All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. this study reports the expression of serotonin-related genes: tryptophan hydroxylase 2 (tph2), serotonin reuptake transporter (sert) and the serotonin 1a autoreceptor (5ht1a) using digoxigenin-ish and image analysis. 2015-10-15 2023-08-13 monkey
Jinting Liu, Pingyuan Gong, Xiaolin Zho. The association between romantic relationship status and 5-HT1A gene in young adults. Scientific reports. vol 4. 2015-10-15. PMID:25412229. as love-related behaviors are associated with serotonin levels in the brain, this study investigated to what extent a polymorphism (c-1019g, rs6295) of 5-ht1a gene is related to relationship status in 579 chinese han people. 2015-10-15 2023-08-13 Not clear
Andrzej Chodkowski, Martyna Z Wróbel, Jadwiga Turło, Jerzy Kleps, Agata Siwek, Gabriel Nowak, Mariusz Belka, Tomasz Bączek, Aleksander P Mazurek, Franciszek Herol. Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. Part 4. European journal of medicinal chemistry. vol 90. 2015-10-02. PMID:25461308. this project describes the synthesis, pharmacological and pharmacodynamic tests on two series of novel derivatives of 2h-pyrido[1,2-c]pyrimidine with potential binary binding to 5-ht1a receptors and ssri + serotonin transporters. 2015-10-02 2023-08-13 human
Melissa A Silverman, Jonathan G Leung, Kathryn M Scha. Aripiprazole-associated hiccups: a case and closer look at the association between hiccups and antipsychotics. Journal of pharmacy practice. vol 27. issue 6. 2015-09-30. PMID:25107419. aripiprazole's pharmacologic properties (including dopamine 2 and 5-hydroxytryptamine 1a [5ht1a] receptor partial agonism and 5ht2a receptors antagonism) may be associated with the onset of hiccups. 2015-09-30 2023-08-13 Not clear
Yuwen Chung-Davidson, Huiyong Wang, Anne M Scott, Weiming L. Pheromone 3kPZS evokes context-dependent serotonin sexual dimorphism in the brain of the sea lamprey (Petromyzon marinus). Integrative zoology. vol 10. issue 1. 2015-09-28. PMID:24920007. we examined the neurotransmitter serotonin (5-hydroxytryptamine, 5-ht) and the expression of 5-ht1a receptors in the forebrain and brainstem of sea lamprey exposed to the vehicle (0.91 ppm methanol) or 10(-10) m 3kpzs for 2 h using high performance liquid chromatography-electrospray ionization tandem mass spectrometry, immunohistochemistry and real-time quantitative polymerase chain reaction. 2015-09-28 2023-08-13 Not clear
Katarina Nikolic, Lazaros Mavridis, Oscar M Bautista-Aguilera, José Marco-Contelles, Holger Stark, Maria do Carmo Carreiras, Ilaria Rossi, Paola Massarelli, Danica Agbaba, Rona R Ramsay, John B O Mitchel. Predicting targets of compounds against neurological diseases using cheminformatic methodology. Journal of computer-aided molecular design. vol 29. issue 2. 2015-09-16. PMID:25425329. the cheminformatic targets identifications were in agreement with four 3d-qsar (h3r/d1r/d2r/5-ht2ar) models and by in vitro assays for serotonin 5-ht1a and 5-ht2a receptor binding of the most promising ligand (71/mba-veg8). 2015-09-16 2023-08-13 Not clear
Xin Peng, Qi Wang, Yogesh Mishra, Jinbin Xu, David E Reichert, Maninder Malik, Michelle Taylor, Robert R Luedtke, Robert H Mac. Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands. Bioorganic & medicinal chemistry letters. vol 25. issue 3. 2015-09-15. PMID:25556097. affinity at dopamine d4 and serotonin 5-ht1a receptors was also determined. 2015-09-15 2023-08-13 human
Stephen M Stah. Modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (MMA): enhancing serotonin release by combining serotonin (5HT) transporter inhibition with actions at 5HT receptors (5HT1A, 5HT1B, 5HT1D, 5HT7 receptors). CNS spectrums. vol 20. issue 2. 2015-09-15. PMID:25831967. modes and nodes explain the mechanism of action of vortioxetine, a multimodal agent (mma): enhancing serotonin release by combining serotonin (5ht) transporter inhibition with actions at 5ht receptors (5ht1a, 5ht1b, 5ht1d, 5ht7 receptors). 2015-09-15 2023-08-13 Not clear
Mar Rubio, Raúl López-Arnau, David Pubill, Elena Escubedo, Jorge Camaras. Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats. Neuroscience letters. vol 590. 2015-09-14. PMID:25641130. with all that, we conclude that hypothermia induced by 4-ma is due to the release of 5-ht which activates postsynaptic 5-ht1a receptors. 2015-09-14 2023-08-13 rat
Xiaona Wang, Yuan Tan, Feng Zhan. Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats. Neuroscience letters. vol 594. 2015-09-14. PMID:25817367. gastrodin treatment prevented the increase of serotonin transporter (sert) and the decrease of serotonin 1a (5-ht1a) receptor expression in the hippocampus of idpn-treated rats. 2015-09-14 2023-08-13 rat
