| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
we found that in mouse brain slices evoked serotonin release produced a 5-ht1a receptor-mediated inhibitory postsynaptic current (ipsc) that resulted in only a transient pause in firing. |
2016-11-04 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
while spillover activation of receptors contributed to evoked ipscs, serotonin reuptake transporters prevented pooling of serotonin in the extrasynaptic space from activating 5-ht1a -ipscs. |
2016-11-04 |
2023-08-13 |
mouse |
| Nicholas A Courtney, Christopher P For. Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. The Journal of physiology. vol 594. issue 4. 2016-11-04. PMID:26634643. |
these results indicate that evoked serotonin transmission in the dorsal raphe nucleus mediated by metabotropic 5-ht1a autoreceptors may occur via point-to-point synapses rather than by paracrine mechanisms. |
2016-11-04 |
2023-08-13 |
mouse |
| R Colle, E Corrubl. [Vortioxetine: a new antidepressant to treat depressive episodes]. L'Encephale. vol 42. issue 1. 2016-10-31. PMID:26358483. |
vortioxetine is a new antidepressant, which mechanism of action is multimodal, targeting the 5-ht1a, 5-ht1b, 5-ht1d, 5-ht3, 5-ht7 receptors and the serotonin transporter (5-htt). |
2016-10-31 |
2023-08-13 |
Not clear |
| Takashi Matsumoto, Hirotaka Kushida, Takeshi Maruyama, Hiroaki Nishimura, Junko Watanabe, Kazuya Maemura, Yoshio Kas. In vitro identification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan. Xenobiotica; the fate of foreign compounds in biological systems. vol 46. issue 4. 2016-10-28. PMID:26337900. |
recently, gm was reported to have a partial agonistic effect on serotonin 5-ht1a receptors. |
2016-10-28 |
2023-08-13 |
human |
| Masakuni Horiguchi, Masanori Miyauchi, Nichole M Neugebauer, Yoshihiro Oyamada, Herbert Y Meltze. Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism. Behavioural brain research. vol 301. 2016-10-20. PMID:26342283. |
we examined the ability of post-pcp subchronic lurasidone, an atypical apd with potent serotonin (5-ht)1a partial agonism and subchronic tandospirone, a selective 5-ht1a partial agonist, to enable prolonged reversal of the subchronic pcp-induced nor deficit. |
2016-10-20 |
2023-08-13 |
rat |
| Vincenzo Crunelli, Giuseppe Di Giovann. Differential Control by 5-HT and 5-HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus. CNS neuroscience & therapeutics. vol 21. issue 12. 2016-10-18. PMID:26555767. |
differential control by 5-ht and 5-ht1a, 2a, 2c receptors of phasic and tonic gabaa inhibition in the visual thalamus. |
2016-10-18 |
2023-08-13 |
Not clear |
| Hamid Moha ou Maati, Céline Bourcier-Lucas, Julie Veyssiere, Ameni Kanzari, Catherine Heurteaux, Marc Borsotto, Nasser Haddjeri, Guillaume Luca. The peptidic antidepressant spadin interacts with prefrontal 5-HT(4) and mGluR(2) receptors in the control of serotonergic function. Brain structure & function. vol 221. issue 1. 2016-10-14. PMID:25233810. |
the combination of spadin with the 5-ht4 agonist rs 67333 paradoxically reduced 5-ht firing, an effect reversed by acutely administering the 5-ht1a agonist flesinoxan. |
2016-10-14 |
2023-08-13 |
Not clear |
| Nicholas V Cozzi, Paul F Dale. Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines. Bioorganic & medicinal chemistry letters. vol 26. issue 3. 2016-10-13. PMID:26739781. |
five of the dalt compounds had affinity in the 10-80 nm range for serotonin 5-ht1a and 5-ht2b receptors, while the affinity of dalt itself at 5-ht1a receptors was slightly lower at 100 nm. |
2016-10-13 |
2023-08-13 |
Not clear |
| Giovanna Paolone, Alberto Brugnoli, Ludovico Arcuri, Daniela Mercatelli, Michele Morar. Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 13. 2016-10-12. PMID:26207892. |
selective serotonin (5-hydroxytryptamine; 5-ht) 5-ht1a or 5-ht1b receptor agonists, and, very recently, the mixed 5-ht1a /5-ht1b receptor agonist, eltoprazine, proved effective in inhibiting l-dopa-induced dyskinesias in experimental animals and parkinsonian patients. |
2016-10-12 |
2023-08-13 |
Not clear |
