| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Wedzony, M Maćkowiak, A Czyrak, K Fijał, B Michalsk. Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187317. |
single doses of mk-801, a non-competitive antagonist of nmda receptors, increase the number of 5-ht1a serotonin receptors in the rat brain. |
1997-08-15 |
2023-08-12 |
rat |
| K Wedzony, M Maćkowiak, A Czyrak, K Fijał, B Michalsk. Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187317. |
in the present study, we investigated the impact of mk-801, a non-competitive nmda receptor antagonist, on the density of serotonergic receptors of the 5-ht1a subtype and on the metabolism of serotonin in various regions of the rat brain containing terminals and cell bodies of serotonergic neurons. |
1997-08-15 |
2023-08-12 |
rat |
| K Wedzony, M Maćkowiak, A Czyrak, K Fijał, B Michalsk. Single doses of MK-801, a non-competitive antagonist of NMDA receptors, increase the number of 5-HT1A serotonin receptors in the rat brain. Brain research. vol 756. issue 1-2. 1997-08-15. PMID:9187317. |
the binding of [3h]8-oh-dpat to 5-ht1a serotonin receptors was increased after mk-801 (0.4 mg/kg) as was shown by autoradiographic studies in the frontal, cingulate and part of enthorinal cortex, subregions of the hippocampus and raphe nuclei. |
1997-08-15 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
on the other hand, risperidone 25-800 micrograms/kg, iv) dose-dependently decreased the firing rate of 5-ht cells in the drn, an effect that was largely antagonized by pretreatment with the selective 5-ht1a receptor antagonist way 100,635 (5.0 micrograms/kg, iv). |
1997-08-13 |
2023-08-12 |
rat |
| P Hertel, G G Nomikos, B Schilström, L Arborelius, T H Svensso. Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of alpha 2-adrenoceptor antagonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 1. 1997-08-13. PMID:9194049. |
the inhibition of 5-ht cell firing by risperidone is probably secondary to increased 5-ht availability, e.g., in the drn, since it could be antagonized by a 5-ht1a receptor antagonist. |
1997-08-13 |
2023-08-12 |
rat |
| C Moret, M Brile. Effects of milnacipran and pindolol on extracellular noradrenaline and serotonin levels in guinea pig hypothalamus. Journal of neurochemistry. vol 69. issue 2. 1997-08-12. PMID:9231743. |
subcutaneous injection of 5-ht1a and beta-adrenergic receptor antagonist (-)-pindolol alone, at 10 mg/kg, had no effect on the extracellular levels of na or 5-ht. |
1997-08-12 |
2023-08-12 |
Not clear |
| C Moret, M Brile. Effects of milnacipran and pindolol on extracellular noradrenaline and serotonin levels in guinea pig hypothalamus. Journal of neurochemistry. vol 69. issue 2. 1997-08-12. PMID:9231743. |
in addition, the antagonism of 5-ht1a autoreceptors by (-)-pindolol potentiates the action of milnacipran on both na and 5-ht systems, without modifying the ratio of these activities. |
1997-08-12 |
2023-08-12 |
Not clear |
| J Q Lu, H Nagayam. Circadian rhythm in the hypothermic response to serotonin1A receptor agonist 8-OH-DPAT in rats. Chronobiology international. vol 14. issue 3. 1997-08-11. PMID:9167887. |
in a recent study, we found a circadian rhythm in the serotonin (5-ht) syndrome (forepaw treading, head weaving, and flat body posture) in the response to the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1997-08-11 |
2023-08-12 |
rat |
| P M Lembo, M H Ghahremani, S J Morris, P R Alber. A conserved threonine residue in the second intracellular loop of the 5-hydroxytryptamine 1A receptor directs signaling specificity. Molecular pharmacology. vol 52. issue 1. 1997-08-08. PMID:9224826. |
sequence alignment of several g protein-coupled receptors identified a highly conserved threonine residue in the i2 loop of the 5-hydroxytryptamine 1a (5-ht1a) receptor that is a putative protein kinase c phosphorylation consensus site and is located in a predicted amphipathic alpha-helical domain. |
1997-08-08 |
2023-08-12 |
Not clear |
| P M Lembo, M H Ghahremani, S J Morris, P R Alber. A conserved threonine residue in the second intracellular loop of the 5-hydroxytryptamine 1A receptor directs signaling specificity. Molecular pharmacology. vol 52. issue 1. 1997-08-08. PMID:9224826. |
a 2.6-fold increase in intracellular calcium (due to phospholipase c-mediated calcium mobilization) was observed for the wild-type receptor upon the addition of 100 nm 5-ht; whereas the t149a 5-ht1a receptor failed to mediate a calcium mobilization response at equivalent receptor levels to wild-type. |
1997-08-08 |
2023-08-12 |
Not clear |
| R A Gillespie, J Eriksen, H L Hao, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 3. 1997-08-07. PMID:9161605. |
