| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
whole-cell voltage-clamp recording in brainstem slices were used to determine concentration-response relationships for the selected girk channel blockers on 5-ht1a autoreceptor-activated inwardly rectifying k+ conductance in rat dorsal raphe 5-ht neurons. |
2016-06-06 |
2023-08-13 |
rat |
| Andrew C McCreary, Adrian Newman-Tancred. Serotonin 5-HT1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs. Current pharmaceutical design. vol 21. issue 26. 2016-06-03. PMID:26044980. |
serotonin 5-ht1a receptors and antipsychotics - an update in light of new concepts and drugs. |
2016-06-03 |
2023-08-13 |
Not clear |
| Sabino Hazael Avila-Rojas, Isabel Velázquez-Lagunas, Ana Belen Salinas-Abarca, Paulino Barragán-Iglesias, Jorge Baruch Pineda-Farias, Vinicio Granados-Sot. Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. Brain research. vol 1622. 2016-06-01. PMID:26168890. |
moreover, both selective 5-ht1a and 5-ht1b/1d receptor antagonists, way-100635 (0.3-1 nmol) and gr-127935 (0.3-1 nmol), respectively, partially diminished the antiallodynic effect of 5-ht or 5-ct by about 30%. |
2016-06-01 |
2023-08-13 |
rat |
| Eunsoo Won, Byung-Joo Ha. Imaging genetics studies on monoaminergic genes in major depressive disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 64. 2016-05-31. PMID:25828849. |
this paper attempts to provide a comprehensive review of available imaging genetics studies, including reports on genetic variants that have most frequently been linked to mdd, such as the monoaminergic genes (serotonin transporter gene, monoamine oxidase a gene, tryptophan hydroxylase-2 gene, serotonin receptor 1a gene and catechol-o-methyl transferase gene), with regard to key structures involved in emotion processing, such as the hippocampus, amygdala, anterior cingulate cortex and orbitofrontal cortex. |
2016-05-31 |
2023-08-13 |
Not clear |
| Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pa. Vilazodone for the Treatment of Depression: An Update. Chonnam medical journal. vol 52. issue 2. 2016-05-27. PMID:27231672. |
vilazodone is a novel antidepressant having a selective serotonin (5-ht) reuptake inhibitor and 5-ht1a receptor partial agonist profile, so it has been regarded as a serotonin partial agonist-reuptake inhibitor (spari). |
2016-05-27 |
2023-08-13 |
Not clear |
| Sarah J Judge, Claire Y Savy, Matthew Campbell, Rebecca Dodds, Larissa Kruger Gomes, Grace Laws, Anna Watson, Peter G Blain, Christopher M Morris, Sarah E Gartsid. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26721196. |
the excitatory responses of drn neurones to α1-adrenoceptor or ampa/kainate receptor activation were not affected by in vivo diazinon exposure but the inhibitory response to 5-ht was attenuated, indicating 5-ht1a autoreceptor down-regulation. |
2016-05-26 |
2023-08-13 |
rat |
| Sarah J Judge, Claire Y Savy, Matthew Campbell, Rebecca Dodds, Larissa Kruger Gomes, Grace Laws, Anna Watson, Peter G Blain, Christopher M Morris, Sarah E Gartsid. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26721196. |
together these data indicate that 1) acute op exposure inhibits drn cholinesterase, leading to acetylcholine accumulation, 2) the acetylcholine activates nicotinic receptors on 5-ht neurones and also on glutamatergic neurones, thus releasing glutamate and activating 5-ht neuronal ampa/kainate receptors 3) the increase in 5-ht neuronal activity, and resulting 5-ht release, may lead to 5-ht1a autoreceptor down-regulation. |
2016-05-26 |
2023-08-13 |
rat |
| Philippe Huot, Tom H Johnston, Susan H Fox, Adrian Newman-Tancredi, Jonathan M Brotchi. The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque. Neuropharmacology. vol 97. 2016-05-24. PMID:26071982. |
modulation of serotonin 1a (5-ht1a) receptors is regarded as an effective way to alleviate dyskinesia, yet this approach has been marred by a reduction of the therapeutic effectiveness of l-dopa. |
2016-05-24 |
2023-08-13 |
monkey |
| Emily C Acker, Elizabeth A Sinclair, Andrew L Beardsley, Sheikh S Ahmed, Blake A Frober. Acute Vilazodone Toxicity in a Pediatric Patient. The Journal of emergency medicine. vol 49. issue 3. 2016-05-23. PMID:26099909. |
vilazodone is a selective serotonin reuptake inhibitor and 5ht1a agonist recently approved to treat depression in adults. |
2016-05-23 |
2023-08-13 |
Not clear |
| Jaroslaw Jacak, Susanne Schaller, Daniela Borgmann, Stephan M Winkle. Characterization of the Distance Relationship Between Localized Serotonin Receptors and Glia Cells on Fluorescence Microscopy Images of Brain Tissue. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. vol 21. issue 4. 2016-05-23. PMID:26173412. |
direct stochastic optical reconstruction microscopy images of 5-ht1a serotonin receptors and glial fibrillary acidic proteins in healthy cryopreserved brain tissues are analyzed. |
2016-05-23 |
2023-08-13 |
Not clear |
