| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Bijak, K Tokarski, J Ma. Repeated treatment with antidepressant drugs induces subsensitivity to the excitatory effect of 5-HT4 receptor activation in the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 1. 1997-06-09. PMID:9007837. |
because inhibitory 5-ht1a and excitatory 5-ht4 receptors are colocalized on pyramidal neurons, and our previous data demonstrated an increase in the 5-ht1a receptor-mediated inhibition after repeated treatment with antidepressants, we conclude that treatment with antidepressant drugs may enhance the inhibitory effect of 5-ht directly, by increasing the 5-ht1a receptor responsiveness, and indirectly, by inducing subsensitivity to the 5-ht4 receptor activation. |
1997-06-09 |
2023-08-12 |
rat |
| A Meneses, E Hon. A pharmacological analysis of serotonergic receptors: effects of their activation of blockade in learning. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 2. 1997-06-05. PMID:9061774. |
the blockade of postsynaptic 5-ht1a, 5-ht1b, 5-ht3 or 5-ht4 receptors and 5-ht inhibition of synthesis and its depletion did no alter learning by themselves. |
1997-06-05 |
2023-08-12 |
Not clear |
| N K Popov. [Serotonin in genetically determined types of defensive behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 47. issue 2. 1997-06-05. PMID:9173739. |
the results suggest that the density of 5ht1a receptors in the frontal cortex is related to the expression of aggressive behavior of both types, while functional state of the brain 5ht system is involved in mechanisms determining the strategy of choice of type of defensive behavior--freezing or aggression. |
1997-06-05 |
2023-08-12 |
Not clear |
| J P Redrobe, C P MacSweeney, M Bouri. The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016908. |
the anti-immobility effects of the selective serotonin reuptake inhibitors in the forced swimming test seem to be mediated by presynaptic 5-ht1a receptors as well as postsynaptic 5-ht1b receptors. |
1997-05-29 |
2023-08-12 |
mouse |
| L M Vicentini, M G Cattaneo, R Fesc. Evidence for receptor subtype cross-talk in the mitogenic action of serotonin on human small-cell lung carcinoma cells. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016944. |
we previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-ht) on human small-cell lung carcinoma cells (sclc, glc-8), mediated by both 5-ht1d and 5-ht1a receptors. |
1997-05-29 |
2023-08-12 |
human |
| L M Vicentini, M G Cattaneo, R Fesc. Evidence for receptor subtype cross-talk in the mitogenic action of serotonin on human small-cell lung carcinoma cells. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016944. |
indeed, both gr127935 and the 5-ht1a antagonist spiperone shift the ec50 for the residual effect of 5-ht from approximately 300 to 120-150 nm, suggesting that blocking one receptor subtype may facilitate activation of the other. |
1997-05-29 |
2023-08-12 |
human |
| P Boulenguez, J N Rawlins, J Chauveau, M H Joseph, S N Mitchell, J A Gra. Modulation of dopamine release in the nucleus accumbens by 5-HT1B agonists: involvement of the hippocampo-accumbens pathway. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025099. |
it is concluded that: (1) serotonin interacts with the mesolimbic dopaminergic system through 5-ht1b, but not 5-ht1a, receptors: and (2) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-ht1b heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter da levels in the n. acc. |
1997-05-28 |
2023-08-12 |
rat |
| K Uvnäs-Moberg, V Hillegaart, P Alster, S Ahleniu. Effects of 5-HT agonists, selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025112. |
adult male sprague-dawley rats were administered the 5-ht subtype selective receptor agonists 8-oh-dpat (0.5-2.0 mg/kg), buspirone (2-8 mg/kg) (5-ht1a), tfmpp (0.125-2.0 mg/kg) (5-ht1b), doi (0.125-2.0 mg/kg) (5-ht2a) and m-cpbg (1.25-20.0 mg/kg) (5-ht3), subcutaneously. |
1997-05-28 |
2023-08-12 |
rat |
| A Ally, D Caringi, D M Koester, T Kobayashi, D J Mokle. Central 5-HT1A modulation of cardiovascular responses to tibial nerve stimulation-evoked muscle contraction. The American journal of physiology. vol 272. issue 4 Pt 2. 1997-05-28. PMID:9139996. |
the effects of administering 8-hydroxy-2-(di-n-propylamine) tetralin [8-oh-dpat, a serotonin 1a (5-ht1a) receptor agonist] into the rostral ventrolateral medulla (rvlm) on cardiovascular responses during tibial nerve stimulation-evoked muscle contraction were investigated using anesthetized rats. |
