| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in our previous paper, we have reported that some 8-alkoxy-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione derivatives possessed high affinity and displayed agonistic activity for the serotonin 5-ht1a receptor. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
in order to examine the influence of the substituent in the position 8 of the purine moiety on the affinity for the serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors, a series of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl (thiq) derivatives of 8-amino-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione were synthesized. |
2016-01-21 |
2023-08-13 |
Not clear |
| Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. |
all the final compounds were investigated in in vitro competition binding experiments for serotonin 5-ht1a , 5-ht2a , and 5-ht7 receptors. |
2016-01-21 |
2023-08-13 |
Not clear |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
new arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-ht1a /5-ht2a /5-ht7 and dopamine d2 receptors. |
2016-01-21 |
2023-08-13 |
mouse |
| Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Adam Bucki, Marcin Kołaczkowski, Maciej Pawłowski, Grzegorz Satała, Andrzej J Bojarski, Anna Partyka, Anna Wesołowska, Elżbieta Pękala, Karolina Słoczyńsk. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773907. |
to obtain potential antidepressants and/or antipsychotics, a series of new long-chain arylpiperazine derivatives of 8-alkoxy-purine-2,6-dione (10-24) and dihydro[1,3]oxazolo[2,3-f]purinedione (30-34) were synthesized and their serotonin (5-ht1a , 5-ht2a , 5-ht6 , 5-ht7 ) and dopamine (d2 ) receptor affinities were determined. |
2016-01-21 |
2023-08-13 |
mouse |
| Ran Ye, Meagan A Quinlan, Hideki Iwamoto, Hsiao-Huei Wu, Noah H Green, Christopher S Jetter, Douglas G McMahon, Jeremy Veestra-VanderWeele, Pat Levitt, Randy D Blakel. Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters. Frontiers in synaptic neuroscience. vol 7. 2016-01-21. PMID:26793096. |
additionally, dorsal raphe 5-ht neurons from nlgn2 null mice exhibit reduced excitability, a loss of gabaa receptor-mediated ipscs, and increased 5-ht1a autoreceptor sensitivity. |
2016-01-21 |
2023-08-13 |
mouse |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
previous pilot clinical studies have shown that the serotonin 5-ht1a receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. |
2016-01-19 |
2023-08-13 |
Not clear |
| Ichiro Kusumi, Shuken Boku, Yoshito Takahash. Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. Psychiatry and clinical neurosciences. vol 69. issue 5. 2016-01-18. PMID:25296946. |
a variety of serotonin (5-ht) receptors, such as 5-ht2a / 2c , 5-ht1a , 5-ht6 and 5-ht7 receptors, may contribute to the mechanisms of action of 'atypicality'. |
2016-01-18 |
2023-08-13 |
Not clear |
| James McKean, Hannah Watts, Robert Mokszyck. Breakthrough seizures after starting vilazodone for depression. Pharmacotherapy. vol 35. issue 3. 2016-01-15. PMID:25809181. |
vilazodone is a new selective serotonin reuptake inhibitor (ssri) and serotonin 5-ht1a partial agonist that is approved by the united states food and drug administration to treat major depression. |
2016-01-15 |
2023-08-13 |
Not clear |
| Francesc Artiga. Developments in the field of antidepressants, where do we go now? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 5. 2016-01-13. PMID:23706576. |
this will lead to the synthesis of new agents blocking the serotonin (and possibly norepinephrine) transporter which will also activate or block 5-ht receptors playing respectively positive (e.g., postsynaptic 5-ht1a, 5-ht4) or negative (e.g., presynaptic 5-ht1a,/1b, 5-ht2a, 5-ht2c,5-ht3, etc.) |
2016-01-13 |
2023-08-12 |
Not clear |
| Antony Loebel, Leslie Citrom. Lurasidone: a novel antipsychotic agent for the treatment of schizophrenia and bipolar depression. BJPsych bulletin. vol 39. issue 5. 2016-01-12. PMID:26755968. |
in addition to full antagonist activity at dopamine d2 (k i(d2) = 1 nm) and serotonin 5-ht2a (k i(5-ht2a) = 0.5 nm) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-ht7 receptors (k i(5-ht7) = 0.5 nm) and its partial agonist activity at 5-ht1a receptors (k i(5-ht1a) = 6.4 nm). |
