All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
S Asano, T Matsuda, T Yoshikawa, P Somboonthum, H Tasaki, M Abe, A Bab. Interaction of orally administered 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole (MKC-242) with 5-HT1A receptors in rat brain. Japanese journal of pharmacology. vol 74. issue 1. 1997-08-05. PMID:9195299. these results suggest that orally administered mkc-242 at the low doses that do not show 5-ht1a-receptor-mediated in vivo responses such as the hypothermic effect, adrenocortical effect and the decrease in 5-ht turnover passes the blood-brain barrier and subsequently binds to 5-ht1a receptors in rat brain. 1997-08-05 2023-08-12 rat
R J Delay, S C Kinnamon, S D Rope. Serotonin modulates voltage-dependent calcium current in Necturus taste cells. Journal of neurophysiology. vol 77. issue 5. 1997-07-30. PMID:9163373. both responses used a 5-ht receptor subtype with a pharmacological profile similar to that of the 5-ht1a receptor, but the potentiation and inhibition of i(ca) by 5-ht were mediated by two different second-messenger cascades. 1997-07-30 2023-08-12 Not clear
A R Allen, A Singh, Z P Zhuang, M P Kung, H F Kung, I Luck. The 5-HT1A receptor antagonist p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164586. pretreatment with p-mppi reduced or blocked the effect of the 5-ht1a receptor agonist 8-oh-dpat on two responses mediated by postsynaptic 5-ht1a receptors, reduction of body temperature and the 5-ht behavioral syndrome. 1997-07-30 2023-08-12 Not clear
A R Allen, A Singh, Z P Zhuang, M P Kung, H F Kung, I Luck. The 5-HT1A receptor antagonist p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. Pharmacology, biochemistry, and behavior. vol 57. issue 1-2. 1997-07-30. PMID:9164586. pretreatment with p-mppi also blocked the ability of 8-oh-dpat to reduce extracellular 5-ht in the striatum, a response mediated by presynaptic 5-ht1a receptors in the dorsal raphe nucleus, but did not alter striatal 5-ht when administered alone. 1997-07-30 2023-08-12 Not clear
P M Callahan, K A Cunningha. Modulation of the discriminative stimulus properties of cocaine: comparison of the effects of fluoxetine with 5-HT1A and 5-HT1B receptor agonists. Neuropharmacology. vol 36. issue 3. 1997-07-24. PMID:9175616. whereas 5-ht agonists do not fully substitute for cocaine, the present results demonstrate that 5-ht1b, but not 5-ht1a, receptor agonists can modulate the discriminative stimulus properties of cocaine in a manner similar to that observed following administration of the 5-ht reuptake inhibitor fluoxetine. 1997-07-24 2023-08-12 rat
M Volonté, E Monferini, M Cerutti, F Fodritto, F Borsin. BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. Journal of neurochemistry. vol 69. issue 1. 1997-07-24. PMID:9202309. in radioligand binding studies, bimg 80, a new putative antipsychotic, displayed good affinity at certain serotonin (5-ht1a, 5-ht2a, 5-ht6), dopamine (d1, d2l, d4), and noradrenergic (alpha1) receptors. 1997-07-24 2023-08-12 rat
F Bosker, D Vrinten, A Klompmakers, H Westenber. The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 3. 1997-07-23. PMID:9089665. the effects of a 5-ht1a receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and way 100635. 1997-07-23 2023-08-12 rat
F Bosker, D Vrinten, A Klompmakers, H Westenber. The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 3. 1997-07-23. PMID:9089665. the modulation of extracellular 5-hydroxytryptamine (5-ht) in the central nucleus of the amygdala (cea) by 5-ht1a receptors was studied by intracerebral microdialysis in awake and freely moving rats. 1997-07-23 2023-08-12 rat
F Bosker, D Vrinten, A Klompmakers, H Westenber. The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 3. 1997-07-23. PMID:9089665. systemic administration of the 5-ht1a receptor agonists 8-oh-dpat and flesinoxan dose-dependently decreased 5-ht levels in the cea. 1997-07-23 2023-08-12 rat
