| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S C Dulawa, R Hen, K Scearce-Levie, M A Geye. 5-HT1B receptor modulation of prepulse inhibition: recent findings in wild-type and 5-HT1B knockout mice. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928242. |
as the direct 5-ht1a agonist 8-oh-dpat increases ppi in mice, the unmasking of these effects may also contribute to the ppi-increasing effects of 5-ht releasers in 5-ht1b knockout mice. |
1999-02-25 |
2023-08-12 |
mouse |
| P Blier, G Piñeyro, M el Mansari, R Bergeron, C de Montign. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928258. |
a very important element controlling serotonin (5-ht) release throughout the brain is the 5-ht1a autoreceptor present on the soma and dendrites of 5-ht neurons since it exerts a negative feedback influence on their firing activity. |
1999-02-25 |
2023-08-12 |
Not clear |
| P Blier, G Piñeyro, M el Mansari, R Bergeron, C de Montign. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928258. |
this 5-ht1a autoreceptor receives an increased activation by endogenous 5-ht at the beginning of a treatment with a selective 5-ht reuptake inhibitor (ssri) and, consequently, a decreased 5-ht neuronal firing activity is obtained. |
1999-02-25 |
2023-08-12 |
Not clear |
| J Sprouse, J Braselton, L Reynolds, T Clarke, H Rollem. Consequences of 5-HT re-uptake blockade on postsynaptic 5-HT1A receptor activation: an electrophysiological and neurochemical study in guinea pig dorsal raphe and hippocampus. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928286. |
consequences of 5-ht re-uptake blockade on postsynaptic 5-ht1a receptor activation: an electrophysiological and neurochemical study in guinea pig dorsal raphe and hippocampus. |
1999-02-25 |
2023-08-12 |
Not clear |
| T Ishikan. [Effects of serotonergic drugs on the up-regulation of dopamine D2 receptors induced by haloperidol in rat striatum]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 73. issue 5. 1999-02-23. PMID:9846274. |
chronic treatment with mk 212, a serotonin (5-ht)2a/2c receptor agonist (2.5 mg/kg), or with citalopram, a 5-ht reuptake inhibitor (10 mg/kg), potentiated the haloperidol (0.1 mg/kg)-induced up-regulation of dopamine d2 receptor, while that with (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), a 5-ht1a receptor agonist (0.1 mg/kg), had no influence on the dopamine d2 receptor up-regulation. |
1999-02-23 |
2023-08-12 |
rat |
| D K Raap, F Garcia, N A Muma, W A Wolf, G Battaglia, L D van de Ka. Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918559. |
long-term exposure to fluoxetine produces a desensitization of hypothalamic postsynaptic 5-hydroxytryptamine (5-ht)1a receptors, indicated by a substantial inhibition of the 5-ht1a receptor-mediated stimulation of oxytocin and adrenocorticotropic hormone (acth) secretion. |
1999-02-22 |
2023-08-12 |
rat |
| L P Martin, D M Jackson, C Wallsten, B L Waszcza. Electrophysiological comparison of 5-Hydroxytryptamine1A receptor antagonists on dorsal raphe cell firing. The Journal of pharmacology and experimental therapeutics. vol 288. issue 2. 1999-02-22. PMID:9918594. |
single-unit recording studies were undertaken in chloral hydrate-anesthetized rats to compare the effects on dorsal raphe cell firing of several putative 5-hydroxytryptamine (ht)1a receptor antagonists, including way 100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide), p-mppi (4-(2-methoxyphenyl)1-[2'-[n-(2"-pyridinyl)-p-iodobenzamido]ethyl] pip erazine), and two newly described 5-ht1a receptor antagonists, ndl-249 [(r)-3-(n-propylamino)-8-fluoro-3, 4-dihydro-2h-1-benzopyran-5-carboxamide] and nad-299 [(r)-3-n, n-dicyclobutylamino-8-fluoro-3, 4-dihydro-2h-1-benzopyran-5-carboxamide]. |
1999-02-22 |
2023-08-12 |
rat |
| C Cappellini, P Malatesta, B Costa, S Marracci, I Nardi, C Martin. Characterization of a cloned xenopus laevis serotonin 5-HT1A receptor expressed in the NIH-3T3 cell line. Brain research. Molecular brain research. vol 63. issue 2. 1999-02-19. PMID:9878840. |
characterization of a cloned xenopus laevis serotonin 5-ht1a receptor expressed in the nih-3t3 cell line. |
1999-02-19 |
2023-08-12 |
xenopus_laevis |
| S J Wang, L L Cheng, P W Gea. Cross-modulation of synaptic plasticity by beta-adrenergic and 5-HT1A receptors in the rat basolateral amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880577. |
the aim of this study was to investigate the cross-regulation of synaptic transmission by beta-adrenergic and serotonin 1a (5-ht1a) receptors and to elucidate their underlying mechanisms. |
1999-02-16 |
2023-08-12 |
rat |
| S J Wang, L L Cheng, P W Gea. Cross-modulation of synaptic plasticity by beta-adrenergic and 5-HT1A receptors in the rat basolateral amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 2. 1999-02-16. PMID:9880577. |
the effect of 5-ht was mimicked by the selective 5-ht1a agonist 8-hydroxy-dipropylaminotetralin and was blocked by the selective 5-ht1a antagonist 1-(2-methoxyphenyl)-4[4-(2-phthalimido)butyl]piperazine, indicating its mediation by 5-ht1a receptors. |
1999-02-16 |
2023-08-12 |
rat |
| K Fuxe, A Jansson, Z Diaz-Cabiale, A Andersson, B Tinner, U B Finnman, I Misane, H Razani, F H Wang, L F Agnati, S O Ogre. Galanin modulates 5-hydroxytryptamine functions. Focus on galanin and galanin fragment/5-hydroxytryptamine1A receptor interactions in the brain. Annals of the New York Academy of Sciences. vol 863. 1999-02-16. PMID:9928178. |
