| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A B Reitz, E W Baxter, E E Codd, C B Davis, A D Jordan, B E Maryanoff, C A Maryanoff, M E McDonnell, E T Powell, M J Renzi, M R Schott, M K Scott, R P Shank, J L Vaugh. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. Journal of medicinal chemistry. vol 41. issue 12. 1998-06-24. PMID:9622541. |
these compounds had notable affinity for dopamine d2, serotonin 5-ht1a, and alpha1-adrenergic receptors. |
1998-06-24 |
2023-08-12 |
human |
| P Blier, R Bergero. The use of pindolol to potentiate antidepressant medication. The Journal of clinical psychiatry. vol 59 Suppl 5. 1998-06-24. PMID:9635544. |
as cell body 5-ht1a autoreceptors desensitize, 5-ht neuronal firing is restored. |
1998-06-24 |
2023-08-12 |
rat |
| P Blier, R Bergero. The use of pindolol to potentiate antidepressant medication. The Journal of clinical psychiatry. vol 59 Suppl 5. 1998-06-24. PMID:9635544. |
the agent pindolol, through its 5-ht1a receptor blocking property, has been shown to prevent the initial decrease in firing of rat 5-ht neurons associated with ssri treatment. |
1998-06-24 |
2023-08-12 |
rat |
| N Sussma. Anxiolytic antidepressant augmentation. The Journal of clinical psychiatry. vol 59 Suppl 5. 1998-06-24. PMID:9635547. |
on the other hand, the anxiolytic agent buspirone does facilitate direct antidepressant response, largely through its ability to activate both presynaptic and postsynaptic 5-ht1a receptors and thus modulate serotonin release. |
1998-06-24 |
2023-08-12 |
Not clear |
| M T Lin, H J Tsay, W H Su, F Y Chue. Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function. The American journal of physiology. vol 274. issue 5. 1998-06-24. PMID:9644038. |
the results indicate that elevating the 5-ht levels in the hypothalamus activates postsynaptic 5-ht2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5-ht1a receptors in the hypothalamus reduces the endogenous 5-ht release and results in hypothermic effects. |
1998-06-24 |
2023-08-12 |
rat |
| N Haddjeri, C De Montigny, O Curet, P Blie. Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570466. |
the suppressant effects on the firing activity of 5-ht neurons of the 5-ht autoreceptor agonist lysergic acid diethylamide (lsd), injected intravenously, and of both 5-ht and the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat), applied by microiontophoresis, were attenuated in rats treated with befloxatone for 2 days, suggesting an early desensitization of the somatodendritic 5-ht1a receptors. |
1998-06-09 |
2023-08-12 |
rat |
| N Haddjeri, C De Montigny, O Curet, P Blie. Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570466. |
in conclusion, these data suggest that when the firing activity of 5-ht neurons is normal in the presence of befloxatone, either after a two-day treatment together with (-)-pindolol or alone for 21 days, the tonic activation of postsynaptic 5-ht1a receptors is enhanced. |
1998-06-09 |
2023-08-12 |
rat |
| D Schmitz, T Gloveli, R M Empson, A Draguhn, U Heineman. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. The Journal of physiology. vol 508 ( Pt 1). 1998-05-29. PMID:9490827. |
the effects of serotonin on intrinsic properties and epsps were partially mimicked by 5-ht1a receptor agonists (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-oh-dpat) and 5-carboxamido-tryptamine maleate (5-ct), and reduced by 5-ht1a receptor antagonists s-(-)-5-fluoro-8-hydroxy-dpat hydrochloride (s-uh-301), 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide (nan-190) and spiperone. |
1998-05-29 |
2023-08-12 |
rat |
| D Schmitz, T Gloveli, R M Empson, A Draguhn, U Heineman. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. The Journal of physiology. vol 508 ( Pt 1). 1998-05-29. PMID:9490827. |
we conclude that serotonin potently suppresses excitatory synaptic transmission via 5-ht1a receptors in layers ii and iii of the medial entorhinal cortex by a presynaptic mechanism. |
1998-05-29 |
2023-08-12 |
rat |
| A Newman-Tancredi, L Verrièle, C Chaput, M J Milla. Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 3. 1998-05-28. PMID:9550290. |
labelling of recombinant human and native rat serotonin 5-ht1a receptors by a novel, selective radioligand, [3h]-s 15535: definition of its binding profile using agonists, antagonists and inverse agonists. |
1998-05-28 |
2023-08-12 |
human |
| A Morán, M M Fernández, C Velasco, M L Martín, L San Romá. Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat. British journal of pharmacology. vol 123. issue 6. 1998-05-28. PMID:9559906. |
the selective 5-ht1a receptor agonist 8-oh-dpat and the selective 5-ht(1b/1d) receptor agonists sumatriptan and l-694,247 inhibited the pressor response, whereas the 5-ht1b receptor agonists cgs-12066b and cp-93,129 and the 5-ht2c receptor agonist m-cpp did not modify the pressor sympathetic responses. |
