| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L L Cheng, S J Wang, P W Gea. Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. The European journal of neuroscience. vol 10. issue 6. 1998-11-09. PMID:9753102. |
taken together, these results suggest that functional 5-ht1a receptors are present in the excitatory terminals and mediate the 5-ht inhibition of synaptic transmission in the amygdala. |
1998-11-09 |
2023-08-12 |
rat |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in vivo, f 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-ht1a agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-ht) levels and to increase plasma corticosterone levels, respectively). |
1998-11-05 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in hela cells expressing human 5-ht1a receptors, f 11440 decreased the forskolin-induced increase in amp, and, based on its maximal effect, was found to have an intrinsic activity of 1.0 relative to that of 5-ht, which was significantly higher than that of buspirone (0.49), ipsapirone (0.46) and flesinoxan (0.93). |
1998-11-05 |
2023-08-12 |
human |
| H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
alterations in the activity of the central 5-ht system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-ht1a receptor, 5-ht1b receptor, and 5-ht transporter mrna in the dorsal raphe nucleus and the hippocampus. |
1998-11-04 |
2023-08-12 |
rat |
| H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology. vol 352. issue 2-3. 1998-11-04. PMID:9716368. |
the expression of 5-ht transporter, 5-ht1a receptor, and 5-ht1b receptor mrna was examined in the dorsal raphe nucleus and in the ca1 of the hippocampus by means of quantitative in situ hybridisation histochemistry. |
1998-11-04 |
2023-08-12 |
rat |
| F Montesano, D Barlocco, V Dal Piaz, A Leonardi, E Poggesi, F Fanelli, P G De Benedett. Isoxazolo-[3,4-d]-pyridazin-7-(6H)-ones and their corresponding 4,5-disubstituted-3-(2H)-pyridazinone analogues as new substrates for alpha1-adrenoceptor selective antagonists: synthesis, modeling, and binding studies. Bioorganic & medicinal chemistry. vol 6. issue 7. 1998-11-04. PMID:9730228. |
a series of phenylpiperazinylalkyl moieties were attached to monocyclic or bicyclic substituted pyridazinones and the new compounds tested for their affinity towards alpha1-adrenoceptor and its alpha1a, alpha1b and alpha1d subtypes, as well as serotonin 5-ht1a receptor. |
1998-11-04 |
2023-08-12 |
Not clear |
| D S Dupuis, F C Colpaert, P J Pauwel. G-protein activation at 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. British journal of pharmacology. vol 124. issue 2. 1998-10-29. PMID:9641544. |
the maximal ly334370-induced [35s]-gtpgammas binding response (83 to 94%) in membranes of recombinant c6-glial/h 5-ht1a and hela/h 5-ht1a cells was close to that of 5-ht, suggesting ly334370 to exert high intrinsic activity at h 5-ht1a receptors. |
1998-10-29 |
2023-08-12 |
human |
| Y D Lapierre, P Silverstone, R T Reesal, B Saxena, P Turner, D Bakish, J Plamondon, P M Vincent, R A Remick, C Kroft, R Payeur, D Rosales, R Lam, M Bolog. A Canadian multicenter study of three fixed doses of controlled-release ipsapirone in outpatients with moderate to severe major depression. Journal of clinical psychopharmacology. vol 18. issue 4. 1998-10-28. PMID:9690691. |
ipsapirone, an azapirone with 5-hydroxytryptamine (5-ht1a) partial agonist activity, has been shown in preliminary studies to be effective in the treatment of major depressive disorder. |
1998-10-28 |
2023-08-12 |
Not clear |
| I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience. vol 10. issue 4. 1998-10-22. PMID:9749777. |
the present studies have examined whether the neuropeptide galanin can modulate brain serotoninergic (5-ht) neurotransmission in vivo and, particularly, 5-ht1a receptor-mediated transmission. |
1998-10-22 |
2023-08-12 |
rat |
| I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience. vol 10. issue 4. 1998-10-22. PMID:9749777. |
this 8-oh-dpat dose produced signs of the 5-ht syndrome indicating a postsynaptic 5-ht1a receptor activation. |
1998-10-22 |
2023-08-12 |
rat |
| I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience. vol 10. issue 4. 1998-10-22. PMID:9749777. |
furthermore, both the impairment of passive avoidance and the 5-ht syndrome were completely blocked by the 5-ht1a receptor antagonist way 100635 (0.1 mg/kg). |
