| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
here, we investigated whether blockade of the terminal 5-ht1b autoreceptor influences a selective 5-ht reuptake inhibitor in the same way, and whether there is an additional effect of blocking both the 5-ht1a and 5-ht1b autoreceptors. |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
), increased extracellular 5-ht about 2 fold in rats pretreated with the 5-ht1a receptor antagonist, way100635. |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
in summary, our results suggest that selective 5-ht reuptake inhibitors may cause a large increase in 5-ht in the frontal cortex when 5-ht autoreceptors on both the somatodendrites (5-ht1a) and nerve terminals (5-ht1b) are blocked. |
1997-09-15 |
2023-08-12 |
rat |
| P Schoeffter, I Bobirnac, E Boddeke, D Hoye. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225266. |
inhibition of camp accumulation via recombinant human serotonin 5-ht1a receptors: considerations on receptor effector coupling across systems. |
1997-09-15 |
2023-08-12 |
human |
| P Schoeffter, I Bobirnac, E Boddeke, D Hoye. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225266. |
it is shown that 5-ht, 8-oh-dpat, buspirone, mdl 73005 behaved as full (or nearly full) and potent agonists, whereas sdz 216-525, nan-190 and way-100135 displayed a limited (and similar) degree of intrinsic activity at human 5-ht1a receptors; on the other hand pindolol, propranolol and way 100635 behaved as "silent" antagonists. |
1997-09-15 |
2023-08-12 |
human |
| A Borella, M Bindra, P M Whitaker-Azmiti. Role of the 5-HT1A receptor in development of the neonatal rat brain: preliminary behavioral studies. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225268. |
as the 5-ht1a receptor has been shown to be involved in much of the developmental functions of serotonin, an agonist for this receptor, 8-hydroxy-dpat (8-oh-dpat), was used. |
1997-09-15 |
2023-08-12 |
human |
| A Newman-Tancredi, C Conte, C Chaput, L Verrièle, M J Milla. Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor:G-protein stoichiometry. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225269. |
agonist and inverse agonist efficacy at human recombinant serotonin 5-ht1a receptors as a function of receptor:g-protein stoichiometry. |
1997-09-15 |
2023-08-12 |
human |
| S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225270. |
way100635-induced augmentation of the 5-ht-elevating action of citalopram: relative importance of the dose of the 5-ht1a (auto)receptor blocker versus that of the 5-ht reuptake inhibitor. |
1997-09-15 |
2023-08-12 |
rat |
| S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225270. |
the elevation of extracellular 5-ht after systemic administration of 5-ht reuptake inhibiting drugs is strongly potentiated by agents capable of blocking 5-ht1a autoreceptors in the midbrain raphe. |
1997-09-15 |
2023-08-12 |
rat |
| S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225270. |
the present in vivo microdialysis study was aimed at assessing the relative importance of 5-ht reuptake inhibition versus 5-ht1a autoreceptor blockade in this interaction. |
1997-09-15 |
2023-08-12 |
rat |
| S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225270. |
the data confirm previous findings that 5-ht1a autoreceptor blockade enhances the citalopram-induced increase of extracellular 5-ht in the forebrain. |
1997-09-15 |
2023-08-12 |
rat |
| Y Wang, A G Ramage, D Jorda. In vivo effects of 5-hydroxytryptamine receptor activation on rat nucleus tractus solitarius neurones excited by vagal C-fibre afferents. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225274. |
further, the subpopulation of nts neurones receiving input from cardiac afferents are excited by 5-ht, possibly by an action on 5-ht1a or 5-ht3 receptors. |
1997-09-15 |
2023-08-12 |
rat |
| F Chaouloff, O Berton, S Aquerre, M Hay, P Mormed. Effects of food deprivation on midbrain 5-HT1A autoreceptors in Lewis and SHR rats. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225273. |
fasting affected neither [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat) binding at 5-ht1a autoreceptors nor 8-oh-dpat-induced inhibition of midbrain 5-ht synthesis (an index of 5-ht1a autoreceptor sensitivity). |
1997-09-15 |
2023-08-12 |
rat |
| F Chaouloff, O Berton, S Aquerre, M Hay, P Mormed. Effects of food deprivation on midbrain 5-HT1A autoreceptors in Lewis and SHR rats. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225273. |
because fasting increased 5-ht precursor (tryptophan) levels to similar extents in the midbrains of saline- and 8-oh-dpat-treated rats, we conclude that food deprivation does not affect 5-ht1a autoreceptors. |
1997-09-15 |
2023-08-12 |
rat |
| R Invernizzi, C Velasco, M Bramante, A Longo, R Samani. Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225271. |
effect of 5-ht1a receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. |
1997-09-15 |
2023-08-12 |
rat |
| R Invernizzi, C Velasco, M Bramante, A Longo, R Samani. Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225271. |
the aim of the present study was to compare the effects of citalopram, either alone or combined with 5-ht1a receptor antagonists, on extracellular serotonin levels in brain regions innervated by the dorsal or median raphe nuclei. |
1997-09-15 |
2023-08-12 |
rat |
| R Invernizzi, C Velasco, M Bramante, A Longo, R Samani. Effect of 5-HT1A receptor antagonists on citalopram-induced increase in extracellular serotonin in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225271. |
the results suggest that only a combined blockade of 5-ht1a and 5-ht1b receptors potentiates the effect of citalopram on extracellular concentrations of serotonin in the dorsal hippocampus. |
1997-09-15 |
2023-08-12 |
rat |
| C Gundlah, S Hjorth, S B Auerbac. Autoreceptor antagonists enhance the effect of the reuptake inhibitor citalopram on extracellular 5-HT: this effect persists after repeated citalopram treatment. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225272. |
administration of the selective 5-ht1a receptor antagonist way 100635 (0.3 mg/kg s.c.) after citalopram challenge significantly enhanced 5-ht in fcx but not dh of both pretreatment groups. |
1997-09-15 |
2023-08-12 |
rat |
| J Sprouse, L Reynolds, H Rollem. Do 5-HT1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225281. |
theoretically, blockade of these autoreceptors would elevate intra-raphe 5-ht which, in turn, would activate somatodendritic 5-ht1a autoreceptors and slow firing rate. |
1997-09-15 |
2023-08-12 |
Not clear |
| J Sprouse, L Reynolds, H Rollem. Do 5-HT1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225281. |
8-oh-dpat in these and similar neurons produced the robust dose-dependent inhibitory response expected of a 5-ht1a agonist; increases in extracellular 5-ht resulting from re-uptake blockade by fluoxetine also suppressed unit activity. |
1997-09-15 |
2023-08-12 |
Not clear |