| Bruno Carabelli, Ana Marcia Delattre, Claudia Pudell, Marco Aurélio Mori, Deborah Suchecki, Ricardo B Machado, Daniel Paulino Venancio, Sílvia Regina Piazzetta, Ivilim Hammerschmidt, Sílvio M Zanata, Marcelo M S Lima, Janaína Menezes Zanoveli, Anete Curte Ferra. The Antidepressant-Like Effect of Fish Oil: Possible Role of Ventral Hippocampal 5-HT1A Post-synaptic Receptor. Molecular neurobiology. vol 52. issue 1. 2016-05-17. PMID:25139282. |
after the behavioral test, the hippocampi were obtained for quantification of serotonin (5-ht) and its metabolite, 5-hydroxyindoleacetic acid (5-hiaa) and for 5-ht1a receptor expression by western blotting analysis. |
2016-05-17 |
2023-08-13 |
rat |
| Laura A Stanquini, Leonardo B M Resstel, Fernando M A Corrêa, Sâmia R L Joca, América A Scopinh. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26143050. |
independent groups of rats were pretreated with intra-pl antagonists of 5-ht receptors: 5-ht1a (way100635), 5-ht2c (sb242084) or 5-ht1b (sb216641). |
2016-05-17 |
2023-08-13 |
rat |
| Laura A Stanquini, Leonardo B M Resstel, Fernando M A Corrêa, Sâmia R L Joca, América A Scopinh. Prelimbic cortex 5-HT1A and 5-HT2C receptors are involved in the hypophagic effects caused by fluoxetine in fasted rats. Pharmacology, biochemistry, and behavior. vol 136. 2016-05-17. PMID:26143050. |
our findings suggest that pl 5-ht neurotransmission modulates the central control of food intake and 5-ht1a and 5-ht2c receptors in the pl could be potential targets for the action of fluoxetine. |
2016-05-17 |
2023-08-13 |
rat |
| Man Luo, Terry-Elinor Reid, Xiang Simon Wan. Discovery of Natural Product-Derived 5-HT1A Receptor Binders by Cheminfomatics Modeling of Known Binders, High Throughput Screening and Experimental Validation. Combinatorial chemistry & high throughput screening. vol 18. issue 7. 2016-05-13. PMID:26138565. |
the human 5-hydroxytryptamine receptor subtype 1a (5-ht1a) is highly expressed in the raphe nuclei region and limbic structures; for that reason 5-ht1a has served as a promising target for treating human mood disorders and neurodegenerative diseases. |
2016-05-13 |
2023-08-13 |
human |
| Joseph McEvoy, Leslie Citrom. Brexpiprazole for the Treatment of Schizophrenia: A Review of this Novel Serotonin-Dopamine Activity Modulator. Clinical schizophrenia & related psychoses. vol 9. issue 4. 2016-05-12. PMID:26757416. |
brexpiprazole acts as a partial agonist at dopamine d2 and serotonin 5-ht1a receptors, and as an antagonist at serotonin 5-ht2a and at adrenergic alpha1b and alpha2c receptors. |
2016-05-12 |
2023-08-13 |
Not clear |
| Anna Castañé, Lucila Kargieman, Pau Celada, Analía Bortolozzi, Francesc Artiga. 5-HT2A receptors are involved in cognitive but not antidepressant effects of fluoxetine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 8. 2016-05-06. PMID:25914158. |
endogenous 5-ht exerts robust actions on the activity of pyramidal neurons in medial pfc (mpfc) via excitatory 5-ht2a and inhibitory 5-ht1a receptors, suggesting the involvement of 5-ht neurotransmission in cortical functions. |
2016-05-06 |
2023-08-13 |
mouse |
| Nikolas Stroth, Mauro Niso, Nicola A Colabufo, Roberto Perrone, Per Svenningsson, Enza Lacivita, Marcello Leopold. Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2. Bioorganic & medicinal chemistry. vol 23. issue 15. 2016-05-04. PMID:26081758. |
arylpiperazine agonists of the serotonin 5-ht1a receptor preferentially activate camp signaling versus recruitment of β-arrestin-2. |
2016-05-04 |
2023-08-13 |
Not clear |
| Nikolas Stroth, Mauro Niso, Nicola A Colabufo, Roberto Perrone, Per Svenningsson, Enza Lacivita, Marcello Leopold. Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2. Bioorganic & medicinal chemistry. vol 23. issue 15. 2016-05-04. PMID:26081758. |
in the present study, we show that several arylpiperazine ligands of the serotonin 5-ht1a receptor (5-ht1ar) preferentially activate 3',5'-cyclic adenosine monophosphate (camp) signaling versus β-arrestin-2 recruitment. |
2016-05-04 |
2023-08-13 |
Not clear |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
compared to non-treated depression-like rats, the increased levels of 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-htaa) in serum and hypothalamus, and the reduced expressions of 5-ht1a receptor and 5-ht2a receptor in hypothalamus were observed after af and fluoxetine oral administration indicating that af-mediated antidepressant-like effect may be related to the normalization of serotonergic system. |
2016-05-03 |
2023-08-13 |
rat |
| Kenichi Fukumoto, Shigeyuki Chak. Involvement of serotonergic system in the effect of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test. Journal of pharmacological sciences. vol 127. issue 1. 2016-04-25. PMID:25704019. |
moreover, the effect of mpep was blocked by a serotonin (5-ht)2a/2c receptor antagonist, ritanserin, but not by a 5-ht1a receptor antagonist, n-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-n-(2-pyridynyl) cyclohexane-carboxamide (way100635). |
2016-04-25 |
2023-08-13 |
mouse |