1998-10-22 |
2023-08-12 |
rat |
| I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience. vol 10. issue 4. 1998-10-22. PMID:9749777. |
8-oh-dpat given at a low dose 0.03 mg/kg, which presumably stimulates somatodendritic 5-ht1a autoreceptors in vivo, did not alter passive avoidance retention or induce any visually detectable signs of the 5-ht syndrome. |
1998-10-22 |
2023-08-12 |
rat |
| C Dugast, F Soulière, P Schmitt, J M Casanovas, C M Fattaccini, E Mocaër, M Lesourd, B Renaud, F Artigas, M Hamon, G Chouve. Is the potent 5-HT1A receptor agonist, alnespirone (S-20499), affecting dopaminergic systems in the rat brain? European journal of pharmacology. vol 350. issue 2-3. 1998-10-19. PMID:9696405. |
interestingly, both alnespirone-induced reduction in 5-ht turnover and increase in dopamine turnover could be prevented by pretreatment with the selective 5-ht1a receptor antagonist way-100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohexa ne carboxamide). |
1998-10-19 |
2023-08-12 |
rat |
| K Watanabe, Y Minabe, C R Ashby, H Katsumor. Effect of acute administration of various 5-HT receptor agonists on focal hippocampal seizures in freely moving rats. European journal of pharmacology. vol 350. issue 2-3. 1998-10-19. PMID:9696406. |
these results suggest that, in this model, stimulation of 5-ht1a, 5-ht2a,c and 5-ht3 receptors does not alter seizure threshold or severity and that the blockade of 5-ht uptake produced by a low dose of fluoxetine appears to increase seizure threshold and decrease seizure severity. |
1998-10-19 |
2023-08-12 |
rat |
| M Alefeld, B Sutor, H J Luhman. Pattern and pharmacology of propagating epileptiform activity in mouse cerebral cortex. Experimental neurology. vol 153. issue 1. 1998-10-19. PMID:9743572. |
the potential role of potassium channel activation in controlling the generation or spread of epileptiform activity was tested by applying the potassium channel opener cromakalim and the serotonin type 1a (5-ht1a) receptor agonist (+/-)-8-hydroxydipropylaminotetralin (8-oh-dpat) to the disinhibited slices. |
1998-10-19 |
2023-08-12 |
mouse |
| Y W Li, D A Baylis. Electrophysical properties, synaptic transmission and neuromodulation in serotonergic caudal raphe neurons. Clinical and experimental pharmacology & physiology. vol 25. issue 6. 1998-10-16. PMID:9673827. |
5-hydroxytryptamine caused hyperpolarization and cessation of spike activity in these neurons by activating inwardly rectifying k+ conductance via somatodendritic 5-ht1a receptors. |
1998-10-16 |
2023-08-12 |
rat |
| Y W Li, D A Baylis. Electrophysical properties, synaptic transmission and neuromodulation in serotonergic caudal raphe neurons. Clinical and experimental pharmacology & physiology. vol 25. issue 6. 1998-10-16. PMID:9673827. |
5-hydroxytryptamine regulates serotonergic neuronal activity of the caudal raphe by decreasing spontaneous activity via somatodendritic 5-ht1a receptors and by inhibiting excitatory synaptic transmission onto these neurons via presynaptic 5-ht1b receptors. |
1998-10-16 |
2023-08-12 |
rat |
| L E Rueter, K Kasamo, C de Montigny, P Blie. Effect of long-term administration of duloxetine on the function of serotonin and noradrenaline terminals in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 6. 1998-10-16. PMID:9686935. |
electrically evoked release of [3h]5-ht from preloaded slices was enhanced in the midbrain, presumably due to a desensitization of the somatodendritic 5-ht1d and 5-ht1a autoreceptors. |
1998-10-16 |
2023-08-12 |
rat |
| M K Osterlund, Y L Hur. Acute 17 beta-estradiol treatment down-regulates serotonin 5HT1A receptor mRNA expression in the limbic system of female rats. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645972. |
acute 17 beta-estradiol treatment down-regulates serotonin 5ht1a receptor mrna expression in the limbic system of female rats. |
1998-10-09 |
2023-08-12 |
rat |
| M K Osterlund, Y L Hur. Acute 17 beta-estradiol treatment down-regulates serotonin 5HT1A receptor mRNA expression in the limbic system of female rats. Brain research. Molecular brain research. vol 55. issue 1. 1998-10-09. PMID:9645972. |
in situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5ht1a receptor mrna levels in limbic-related brain areas in the female ovariectomized rat. |
1998-10-09 |
2023-08-12 |
rat |