| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A L Garcia-Garcia, Q Meng, J Richardson-Jones, A Dranovsky, E D Leonard. Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. vol 321. 2016-12-13. PMID:26049143. |
however, little is known about the role of serotonin signaling through 5-ht1a receptors between the emergence of normal anxiety behavior after weaning, and the mature adult phenotype. |
2016-12-13 |
2023-08-13 |
mouse |
| A L Garcia-Garcia, Q Meng, J Richardson-Jones, A Dranovsky, E D Leonard. Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. vol 321. 2016-12-13. PMID:26049143. |
the treatment with way 100,635 does not affect adult 5-ht1a expression levels, but leads to increased expression of the serotonin transporter in the raphe, along with enhanced serotonin levels in both the prefrontal cortex and raphe that correlate with the behavioral changes observed in adult mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Helene M Savignac, Yvonne Couch, Michael Stratford, David M Bannerman, George Tzortzis, Daniel C Anthony, Philip W J Burne. Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice. Brain, behavior, and immunity. vol 52. 2016-12-13. PMID:26476141. |
this significant bgos×lps interaction was also observed for 5ht2a receptors, but not for 5ht1a receptors, 5ht, 5hiaa, nmda receptor subunits, or other cytokines. |
2016-12-13 |
2023-08-13 |
mouse |
| Jogeshwar Mukherjee, Alisha K Bajwa, Dustin W Wooten, Ansel T Hillmer, Min-Liang Pan, Suresh K Pandey, Neil Saigal, Bradley T Christia. Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans. The Journal of comparative neurology. vol 524. issue 7. 2016-12-13. PMID:26509362. |
comparative assessment of (18) f-mefway as a serotonin 5-ht1a receptor pet imaging agent across species: rodents, nonhuman primates, and humans. |
2016-12-13 |
2023-08-13 |
mouse |
| Jogeshwar Mukherjee, Alisha K Bajwa, Dustin W Wooten, Ansel T Hillmer, Min-Liang Pan, Suresh K Pandey, Neil Saigal, Bradley T Christia. Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans. The Journal of comparative neurology. vol 524. issue 7. 2016-12-13. PMID:26509362. |
we have developed (18) f-trans-mefway ((18) f-mefway) for positron emission tomography (pet) imaging studies of serotonin 5-ht1a receptors which are implicated in various brain functions. |
2016-12-13 |
2023-08-13 |
mouse |
| Jessica A Waller, Fenghua Chen, Connie Sánche. Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures. Neuropharmacology. vol 103. 2016-12-13. PMID:26702943. |
the multimodal-acting antidepressant vortioxetine is an antagonist at 5-ht3, 5-ht7, and 5-ht1d receptors, a partial agonist at 5-ht1b receptors, an agonist at 5-ht1a receptors, and an inhibitor of the serotonin (5-ht) transporter (sert) and has pro-cognitive properties. |
2016-12-13 |
2023-08-13 |
Not clear |
| Audrey Franceschi Biagioni, Rithiele Cristina de Oliveira, Ricardo de Oliveira, Juliana Almeida da Silva, Tayllon dos Anjos-Garcia, Camila Marroni Roncon, Alexandre Pinto Corrado, Hélio Zangrossi, Norberto Cysne Coimbr. 5-Hydroxytryptamine 1A receptors in the dorsomedial hypothalamus connected to dorsal raphe nucleus inputs modulate defensive behaviours and mediate innate fear-induced antinociception. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26749090. |
however, dmh treatment with way-100635 failed to alter bicuculline-induced defensive responses, suggesting that 5-ht exerts a phasic influence on 5-ht1a dmh neurons. |
2016-12-13 |
2023-08-13 |
Not clear |
| Carla García-Barba, Laura Medina-Cej. Serotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid. Brain research bulletin. vol 121. 2016-12-13. PMID:26772625. |
in conclusion, these results support the modulation of fr by serotonin with participation of the 5ht1a receptor as a possible mediator of the effect. |
2016-12-13 |
2023-08-13 |
rat |
| Jani Penttilä, Jussi Hirvonen, Lauri Tuominen, Ville Lumme, Tuula Ilonen, Kjell Någren, Jarmo Hietal. Verbal memory and 5-HT1A receptors in healthy volunteers--A PET study with [carbonyl-(11)C]WAY-100635. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26775837. |
the serotonin 5-ht1a receptor is a putative drug development target in disorders with cognitive and in particular memory deficits. |
2016-12-13 |
2023-08-13 |