galanin and its nh2-terminal fragments antagonize 5-ht1a receptor-mediated transmission at the postjunctional level, whereas galanin receptor activation mimics the inhibitory action of 5-ht1a receptor activation at the soma-dendritic level, leading to reductions of 5-ht metabolism and release. |
1999-02-16 |
2023-08-12 |
rat |
| A Kostic-Rajacic, V Soskic, J Joksimovi. Synthesis and dopaminergic features of six novel 3-arylpiperidines. Bollettino chimico farmaceutico. vol 137. issue 10. 1999-02-16. PMID:10025971. |
four substituted 3-aryl-1-¿2-[5-(1h-benzimidazole)]ethyl¿piperidines and two 3-aryl-1-¿2-[6-(1,4-dihydroxyquinoxaline-2,3-dione)]ethyl¿ piperidines were synthesized, characterized and evaluated for in vitro binding affinity at the d1 and d2 dopamine and 5-ht1a serotonin receptors using synaptosomal membranes of fresh bovine caudate nuclei and hippocampi as a source of the dopamine and serotonin receptors, respectively, and the corresponding specific radioligands. |
1999-02-16 |
2023-08-12 |
cattle |
| N A Darmani, B Ahma. Long-term sequential determination of behavioral ontogeny of 5-HT1A and 5-HT2 receptor functions in the rat. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862777. |
activation of 5-hydroxytryptamine1a (5-ht1a) receptors in rats produces hypothermia and a number of behaviors [hindleg abduction (hla), lateral head-weaving (lhw), forepaw treading (fpt), flat body posture (fbp), rollover (ro), tremor (t), and straub tail (st)] known collectively as the serotonin syndrome (ss). |
1999-02-05 |
2023-08-12 |
rat |
| P J Winsauer, F H Rodriguez, A E Cha, J M Moerschbaeche. Full and partial 5-HT1A receptor agonists disrupt learning and performance in rats. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862788. |
as a means of characterizing the role of 5-hydroxytryptamine (5-ht1a) receptors in learning, a full 5-ht1a receptor agonist, 8-hydroxy-dipropylaminotetralin (8-oh-dpat), was administered both alone and in combination with two partial agonists (buspirone and 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190)) and a 5-ht1a receptor antagonist (p-mppi) to rats responding under a multiple schedule of repeated acquisition and performance of response sequences. |
1999-02-05 |
2023-08-12 |
rat |
| E Heidel, H Davidow. Interactive effects of cholecystokinin-8S and serotonin on spontaneously active neurons in ventromedial hypothalamic slices. Neuropeptides. vol 32. issue 5. 1999-02-04. PMID:9845002. |
the main response to serotonin application (2-20 microm) was an inhibition that could be mimicked by 8-oh-dpat (a 5-ht1a receptor agonist). |
1999-02-04 |
2023-08-12 |
Not clear |
| M Got. Effects of 5-hydroxytryptamine on neuronal activities in the rat dorsolateral septal nucleus. The Kurume medical journal. vol 45. issue 4. 1999-02-03. PMID:9914716. |
8-hydroxy-di-n-propylamino tetralin (8-oh-dpat; 3 microm), a selective agonist for the 5-ht1a receptor, mimicked 5-ht in producing the hyperpolarization. |
1999-02-03 |
2023-08-12 |
rat |
| M Got. Effects of 5-hydroxytryptamine on neuronal activities in the rat dorsolateral septal nucleus. The Kurume medical journal. vol 45. issue 4. 1999-02-03. PMID:9914716. |
the 5-ht hyperpolarization was blocked by nan-190 (5 microm), a 5-ht1a receptor antagonist. |
1999-02-03 |
2023-08-12 |
rat |
| b' V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Bioisosteric approach in the design of new dopaminergic/serotonergic ligands. Current medicinal chemistry. vol 5. issue 6. 1999-02-02. PMID:9873112.' |
with this purpose, benzimidazole and its derivatives were incorporated into phenylethylamine, 3- and 4-substituted phenylethylpiperidine, 1-substituted 4-arylpiperazine and semirigid 2-aminotetralin frame and the resulting ligands were checked for the binding affinity at the d1 and d2 dopamine and 5-ht1a serotonin receptors in radioligand binding assays in vitro. |
1999-02-02 |
2023-08-12 |
cattle |
| E J Homan, S Copinga, L Elfström, T van der Veen, J P Hallema, N Mohell, L Unelius, R Johansson, H V Wikström, C J Gro. 2-aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: a novel class of potential atypical antipsychotic agents. Bioorganic & medicinal chemistry. vol 6. issue 11. 1999-02-02. PMID:9881101. |
2-aminotetralin-derived substituted benzamides with mixed dopamine d2, d3, and serotonin 5-ht1a receptor binding properties: a novel class of potential atypical antipsychotic agents. |
1999-02-02 |
2023-08-12 |
human |
| E J Homan, S Copinga, L Elfström, T van der Veen, J P Hallema, N Mohell, L Unelius, R Johansson, H V Wikström, C J Gro. 2-aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: a novel class of potential atypical antipsychotic agents. Bioorganic & medicinal chemistry. vol 6. issue 11. 1999-02-02. PMID:9881101. |
a new chemical class of potential atypical antipsychotic agents, based on the pharmacological concept of mixed dopamine d2 receptor antagonism and serotonin 5-ht1a receptor agonism, was designed by combining the structural features of the 2-(n,n-di-n-propylamino)tetralins (dpats) and the 2-pyrrolidinylmethyl-derived substituted benzamides in a structural hybrid. |
1999-02-02 |
2023-08-12 |
human |