1997-05-28 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
5-ht1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. |
1997-05-27 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
therefore, 5-ht1a receptors represented a likely candidate for the mediation of the effects of 5-ht on developing granule cells. |
1997-05-27 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
the present study used the drugs buspirone and nan-190, which have been shown to be an agonist and antagonist respectively at postsynaptic 5-ht1a receptors in vivo, to test the idea that neurotrophic actions of 5-ht result from 5-ht1a receptor stimulation. |
1997-05-27 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
the nan-190 experiment also shows that the loss of dendritic spines is a function of decreased stimulation of 5-ht1a receptors and not the loss of 5-ht terminal membrane. |
1997-05-27 |
2023-08-12 |
rat |
| H Yu, Y Liu, H B Li, A R Martin, U Hacksell, T Lewande. Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-Furyl)- and R-8-phenyl-2-(di-n-propylamino) tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055190. |
it was also found that the enantiomers of ly-55 behaved as typical 5-ht1a receptor agonists in rats in-vivo by inducing a typical behavioural 5-ht syndrome, hypothermia and a decrease in 5-ht synthesis and turnover, indicating effects both on postsynaptic 5-ht1a receptors and somatodendritic 5-ht1a autoreceptors. |
1997-05-22 |
2023-08-12 |
rat |
| H Yu, Y Liu, H B Li, A R Martin, U Hacksell, T Lewande. Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-Furyl)- and R-8-phenyl-2-(di-n-propylamino) tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055190. |
in contrast, r- and s-ly-49 did not cause any 5-ht1a receptor-related effects in-vivo except for a partial inhibition of 5-ht synthesis after high doses. |
1997-05-22 |
2023-08-12 |
rat |
| H Yu, Y Liu, H B Li, A R Martin, U Hacksell, T Lewande. Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-Furyl)- and R-8-phenyl-2-(di-n-propylamino) tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055190. |
the 5-ht1a receptor antagonist way-100635 was shown to attenuate the r-ly-49-induced inhibition of 5-ht synthesis, indicating the compound to be a weak agonist at somatodendritic 5-ht1a autoreceptors. |
1997-05-22 |
2023-08-12 |
rat |
| H Yu, Y Liu, H B Li, A R Martin, U Hacksell, T Lewande. Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-Furyl)- and R-8-phenyl-2-(di-n-propylamino) tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo. The Journal of pharmacy and pharmacology. vol 49. issue 2. 1997-05-22. PMID:9055190. |
r-ly-49 at a high dose and with a long pre-treatment time interval inhibited the hypothermic and behavioural effects, but not the inhibition of 5-ht synthesis induced by the 5-ht1a receptor agonist r-8-hydroxy-(dipropylamino)tetralin (r-8-oh-dpat). |
1997-05-22 |
2023-08-12 |
rat |
| B Olde, W R McCombi. Molecular cloning and functional expression of a serotonin receptor from Caenorhabditis elegans. Journal of molecular neuroscience : MN. vol 8. issue 1. 1997-05-21. PMID:9061615. |
sequence analysis and the pharmacological profiles demonstrate its relatedness not only to drosophila and lymnae 5ht receptors but also to mammalian 5ht1a receptors. |
1997-05-21 |
2023-08-12 |
caenorhabditis_elegans |
| C Maudhuit, T Jolas, M Chastanet, M Hamon, J Adrie. Reduced inhibitory potency of serotonin reuptake blockers on central serotoninergic neurons in rats selectively deprived of rapid eye movement sleep. Biological psychiatry. vol 40. issue 10. 1997-05-13. PMID:8915559. |
these observations suggest that rem sleep deprivation renders serotoninergic drn neurons less sensitive to the inhibitory effect of 5-ht reuptake blockers, probably because of functional desensitization of somatodendritic 5-ht1a autoreceptors, like that previously reported after chronic treatment with several antidepressants. |
1997-05-13 |
2023-08-12 |
rat |
| T Sharp, S E Gartside, V Umber. Effects of co-administration of a monoamine oxidase inhibitor and a 5-HT1A receptor antagonist on 5-hydroxytryptamine cell firing and release. European journal of pharmacology. vol 320. issue 1. 1997-05-13. PMID:9049597. |
effects of co-administration of a monoamine oxidase inhibitor and a 5-ht1a receptor antagonist on 5-hydroxytryptamine cell firing and release. |
1997-05-13 |
2023-08-12 |
rat |