F Bosker, D Vrinten, A Klompmakers, H Westenber. The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 3. 1997-07-23. PMID:9089665. these data show that a major part of the extracellular 5-ht in the cea stems from 5-ht neurons and that the amount of 5-ht released into this brain region can be modulated by 5-ht1a receptors. 1997-07-23 2023-08-12 rat
M U Ehrengruber, C A Doupnik, Y Xu, J Garvey, M C Jasek, H A Lester, N Davidso. Activation of heteromeric G protein-gated inward rectifier K+ channels overexpressed by adenovirus gene transfer inhibits the excitability of hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 94. issue 13. 1997-07-21. PMID:9192693. typical girk currents could be activated by endogenous gabab, serotonin 5-ht1a, and adenosine a1 receptors in neurons coinfected with girk1+2 or girk1+4. 1997-07-21 2023-08-12 rat
Y Levkovitz, M Sega. Serotonin 5-HT1A receptors modulate hippocampal reactivity to afferent stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204940. serotonin 5-ht1a receptors modulate hippocampal reactivity to afferent stimulation. 1997-07-21 2023-08-12 rat
Y Levkovitz, M Sega. Serotonin 5-HT1A receptors modulate hippocampal reactivity to afferent stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 14. 1997-07-21. PMID:9204940. these results indicate that serotonin released from terminals in the hippocampus activates a 5-ht1a receptor on interneurons that suppresses their activity and thus enhances dentate granular cell population spike response to pp stimulation. 1997-07-21 2023-08-12 rat
R K Raghupathi, P McGonigl. Differential effects of three acute stressors on the serotonin 5-HT1A receptor system in rat brain. Neuroendocrinology. vol 65. issue 4. 1997-07-18. PMID:9142996. differential effects of three acute stressors on the serotonin 5-ht1a receptor system in rat brain. 1997-07-18 2023-08-12 rat
J N Wilkin. Pharmacotherapy of schizophrenia patients with comorbid substance abuse. Schizophrenia bulletin. vol 23. issue 2. 1997-07-15. PMID:9165632. new generations of neuroleptics with serotonin (5-ht2) receptor antagonism and/or 5-ht1a agonist activity may reduce substance abuse in schizophrenia patients who self-medicate negative symptoms or neuroleptic side effects. 1997-07-15 2023-08-12 Not clear
J A Stanton, M S Bee. Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding. European journal of pharmacology. vol 320. issue 2-3. 1997-07-14. PMID:9059863. this study describes a method whereby the degree of receptor reserve, with respect to 5-hydroxytryptamine (5-ht), was determined for a hela cell line expressing the human 5-ht1a receptor using the agonist-induced [35s]guanosine 5'[gamma-thio]triphosphate ([35s]gtp gamma s) binding assay, followed by a comparison of the potencies and relative efficacies of several compounds. 1997-07-14 2023-08-12 human
N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. to clarify the serotonergic mechanisms involved in the protection against ischemic neuronal damage, zd-211 (citalopram hbr), a serotonin (5-hydroxytryptamine; 5-ht) re-uptake inhibitor, or buspirone, a 5-ht1a agonist, was locally administered into the hippocampus of gerbils. 1997-07-09 2023-08-12 Not clear
D S Kreiss, I Luck. Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021891. the present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-ht) release by 5-ht1a autoreceptors following single and repeated treatment with the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat). 1997-07-07 2023-08-12 rat
D S Kreiss, I Luck. Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021891. the decrease of 5-ht release in the striatum produced by the challenge dose of the 5-ht1a receptor agonist was diminished following 7 and 14 days of pretreatment, but not after 1 day of pretreatment, with 8-oh-dpat. 1997-07-07 2023-08-12 rat
D S Kreiss, I Luck. Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021891. the results of the present study indicate that desensitization of 5-ht1a autoreceptors regulating 5-ht release in different brain regions by repeated treatment with 8-oh-dpat occurs at different rates. 1997-07-07 2023-08-12 rat