All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
E J Homan, S Copinga, L Elfström, T van der Veen, J P Hallema, N Mohell, L Unelius, R Johansson, H V Wikström, C J Gro. 2-aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: a novel class of potential atypical antipsychotic agents. Bioorganic & medicinal chemistry. vol 6. issue 11. 1999-02-02. PMID:9881101. the lead compound of the series, 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (12a), displayed high affinities for the dopamine d2a receptor (ki = 3.2 nm), the dopamine d3 receptor (ki = 0.58 nm) as well as the serotonin 5-ht1a receptor (ki = 0.82 nm). 1999-02-02 2023-08-12 human
K E Scrogin, A K Johnson, H A Schmi. Multiple receptor subtypes mediate the effects of serotonin on rat subfornical organ neurons. The American journal of physiology. vol 275. issue 6 Pt 2. 1999-02-01. PMID:9843894. the results suggest that excitatory responses to serotonin are mediated by 5-ht2a or 5-ht2c receptors and that inhibitory responses may be mediated by 5-ht1a receptors. 1999-02-01 2023-08-12 rat
M J Carmena, A Camacho, R M Solano, L Montalvo, E Garcia-López, A Arias, J C Priet. 5-hydroxytryptamine1A receptor-mediated effects on adenylate cyclase and nitric oxide synthase activities in rat ventral prostate. Cellular signalling. vol 10. issue 8. 1999-01-25. PMID:9794257. the rat ventral prostate possesses specific 5-hydroxytryptamine (5-ht1a) receptors coupled to adenylate cyclase. 1999-01-25 2023-08-12 rat
M J Carmena, A Camacho, R M Solano, L Montalvo, E Garcia-López, A Arias, J C Priet. 5-hydroxytryptamine1A receptor-mediated effects on adenylate cyclase and nitric oxide synthase activities in rat ventral prostate. Cellular signalling. vol 10. issue 8. 1999-01-25. PMID:9794257. thus, serotonin appears to be able to act in the rat prostate gland through specific 5-ht1a receptors coupled to a complex system of signal transduction involving an inhibitory response of adenylate cyclase that can become stimulatory, as well as an enhancement of nos activity. 1999-01-25 2023-08-12 rat
M Dooley, K L Go. Urapidil. A reappraisal of its use in the management of hypertension. Drugs. vol 56. issue 5. 1999-01-25. PMID:9829161. urapidil is a peripheral postsynaptic alpha 1-adrenoceptor antagonist with central agonistic action at serotonin 5-ht1a receptors. 1999-01-25 2023-08-12 Not clear
M Perez, P J Pauwels, I Pallard-Sigogneau, C Fourrier, P Chopin, C Palmier, V Colovray, S Halaz. Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors. Bioorganic & medicinal chemistry letters. vol 8. issue 23. 1999-01-21. PMID:9873746. design and synthesis of new potent, silent 5-ht1a antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors. 1999-01-21 2023-08-12 Not clear
J M Casanovas, M T Vilaró, G Mengod, F Artiga. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886078. differential regulation of somatodendritic serotonin 5-ht1a receptors by 2-week treatments with the selective agonists alnespirone (s-20499) and 8-hydroxy-2-(di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. 1999-01-21 2023-08-12 rat
J M Casanovas, M T Vilaró, G Mengod, F Artiga. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886078. single treatment with the serotonin (5-hydroxytryptamine) 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and alnespirone (s-20499) reduces the extracellular 5-ht concentration (5-htext) in the rat midbrain and forebrain. 1999-01-21 2023-08-12 rat
J M Casanovas, M T Vilaró, G Mengod, F Artiga. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886078. these data indicate that continuous treatment for 2 weeks with alnespirone, but not with 8-oh-dpat, causes a functional desensitization of somatodendritic 5-ht1a receptors controlling 5-ht release in the drn and frontal cortex. 1999-01-21 2023-08-12 rat
M C Antle, E G Marchant, L Niel, R E Mistlberge. Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824687. ), (+)-way100135 (5-ht1a postsynaptic antagonist, which may also reduce 5-ht release by an agonist effect at 5-ht1a raphe autoreceptors; i.p. 1999-01-20 2023-08-12 Not clear
M C Antle, E G Marchant, L Niel, R E Mistlberge. Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster. Brain research. vol 813. issue 1. 1999-01-20. PMID:9824687. ), nan-190 (5-ht1a postsynaptic antagonist, which also reduces 5-ht release via an agonist effect at 5-ht1a raphe autoreceptors; i.p.) 1999-01-20 2023-08-12 Not clear