previously, it was shown that in utero ethanol exposure results in decreased serotonin (5-ht) and altered concentrations of 5-ht reuptake sites and 5-ht1a receptors in fetal and/or postnatal rats. |
1997-08-07 |
2023-08-12 |
rat |
| R A Gillespie, J Eriksen, H L Hao, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 3. 1997-08-07. PMID:9161605. |
because fetal 5-ht is an essential trophic factor, this laboratory previously investigated the hypotheses that the early ethanol-associated 5-ht deficit contributed to subsequent development abnormalities in the serotonergic system and that the effects of the fetal 5-ht deficit could be prevented by maternal treatment with buspirone, a 5-ht1a receptor agonist. |
1997-08-07 |
2023-08-12 |
rat |
| S W Ying, B Rusa. 5-HT7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nucleus neurons. Brain research. vol 755. issue 2. 1997-08-07. PMID:9175892. |
we therefore studied the effects of 5-ht agonists and antagonists with differential affinities for 5-ht7 and 5-ht1a receptors on responses of hamster scn cells to retinal illumination. |
1997-08-07 |
2023-08-12 |
Not clear |
| S Okuyama, S Chaki, R Yoshikawa, Y Suzuki, S Ogawa, Y Imagawa, N Kawashima, Y Ikeda, T Kumagai, A Nakazato, M Nagamine, K Tomisaw. In vitro and in vivo characterization of the dopamine D4 receptor, serotonin 5-HT2A receptor and alpha-1 adrenoceptor antagonist (R)-(+)-2-amino-4-(4-fluorophenyl)-5-[1-[4-(4-fluorophenyl)-4-oxobutyl] pyrrolidin-3-yl]thiazole (NRA0045). The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223539. |
nra0045 also has high affinities for the serotonin (5-ht)2a receptor (ki = 1.92 nm) and alpha-1 adrenoceptor (ki = 1.40 nm) but weak affinities (ic50 values are approximately 1 microm) for six other neurotransmitter receptors (adenosine1, 5-ht1a, 5-ht1c, dopamine transporter, alpha2a and alpha2a) and negligible affinities (ic50 values are over 10(-5) m) for 42 other receptors, including neurotransmitters and hormones, ion channels and second messenger systems. |
1997-08-07 |
2023-08-12 |
mouse |
| M J Millan, A Newman-Tancredi, J M Rivet, M Brocco, P Lacroix, V Audinot, L Cistarelli, A Gober. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223549. |
s 15535, a novel benzodioxopiperazine ligand of serotonin (5-ht)1a receptors: i. interaction with cloned human (h)5-ht1a, dopamine hd2/hd3 and h alpha2a-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. |
1997-08-07 |
2023-08-12 |
human |
| M J Millan, A Newman-Tancredi, J M Rivet, M Brocco, P Lacroix, V Audinot, L Cistarelli, A Gober. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223549. |
the selective 5-ht1a antagonist, way 100,635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide (0.16) transiently elicited a slight increase in cortical levels of 5-ht, an action opposite to that of s 15535. |
1997-08-07 |
2023-08-12 |
human |
| M J Millan, A Newman-Tancredi, J M Rivet, M Brocco, P Lacroix, V Audinot, L Cistarelli, A Gober. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223549. |
its agonist actions at 5-ht1a autoreceptors underlie its ability to decrease extracellular levels of 5-ht in the fcx, and likely contribute to the increase in extracellular levels of da and nad evoked by s 15535 in this structure. |
1997-08-07 |
2023-08-12 |
human |
| M J Millan, S Hjorth, R Samanin, R Schreiber, R Jaffard, B De Ladonchamps, S Veiga, B Goument, J L Peglion, M Spedding, M Brocc. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223550. |
in these studies, we characterized the influence of the novel benzodioxopiperazine serotonin (5-ht)1a ligand, s 15535, on the release of 5-ht in rat hippocampus and compared its potential anxiolytic properties with those of the 5-ht1a receptor partial agonist, buspirone, the 5-ht1a antagonist, way 100,635 and the benzodiazepine, diazepam (dzm). |
1997-08-07 |
2023-08-12 |
mouse |
| C Roberts, G W Price, B J Jone. The role of 5-HT(1B/1D) receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European journal of pharmacology. vol 326. issue 1. 1997-08-05. PMID:9178651. |
in addition, extracellular 5-ht levels were lowered by the 5-ht(1b/1d) receptor agonist, sumatriptan, and the 5-ht1a receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, while perfusion of the selective serotonin re-uptake inhibitor, paroxetine, increased 5-ht in a concentration-dependent manner. |
1997-08-05 |
2023-08-12 |
Not clear |
| C Roberts, G W Price, B J Jone. The role of 5-HT(1B/1D) receptors in the modulation of 5-hydroxytryptamine levels in the frontal cortex of the conscious guinea pig. European journal of pharmacology. vol 326. issue 1. 1997-08-05. PMID:9178651. |
such an increase in local 5-ht levels could then stimulate 5-ht1a receptors to inhibit cell firing and hence decrease 5-ht levels in the terminal regions. |
1997-08-05 |
2023-08-12 |
Not clear |