| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Iderberg, A C McCreary, M A Varney, M A Cenci, A Newman-Tancred. Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia. Neuropharmacology. vol 93. 2016-01-01. PMID:25645393. |
serotonin 5-ht1a receptor agonists reduce l-dopa-induced dyskinesia (lid) in animal models of parkinson's disease (pd). |
2016-01-01 |
2023-08-13 |
rat |
| Hai-Juan Li, Rui-Yun Peng, Chang-Zhen Wang, Si-Mo Qiao, Zou Yong, Ya-Bing Gao, Xin-Ping Xu, Shao-Xia Wang, Ji Dong, Hong-Yan Zuo, Zhao Li, Hong-Mei Zhou, Li-Feng Wang, Xiang-Jun H. Alterations of cognitive function and 5-HT system in rats after long term microwave exposure. Physiology & behavior. vol 140. 2015-12-28. PMID:25542888. |
expressions of serotonin receptors including 5-ht1a, 2a, 2c receptors were measured. |
2015-12-28 |
2023-08-13 |
rat |
| Yifat Glikmann-Johnston, Michael M Saling, David C Reutens, Julie C Stou. Hippocampal 5-HT1A Receptor and Spatial Learning and Memory. Frontiers in pharmacology. vol 6. 2015-12-23. PMID:26696889. |
the hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-ht) receptor binding sites, particularly of the 1a receptor (5-ht1a) subtype. |
2015-12-23 |
2023-08-13 |
mouse |
| Yifat Glikmann-Johnston, Michael M Saling, David C Reutens, Julie C Stou. Hippocampal 5-HT1A Receptor and Spatial Learning and Memory. Frontiers in pharmacology. vol 6. 2015-12-23. PMID:26696889. |
these findings, along with evidence from recent cognitive imaging studies using positron emission tomography (pet) with 5-ht1a receptor ligands, and studies of individual genetic variance in 5-ht1a receptor availability, strongly suggests that 5-ht, mediated by the 5-ht1a receptor subtype, plays a key role in spatial learning and memory. |
2015-12-23 |
2023-08-13 |
mouse |
| Shilpa Rele, Robert Millet, Sungman Kim, Jong-Woo Paik, Seonghwan Kim, Prakash S Masand, Ashwin A Patka. An 8-Week Randomized, Double-Blind Trial Comparing Efficacy, Safety, and Tolerability of 3 Vilazodone Dose-Initiation Strategies Following Switch From SSRIs and SNRIs in Major Depressive Disorder. The primary care companion for CNS disorders. vol 17. issue 4. 2015-12-22. PMID:26693034. |
vilazodone, a selective and potent 5-ht1a partial agonist and 5-ht reuptake inhibitor, has been approved for treatment of major depressive disorder (mdd) in adults. |
2015-12-22 |
2023-08-13 |
human |
| Luc Jaber, Fang-li Zhao, Tamara Kolli, Scott Hernes. A physiologic role for serotonergic transmission in adult rat taste buds. PloS one. vol 9. issue 11. 2015-12-21. PMID:25386961. |
collectively, these data support the hypothesis that serotonin is a crucial element in a finely-tuned feedback loop involving the 5-ht1a receptor, atp, and purinoceptors. |
2015-12-21 |
2023-08-13 |
rat |
| Maria N Modica, Sebastiano Intagliata, Valeria Pittalà, Loredana Salerno, Maria A Siracusa, Alfredo Cagnotto, Mario Salmona, Giuseppe Rome. Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands. Bioorganic & medicinal chemistry letters. vol 25. issue 7. 2015-12-21. PMID:25759032. |
new long-chain 4-substituted piperazines linked to a thienopyrimidine or a quinazoline system were synthesized and tested for their binding properties on human cloned 5-ht1a and 5-ht7 serotonin receptors. |
2015-12-21 |
2023-08-13 |
human |
| Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Yasushi Ikarashi, Tomohisa Hattori, Yoshio Kas. Yokukansan Increases 5-HT1A Receptors in the Prefrontal Cortex and Enhances 5-HT1A Receptor Agonist-Induced Behavioral Responses in Socially Isolated Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-12-18. PMID:26681968. |
in this study, to investigate the underlying mechanisms, we examined the effects of repeated yokukansan administration on serotonin 1a (5-ht1a) receptor density and affinity and its expression at both mrna and protein levels in the prefrontal cortex (pfc) of socially isolated mice. |
2015-12-18 |
2023-08-13 |
mouse |
| Noriko Yoshimi, Takashi Futamura, Kenji Hashimot. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25600995. |
finally, the effect of brexpiprazole on dizocilpine-induced social recognition deficits was antagonized by way-100,635, a selective serotonin 5-ht1a antagonist. |
2015-12-15 |
2023-08-13 |
mouse |
| Christoph Kraus, Pia Baldinger, Christina Rami-Mark, Gregor Gryglewski, Gregor Gryglewsky, Georg S Kranz, Daniela Haeusler, Andreas Hahn, Wolfgang Wadsak, Markus Mitterhauser, Dan Rujescu, Siegfried Kasper, Rupert Lanzenberge. Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding. PloS one. vol 9. issue 9. 2015-12-07. PMID:25188405. |
the brain-derived neurotrophic factor (bdnf) val66met polymorphism (rs6265) may impact on the in-vivo binding of important serotonergic structures such as the serotonin transporter (5-htt) and the serotonin-1a (5-ht1a) receptor. |
2015-12-07 |
2023-08-13 |
Not clear |