2016-01-12 |
2023-08-13 |
Not clear |
| Tamaki Ishima, Takashi Futamura, Yuta Ohgi, Noriko Yoshimi, Tetsuro Kikuchi, Kenji Hashimot. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25687838. |
potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-ht1a and 5-ht2a receptors. |
2016-01-11 |
2023-08-13 |
Not clear |
| Granville J Matheson, Martin Schain, Rita Almeida, Johan Lundberg, Zsolt Cselényi, Jacqueline Borg, Andrea Varrone, Lars Farde, Simon Cervenk. Diurnal and seasonal variation of the brain serotonin system in healthy male subjects. NeuroImage. vol 112. 2016-01-11. PMID:25772667. |
we used positron emission tomography to examine diurnal and seasonal changes in the serotonin 5-ht1a receptor and serotonin transporter in two large cohorts of healthy male subjects, employing a cross-sectional design. |
2016-01-11 |
2023-08-13 |
human |
| Granville J Matheson, Martin Schain, Rita Almeida, Johan Lundberg, Zsolt Cselényi, Jacqueline Borg, Andrea Varrone, Lars Farde, Simon Cervenk. Diurnal and seasonal variation of the brain serotonin system in healthy male subjects. NeuroImage. vol 112. 2016-01-11. PMID:25772667. |
we also found seasonal changes in the 5-ht1a receptor in serotonin projection regions, with higher availability on days with a longer duration of daylight. |
2016-01-11 |
2023-08-13 |
human |
| Małgorzata Zygmunt, Grażyna Chłoń-Rzepa, Jacek Sap. THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE. Acta poloniae pharmaceutica. vol 72. issue 3. 2016-01-11. PMID:26642666. |
the effect of serotonin 5-ht1a, 5-ht2 receptor ligands, ketoprofen and their combination in models of induced pain in mice. |
2016-01-11 |
2023-08-13 |
mouse |
| K A Rahn, Y-J Cao, C W Hendrix, A I Kapli. The role of 5-HT1A receptors in mediating acute negative effects of antidepressants: implications in pediatric depression. Translational psychiatry. vol 5. 2016-01-07. PMID:25942044. |
co-administration of the 5-ht1a receptor (5-ht1ar) antagonist way-100635 reversed the negative effects of acute fluoxetine, a serotonin reuptake inhibitor, but not reboxetine, a norepinephrine reuptake inhibitor, supporting the involvement of 5-ht1ar in mediating the negative consequences of acute selective serotonin reuptake inhibitor (ssri) treatment. |
2016-01-07 |
2023-08-13 |
Not clear |
| Yann S Mineur, Emily B Einstein, Matthew P Bentham, Mattis B Wigestrand, Sam Blakeman, Sylvia A Newbold, Marina R Picciott. Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25288485. |
this study suggests that serotonin signaling through postsynaptic 5-ht1a receptors in the hippocampus is critical for the antidepressant-like effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders. |
2016-01-05 |
2023-08-13 |
mouse |
| Cécile Bétry, Adeline Etiévant, Alan Pehrson, Connie Sánchez, Nasser Haddjer. Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25524057. |
vortioxetine is a multimodal acting antidepressant that functions as a 5-ht3 and 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of the 5-ht transporter. |
2016-01-05 |
2023-08-13 |
human |
| Cynthia L Bethea, Arubala P Reddy, Matthew Flowers, Robert A Shapiro, Ricki J Colman, David H Abbott, Jon E Levin. High fat diet decreases beneficial effects of estrogen on serotonin-related gene expression in marmosets. Progress in neuro-psychopharmacology & biological psychiatry. vol 58. 2016-01-05. PMID:25542371. |
the serotonin reuptake transporter (sert), the serotonin 1a receptor (5ht1a), estrogen receptor beta (erβ) and progestin receptor (pr) expressions were not different between groups. |
2016-01-05 |
2023-08-13 |
marmoset |
| Anthony Y Huang, Sandy Y W. Calcitonin Gene-Related Peptide Reduces Taste-Evoked ATP Secretion from Mouse Taste Buds. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377461. |
further, our previous studies showed that 5-ht released from presynaptic (type iii) cells provides negative paracrine feedback onto receptor (type ii) cells by activating 5-ht1a receptors, and reducing atp secretion. |
2016-01-04 |
2023-08-13 |
mouse |