| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Williams, M Serafin, M Mühlethaler, L Bernhei. The serotonin inhibition of high-voltage-activated calcium currents is relieved by action potential-like depolarizations in dissociated cholinergic nucleus basalis neurons of the guinea-pig. The European journal of neuroscience. vol 10. issue 10. 1999-06-07. PMID:9786223. |
in dissociated cholinergic basal forebrain neurons using whole-cell recordings, it is shown that a selective serotonin 5-ht1a agonist (8-oh-dpat) predominantly blocks n-type hva calcium current, although a minor reduction of p-type current was also observed. |
1999-06-07 |
2023-08-12 |
Not clear |
| E Smeraldi, F Benedetti, B Barbini, E Campori, C Colomb. Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression. A placebo-controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 4. 1999-06-03. PMID:10088139. |
pindolol blocks the serotonergic 5-ht1a autoreceptor, thus improving the antidepressant effect of selective serotonin reuptake inhibitors. |
1999-06-03 |
2023-08-12 |
Not clear |
| L Lang, E Jagoda, B Schmall, B K Vuong, H R Adams, D L Nelson, R E Carson, W C Eckelma. Development of fluorine-18-labeled 5-HT1A antagonists. Journal of medicinal chemistry. vol 42. issue 9. 1999-06-03. PMID:10229627. |
these studies suggest that [18f]4c should be a useful compound to assess dynamic changes in serotonin levels while [18f]4d, with its high contrast and f-18 label, should provide better statistics and quantification for static measurement of 5-ht1a receptor distribution. |
1999-06-03 |
2023-08-12 |
rat |
| L W Maines, B J Keck, J E Smith, J M Lakosk. Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188639. |
corticosterone regulation of serotonin transporter and 5-ht1a receptor expression in the aging brain. |
1999-06-01 |
2023-08-12 |
rat |
| L E Rueter, P Blie. Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188973. |
following 7 days of administration, 5-ht neuronal firing activity had returned to normal and the somatodendritic 5-ht1a autoreceptors were desensitized. |
1999-05-27 |
2023-08-12 |
rat |
| L E Rueter, P Blie. Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188973. |
the responsiveness of postsynaptic 5-ht1a receptors located on ca3 hippocampus pyramidal neurons and mpfc neurons, examined using microiontophoretically-applied 5-ht and gepirone, was unchanged following a 7-day flibanserin treatment. |
1999-05-27 |
2023-08-12 |
rat |
| D S Dupuis, P J Pauwels, D Radu, H Hal. Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgammaS-binding responses in the human and monkey brain. The European journal of neuroscience. vol 11. issue 5. 1999-05-26. PMID:10215933. |
g-protein activation mediated by serotonin 5-ht1a receptors in human and monkey brain was investigated by using quantitative autoradiography of agonist-stimulated [35s]gtpgammas binding to whole-hemisphere brain sections. |
1999-05-26 |
2023-08-12 |
human |
| A R Ase, F Amdiss, C Hébert, N Huang, N M van Gelder, T A Reade. Effects of antipsychotic drugs on dopamine and serotonin contents and metabolites, dopamine and serotonin transporters, and serotonin1A receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 1. 1999-05-25. PMID:10195336. |
in this study, we examined the effects of clozapine and haloperidol on the distribution of da and 5-ht transporters, on endogenous da, 5-ht and their major metabolites, and on 5-ht1a receptors. |
1999-05-25 |
2023-08-12 |
rat |
| A R Ase, F Amdiss, C Hébert, N Huang, N M van Gelder, T A Reade. Effects of antipsychotic drugs on dopamine and serotonin contents and metabolites, dopamine and serotonin transporters, and serotonin1A receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 1. 1999-05-25. PMID:10195336. |
tissue levels of da and 5-ht and their metabolites were measured by high-performance liquid chromatography in 16 brain regions, while quantitative autoradiography with [125i]rti-121, [3h]citalopram and [3h]8-oh-dpat was employed to label da transporters, 5-ht transporters and 5-ht1a receptors, respectively. |
1999-05-25 |
2023-08-12 |
rat |
| A R Ase, F Amdiss, C Hébert, N Huang, N M van Gelder, T A Reade. Effects of antipsychotic drugs on dopamine and serotonin contents and metabolites, dopamine and serotonin transporters, and serotonin1A receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 1. 1999-05-25. PMID:10195336. |
after haloperidol, densities of 5-ht transporters were increased in the dorsal insular cortex and in the ventral half of caudal neostriatum, while 5-ht1a receptors augmented in cingulate cortex but decreased in the entorhinal area. |
