| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
serotonin's homeostasis involves serotoninergic autoreceptor such as 5-ht1a, 5-ht1b, 5-ht1d, the enzymatic degradation of serotonin by monoamine oxidase a (mao-a), and a transporter (serotoninergic transporter [sert]). |
2017-09-20 |
2023-08-13 |
Not clear |
| D J David, A M Gardie. [The pharmacological basis of the serotonin system: Application to antidepressant response]. L'Encephale. vol 42. issue 3. 2017-09-20. PMID:27112704. |
among all the 5-ht receptors, 5-ht1a, 5-ht1b, 5-ht1d, 5-ht2b and 5-ht4 receptors activation would mediate antidepressant effects. |
2017-09-20 |
2023-08-13 |
Not clear |
| C William Heise, Hannah Malashock, Daniel E Brook. A review of vilazodone exposures with focus on serotonin syndrome effects. Clinical toxicology (Philadelphia, Pa.). vol 55. issue 9. 2017-09-11. PMID:28594246. |
vilazodone is an antidepressant with selective serotonin reuptake inhibition and partial 5ht1a agonism. |
2017-09-11 |
2023-08-13 |
Not clear |
| C William Heise, Hannah Malashock, Daniel E Brook. A review of vilazodone exposures with focus on serotonin syndrome effects. Clinical toxicology (Philadelphia, Pa.). vol 55. issue 9. 2017-09-11. PMID:28594246. |
serotonin syndrome is believed to be due to excessive stimulation of 5-ht2a and 5-ht1a receptors, resulting in the clinical triad of altered mentation, autonomic instability and neuromuscular abnormalities. |
2017-09-11 |
2023-08-13 |
Not clear |
| Kristian Gaarn du Jardin, Heidi Kaastrup Müller, Betina Elfving, Elena Dale, Gregers Wegener, Connie Sanche. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review. Progress in neuro-psychopharmacology & biological psychiatry. vol 71. 2017-08-30. PMID:27262695. |
recent imaging and behavioral data predominantly support a role for 5-ht1a or 5-ht1b receptors, but the full range of 5-ht receptors has currently not been systematically investigated in this context. |
2017-08-30 |
2023-08-13 |
rat |
| Mustafa Küçükköse, Bürge Kabukçu Başa. [Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 28. issue 1. 2017-08-28. PMID:28291301. |
aripiprazole is a partial agonist for the dopamine d2, serotonin 5-ht1a receptors, and an antagonist for 5ht2a receptors. |
2017-08-28 |
2023-08-13 |
Not clear |
| Kwang Woo Ko, Matthew N Rasband, Victor Meseguer, Richard H Kramer, Nace L Goldin. Serotonin modulates spike probability in the axon initial segment through HCN channels. Nature neuroscience. vol 19. issue 6. 2017-08-02. PMID:27110919. |
furthermore, the control of spike threshold by hcn channels in the ais can be altered through serotonergic modulation of 5-hydroxytryptamine 1a (5-ht1a) receptors, which hyperpolarizes the activation range of hcn channels. |
2017-08-02 |
2023-08-13 |
Not clear |
| Sebastiano Intagliata, Maria N Modica, Valeria Pittalà, Loredana Salerno, Maria A Siracusa, Alfredo Cagnotto, Mario Salmona, Giuseppe Rome. Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR. Bioorganic & medicinal chemistry letters. vol 26. issue 16. 2017-07-26. PMID:27396505. |
these newly synthesized compounds possess a 4-arylpiperazine linked through an acyl spacer to another substituted piperazine system and were tested for their binding properties on human cloned 5-ht1a and 5-ht7 serotonin receptors. |
2017-07-26 |
2023-08-13 |
human |
| R R Dhingra, M Dutschmann, T E Dic. Blockade of dorsolateral pontine 5HT1A receptors destabilizes the respiratory rhythm in C57BL6/J wild-type mice. Respiratory physiology & neurobiology. vol 226. 2017-07-24. PMID:26840837. |
the neurotransmitter serotonin (5ht) acting via 5ht1a receptors (5ht1ar) is a potent determinant of respiratory rhythm variability. |
2017-07-24 |
2023-08-13 |
mouse |
| Feipu Yang, Xiangrui Jiang, Jianfeng Li, Yu Wang, Yongjian Liu, Minghao Bi, Chunhui Wu, Qingjie Zhao, Weiming Chen, Jingjing Yin, Jian Zhang, Yuanchao Xie, Tianwen Hu, Mingshuo Xu, Shuang Guo, Zhen Wang, Yang He, Jingshan She. Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics. Bioorganic & medicinal chemistry letters. vol 26. issue 13. 2017-07-18. PMID:27173799. |
in the present study, a series of benzamides, endowed with potent dopamine d2, serotonin 5-ht1a and 5-ht2a receptors properties, was synthesized and evaluated as potential antipsychotics. |
2017-07-18 |
2023-08-13 |
Not clear |
| Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowsk. Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. Neurotoxicity research. vol 30. issue 4. 2017-07-18. PMID:27461536. |
