| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D S Kreiss, I Luck. Chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT differentially desensitizes 5-HT1A autoreceptors of the dorsal and median raphe nuclei. Synapse (New York, N.Y.). vol 25. issue 2. 1997-07-07. PMID:9021891. |
the results of the present study indicate that desensitization of 5-ht1a autoreceptors regulating 5-ht release in different brain regions by repeated treatment with 8-oh-dpat occurs at different rates. |
1997-07-07 |
2023-08-12 |
rat |
| b' S Duki\\xc4\\x87, M Vujovi\\xc4\\x87, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Structure-affinity relationship studies on D-2/5-HT1A receptor ligands. 4-(2-Heteroarylethyl)-1-arylpiperazines. Arzneimittel-Forschung. vol 47. issue 3. 1997-07-07. PMID:9105540.' |
all new compounds were checked for in vitro binding affinity at the dopamine (d-1 and d-2) and serotonin (5-ht1a) receptors. |
1997-07-07 |
2023-08-12 |
cattle |
| b' S Duki\\xc4\\x87, M Vujovi\\xc4\\x87, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Structure-affinity relationship studies on D-2/5-HT1A receptor ligands. 4-(2-Heteroarylethyl)-1-arylpiperazines. Arzneimittel-Forschung. vol 47. issue 3. 1997-07-07. PMID:9105540.' |
synaptosomal membranes prepared from fresh bovine caudate nuclei and hippocampus were used as a source of dopamine and serotonin receptors, respectively, [3h]sch 23390 (d-1 selective), [3h]spiperone (d-2 selective) and 8-oh-[3h]dpat (5-ht1a selective) were employed as the radioligands. |
1997-07-07 |
2023-08-12 |
cattle |
| N Andrews, S E File, C Fernandes, L E Gonzalez, N M Barne. Evidence that the median raphé nucleus--dorsal hippocampal pathway mediates diazepam withdrawal-induced anxiety. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151356. |
5-ht1a receptor agonists injected into the mrn decrease the mrn firing rate, and hence the release of 5-ht in the dorsal hippocampus. |
1997-07-07 |
2023-08-12 |
rat |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
inhibition of 5-ht cell firing in the drn by non-selective 5-ht reuptake inhibitors: studies on the role of 5-ht1a autoreceptors and noradrenergic mechanisms. |
1997-07-07 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
here we examined whether inhibition of 5-ht cell firing by non-selective 5-ht uptake inhibiting antidepressant drugs is reversed by a selective 5-ht1a receptor antagonist. |
1997-07-07 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
the selective 5-ht1a receptor antagonist, way 100635, reversed the inhibition of 5-ht cell firing induced by clomipramine, amitriptyline, venlafaxine, and paroxetine, but not that induced by the alpha 1 adrenoceptor antagonist, prazosin. |
1997-07-07 |
2023-08-12 |
Not clear |
| S E Gartside, V Umbers, T Shar. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology. vol 130. issue 3. 1997-07-07. PMID:9151361. |
our data indicate that antidepressant drugs with 5-ht uptake blocking properties inhibit 5-ht cell firing via activation of 5-ht1a autoreceptors, and do so irrespective of their effects on na uptake. |
1997-07-07 |
2023-08-12 |
Not clear |
| T Ishikane, I Kusumi, R Matsubara, S Matsubara, T Koyam. Effects of serotonergic agents on the up-regulation of dopamine D2 receptors induced by haloperidol in rat striatum. European journal of pharmacology. vol 321. issue 2. 1997-07-01. PMID:9063684. |
chronic treatment with 6-chloro-2-(1-piperazinyl)pyrazine (mk-212), a nonselective serotonin (5-hydroxytryptamine, 5-ht) receptor agonist (2.5 mg/kg), or with citalopram, a 5-ht reuptake inhibitor (10 mg/kg), potentiated the haloperidol (0.1 mg/kg)-induced up-regulation of dopamine d2 receptors, while that with (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), a 5-ht1a receptor agonist (0.1 mg/kg) had no influence on the dopamine d2 receptor up-regulation. |
1997-07-01 |
2023-08-12 |
rat |
| P Blier, R Bergeron, C de Montign. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 5. 1997-06-27. PMID:9109104. |
it has been reported that the 5-ht1a autoreceptor antagonist pindolol can accelerate the antidepressant response to the selective serotonin (5-ht) reuptake inhibitor (ssri) paroxetine, presumably by preventing the initial decrease in firing activity of 5-ht neurons produced by the ssri. |
1997-06-27 |
2023-08-12 |
Not clear |
