| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tim D Ostrowski, Daniela Ostrowski, Eileen M Hasser, David D Klin. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function. Journal of neurophysiology. vol 111. issue 12. 2015-01-28. PMID:24671532. |
serotonin (5-ht), and its 5-ht1a receptor (5-ht1ar) subtype, is a powerful modulator of the cardiorespiratory system and its sensory reflexes. |
2015-01-28 |
2023-08-12 |
rat |
| Valquíria Camin de Bortoli, Paula Shimene de Melo Yamashita, Hélio Zangross. 5-HT1A and 5-HT2A receptor control of a panic-like defensive response in the rat dorsomedial hypothalamic nucleus. Journal of psychopharmacology (Oxford, England). vol 27. issue 12. 2015-01-27. PMID:23787365. |
in the dorsal periaqueductal gray matter (dpag), another key panic-associated area, serotonin, through the activation of 5-ht1a and 5-ht2a receptors, exerts an inhibitory role on escape expression. |
2015-01-27 |
2023-08-12 |
rat |
| Xiaofang Lan, Meng Zhang, Wan Yang, Zongju Zheng, Yuan Wu, Qian Zeng, Shudong Liu, Ke Liu, Guangqin L. Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24326625. |
effect of treadmill exercise on 5-ht, 5-ht1a receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion. |
2015-01-27 |
2023-08-12 |
rat |
| Xiaofang Lan, Meng Zhang, Wan Yang, Zongju Zheng, Yuan Wu, Qian Zeng, Shudong Liu, Ke Liu, Guangqin L. Effect of treadmill exercise on 5-HT, 5-HT1A receptor and brain derived neurophic factor in rats after permanent middle cerebral artery occlusion. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24326625. |
this study aimed to discuss the effect of treadmill exercise on expression levels of 5-ht, 5-ht1a receptor (5-ht1ar) and brain derived neurophic factor (bdnf) in rat brains after permanent middle cerebral artery occlusion (pmcao). |
2015-01-27 |
2023-08-12 |
rat |
| Margherita Brindisi, Stefania Butini, Silvia Franceschini, Simone Brogi, Francesco Trotta, Sindu Ros, Alfredo Cagnotto, Mario Salmona, Alice Casagni, Marco Andreassi, Simona Saponara, Beatrice Gorelli, Pia Weikop, Jens D Mikkelsen, Jorgen Scheel-Kruger, Karin Sandager-Nielsen, Ettore Novellino, Giuseppe Campiani, Sandra Gemm. Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. Journal of medicinal chemistry. vol 57. issue 22. 2015-01-27. PMID:25343529. |
targeting dopamine d3 and serotonin 5-ht1a and 5-ht2a receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. |
2015-01-27 |
2023-08-13 |
Not clear |
| Margherita Brindisi, Stefania Butini, Silvia Franceschini, Simone Brogi, Francesco Trotta, Sindu Ros, Alfredo Cagnotto, Mario Salmona, Alice Casagni, Marco Andreassi, Simona Saponara, Beatrice Gorelli, Pia Weikop, Jens D Mikkelsen, Jorgen Scheel-Kruger, Karin Sandager-Nielsen, Ettore Novellino, Giuseppe Campiani, Sandra Gemm. Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies. Journal of medicinal chemistry. vol 57. issue 22. 2015-01-27. PMID:25343529. |
combination of dopamine d3 antagonism, serotonin 5-ht1a partial agonism, and antagonism at 5-ht2a leads to a novel approach to potent atypical antipsychotics. |
2015-01-27 |
2023-08-13 |
Not clear |
| Michelle R Lofwall, Paul A Nuzzo, Charles Campbell, Sharon L Wals. Aripiprazole effects on self-administration and pharmacodynamics of intravenous cocaine and cigarette smoking in humans. Experimental and clinical psychopharmacology. vol 22. issue 3. 2015-01-26. PMID:24467369. |
aripiprazole is a partial agonist at dopamine (d2) and serotonin (5-ht1a) receptors and 5-ht2 antagonist. |
2015-01-26 |
2023-08-12 |
human |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
autoradiographic studies demonstrated down-regulation of 5-ht transporters ([(3)h]citalopram binding) and decreased functionality of 5-ht1a receptors (8-oh-dpat-stimulated [(35)s]gtpγs binding) in the dorsal horn of the lumbar spinal cord in ob rats. |
2015-01-26 |
2023-08-12 |
rat |
| Antonio Rodríguez-Gaztelumendi, María Luisa Rojo, Angel Pazos, Alvaro Día. An altered spinal serotonergic system contributes to increased thermal nociception in an animal model of depression. Experimental brain research. vol 232. issue 6. 2015-01-26. PMID:24584836. |
in these animals, autoradiographic studies revealed further down-regulation of 5-ht transporters and normalization in the functionality of 5-ht1a receptors on the spinal cord. |