Francisco García-Oscos, Oswaldo Torres-Ramírez, Lu Dinh, Luis Galindo-Charles, Elsy Arlene Pérez Padilla, Juan Carlos Pineda, Marco Atzori, Humberto Salgad. Activation of 5-HT receptors inhibits GABAergic transmission by pre-and post-synaptic mechanisms in layer II/III of the juvenile rat auditory cortex. Synapse (New York, N.Y.). vol 69. issue 3. 2015-09-10. PMID:25482075. the inhibiting influence of 5-ht in the gabaergic synaptic activity was mimicked by using the selective agonists of the 5-ht1a and 5-ht2a receptors, 8(oh)-dpat (10 µm) and doi (10 µm), respectively; and it was prevented by their respective antagonists nan-190 (1 µm) and ritanserin (1 μm). 2015-09-10 2023-08-13 rat
Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. cotreatment with fgf2 and the 5-ht1a agonist induced rn33b cell differentiation as seen from development of an increased number and length of extensions per cell and their increased 5-ht immunoreactivity. 2015-09-10 2023-08-13 rat
Dasiel O Borroto-Escuela, Mileidys Pérez-Alea, Manuel Narvaez, Alexander O Tarakanov, Giuseppa Mudó, Antonio Jiménez-Beristain, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochemical and biophysical research communications. vol 463. issue 3. 2015-09-10. PMID:25957476. taken together, the 5-ht1a autoreceptors by being part of a fgfr1-5-ht1a heteroreceptor complex in the midbrain raphe 5-ht nerve cells appears to have also a trophic role in the central 5-ht neuron systems besides playing a key role in reducing the firing of these neurons. 2015-09-10 2023-08-13 rat
Yan Ping Hui, Tao Wang, Ling Na Han, Li Bo Li, Yi Na Sun, Jian Liu, Hong Fei Qiao, Qiao Jun Zhan. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat. Behavioural brain research. vol 277. 2015-09-08. PMID:24906197. this study sought to assess whether unilateral lesions of the medial forebrain bundle (mfb) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1a (5-ht1a) receptors of the prelimbic (prl) sub-region of ventral medial prefrontal cortex in the regulation of these behaviors, the density of 5-ht neurons in the dorsal raphe nucleus (drn) and co-localization of 5-ht1a receptor and neuronal glutamate transporter eaac1-immunoreactive (eaac1-ir) cells in the prl. 2015-09-08 2023-08-13 rat
Yan Ping Hui, Tao Wang, Ling Na Han, Li Bo Li, Yi Na Sun, Jian Liu, Hong Fei Qiao, Qiao Jun Zhan. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat. Behavioural brain research. vol 277. 2015-09-08. PMID:24906197. unilateral mfb lesion decreased the density of 5-ht neurons in the drn, and percentage of eaac1-ir cells expressing 5-ht1a receptors in the prl. 2015-09-08 2023-08-13 rat
Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-ht1a, 5-ht2a and 5-ht3 receptors. 2015-09-08 2023-08-13 rat
Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. given that the major serotonergic circuit in the rat brain comprises the dorsal raphe nuclei and the medial prefrontal cortex (mpfc), and because the latter structure is involved in the control of complex behaviors and expresses 1a (5-ht1a), 2a (5-ht2a), and 3 (5-ht3) receptors, the aim was to study the role of 5-ht and of these receptors in the acquisition and extinction of a reward-dependent operant conditioning task. 2015-09-08 2023-08-13 rat
Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. long evans rats were trained in an operant conditioning task while receiving fluoxetine (serotonin reuptake inhibitor, 10mg/kg), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone (5-ht1a partial agonist, 10mg/kg), risperidone (5-ht2a antagonist, 1mg/kg), ondansetron (5-ht3 antagonist, 2mg/kg) or vehicle. 2015-09-08 2023-08-13 rat
Stefano Puglisi-Allegra, Diego Andolin. Serotonin and stress coping. Behavioural brain research. vol 277. 2015-09-08. PMID:25108244. based on growing evidence pointing to a medial prefrontal cortex-amygdala system in mediating adaptive and maladaptive stress responses, we propose a brain circuit in which serotonin neurons in the dorsal raphe depending on the crf (corticotropin releasing factor) regulatory action engage a prefrontal cortical-amygdala pathway through 5-ht1a receptors, gaba and glutamate to moderate coping behavior. 2015-09-08 2023-08-13 human
Xiao-Fei Zhang, Lei Wu, Dong-Jun Wan, Ruo-Zhuo Liu, Zhao Dong, Min Chen, Sheng-Yuan Y. Evaluation of the efficacy and safety of vilazodone for treating major depressive disorder. Neuropsychiatric disease and treatment. vol 11. 2015-09-08. PMID:26345981. vilazodone is a novel serotonin (5-ht)-reuptake inhibitor and 5-ht1a partial agonist that was recently developed for the treatment of major depressive disorder (mdd). 2015-09-08 2023-08-13 Not clear