| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Aguirre, S Ballaz, B Lasheras, J Del Rí. MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652358. |
mdma ('ecstasy') enhances 5-ht1a receptor density and 8-oh-dpat-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion. |
1998-09-16 |
2023-08-12 |
rat |
| N Aguirre, S Ballaz, B Lasheras, J Del Rí. MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652358. |
), given 15 min prior to mdma, prevented the depletion of 5-hydroxytryptamine (5-ht) induced by mdma and also blocked the effects of this neurotoxin on 5-ht1a receptor density and on 8-oh-dpat-induced hypothermia. |
1998-09-16 |
2023-08-12 |
rat |
| N Aguirre, S Ballaz, B Lasheras, J Del Rí. MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652358. |
the present results indicate that drugs able to prevent or to attenuate mdma-induced 5-ht loss also prevent the changes in 5-ht1a receptor density as well as the enhanced hypothermic response to the 5-ht1a receptor agonist 8-oh-dpat in mdma-treated rats. |
1998-09-16 |
2023-08-12 |
rat |
| L G Larsson, C Stenfors, S B Ros. Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. European journal of pharmacology. vol 346. issue 2-3. 1998-09-16. PMID:9652362. |
differential regional antagonism of 8-oh-dpat-induced decrease in serotonin synthesis by two 5-ht1a receptor antagonists. |
1998-09-16 |
2023-08-12 |
rat |
| P J Currie, D V Coscina, P J Fletche. Reversal of fenfluramine and fluoxetine anorexia by 8-OH-DPAT is attenuated following raphe injection of 5,7-dihydroxytryptamine. Brain research. vol 800. issue 1. 1998-09-16. PMID:9685586. |
these findings suggest that the reversal of fen and flu anorexia by 8-oh-dpat is partially dependent on the integrity of brain 5-ht systems since their disruption compromises the ability of this 5-ht1a agonist to antagonize the feeding suppressant action of either fen or flu. |
1998-09-16 |
2023-08-12 |
rat |
| b' S Kosti\\xc4\\x87-Rajaci\\xc4\\x87, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. New substituted 2-methylthiomethyl- and 2-methylsulphinylmethylenebenzimidazoles with D2/5-HT1A activity. Die Pharmazie. vol 53. issue 7. 1998-09-16. PMID:9699220.' |
several 2-methylthiomethylbenzimidazoles (3a-e) and the corresponding sulphinyl derivatives 4a-e were synthesized and evaluated measuring their in vitro binding affinity at the d1 and d2 dopamine (source: synaptosomal membranes of the bovine nucleus caudatus) and 5-ht1a serotonin (source: synaptosomal membranes of the bovine hippocampus) receptors. |
1998-09-16 |
2023-08-12 |
cattle |
| M Balcells-Olivero, M S Cousins, L S Seide. Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694929. |
a dose-response determination for the tricyclic antidepressants, imipramine and desipramine, the selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitor, fluoxetine, the 5-ht2 receptor antagonist, ketanserin, the 5-ht1a receptor agonist, (+/-)8-hydroxy-di-propylamino tetralin (8-oh-dpat) and the dopamine releasing compound, amphetamine, were assessed in both rat stocks. |
1998-09-02 |
2023-08-12 |
rat |
| Q Q Sun, N Dal. Differential inhibition of N and P/Q Ca2+ currents by 5-HT1A and 5-HT1D receptors in spinal neurons of Xenopus larvae. The Journal of physiology. vol 510 ( Pt 1). 1998-09-01. PMID:9625870. |
the effects of 5-ht on hva ca2+ currents were mediated by 5-ht1a and 5-ht1d receptors. |
1998-09-01 |
2023-08-12 |
xenopus_laevis |
| E J Pappert, C G Goetz, G T Stebbins, M Belden, P M Carve. 5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes. European journal of pharmacology. vol 347. issue 1. 1998-09-01. PMID:9650847. |
guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-ht antagonists: (-)-n-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-way 100135) (5-ht1a), n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2-pyridyl)-cy clohexancarboxamide (way 100635) (5-ht1a), methiothepin mesylate (5-ht1/2), mesulergine hydrochloride (5-ht2a/2c), n[4-methoxy-3-(4-methyl-l-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (gr 127935) (5-ht1d), trans-4-[(3z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (sr 46349) (5-ht2), ondansetron hydrochloride (5-ht3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1h-indole-3-carboxylate (gr 125487) (5-ht4). |
1998-09-01 |
2023-08-12 |
Not clear |
| M Santiago, E R Matarredona, A Machado, J Can. Influence of serotoninergic drugs on in vivo dopamine extracellular output in rat striatum. Journal of neuroscience research. vol 52. issue 5. 1998-08-21. PMID:9632315. |
the following serotoninergic drugs were perfused in the absence or presence of nomifensine (5 microm) or tetrodotoxin (ttx; 2 microm): clomipramine (10, 500 and 1,000 microm), a selective 5-ht reuptake inhibitor; 8-oh-dpat (50 and 500 microm), a 5-ht1a receptor agonist; and alpha-methyl-5-ht (1, 5 and 50 microm), a 5-ht2 receptor agonist. |