human |
| Joshua Kaufman, Christine DeLorenzo, Sunia Choudhury, Ramin V Parse. The 5-HT1A receptor in Major Depressive Disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26851834. |
the purpose of this review is to describe the evolution of our current understanding of the serotonin 1a (5-ht1a) receptor and its role in the pathophysiology mdd through the discussion of animal, post-mortem, positron emission tomography (pet), pharmacologic and genetic studies. |
2016-12-13 |
2023-08-13 |
Not clear |
| A Inaba, Y Komori, Y Muroi, K Kinoshita, T Ishi. Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice. Neuroscience. vol 320. 2016-12-13. PMID:26868970. |
direct injection of npy or 8-oh-dpat (a 5-ht1a receptor agonist that inhibits the activity of 5-ht neurons) into the drn inhibited male sexual behavior in fed males. |
2016-12-13 |
2023-08-13 |
mouse |
| D J David, L Tritschler, J-P Guilloux, A M Gardier, C Sanchez, R Gaillar. [Pharmacological properties of vortioxetine and its pre-clinical consequences]. L'Encephale. vol 42. issue 1 Suppl 1. 2016-12-13. PMID:26879252. |
compared to the ssris, vortioxetine is defined as a multimodal antidepressant drug since it is not only a serotonin reuptake inhibitor, but also a 5-ht1d, 5-ht3, 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist and 5-ht1a receptor agonist. |
2016-12-13 |
2023-08-13 |
Not clear |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-ht1a serotonin receptors in rat brain. |
2016-12-13 |
2023-08-13 |
rat |
| Mathieu Verdurand, Fabien Chauveau, Alexia Daoust, Anne-Laure Morel, Frédéric Bonnefoi, François Liger, Anne Bérod, Luc Zimme. Differential effects of amyloid-beta 1-40 and 1-42 fibrils on 5-HT1A serotonin receptors in rat brain. Neurobiology of aging. vol 40. 2016-12-13. PMID:26973100. |
we have previously reported an overexpression of serotonin 5-ht1a receptors (5-ht(1a)r) after intrahippocampal injections of amyloid-beta 1-40 (aβ40) fibrils in rats. |
2016-12-13 |
2023-08-13 |
rat |
| Ikuko Miyazaki, Masato Asanum. Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease. Current medicinal chemistry. vol 23. issue 7. 2016-11-10. PMID:26795196. |
we reported recently that stimulation of serotonin 1a (5-ht1a) receptors on astrocytes promoted astrocyte proliferation and upregulated antioxidative molecules to act as a neuroprotectant in parkinsonian mice. |
2016-11-10 |
2023-08-13 |
mouse |
| Jean-François Perrie. Modulation of motoneuron activity by serotonin. Danish medical journal. vol 63. issue 2. 2016-11-07. PMID:26836802. |
by activating 5-ht1a receptors, serotonin inhibits twik-related acid-sensitive potassium channels and small conductance calcium-activated potassium channels. |
2016-11-07 |
2023-08-13 |
Not clear |
| Jean-François Perrie. Modulation of motoneuron activity by serotonin. Danish medical journal. vol 63. issue 2. 2016-11-07. PMID:26836802. |
the reuptake systems saturate and serotonin spills over to reach extrasynaptic 5-ht1a receptors located on the axon initial segment of motoneurons. |
2016-11-07 |
2023-08-13 |
Not clear |
| Katarzyna Kucwaj-Brysz, Dawid Warszycki, Sabina Podlewska, Jagna Witek, Karolina Witek, Andrea González Izquierdo, Grzegorz Satała, María I Loza, Annamaria Lubelska, Gniewomir Latacz, Andrzej J Bojarski, Marián Castro, Katarzyna Kieć-Kononowicz, Jadwiga Handzli. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. European journal of medicinal chemistry. vol 112. 2016-11-07. PMID:26900658. |
a series of novel arylpiperazine 5-(4-fluorophenyl)-5-methylhydantoins with 2-hydroxypropyl linker (2-15) was synthesized and evaluated on their affinity towards serotonin 5-ht7 receptor (5-ht7r) in comparison to other closely related gpcrs: serotonin 5-ht1a, and dopamine d2 receptors. |
2016-11-07 |
2023-08-13 |
human |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
mechanisms of 5-ht1a receptor-mediated transmission in dorsal raphe serotonin neurons. |
2016-11-04 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
in the dorsal raphe nucleus, it is known that serotonin release activates metabotropic 5-ht1a autoreceptors located on serotonin neurons that leads to an inhibition of firing through the activation of g-protein-coupled inwardly rectifying potassium channels. |
2016-11-04 |
2023-08-13 |
mouse |