Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
M Urbina, C Schmeer, L Lim. 5HT1A receptor agonist differentially increases cyclic AMP concentration in intact and lesioned goldfish retina. In vitro inhibition of outgrowth by forskolin. Neurochemistry international. vol 29. issue 5. 1997-05-12. PMID:8939455. |
the activation of other subtypes of 5ht receptors positively coupled to adenylate cyclase by the 5ht1a agonist, such as 5ht7, cannot be discarded. |
1997-05-12 |
2023-08-12 |
rat |
N A Darmani, S L Reeve. The stimulatory and inhibitory components of cocaine's actions on the 5-HTP-induced 5-HT2A receptor response. Pharmacology, biochemistry, and behavior. vol 55. issue 3. 1997-05-08. PMID:8951980. |
this inhibition appears to be due to cocaine-induced indirect stimulation of the inhibitory serotonergic 5-ht1a and noradrenergic alpha 2 receptors via the inhibition of reuptake of synaptic serotonin (5-ht) and norepinephrine (ne), respectively. |
1997-05-08 |
2023-08-12 |
mouse |
T Sumiyoshi, J Ichikawa, H Y Meltze. The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 16. issue 3. 1997-05-08. PMID:9138434. |
the effect of streptozotocin (stz)-induced diabetes and a combination of chronic treatment with haloperidol (hpd) on dopamine (da)d2, serotonin (5-ht) 5-ht1a and 5-ht2a receptors was investigated in rat brain. |
1997-05-08 |
2023-08-12 |
rat |
S G Beck, S Birnstiel, K C Choi, W A Poulio. Fluoxetine selectively alters 5-hydroxytryptamine1A and gamma-aminobutyric acidB receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103487. |
fluoxetine treatment increased the potency of 5-ht for the 5-ht1a receptor-mediated hyperpolarization in area ca1, but not area ca3, and decreased the potency of baclofen for the gaba(b) receptor-mediated hyperpolarization in area ca1, but not area ca3. |
1997-05-02 |
2023-08-12 |
rat |
A Newman-Tancredi, C Conte, C Chaput, M Spedding, M J Milla. Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635. British journal of pharmacology. vol 120. issue 5. 1997-05-02. PMID:9138675. |
at recombinant human 5-hydroxytryptamine (5-ht)5-ht1a receptors expressed in chinese hamster ovary cells (cho-5-ht1a), 5-carboxamidotryptamine (5-ct), acted as a full agonist (relative to 5-ht = 100%) for stimulation of receptor-mediated [35s]-gtp gamma s (guanylyl 5'-[gamma-thio]-tryphosphate) binding. |
1997-05-02 |
2023-08-12 |
human |
N Haddjeri, C de Montigny, P Blie. Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5-hydroxtryptamine system. British journal of pharmacology. vol 120. issue 5. 1997-05-02. PMID:9138693. |
administration of way 100635 antagonized the suppressant effect of microiontophorectically-applied 5-ht on the firing activity of ca3 pyramidal neurones, indicating its antagonistic effect on postsynaptic 5-ht1a receptors. |
1997-05-02 |
2023-08-12 |
rat |
N Haddjeri, C de Montigny, P Blie. Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5-hydroxtryptamine system. British journal of pharmacology. vol 120. issue 5. 1997-05-02. PMID:9138693. |
it is concluded that the suppressant effect of way 100635 on the firing activity of lc na neurones is due to an enhancement of the function of 5-ht neurones via a presynaptic 5-ht1a receptor. |
1997-05-02 |
2023-08-12 |
rat |
H M van Praa. Faulty cortisol/serotonin interplay. Psychopathological and biological characterisation of a new, hypothetical depression subtype (SeCA depression) Psychiatry research. vol 65. issue 3. 1997-04-30. PMID:9029663. |
biologically, these patients are characterized by impaired 5-ht synthesis and reduced 5-ht1a receptor sensitivity. |
1997-04-30 |
2023-08-12 |
Not clear |
H Hall, C Lundkvist, C Halldin, L Farde, V W Pike, J A McCarron, A Fletcher, I A Cliffe, T Barf, H Wikström, G Sedval. Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]way-100635. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037397. |
the labeling of human 5-ht1a receptors with [3h]way-100635 was antagonised by the addition of 5-ht1a receptor ligands, 5-ht, buspirone, pindolol or 8-oh-dpat (10 microm), leaving a very low background of non-specific binding. |
1997-04-29 |
2023-08-12 |
human |
J Katayama, T Yakushiji, N Akaik. Characterization of the K+ current mediated by 5-HT1A receptor in the acutely dissociated rat dorsal raphe neurons. Brain research. vol 745. issue 1-2. 1997-04-29. PMID:9037420. |
the action of 5-hydroxytryptamine (5-ht) via the 5-ht1a receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. |
1997-04-29 |
2023-08-12 |
rat |
