| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| João P F Kurita, Anderson H F F Leão, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, Débora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience. 2022-12-22. PMID:36548050. |
the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. |
2022-12-22 |
2023-08-14 |
rat |
| Martin Kubitschke, Monika Müller, Lutz Wallhorn, Mauro Pulin, Manuel Mittag, Stefan Pollok, Tim Ziebarth, Svenja Bremshey, Jill Gerdey, Kristin Carolin Claussen, Kim Renken, Juliana Groß, Pascal Gneiße, Niklas Meyer, J Simon Wiegert, Andreas Reiner, Martin Fuhrmann, Olivia Andrea Massec. Next generation genetically encoded fluorescent sensors for serotonin. Nature communications. vol 13. issue 1. 2022-12-06. PMID:36473867. |
we developed a family of genetically encoded serotonin (5-ht) sensors (sdarken) on the basis of the native 5-ht1a receptor and circularly permuted gfp. |
2022-12-06 |
2023-08-14 |
Not clear |
| Carla V Argañaraz, Tamara S Adjimann, Paula P Perissinotti, Mariano Soiza-Reill. Selective refinement of glutamate and GABA synapses on dorsal raphe 5-HT neurons during postnatal life. Development (Cambridge, England). 2022-12-02. PMID:36458556. |
this refinement of drn inputs is not accompanied by changes in 5-ht1a receptor-mediated inhibition over 5-ht neurons. |
2022-12-02 |
2023-08-14 |
mouse |
| Jeanette Tour, Angelica Sandström, Diana Kadetoff, Martin Schalling, Eva Kose. The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls. PloS one. vol 17. issue 11. 2022-11-07. PMID:36342939. |
all subjects were genotyped for relevant functional polymorphisms in the genes coding for the μ-opioid receptor (oprm1, rs1799971), the serotonin transporter (5-htt, 5-httlpr/rs25531) and the serotonin 1a receptor (5-ht1a, rs6295). |
2022-11-07 |
2023-08-14 |
human |
| Ho-Geun Kang, Hee-Yun Kim, Hyunwoo Jee, Hwanseok Jun, Hosong Cho, Dongjun Park, Hyun-Jong Ahn, Hyung-Min Kim, Hyun-Ja Jeon. Compound of Cynanchum wilfordii and Humulus lupulus L. Ameliorates Menopausal Symptoms in Ovariectomized Mice. Reproductive sciences (Thousand Oaks, Calif.). 2022-11-05. PMID:36333646. |
values for hypothalamic serotonin (5-ht), dopamine, norepinephrine, estrogen receptor (er)-β, 5-ht1a, and 5-ht2a were significantly enhanced, while value for hypothalamic monoamine oxidase a was reduced in cwhl and caudatin groups compared with the ovx group. |
2022-11-05 |
2023-08-14 |
mouse |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
in subsequent experiments, we investigated the estrous cycle effects and the contribution of dorsal hippocampus (dh) serotonin 1a (5-ht1a) and cannabinoid types 1 (cb1) and 2 (cb2) receptors to cbd-induced effects on memory retrieval/expression. |
2022-11-05 |
2023-08-14 |
human |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E Bartlet. Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice. Molecular psychiatry. 2022-10-04. PMID:36195637. |
we have previously shown using the "drinking-in-the-dark" model in mice that the stimulation of the serotonin receptor 1a (5-ht |
2022-10-04 |
2023-08-14 |
mouse |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Doo Ri Park, Chang Hwan Yeo, Jee Eun Yoon, Eun Young Hong, Bo Ram Choi, Yoon Jae Lee, In-Hyuk H. Polygonatum sibiricum improves menopause symptoms by regulating hormone receptor balance in an ovariectomized mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-09-09. PMID:36076523. |
ps restored vaginal epithelium thickness, by increasing the expression of estrogen receptors erα (esr1) and erβ (esr2), and increased serotonin concentration by reducing serotonin receptor 1 a (5-ht1a) and glucocorticoid receptor (gr) expression. |
2022-09-09 |
2023-08-14 |
mouse |
| Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. |
when compared to control hippocampal samples, the t3 group exhibited attenuated glycogen synthase kinase-3 (gsk3), metalloproteinase 10 (adam10), amyloid-beta precursor-protein (app), serotonin transporter (sert), 5ht1a receptor, monocarboxylate transporter 8 (mct8) and bone morphogenetic protein 7 (bmp-7) gene expression, whereas augmented superoxide dismutase 2 (sod2) and hairless gene expression. |
2022-08-11 |
2023-08-14 |
mouse |