| Sietse F de Boer, Adrian Newman-Tancred. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology. vol 233. issue 6. 2016-10-12. PMID:26694810. |
the serotonin (5-ht) deficiency hypothesis of aggression is being seriously challenged by pharmacological data showing robust anti-aggressive effects of 5-ht1a receptor agonists in dose ranges that concomitantly inhibit 5-ht neurotransmission. |
2016-10-12 |
2023-08-13 |
rat |
| Sietse F de Boer, Adrian Newman-Tancred. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology. vol 233. issue 6. 2016-10-12. PMID:26694810. |
hence, an adequate interpretation of the role of 5-ht activity in regulating aggression depends on elucidating the predominant site of action, i.e., raphe presynaptic autoreceptors versus forebrain postsynaptic heteroreceptors, of these 5-ht1a receptor agonists. |
2016-10-12 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Alexander O Tarakanov, Kjell Fux. FGFR1-5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression. Trends in neurosciences. vol 39. issue 1. 2016-10-07. PMID:26687454. |
they were first described in the hippocampus and later in midbrain 5-ht neurons, where these heterocomplexes are enriched in 5-ht1a autoreceptors. |
2016-10-07 |
2023-08-13 |
Not clear |
| Anna M Waszkielewicz, Marek Cegła, Ewa Żesławska, Wojciech Nitek, Karolina Słoczyńska, Henryk Maron. N-[(2,6-Dimethylphenoxy)alkyl]aminoalkanols-their physicochemical and anticonvulsant properties. Bioorganic & medicinal chemistry. vol 23. issue 15. 2016-09-28. PMID:26164622. |
the compound binds to σ, 5-ht1a, and α2 receptors as well as 5-ht transporter and it does not exhibit mutagenic properties. |
2016-09-28 |
2023-08-13 |
mouse |
| Rizwan ul Haq, Marlene L Anderson, Jan-Oliver Hollnagel, Franziska Worschech, Muhammad Azahr Sherkheli, Christoph J Behrens, Uwe Heineman. Serotonin dependent masking of hippocampal sharp wave ripples. Neuropharmacology. vol 101. 2016-09-22. PMID:26409781. |
5-ht, as well as a 5-ht1a agonist, augmented paired pulse facilitation and affected the coefficient of variance. |
2016-09-22 |
2023-08-13 |
mouse |
| Paul L McCormac. Vilazodone: a review in major depressive disorder in adults. Drugs. vol 75. issue 16. 2016-09-19. PMID:26496736. |
vilazodone (viibryd(®)) exhibits the combined properties of a selective serotonin reuptake inhibitor (ssri) and a serotonin 5-ht1a receptor partial agonist, and is approved in the us for the treatment of major depressive disorder (mdd) in adults. |
2016-09-19 |
2023-08-13 |
Not clear |
| Sonoe Kitamura, Takashi Kawano, Satomi Kaminaga, Daiki Yamanaka, Hiroki Tateiwa, Fabricio M Locatelli, Masataka Yokoyam. Effects of fentanyl on serotonin syndrome-like behaviors in rats. Journal of anesthesia. vol 30. issue 1. 2016-09-15. PMID:26499475. |
rats were s.c. injected with 0.75 mg/kg 8-oh-dpat, a full 5-ht1a agonist, as an animal model of serotonin syndrome. |
2016-09-15 |
2023-08-13 |
rat |
| Sonoe Kitamura, Takashi Kawano, Satomi Kaminaga, Daiki Yamanaka, Hiroki Tateiwa, Fabricio M Locatelli, Masataka Yokoyam. Effects of fentanyl on serotonin syndrome-like behaviors in rats. Journal of anesthesia. vol 30. issue 1. 2016-09-15. PMID:26499475. |
in contrast, pretreatment with way-100653, a serotonin 5-ht1a receptor antagonist (0.5 mg/kg, i.p. |
2016-09-15 |
2023-08-13 |
rat |
| Paul L McCormac. Cariprazine: First Global Approval. Drugs. vol 75. issue 17. 2016-09-09. PMID:26510944. |
cariprazine also has partial agonist activity at serotonin 5-ht1a receptors. |
2016-09-09 |
2023-08-13 |
Not clear |
| Huali Lin, Ying Lei, Bo Zhang, Zunxiao Dai, Xiaoyun L. Common variants of HTR1A and SLC6A4 confer the increasing risk of Schizophrenia susceptibility: A population-based association and epistasis analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 168. issue 8. 2016-09-08. PMID:26408209. |
recent studies evaluating the association between sz and genetic polymorphisms in a serotonin transporter (encoded by slc6a4) and serotonin receptor 1a (encoded by htr1a) show conflicting results. |
2016-09-08 |
2023-08-13 |
human |