| Masaru Ihara, Asuka Inoue, Seiya Hanamoto, Han Zhang, Junken Aoki, Hiroaki Tanak. Detection of physiological activities of G protein-coupled receptor-acting pharmaceuticals in wastewater. Environmental science & technology. vol 49. issue 3. 2015-12-04. PMID:25556879. |
we applied the in vitro transforming growth factor-α (tgfα) shedding assay, which accurately and sensitively detect gpcr activation, to investigate the agonistic/antagonistic activities of wastewater extracts against receptors for angiotensin (at1), dopamine (d2, d4), adrenergic family members (α1b, α2a, β1, β3), acetylcholine (m1, m3), cannabinoid (cb1), vasopressin (v1a, v2), histamine (h1, h2, h3), 5-hydroxytryptamine (5-ht1a, 5-ht2c), prostanoid (ep3), and leukotriene (blt1). |
2015-12-04 |
2023-08-13 |
Not clear |
| Katsumasa Muneoka, Makiko Kuwagata, Tetsuo Ogawa, Seiji Shiod. Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders. Cerebellum (London, England). vol 14. issue 2. 2015-12-01. PMID:25315739. |
recent studies have revealed the neuropharmacological properties of yokukansan (yks), including its 5-ht1a (serotonin) receptor agonistic effects. |
2015-12-01 |
2023-08-13 |
rat |
| Katarzyna Panczyk, Sylwia Golda, Anna Waszkielewicz, Dorota Zelaszczyk, Agnieszka Gunia-Krzyzak, Henryk Maron. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Current pharmaceutical design. vol 21. issue 13. 2015-11-23. PMID:25412650. |
so far, participation in the epileptogenesis and maintenance of epilepsy was proved for 5-ht1a, 5-ht2c, 5-ht3, 5-ht4 and 5-ht7 receptors as well as 5-htt serotonin transporter. |
2015-11-23 |
2023-08-13 |
Not clear |
| Ismet Sarikay. PET studies in epilepsy. American journal of nuclear medicine and molecular imaging. vol 5. issue 5. 2015-11-09. PMID:26550535. |
pet receptor imaging studies have demonstrated reduced (11)c-flumazenil (gabaa-cbdz) and (18)f-mppf (5-ht1a serotonin) and increased (11)c-cerfentanil (mu opiate) and (11)c-menti (delta opiate) bindings in the area of seizure. |
2015-11-09 |
2023-08-13 |
Not clear |
| Maju Mathews, Carl Gommoll, Dalei Chen, Rene Nunez, Arif Kha. Efficacy and safety of vilazodone 20 and 40 mg in major depressive disorder: a randomized, double-blind, placebo-controlled trial. International clinical psychopharmacology. vol 30. issue 2. 2015-11-06. PMID:25500685. |
vilazodone is a selective serotonin reuptake inhibitor and 5-ht1a partial agonist approved for major depressive disorder (mdd) treatment in adults. |
2015-11-06 |
2023-08-13 |
Not clear |
| Ansel T Hillmer, Dustin W Wooten, Dana L Tudorascu, Todd E Barnhart, Elizabeth O Ahlers, Leslie M Resch, Julie A Larson, Alexander K Converse, Colleen F Moore, Mary L Schneider, Bradley T Christia. The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates. Drug and alcohol dependence. vol 144. 2015-10-30. PMID:25220896. |
the goal of this work was to directly observe in vivo effects of chronic ethanol self-administration on serotonin 5-ht1a receptor binding with [(18)f]mefway pet neuroimaging in rhesus monkeys. |
2015-10-30 |
2023-08-13 |
human |
| Clinton E Canal, Daniel E Felsing, Yue Liu, Wanying Zhu, JodiAnne T Wood, Charles K Perry, Rajender Vemula, Raymond G Boot. Correction to an orally active phenylaminotetralin-chemotype serotonin 5-HT7 and 5-HT1A receptor partial agonist that corrects motor stereotypy in mouse models. ACS chemical neuroscience. vol 6. issue 8. 2015-10-27. PMID:26225542. |
correction to an orally active phenylaminotetralin-chemotype serotonin 5-ht7 and 5-ht1a receptor partial agonist that corrects motor stereotypy in mouse models. |
2015-10-27 |
2023-08-13 |
mouse |
| Anna Partyka, Grażyna Chłoń-Rzepa, Anna Wasik, Magdalena Jastrzębska-Więsek, Adam Bucki, Marcin Kołaczkowski, Grzegorz Satała, Andrzej J Bojarski, Anna Wesołowsk. Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25435254. |
continuing our earlier study in a group of purine-2,6-dione derivatives of long chain arylpiperazines (lcaps), a series of 8-unsubstituted 7-phenylpiperazin-4-yl-alkyl (4-14) and 7-tetrahydroisoquinolinyl-alkyl (15-17) analogues were synthesized and their serotonin 5-ht1a, 5-ht2a, 5-ht6, 5-ht7 and dopamine d2 receptor affinities were determined. |
2015-10-22 |
2023-08-13 |
mouse |
| Yunfei Wang, Shu-e Cao, Jianmin Tian, Guozhe Liu, Xiaoran Zhang, Pingfa L. Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors. Scientific reports. vol 3. 2015-10-21. PMID:24287473. |
auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-ht1a receptors. |
2015-10-21 |
2023-08-12 |
mouse |
| Yunfei Wang, Shu-e Cao, Jianmin Tian, Guozhe Liu, Xiaoran Zhang, Pingfa L. Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors. Scientific reports. vol 3. 2015-10-21. PMID:24287473. |
in addition, the anti-hyperalgesic effect of auraptenol was significantly blocked by a selective serotonin 5-ht1a receptor antagonist way100635 (1 mg/kg). |
2015-10-21 |
2023-08-12 |
mouse |