1999-05-25 |
2023-08-12 |
rat |
| A R Ase, F Amdiss, C Hébert, N Huang, N M van Gelder, T A Reade. Effects of antipsychotic drugs on dopamine and serotonin contents and metabolites, dopamine and serotonin transporters, and serotonin1A receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 1. 1999-05-25. PMID:10195336. |
the changes in 5-ht transporters in nucleus raphe dorsalis and substantia nigra, as well as the 5-ht1a receptor down-regulations caused by clozapine but not by haloperidol, may explain effects obtained with clozapine and other atypical neuroleptics. |
1999-05-25 |
2023-08-12 |
rat |
| W J McBride, T K L. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Critical reviews in neurobiology. vol 12. issue 4. 1999-05-24. PMID:10348615. |
systemic administration of agents that (1) increase synaptic levels of serotonin (5-ht) or dopamine (da); (2) activate 5-ht1a, 5-ht2, d2, d3, or gaba(a) receptors; or (3) block opioid and 5-ht3 receptors decrease ethanol intake in most animal models. |
1999-05-24 |
2023-08-12 |
rat |
| D S Dupuis, M Perez, S Halazy, F C Colpaert, P J Pauwel. Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101238. |
the present study reports on g-protein activation by recombinant 5-ht receptors and by native 5-ht1a and 5-ht1b receptors in guinea-pig and rat brain using agonist-stimulated [35s]gtpgammas binding responses mediated by a new 5-ht ligand, a dimer of sumatriptan. |
1999-05-21 |
2023-08-12 |
rat |
| A Cologer-Clifford, N G Simon, M L Richter, S A Smoluk, S L. Androgens and estrogens modulate 5-HT1A and 5-HT1B agonist effects on aggression. Physiology & behavior. vol 65. issue 4-5. 1999-05-17. PMID:10073487. |
intermale offensive aggressive behavior is facilitated by gonadal steroids and inhibited by serotonin (5-ht), presumably through its effects at 5-ht1a and 5-ht1b receptor sites. |
1999-05-17 |
2023-08-12 |
mouse |
| T E Dudley, L A Dinardo, J D Glas. In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. Journal of neurophysiology. vol 81. issue 4. 1999-05-13. PMID:10200183. |
microinjections of the 5-ht1a autoreceptor agonist 8-oh-dpat or antagonist way 100635 into the mrn caused significant inhibition and stimulation of scn 5-ht release, respectively. |
1999-05-13 |
2023-08-12 |
Not clear |
| T E Dudley, L A Dinardo, J D Glas. In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. Journal of neurophysiology. vol 81. issue 4. 1999-05-13. PMID:10200183. |
these differential drug actions indicate that somatodendritic 5-ht1a autoreceptors on mrn neurons provide the prominent raphe autoregulation of 5-ht output in the scn. |
1999-05-13 |
2023-08-12 |
Not clear |
| S Mehta, I Kitche. Regional changes in 5-HT1A but not in 5-HT2A receptors in mouse brain after Semliki Forest virus infection: radioligand binding and autoradiographic studies. Journal of neurovirology. vol 4. issue 6. 1999-05-07. PMID:10065902. |
the effect of semliki forest virus (sfv) on 5-hydroxytryptamine (5-ht1a and 5-ht2a) receptors in mouse brain has been assessed by membrane homogenate binding and autoradiography. |
1999-05-07 |
2023-08-12 |
mouse |
| F Héry, P Boulenguez, A Sémont, M Héry, D Becquet, M Faudon, P Deprez, M P Fach. Identification and role of serotonin 5-HT1A and 5-HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217255. |
identification and role of serotonin 5-ht1a and 5-ht1b receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. |
1999-05-06 |
2023-08-12 |
rat |
| F Héry, P Boulenguez, A Sémont, M Héry, D Becquet, M Faudon, P Deprez, M P Fach. Identification and role of serotonin 5-HT1A and 5-HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217255. |
the involvement of 5-ht1a and 5-ht1b receptors in the control of the synthesis and release of [3h]5-ht was studied using biochemical approaches with several serotoninergic receptor ligands. |
1999-05-06 |
2023-08-12 |
rat |
| F Héry, P Boulenguez, A Sémont, M Héry, D Becquet, M Faudon, P Deprez, M P Fach. Identification and role of serotonin 5-HT1A and 5-HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217255. |
a mean decrease of 30% in [3h]5-ht synthesis and release was observed in the presence of 5-ht (10(-8) m), the 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), the 5ht1b/1a agonist 5-methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1h-indole (ru 24969), the 5-ht1b agonist 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (cp-93,129), and the 5-ht(1d/1b) agonist sumatriptan. |
1999-05-06 |
2023-08-12 |
rat |