2015-01-26 |
2023-08-12 |
rat |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
in the present study, platelet expression of 5-ht1a receptors and serotonin transporter (sert) proteins, and serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) were quantified in 53 patients with mdd and 22 unaffected controls. |
2015-01-22 |
2023-08-12 |
Not clear |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
patients with mdd had significantly higher expression of platelet 5-ht1a receptors but significantly lower contents of platelet 5-ht, platelet-poor plasma (ppp) 5-ht and ppp 5-hiaa compared to healthy controls, and this was correlated with the severity of depression. |
2015-01-22 |
2023-08-12 |
Not clear |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
correlation analysis confirmed a strong, inverse relationship between the 5-ht1a receptor expression and the 5-ht and 5-hiaa levels. |
2015-01-22 |
2023-08-12 |
Not clear |
| Zhang-Jin Zhang, Di Wang, Sui Cheung Man, Roger Ng, Grainne M McAlonan, Hei Kiu Wong, Wendy Wong, Jade Lee, Qing-Rong Ta. Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 53. 2015-01-22. PMID:24657886. |
thus overexpression of platelet 5-ht1a receptors and reduced 5-ht tone may function as a peripheral marker of depression. |
2015-01-22 |
2023-08-12 |
Not clear |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
also, the local administration of a drug using the intracranial microinjection technique has shown that activation of specific subtypes of 5-ht receptors (5-ht1a and 5-ht1b) in mesocorticolimbic areas can reduce species-typical and other aggressive behaviors, but the same receptors in the medial prefrontal cortex or septal area promote escalated forms of aggression. |
2015-01-20 |
2023-08-12 |
mouse |
| Kellianne J Richardson, Keith L Shelto. N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. The Journal of pharmacology and experimental therapeutics. vol 352. issue 1. 2015-01-19. PMID:25368340. |
the μ-, κ-, and δ-opioid agonists, as well as 5-hydroxytryptamine (serotonin) 1b/2c (5-ht1b/2c) and 5-ht1a agonists, also failed to produce n2o-like stimulus effects. |
2015-01-19 |
2023-08-13 |
mouse |
| Kate McKeag. Aripiprazole: a review of its use in the treatment of manic episodes in adolescents with bipolar I disorder. CNS drugs. vol 28. issue 2. 2015-01-13. PMID:24399490. |
unlike other currently available atypical antipsychotics that primarily have varying degrees of dopamine d2 receptor antagonism, aripiprazole is a partial agonist at d2 and serotonin 5-ht1a receptors, which may explain differences in tolerability profiles. |
2015-01-13 |
2023-08-12 |
human |
| Yi Yang, Yi Guo, Yifang Kuang, Shan Wang, Yan Jiang, Yao Ding, Shuang Wang, Meiping Din. Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats. Neuroscience bulletin. vol 30. issue 3. 2015-01-12. PMID:24429728. |
the serotonin 1a (5-ht1a) receptor is a possible target for the treatment of se, but its role in animal models and the precise area of brain involved remain controversial. |
2015-01-12 |
2023-08-12 |
rat |
| Nobuhito Murai, Mina Tsukamoto, Seiji Tamura, Toshiaki Aoki, Nobuya Matsuok. Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. European journal of pharmacology. vol 733. 2015-01-05. PMID:24704374. |
these broad antinociceptive effects of as1069562 may be due not only to 5-ht and norepinephrine reuptake inhibition but also to its effects on 5-ht receptors such as 5-ht1a and 5-ht3 receptors. |
2015-01-05 |
2023-08-13 |
mouse |
| Kadri Kõiv, Jaanus Harr. Differences in 5-HT1A receptor-mediated hypothermia in rats with low or high exploratory activity. Behavioural pharmacology. vol 21. issue 8. 2014-12-22. PMID:20926946. |
alterations in the serotonin (5-ht) system and the 5-ht1a receptor function have a significant role in anxiety-related and depression-related states. |
2014-12-22 |
2023-08-12 |
rat |
| Rachel Lynn Dennis, Heng-Wei Chen. Differential serotonergic mediation of aggression in roosters bred for resistance and susceptibility to Marek's disease. British poultry science. vol 55. issue 1. 2014-12-18. PMID:24697575. |
antagonism of 5-ht1a receptors increased aggressiveness and reduced serotonin turnover in strain 72, but not strain 63 cocks. |
2014-12-18 |
2023-08-13 |
Not clear |