| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elske N de Haas, Jerine A J van der Eij. Where in the serotonergic system does it go wrong? Unravelling the route by which the serotonergic system affects feather pecking in chickens. Neuroscience and biobehavioral reviews. vol 95. 2019-02-11. PMID:30055196. |
birds with deficient functioning of the somatodendritic 5-ht1a autoreceptor and 5-ht metabolism appear predisposed to develop fp. |
2019-02-11 |
2023-08-13 |
Not clear |
| Mirella Stuivenga, Erik J Giltay, Olivia Cools, Laurence Roosens, Hugo Neels, Bernard Sabb. Evaluation of vilazodone for the treatment of depressive and anxiety disorders. Expert opinion on pharmacotherapy. vol 20. issue 3. 2019-01-28. PMID:30475091. |
vilazodone, a combined serotonin reuptake inhibitor and 5-ht1a partial agonist, is an approved therapy for the treatment of mdd and which has been further investigated for gad. |
2019-01-28 |
2023-08-13 |
Not clear |
| Jarosław Walory, Lidia Mielczarek, Małgorzata Jarończyk, Mirosława Koronkiewicz, Jerzy Kossakowski, Ryszard Bugno, Andrzej J Bojarski, Zdzisław Chilmonczy. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT International journal of molecular sciences. vol 19. issue 10. 2019-01-15. PMID:30347827. |
oncotoxic properties of serotonin transporter inhibitors and 5-ht the cytotoxic activity of several serotonin transporter (sert) inhibitors and subtype of serotonin receptor 1a (5-ht |
2019-01-15 |
2023-08-13 |
Not clear |
| Asli Ekinci, Okan Ekinc. Brexpiprazole: A Partial Dopamine Agonist for the Treatment of Schizophrenia. Reviews on recent clinical trials. vol 13. issue 1. 2019-01-04. PMID:28828976. |
brexpiprazole acts both as a partial agonist at the serotonin 5-ht1a and dopamine d2 receptors and as an antagonist at the serotonin 5- ht2a and noradrenaline alpha1b and alpha2c receptors, all with similar potency. |
2019-01-04 |
2023-08-13 |
Not clear |
| A S Tsybko, T V Ilchibaeva, D V Bazovkina, V S Naumenk. [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy]. Molekuliarnaia biologiia. vol 52. issue 2. 2018-12-11. PMID:29695693. |
the chronic activation of 5-ht1a receptor downregulated 5-ht1a gene expression, as well as the expression of the gene that encodes tryptophan hydroxylase 2, a key enzyme of 5-ht biosynthesis, in the midbrain and the expression of the gene that encodes the 5-ht2a receptor in the frontal cortex of cba, but not c57bl/6 mice. |
2018-12-11 |
2023-08-13 |
mouse |
| Gregory T Collins, Charles P Franc. Effects of lorcaserin and buspirone, administered alone and as a mixture, on cocaine self-administration in male and female rhesus monkeys. Experimental and clinical psychopharmacology. vol 26. issue 5. 2018-12-11. PMID:29952618. |
two such drugs, lorcaserin (belviq; a drug with serotonin [5-ht]2c receptor agonist properties) and buspirone (buspar; a drug with 5-ht1a receptor partial agonist and dopamine d3/d4 receptor antagonist properties) can produce modest decreases in cocaine self-administration in rhesus monkeys. |
2018-12-11 |
2023-08-13 |
monkey |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
receptor⁻receptor interactions in multiple 5-ht1a heteroreceptor complexes in raphe-hippocampal 5-ht transmission and their relevance for depression and its treatment. |
2018-10-22 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narváez, Patrizia Ambrogini, Luca Ferraro, Ismel Brito, Wilber Romero-Fernandez, Yuniesky Andrade-Talavera, Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Jose Angel Narvaez, Yuji Odagaki, Miklos Palkovits, Zaida Diaz-Cabiale, Kjell Fux. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules (Basel, Switzerland). vol 23. issue 6. 2018-10-22. PMID:29865267. |
a number of serotonin 5-ht1a heteroreceptor complexes were recently found to be linked to the ascending 5-ht pathways known to have a significant role in depression. |
2018-10-22 |
2023-08-13 |
rat |
| Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa, Ricardo Menegatt. Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)- New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-09. PMID:29677541. |
the participation of the serotonergic system was evaluated by pretreatment with a 5-ht1a antagonist receptor (way100635) and serotonin (5-ht) synthesis inhibitor (p-chlorphenylalanine, pcpa) before oral administration of lqfm104 and behavioral tests. |
2018-10-09 |
2023-08-13 |
mouse |
| Shuguang Yuan, Qian Peng, Krzysztof Palczewski, Horst Vogel, Slawomir Filipe. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angewandte Chemie (International ed. in English). vol 55. issue 30. 2018-08-20. PMID:27244650. |