D M Jackson, C E Wallsten, E Jerning, P S Hu, A M Devene. Two selective 5-HT1A receptor antagonists, WAY-100 635 and NDL-249, stimulate locomotion in rats acclimatised to their environment and alter their behaviour: a behavioural analysis. Psychopharmacology. vol 139. issue 4. 1999-01-19. PMID:9809851. the aim was to study firstly, the motor effects of a new 5-ht1a antagonist, ndl-249 [(r)-3-(n-cyclopentyl-n-propylamino)-8-fluoro-3,4-dihydro-2h-1-benzopyra n-5-carboxamide hydrochloride] and of the reference 5-ht1a antagonist way-100 635 [n-(2-(1-(4-(2-methoxyphenyl)piperazinyl))ethyl)-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride], in comparison to the 5-ht1a agonist (+/-)-8-oh-dpat [(8-hydroxy-2-(di-n-propylamino) tetralin, hereafter 8-oh-dpat], in rats acclimatised to the automated activity cages; secondly, to study whether the behavioural effects of ndl-249 and 8-oh-dpat are sensitive to the 5-ht depleting effects of p-chlorophenylalanine (pcpa); thirdly, to characterise the nature of the antagonist-induced activation seen in the automatic activity cages with the aid of a behavioural observation analysis; fourthly, to examine the interaction between the 5-ht1a receptors mediating the behavioural effects and dopamine (da) receptors. 1999-01-19 2023-08-12 rat
P J Pauwels, D S Dupuis, M Perez, S Halaz. Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 4. 1999-01-14. PMID:9826061. dimerization of 8-oh-dpat increases activity at serotonin 5-ht1a receptors. 1999-01-14 2023-08-12 human
L K Heisler, H M Chu, T J Brennan, J A Danao, P Bajwa, L H Parsons, L H Tecot. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 25. 1999-01-14. PMID:9844013. elevated anxiety and antidepressant-like responses in serotonin 5-ht1a receptor mutant mice. 1999-01-14 2023-08-12 mouse
L K Heisler, H M Chu, T J Brennan, J A Danao, P Bajwa, L H Parsons, L H Tecot. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 25. 1999-01-14. PMID:9844013. to evaluate the contribution of serotonin 5-ht1a receptors to the regulation of these processes, we have used gene-targeting technology to generate 5-ht1a receptor-mutant mice. 1999-01-14 2023-08-12 mouse
R Mongeau, M Weiss, C de Montigny, P Blie. Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons. Neuropharmacology. vol 37. issue 7. 1999-01-07. PMID:9776386. the suppressant effect of 5-ht and of the 5-ht1a agonist 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin) on the firing rate of 5-ht neurons was also unaltered after milnacipran (60 mg/kg/day x 14 days, s.c.). 1999-01-07 2023-08-12 rat
M A Re. Photic entrainment of circadian rhythms in rodents. Chronobiology international. vol 15. issue 5. 1999-01-07. PMID:9787933. in addition, serotonin appears to regulate the response of the scn circadian clock to light through postsynaptic 5-ht1a or 5-ht7 receptors, as well as presynaptic 5-ht1b heteroreceptors on rht terminals. 1999-01-07 2023-08-12 Not clear
A C Trillat, I Malagié, M Mathe-Allainmat, M C Anmella, C Jacquot, M Langlois, A M Gardie. Synergistic neurochemical and behavioral effects of fluoxetine and 5-HT1A receptor antagonists. European journal of pharmacology. vol 357. issue 2-3. 1999-01-07. PMID:9797034. two selective 5-ht1a receptor antagonists, to potentiate: (1) the enhancement of extracellular 5-ht levels ([5-ht(ext)]) induced by a single administration of 5 mg/kg i.p. 1999-01-07 2023-08-12 rat
A C Trillat, I Malagié, M Mathe-Allainmat, M C Anmella, C Jacquot, M Langlois, A M Gardie. Synergistic neurochemical and behavioral effects of fluoxetine and 5-HT1A receptor antagonists. European journal of pharmacology. vol 357. issue 2-3. 1999-01-07. PMID:9797034. thus, fluoxetine increased [5-ht(ext)] in serotonergic nerve terminal areas and consequently, induced hypophagia, both effects being limited by indirect activation of somatodendritic 5-ht1a autoreceptors. 1999-01-07 2023-08-12 rat
M N Subhash, B N Srinivas, K Y Vinod, S Jagadees. Inactivation of 5-HT1A and [3H]5-HT binding sites by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in rat brain. Neurochemical research. vol 23. issue 10. 1999-01-07. PMID:9804289. inactivation of 5-ht1a and [3h]5-ht binding sites by n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (eedq) in rat brain. 1999-01-07 2023-08-12 rat