in vitro data have shown that 5-meo-dipt acts as a potent serotonin transporter (sert) inhibitor and displays high affinity at serotonin 5-ht1a, 5-ht2a, and 5-ht2c receptors. |
2017-07-18 |
2023-08-13 |
rat |
| M Gertrude Gutierrez, Kylee S Mansfield, Noah Malmstad. The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition. Biophysical journal. vol 110. issue 11. 2017-07-04. PMID:27276266. |
the functional activity of the human serotonin 5-ht1a receptor is controlled by lipid bilayer composition. |
2017-07-04 |
2023-08-13 |
human |
| M Gertrude Gutierrez, Kylee S Mansfield, Noah Malmstad. The Functional Activity of the Human Serotonin 5-HT1A Receptor Is Controlled by Lipid Bilayer Composition. Biophysical journal. vol 110. issue 11. 2017-07-04. PMID:27276266. |
here, we examine the lipid dependence of the human serotonin 5-ht1a receptor, a gpcr that is central to neuronal function. |
2017-07-04 |
2023-08-13 |
human |
| Laura Orsolini, Carmine Tomasetti, Alessandro Valchera, Felice Iasevoli, Elisabetta Filomena Buonaguro, Federica Vellante, Michele Fornaro, Annastasia Fiengo, Monica Mazza, Roberta Vecchiotti, Giampaolo Perna, Andrea de Bartolomeis, Giovanni Martinotti, Massimo Di Giannantonio, Domenico De Berardi. New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. Expert review of neurotherapeutics. vol 16. issue 5. 2017-06-27. PMID:27050932. |
vortioxetine (vrx) is a multimodal antidepressant with a unique mechanism of action, by acting as 5-ht3a, 5-ht1d and 5-ht7 receptor antagonist, partial agonist at the 5-ht1a and 5-ht1b receptors and inhibitor at the 5-ht transporter. |
2017-06-27 |
2023-08-13 |
Not clear |
| Ronald S Oosting, Johnny S W Chan, Berend Olivier, Pradeep Banerje. Vilazodone does not inhibit sexual behavior in male rats in contrast to paroxetine: A role for 5-HT1A receptors? Neuropharmacology. vol 107. 2017-06-19. PMID:27040795. |
vilazodone (vlz) is a selective serotonin reuptake inhibitor (ssri) and 5-ht1a receptor partial agonist approved for the treatment of major depressive disorder in adults. |
2017-06-19 |
2023-08-13 |
rat |
| Sylwia Łukasiewicz, Ewa Błasiak, Kinga Szafran-Pilch, Marta Dziedzicka-Wasylewsk. Dopamine D2 and serotonin 5-HT1A receptor interaction in the context of the effects of antipsychotics - in vitro studies. Journal of neurochemistry. vol 137. issue 4. 2017-06-05. PMID:26876117. |
dopamine d2 and serotonin 5-ht1a receptor interaction in the context of the effects of antipsychotics - in vitro studies. |
2017-06-05 |
2023-08-13 |
mouse |
| Sylwia Łukasiewicz, Ewa Błasiak, Kinga Szafran-Pilch, Marta Dziedzicka-Wasylewsk. Dopamine D2 and serotonin 5-HT1A receptor interaction in the context of the effects of antipsychotics - in vitro studies. Journal of neurochemistry. vol 137. issue 4. 2017-06-05. PMID:26876117. |
the serotonin 5-ht1a receptor (5-ht1 a r) and dopamine d2 receptor (d2 r) have been implicated as important sites of action in antipsychotics. |
2017-06-05 |
2023-08-13 |
mouse |
| Suresh Durgam, Carl Gommoll, Giovanna Forero, Rene Nunez, Xiongwen Tang, Maju Mathews, David V Sheeha. Efficacy and Safety of Vilazodone in Patients With Generalized Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Trial. The Journal of clinical psychiatry. vol 77. issue 12. 2017-06-05. PMID:27232052. |
vilazodone is a selective serotonin reuptake inhibitor and 5-ht1a receptor partial agonist approved for the treatment of major depressive disorder in adults. |
2017-06-05 |
2023-08-13 |
Not clear |
| Katarina Varnäs, Anders Juréus, Peter Johnström, Charlotte Ahlgren, Pär Schött, Magnus Schou, Susanne Gruber, Eva Jerning, Jonas Malmborg, Christer Halldin, Lovisa Afzelius, Lars Fard. Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27402278. |
azd3676 [n,n-dimethyl-7-(4-(2-(pyridin-2-yl)ethyl)piperazin-1-yl) benzofuran-2-carboxamide] is a novel combined serotonin (5-hydroxytryptamine) 5-ht1a and 5-ht1b receptor antagonist that was developed for the treatment of cognitive impairment in alzheimer's disease. |
2017-05-26 |
2023-08-13 |
monkey |
| K Kaminska, Z Rogo. The antidepressant- and anxiolytic-like effects following co-treatment with escitalopram and risperidone in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 3. 2017-05-09. PMID:27512008. |
way 100635 (a serotonin 5-ht1a receptor antagonist) at a dose of 0.1 mg/kg abolished the antidepressant-like effect induced by co-administration of escitalopram and risperidone. |
2017-05-09 |
2023-08-13 |
rat |