M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain. Life sciences. vol 60. issue 16. 1997-04-25. PMID:9096260. |
streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-ht1a and 5-ht2 receptors in the rat brain. |
1997-04-25 |
2023-08-12 |
rat |
D Salgado-Commissariat, K A Alkadh. Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats. Brain research. vol 743. issue 1-2. 1997-04-17. PMID:9017248. |
the effects of the selective serotonin 5-ht1a receptor agonist, 8-oh-dpat (20 microm) on gepr-9 pyramidal ca1 neurons were similar to those of serotonin, except the magnitude of hyperpolarization and reduction of membrane input resistance were less than those produced by serotonin. |
1997-04-17 |
2023-08-12 |
rat |
D Salgado-Commissariat, K A Alkadh. Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats. Brain research. vol 743. issue 1-2. 1997-04-17. PMID:9017248. |
we conclude that the apparent decrease in sensitivity of the gepr-9 ca1 pyramidal neurons to serotonin may represent a deficiency of serotonin 5-ht1a receptor. |
1997-04-17 |
2023-08-12 |
rat |
T Kuroki, J Ichikawa, J Dai, H Y Meltze. R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex. Brain research. vol 743. issue 1-2. 1997-04-17. PMID:9017269. |
r(+)-8-oh-dpat, a 5-ht1a receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex. |
1997-04-17 |
2023-08-12 |
rat |
T Kuroki, J Ichikawa, J Dai, H Y Meltze. R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced serotonin and dopamine release in rat medial prefrontal cortex. Brain research. vol 743. issue 1-2. 1997-04-17. PMID:9017269. |
these results suggest that stimulation of 5-ht1a receptors may inhibit amphetamine-induced release of 5-ht and da in the medial prefrontal cortex. |
1997-04-17 |
2023-08-12 |
rat |
L Palego, D Marazziti, A Rotondo, A Batistini, A Lucacchini, A G Naccarato, G Bevilacqua, F Borsini, H Ladinsky, G B Cassan. Further characterisation of [3H]8-hydroxy-2-(di-N-propylamino)tetralin binding sites in human brain postmortem. Neurochemistry international. vol 30. issue 2. 1997-04-17. PMID:9017662. |
the saturation parameters and the pharmacological characteristics of the binding of the serotonin 1a (5-ht1a) receptor agonist [3h]8-hydroxy-2-(di-n-propylamino)tetralin ([3h]8-oh-dpat), as well as the effects of nucleotides and divalent cations (mg2+, mn2+) on it, were compared in some human postmortem brain regions: the main cortical areas, hippocampus and striatum. |
1997-04-17 |
2023-08-12 |
human |
L Palego, D Marazziti, A Rotondo, A Batistini, A Lucacchini, A G Naccarato, G Bevilacqua, F Borsini, H Ladinsky, G B Cassan. Further characterisation of [3H]8-hydroxy-2-(di-N-propylamino)tetralin binding sites in human brain postmortem. Neurochemistry international. vol 30. issue 2. 1997-04-17. PMID:9017662. |
the pharmacological profile of the [3h]8-oh-dpat binding sites was consistent with the labelling of the 5-ht1a receptor in the hippocampus and cortex, whereas the striatal site shared strong similarity to the presynaptic serotonin transporter. |
1997-04-17 |
2023-08-12 |
human |
G Soslau, M Silverberg, I Brodsky, P P McCart. ATP modification of serotonin-induced contraction of the rat pulmonary artery. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 214. issue 3. 1997-04-16. PMID:9083256. |
the possible presence of 5ht2 and 5ht1a receptor types in the rat pulmonary artery was demonstrated by vasoconstrictions induced by 5ht and (+)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (dpat). |
1997-04-16 |
2023-08-12 |
rat |
I M Anderson, J F Deakin, H E Mille. The effect of chronic fluvoxamine on hormonal and psychological responses to buspirone in normal volunteers. Psychopharmacology. vol 128. issue 1. 1997-04-15. PMID:8944409. |
we studied the effect of 3 weeks treatment with the selective serotonin reuptake inhibitor (ssri), fluvoxamine, on hormonal and psychological responses to buspirone, a 5-ht1a receptor partial agonist which also binds to dopamine receptors, in normal male volunteers. |
1997-04-15 |
2023-08-12 |
human |
N Aguirre, D Frechilla, A García-Osta, B Lasheras, J Del Rí. Differential regulation by methylenedioxymethamphetamine of 5-hydroxytryptamine1A receptor density and mRNA expression in rat hippocampus, frontal cortex, and brainstem: the role of corticosteroids. Journal of neurochemistry. vol 68. issue 3. 1997-04-07. PMID:9048755. |
adrenalectomy by itself did not modify 5-ht content in the brain regions examined and increased 5-ht1a receptor density in the hippocampus (+20%) but produced no change in the frontal cortex and brainstem. |
1997-04-07 |
2023-08-12 |
rat |