mechanistic studies on the stereoselectivity of the serotonin 5-ht1a receptor. |
2018-08-20 |
2023-08-13 |
Not clear |
| Shuguang Yuan, Qian Peng, Krzysztof Palczewski, Horst Vogel, Slawomir Filipe. Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angewandte Chemie (International ed. in English). vol 55. issue 30. 2018-08-20. PMID:27244650. |
to address this question, we employed all-atom, long-timescale molecular dynamics simulations to investigate how two diastereomers (epimers) of dihydrofuroaporphine bind to the serotonin 5-ht1a receptor and exert opposite effects. |
2018-08-20 |
2023-08-13 |
Not clear |
| Shannon O'Hearn, Patrick Diaz, Bo Angela Wan, Carlo DeAngelis, Nicholas Lao, Leila Malek, Edward Chow, Alexia Blak. Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies. Annals of palliative medicine. vol 6. issue Suppl 2. 2018-08-13. PMID:29156899. |
in addition, their results suggest that anti-allodynic effects may also be mediated by additional receptors, including trpv1 and 5-hydroxytryptamine (5-ht1a). |
2018-08-13 |
2023-08-13 |
mouse |
| William Pote, Shamiso Musarira, Donald Chuma, Louis L Gadaga, Ellen Mwandiringana, Dexter Tagwirey. Effects of a hydroethanolic extract of Boophone disticha bulb on anxiety-related behaviour in naive BALB/c mice. Journal of ethnopharmacology. vol 214. 2018-08-13. PMID:29223391. |
previous in vitro studies have shown that it's crude ethanolic extracts and some alkaloidal phytoconstituents possesses high affinity for the serotonin transporter protein (sert) and serotonin receptor 1a (5ht |
2018-08-13 |
2023-08-13 |
mouse |
| Sha Liao, Jinpeng Lv, Jia Zhou, Praveen Kumar Kalavagunta, Jing Shan. Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice. Experimental dermatology. vol 26. issue 11. 2018-07-20. PMID:28480983. |
we found that stress changed hippocampal morphology, decreased 5-ht level in brain and skin and down-regulated 5-ht1a receptor expression in hippocampal ca1 region and skin. |
2018-07-20 |
2023-08-13 |
mouse |
| Sha Liao, Jinpeng Lv, Jia Zhou, Praveen Kumar Kalavagunta, Jing Shan. Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice. Experimental dermatology. vol 26. issue 11. 2018-07-20. PMID:28480983. |
the alterations of 5-ht and 5-ht1a receptor might be a threshold of central stress to associate with the behaviour changes. |
2018-07-20 |
2023-08-13 |
mouse |
| Jeannine Del Pizzo, Elon K Fernandez, Kathryn T Kopec, Jesse Wenger, Erin M Noyes, Matthew Salzman, Fred M Henreti. Seizures After Pediatric Vilazodone Ingestion: A Case Series. Pediatric emergency care. vol 34. issue 3. 2018-07-17. PMID:28590988. |
it has a combined mechanism of action of a selective serotonin reuptake inhibitor and a partial agonist of serotonin 5-ht1a receptors. |
2018-07-17 |
2023-08-13 |
Not clear |
| b' Eldina Rizvi\\xc4\\x87, Goran Jankovi\\xc4\\x87, Sla\\xc4\\x91ana Kosti\\xc4\\x87-Raja\\xc4\\x8di\\xc4\\x87, Miroslav M Savi\\xc4\\x8. Atypical sympathomimetic drug lerimazoline mediates contractile effects in rat aorta predominantly by 5-HT2A receptors. Bosnian journal of basic medical sciences. vol 17. issue 3. 2018-07-12. PMID:28628756.' |
here, we analyzed the affinity of lerimazoline for dopamine receptor d2, serotonin 5-ht1a and 5-ht2a receptors and α1-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. |
2018-07-12 |
2023-08-13 |
rat |
| Fanglin Guan, Huali Lin, Gang Chen, Lu Li, Teng Chen, Xinshe Liu, Jiuqiang Han, Tao L. Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function. Scientific reports. vol 6. 2018-05-30. PMID:27897266. |
the 5-ht1a receptor (htr1a) and the 5-ht5a receptor (htr5a) are key 5-ht receptors with distinct inhibitory functions. |
2018-05-30 |
2023-08-13 |
Not clear |
| Lauren Hatherall, Connie Sánchez, David A Morila. Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats. The international journal of neuropsychopharmacology. vol 20. issue 4. 2018-05-18. PMID:27927740. |
vortioxetine, a novel multimodal antidepressant, is a serotonin transporter inhibitor; 5-ht3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b partial agonist; and 5-ht1a agonist. |
2018-05-18 |
2023-08-13 |
rat |
| R L Carhart-Harris, D J Nut. Serotonin and brain function: a tale of two receptors. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28858536. |
in this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-ht1a and 5-ht2a receptors. |
2018-05-17 |
2023-08-13 |
Not clear |