| P Blier, R Bergeron, C de Montign. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 5. 1997-06-27. PMID:9109104. |
these results provide further evidence that pindolol may accelerate the antidepressant effect of drugs that alter the function of the 5-ht neurons and that the selective activation of postsynaptic 5-ht1a receptors may induce a rapid and robust antidepressant response. |
1997-06-27 |
2023-08-12 |
Not clear |
| M C Buho. Serotonin receptors in cognitive behaviors. Current opinion in neurobiology. vol 7. issue 2. 1997-06-27. PMID:9142756. |
the serotonergic system appears to play a role in behaviors that involve a high cognitive demand and in memory improvement or recovery from impaired cognitive performance, as made evident after administration of serotonin 5-ht2a/5-ht2c or 5-ht4 receptor agonists or 5-ht1a or 5-ht3 receptor antagonists. |
1997-06-27 |
2023-08-12 |
mouse |
| K Tokarski, M Bija. Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Polish journal of pharmacology. vol 48. issue 6. 1997-06-26. PMID:9112695. |
antidepressant-induced adaptive changes in the effects of 5-ht, 5-ht1a and 5-ht4 agonists on the population spike recorded in hippocampal ca1 cells do not involve presynaptic effects on excitatory synaptic transmission. |
1997-06-26 |
2023-08-12 |
rat |
| K Tokarski, M Bija. Antidepressant-induced adaptive changes in the effects of 5-HT, 5-HT1A and 5-HT4 agonists on the population spike recorded in hippocampal CA1 cells do not involve presynaptic effects on excitatory synaptic transmission. Polish journal of pharmacology. vol 48. issue 6. 1997-06-26. PMID:9112695. |
effects of repeated treatment with antidepressant drugs on the reactivity of ca1 neurons to 5-hydroxytryptamine (5-ht), (+/-)-8-hydroxy-2-(dipropyl-amino)-tetralin (8-oh-dpat)--the 5-ht1a receptor agonist, and the zacopride-5-ht4 receptor agonist were examined in the rat hippocampus ex vivo. |
1997-06-26 |
2023-08-12 |
rat |
| M Carli, S Afkhami-Dastjerdian, T A Reade. Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT1A receptors. Neurochemical research. vol 22. issue 4. 1997-06-19. PMID:9130253. |
effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-ht1a receptors. |
1997-06-19 |
2023-08-12 |
human |
| M Carli, S Afkhami-Dastjerdian, T A Reade. Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT1A receptors. Neurochemical research. vol 22. issue 4. 1997-06-19. PMID:9130253. |
the objectives of this study were to characterize the effects of a chronic lithium (li+) treatment on serotonin (5-ht) uptake sites and on 5-ht1a receptors, and to determine the eventual reversibility of the treatment. |
1997-06-19 |
2023-08-12 |
human |
| M Carli, S Afkhami-Dastjerdian, T A Reade. Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT1A receptors. Neurochemical research. vol 22. issue 4. 1997-06-19. PMID:9130253. |
the experiments were carried out with membranes from rat cerebral cortex using 8-hydroxy-2-(propylamino)tetralin, or [3h]8-oh-dpat, and [3h]citalopram to label 5-ht1a receptors and 5-ht uptake sites, respectively. |
1997-06-19 |
2023-08-12 |
human |
| M Carli, S Afkhami-Dastjerdian, T A Reade. Effects of a chronic lithium treatment on cortical serotonin uptake sites and 5-HT1A receptors. Neurochemical research. vol 22. issue 4. 1997-06-19. PMID:9130253. |
however, competition curves with 5-ht to inhibit [3h]8-oh-dpat binding revealed a decreased proportion of sites with high affinity for the agonist, together with an increased density of sites with low affinity for 5-ht, suggesting an alteration in the coupling efficacy between 5-ht1a receptors and their transduction systems. |
1997-06-19 |
2023-08-12 |
human |
| M E Tancer, T W Uhd. Role of serotonin drugs in the treatment of social phobia. The Journal of clinical psychiatry. vol 58 Suppl 5. 1997-06-19. PMID:9184626. |
these include the serotonin selective reuptake inhibitors (ssris), the partial 5-ht1a agonist buspirone, and the 5-ht3 antagonist ondansetron. |
1997-06-19 |
2023-08-12 |
Not clear |
| M J Owen. Molecular and cellular mechanisms of antidepressant drugs. Depression and anxiety. vol 4. issue 4. 1997-06-18. PMID:9166647. |
serotonin transporter antagonists enhance serotonergic neurotransmission by decreasing the functional activity of the 5-ht1a and 5-ht1b autoreceptors. |
1997-06-18 |
2023-08-12 |
Not clear |