1998-08-21 |
2023-08-12 |
rat |
| V Compan, L Segu, M C Buhot, A Daszut. Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B/1D and 5-HT2A/2C receptor binding sites in the rat cerebral cortex. Brain research. vol 795. issue 1-2. 1998-08-19. PMID:9622647. |
differential effects of serotonin (5-ht) lesions and synthesis blockade on neuropeptide-y immunoreactivity and 5-ht1a, 5-ht1b/1d and 5-ht2a/2c receptor binding sites in the rat cerebral cortex. |
1998-08-19 |
2023-08-12 |
rat |
| V Compan, L Segu, M C Buhot, A Daszut. Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B/1D and 5-HT2A/2C receptor binding sites in the rat cerebral cortex. Brain research. vol 795. issue 1-2. 1998-08-19. PMID:9622647. |
the present study was aimed at comparing the effects of serotonin (5-ht) synthesis blockade using chronic administration of p-chlorophenylalanine (pcpa) and 5,7-dihydroxytryptamine injections of variable volume (3 vs. 6 microl) on the density of npy immunoreactive (ir) neurons and binding of [3h]8-oh-dpat, s-cm-g[125i]tnh2 and [125i]doi to 5-ht1a, 5-ht1b/1d, and 5-ht2a/2c receptors in rat cortical regions. |
1998-08-19 |
2023-08-12 |
rat |
| V Compan, L Segu, M C Buhot, A Daszut. Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B/1D and 5-HT2A/2C receptor binding sites in the rat cerebral cortex. Brain research. vol 795. issue 1-2. 1998-08-19. PMID:9622647. |
the changes in npy immunoreactivity and 5-ht2a/2c binding detected in the upper regions of the cortex after complete 5-ht lesions probably result from local cellular rearrangements, whereas blocking 5-ht synthesis has more widespread influence on npy neurons and on 5-ht1a and 5-ht1b/1d receptor subtypes. |
1998-08-19 |
2023-08-12 |
rat |
| P Vanhoenacker, W Gommeren, W H Luyten, J E Leysen, G Haegema. Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system. Receptors & channels. vol 5. issue 3-4. 1998-08-11. PMID:9606717. |
next, l929 cells were transfected with four different human serotonin (5ht) receptor cdnas (5ht1a, 5ht2a, 5ht1d beta and 5ht1e) under the control of the same mxl promoter fragment. |
1998-08-11 |
2023-08-12 |
mouse |
| S N Mandhane, R T Khisti, C T Chopd. Effect of serotonergic agents on adenosine A2 receptor mediated catalepsy in mice. Psychopharmacology. vol 137. issue 2. 1998-08-06. PMID:9629997. |
the 5-ht releaser fenfluramine, the 5-ht1a agonist 8-oh-dpat, the 5-ht(2a/1c) receptor agonist doi and the 5-ht(2a/1c) receptor antagonists ketanserin and mianserin reversed neca-induced catalepsy. |
1998-08-06 |
2023-08-12 |
mouse |
| S N Mandhane, R T Khisti, C T Chopd. Effect of serotonergic agents on adenosine A2 receptor mediated catalepsy in mice. Psychopharmacology. vol 137. issue 2. 1998-08-06. PMID:9629997. |
further, the 5-ht reuptake inhibitor fluoxetine, the 5-ht(1b/1c) receptor agonist tfmpp, the 5-ht synthesis inhibitor p-cpa, the selective 5-ht1a receptor antagonist p-mppi, the 5-ht(1a/1b) receptor antagonist pindolol and the 5-ht3 receptor antagonist ly 278, 584 had no effect on neca-induced catalepsy. |
1998-08-06 |
2023-08-12 |
mouse |
| S N Mandhane, R T Khisti, C T Chopd. Effect of serotonergic agents on adenosine A2 receptor mediated catalepsy in mice. Psychopharmacology. vol 137. issue 2. 1998-08-06. PMID:9629997. |
it is concluded that modulation of serotonergic neurotransmission at 5-ht1a and 5-ht(2a/1c) receptors affects the cataleptic action of experimental antipsychotic agents with adenosine a2 receptor agonistic activity. |
1998-08-06 |
2023-08-12 |
mouse |
| A M Pugliese, M B Passani, R Corradett. Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices. British journal of pharmacology. vol 124. issue 1. 1998-08-04. PMID:9630348. |
effect of the selective 5-ht1a receptor antagonist way 100635 on the inhibition of e.p.s.ps produced by 5-ht in the ca1 region of rat hippocampal slices. |
1998-08-04 |
2023-08-12 |
rat |
| A M Pugliese, M B Passani, R Corradett. Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices. British journal of pharmacology. vol 124. issue 1. 1998-08-04. PMID:9630348. |
since way 100635 selectively antagonizes 5-ht1a receptor-mediated actions of 5-ht, our data also demonstrate that the inhibitory action of 5-ht on excitatory synaptic transmission in ca1 is mediated by 5-ht1a receptors. |
1998-08-04 |
2023-08-12 |
rat |
| E M Clifford, S E Gartside, V Umbers, P J Cowen, M Hajós, T Shar. Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo. British journal of pharmacology. vol 124. issue 1. 1998-08-04. PMID:9630361. |
here we investigated the actions of pindolol at the 5-ht1a autoreceptor by measuring its effect on 5-ht neuronal activity and release in the anaesthetized rat. |
1998-08-04 |
2023-08-12 |
rat |