1998-05-28 |
2023-08-12 |
rat |
| A Morán, M M Fernández, C Velasco, M L Martín, L San Romá. Characterization of prejunctional 5-HT1 receptors that mediate the inhibition of pressor effects elicited by sympathetic stimulation in the pithed rat. British journal of pharmacology. vol 123. issue 6. 1998-05-28. PMID:9559906. |
the selective 5-ht1a receptor antagonist way-100,635 (100 microg kg(-1)) blocked the inhibition induced by 8-oh-dpat and the selective 5-ht(1b/1d) receptor antagonist gr127935t (250 microg kg(-1)) abolished the inhibition induced either by l-694,247 or sumatriptan. |
1998-05-28 |
2023-08-12 |
rat |
| G Skuza, Z Rogóz, K Gołembiowsk. EMD 57445, the selective sigma receptor ligand, has no effect on the 5-hydroxytryptamine system. Polish journal of pharmacology. vol 49. issue 6. 1998-05-28. PMID:9566054. |
the results indicate that emd 57445 does not interact with 5-ht (5-ht1a, 5-ht1b, 5-ht2a) receptor subpopulations and does not affect 5-ht metabolism. |
1998-05-28 |
2023-08-12 |
mouse |
| Y Odagaki, N Nishi, T Koyam. Receptor-mediated and receptor-independent activation of G-proteins in rat brain membranes. Life sciences. vol 62. issue 17-18. 1998-05-26. PMID:9585132. |
receptor-mediated high-affinity gtpase activity was detectable preferentially for the gi subfamily associated with adenylyl cyclase inhibition mediated by group ii metabotropic glutamate, pirenzepine-insensitive muscarinic acetylcholine, gaba(b), adenosine a1, dopamine d2-like (striatum), and serotonin 5-ht1a (hippocampus) receptors. |
1998-05-26 |
2023-08-12 |
rat |
| F C Zhou, D L McKinzie, T D Patel, L Lumeng, T K L. Additive reduction of alcohol drinking by 5-HT1A antagonist WAY 100635 and serotonin uptake blocker fluoxetine in alcohol-preferring P rats. Alcoholism, clinical and experimental research. vol 22. issue 1. 1998-05-21. PMID:9514317. |
additive reduction of alcohol drinking by 5-ht1a antagonist way 100635 and serotonin uptake blocker fluoxetine in alcohol-preferring p rats. |
1998-05-21 |
2023-08-12 |
rat |
| F C Zhou, D L McKinzie, T D Patel, L Lumeng, T K L. Additive reduction of alcohol drinking by 5-HT1A antagonist WAY 100635 and serotonin uptake blocker fluoxetine in alcohol-preferring P rats. Alcoholism, clinical and experimental research. vol 22. issue 1. 1998-05-21. PMID:9514317. |
because 5-ht uptake blockers increase synaptic 5-ht content and 5-ht1a receptor antagonists increase 5-ht release by disinhibiting 5-ht autoinnervation, in the present study, our intent was to determine whether increased synaptic 5-ht content and/or 5-ht release in p rats would effectively reduce alcohol consumption. |
1998-05-21 |
2023-08-12 |
rat |
| R Schreiber, C Melon, J De Vr. The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test. Psychopharmacology. vol 135. issue 4. 1998-05-21. PMID:9539263. |
we evaluated whether the anxiolytic effects of selective serotonin reuptake inhibitors (ssris) in the rat ultrasonic vocalization (usv) test are preferentially mediated by (indirect) activation of 5-ht1a, 5-ht1b/1d, 5-ht2a, 5-ht3 or 5-ht4 receptors. |
1998-05-21 |
2023-08-12 |
rat |
| S D Gleason, H E Shanno. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543230. |
the present study investigated the effects of m-cpp alone and in the presence of the 5-ht2 receptor antagonist 6-methyl-1-(-methyethyl)-ergoline-8beta-carboxylic acid 2-hydroxy-1-methylpropyl ester maleate (ly53857), the 5-ht1a receptor antagonist n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-n-(2pyridinyl)c yclohexanecarboxamide trihydrochloride (way 100,635), and the 5-ht(1b/1d) receptor antagonist 2'-methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-corbox ylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]amide (gr 127935) on locomotor activity. |
1998-05-21 |
2023-08-12 |
mouse |
| S D Gleason, H E Shanno. Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543230. |
furthermore, the hyperlocomotion produced by m-cpp in the presence of ly53857 (1.0 mg/kg) was blocked by both the 5-ht(1b/1d) receptor antagonist gr 127935 (3.0 mg/kg) and the 5-ht1a receptor antagonist way 100,635 (1.0 mg/kg). |
1998-05-21 |
2023-08-12 |
mouse |
| M J Millan, M Brocco, S Veiga, L Cistarelli, C Melon, A Gober. WAY 100,635 enhances both the 'antidepressant' actions of duloxetine and its influence on dialysate levels of serotonin in frontal cortex. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543235. |
its influence on serotonin, but not dopamine or noradrenaline, levels was enhanced by the 5-ht1a receptor antagonist, way 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclo-hexanecarboxamide 3hcl) (0.16 mg kg(-1), s.c). |
1998-05-21 |
2023-08-12 |
rat |