| Andréa V Maglione, Bruna P P do Nascimento, Miriam O Ribeiro, Talytha J L de Souza, Renata E C da Silva, Monica A Sato, Carlos A A Penatti, Luiz R G Britto, Janaina S de Souza, Rui M B Maciel, Rodrigo Rodrigues da Conceição, Roberto Laureano-Melo, Gisele Giannocc. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. Metabolic brain disease. 2022-08-11. PMID:35951206. |
therefore, our findings suggest that in an ad mouse model, t3 supplementation promotes improvements in depression-like behavior, through the modulation of the serotonergic related genes involved in the transmission mediated by 5ht1a receptors and serotonin reuptake, and attenuated disease progression. |
2022-08-11 |
2023-08-14 |
mouse |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR. vol 15. 2022-06-27. PMID:35757086. |
to determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-ht) in the striatum, expression of serotonin-1a (5-ht1a) auto-receptor in the raphe nuclei and circulating levels of leptin and corticosterone were determined in female wistar rats kept on excessive food restriction schedule. |
2022-06-27 |
2023-08-14 |
rat |
| Raheel Saeed, Khalid Mahmood, Sadia Basharat Ali, Darakhshan Jabeen Halee. Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats. International journal of tryptophan research : IJTR. vol 15. 2022-06-27. PMID:35757086. |
these changes in 5-ht metabolism and 5-ht1a auto-receptor expression were more profound in dr animals as compare to trf animals. |
2022-06-27 |
2023-08-14 |
rat |
| Mohit Chauhan, Rebecca Parry, William V Bob. Vilazodone for Major Depression in Adults: Pharmacological Profile and an Updated Review for Clinical Practice. Neuropsychiatric disease and treatment. vol 18. 2022-06-21. PMID:35726313. |
hypothesized differences in efficacy and adverse effects between other antidepressants and vilazodone based on its multimodal mechanism of action (combining serotonin reuptake inhibition with serotonin 5-ht1a partial agonist effects) have not been comprehensively demonstrated in clinical studies and its effectiveness as a continuation- or maintenance-phase therapeutic is not yet established. |
2022-06-21 |
2023-08-14 |
Not clear |
| Roberto Laureano-Melo, Raoni Conceição Dos-Santos, Rodrigo Rodrigues da Conceição, Janaina Sena de Souza, Claudio da Silva Almeida, Luís Carlos Reis, Bruno Guimarães Marinho, Gisele Giannocco, Ahmed Rg, Wellington da Silva Côrte. Neonatal D-fenfluramine Treatment Promotes Long-Term Behavioral Changes in Adult Mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-06-19. PMID:35718760. |
the programmed animals had a decrease in 5ht1a, serotonin transporter (sert), and brain-derived neurotrophic factor (bdnf) expression in the mesencephalic raphe region. |
2022-06-19 |
2023-08-14 |
mouse |
| Filipa Viegas, Tiago Ferreira, Cláudia Campo. Using Cariprazine to Ameliorate Negative Symptoms and Metabolic Side Effects of Clozapine and Paliperidone - Clinical Cases. Neuropsychiatric disease and treatment. vol 18. 2022-06-17. PMID:35712695. |
it presents distinct pharmacodynamic properties, such as d3/d2 partial agonism, preferential binding to d3 receptors, antagonism at the serotonin 5-ht2a and 5-ht2b receptors, partial agonism at 5-ht1a receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). |
2022-06-17 |
2023-08-14 |
Not clear |
| Magdalena Jastrzębska-Więsek, Anna Wesołowska, Marcin Kołaczkowski, Mark A Varney, Adrian Newman-Tancredi, RonanY Depoorter. The selective 5-HT1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat. Behavioural pharmacology. 2022-06-13. PMID:35695543. |
befiradol/f13640) is a highly selective, potent and efficacious serotonin 5-ht1a agonist. |
2022-06-13 |
2023-08-14 |
rat |
| Yusuf Oloruntoyin Ayipo, Waleed A Alananzeh, Sani Najib Yahayaa, Mohd Nizam Mord. Molecular Modelling and Virtual Screening to Identify New Piperazine Derivatives as Potent Human 5-HT1A Antagonists and Reuptake Inhibitors. Combinatorial chemistry & high throughput screening. 2022-05-25. PMID:35611784. |
serotonin/5-ht antagonist and reuptake inhibitors (saris) ameliorate depression by increasing the terminal 5-ht through the activation of somatodendritic 5-ht1a autoreceptors. |
2022-05-25 |
2023-08-13 |
human |