/2c agonists were administered in combination, and (iv) combined administration of quinpirole and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane resulted in a significant decrease in nerve growth factor-inducible b expression. 1999-10-08 2023-08-12 rat
V W Pik. Serotonin 5-HT1A receptor imaging in the human brain with PET. Co-ordination of the standardisation and dissemination of methodology. Workshop on [carbonyl-11C]WAY-100635 radiochemistry and metabolite analysis 30-31 March 1999. MRC Cyclotron Unit, London, UK. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10515716. serotonin 5-ht1a receptor imaging in the human brain with pet. 1999-10-07 2023-08-12 human
A Newman-Tancredi, D Cussac, V Audinot, M J Milla. Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 6. 1999-10-04. PMID:10431754. actions of roxindole at recombinant human dopamine d2, d3 and d4 and serotonin 5-ht1a, 5-ht1b and 5-ht1d receptors. 1999-10-04 2023-08-12 human
R Markstein, M Matsumoto, C Kohler, H Togashi, M Yoshioka, D Hoye. Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 6. 1999-10-04. PMID:10431755. cyclic amp accumulation induced by 1 microm 5-ht was partly inhibited by the selective 5-ht1a receptor antagonist way 100,635 (1 microm), the selective 5-ht4 receptor antagonist sb 203,186 (1 microm), and the 5-ht2a/c/ 5-ht7 receptor antagonist mesulergine (25 microm). 1999-10-04 2023-08-12 rat
N A Khan, J P Poisso. 5-HT3 receptor-channels coupled with Na+ influx in human T cells: role in T cell activation. Journal of neuroimmunology. vol 99. issue 1. 1999-10-04. PMID:10496177. serotonin and an agonist of 5-ht3 receptor-channels, 2-methyl-5ht, evoked na+ influx, whereas the agonists of other serotonergic receptor subtypes, i.e., 5-ht1a and 5-ht1b receptors, failed to induce na+ influx in these cells. 1999-10-04 2023-08-12 human
S T Kaehler, N Singewald, A Philipp. Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 5. 1999-09-28. PMID:10498288. microinjection of the 5-ht1a receptor agonist (+/-)-8-hydroxy-dipropylaminotetralin (8-oh-dpat; 7.5 nmol, 50 nl) into the drn led to a long-lasting reduction of the release rate of serotonin in the locus coeruleus. 1999-09-28 2023-08-12 rat
S T Kaehler, N Singewald, A Philipp. Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 5. 1999-09-28. PMID:10498288. the neuronal serotonin release in the locus coeruleus is modulated by 5-ht1a receptors lying within the drn. 1999-09-28 2023-08-12 rat
F Chaouloff, O Berton, P Mormèd. Serotonin and stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432486. in addition to the multiplicity of postsynaptic 5-ht receptors and their specific regulation by corticoids, specificity to stressors is also underscored when considering one receptor type such as the 5-ht1a receptor. 1999-09-17 2023-08-12 human
E Goul. Serotonin and hippocampal neurogenesis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432488. recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5ht1a receptor. 1999-09-17 2023-08-12 Not clear
X Zhuang, C Gross, L Santarelli, V Compan, A C Trillat, R He. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432489. specifically, we have created mice that lack or express reduced levels of two serotonin receptors: 5-ht1a and 5-ht1b receptors. 1999-09-17 2023-08-12 mouse