| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rachel Lynn Dennis, Heng-Wei Chen. Differential serotonergic mediation of aggression in roosters bred for resistance and susceptibility to Marek's disease. British poultry science. vol 55. issue 1. 2014-12-18. PMID:24697575. |
levels of the serotonin metabolite 5-hiaa, but not absolute central 5-ht levels, were altered in both strains following 5-ht1b antagonism, but only in strain 72 cocks following 5-ht1a antagonism. |
2014-12-18 |
2023-08-13 |
Not clear |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
second, the effects produced by intravenous administration of 5-ht1a ligands (partial agonist buspirone 10mgkg(-1), antagonist way100135 0.5-5mgkg(-1)), 5-ht2a antagonist sarpogrelate (10mgkg(-1)), 5-ht3 antagonist alosetron (0.1mgkg(-1)), 5-ht4 antagonist gr125487 (5mgkg(-1)) and 5-ht re-uptake inhibitor fluoxetine (10mgkg(-1)) on i/r-induced inflammatory response were investigated in i/r mice and compared to those obtained in sham-operated animals (s). |
2014-12-15 |
2023-08-12 |
mouse |
| R Ferreira, M J Nobr. Conditioned fear in low- and high-anxious rats is differentially regulated by cortical subcortical and midbrain 5-HT(1A) receptors. Neuroscience. vol 268. 2014-12-12. PMID:24657773. |
in the present study, the role of 5-ht neurotransmission of the prelimbic cortex, basolateral amygdala or the dpag on the unconditioned and conditioned fear responses in rats previously selected as low- (la) or high-anxious (ha) were assessed through local infusions of 5-ht itself (10nmol/0.2μl) or the selective 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat - 0.3μg/0.2μl). |
2014-12-12 |
2023-08-12 |
human |
| R Ferreira, M J Nobr. Conditioned fear in low- and high-anxious rats is differentially regulated by cortical subcortical and midbrain 5-HT(1A) receptors. Neuroscience. vol 268. 2014-12-12. PMID:24657773. |
our findings suggest that, on the prelimbic cortex, 5-ht modulates the expression of conditioned fear response in ha rats and this modulation is dependent on 5-ht1a receptors. |
2014-12-12 |
2023-08-12 |
human |
| Peipei Lin, Chuang Wang, Bing Xu, Siyun Gao, Jiejie Guo, Xin Zhao, Huihui Huang, Junfang Zhang, Xiaowei Chen, Qinwen Wang, Wenhua Zho. The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF/TrkB/CREB signaling pathway. Pharmacology, biochemistry, and behavior. vol 120. 2014-12-09. PMID:24631486. |
in contrast, none of these effects were diminished by pretreatment with the non-specific 5-ht receptor antagonist metergoline, the selective 5-ht1a receptor antagonist nan-190, the 5-ht synthase inhibitor parachlorophenylalanine, the selective α1-adrenoceptor antagonist prazosin, the β receptor antagonist propranolol, or the d2 receptor antagonist raclopride. |
2014-12-09 |
2023-08-12 |
mouse |
| Eiji Kirin. Profile of aripiprazole in the treatment of bipolar disorder in children and adolescents. Adolescent health, medicine and therapeutics. vol 5. 2014-12-04. PMID:25473324. |
aripiprazole acts as a serotonin 5-ht2a receptor antagonist, as well as a partial agonist of the serotonin 5-ht1a and dopamine d2 receptors. |
2014-12-04 |
2023-08-13 |
Not clear |
| Takahiro Masuda, Hiroyuki Nishikawa, Takeshi Inoue, Hiroyuki Toda, Shin Nakagawa, Shuken Boku, Tsukasa Koyam. 5-HT depletion, but not 5-HT1A antagonist, prevents the anxiolytic-like effect of citalopram in rat contextual conditioned fear stress model. Acta neuropsychiatrica. vol 25. issue 2. 2014-12-02. PMID:25287308. |
5-ht depletion, but not 5-ht1a antagonist, prevents the anxiolytic-like effect of citalopram in rat contextual conditioned fear stress model. |
2014-12-02 |
2023-08-13 |
rat |
| Allison C Nugent, Paul J Carlson, Earle E Bain, William Eckelman, Peter Herscovitch, Husseini Manji, Carlos A Zarate, Wayne C Drevet. Mood stabilizer treatment increases serotonin type 1A receptor binding in bipolar depression. Journal of psychopharmacology (Oxford, England). vol 27. issue 10. 2014-11-15. PMID:23926239. |
abnormal serotonin type 1a (5-ht1a) receptor function and binding have been implicated in the pathophysiology of mood disorders. |
2014-11-15 |
2023-08-12 |
human |
| S Wang, Y Ni, F Guo, Z Sun, A Ahmed, R Zha. Differential expression of hypothalamic fear- and stress-related genes in broiler chickens showing short or long tonic immobility. Domestic animal endocrinology. vol 47. 2014-11-03. PMID:24360202. |
the sti broilers had significantly lower (p < 0.01) hypothalamic expression of serotonin reuptake transporter and serotonin receptor 1a. |
2014-11-03 |
2023-08-12 |
Not clear |
| Jorge J Pérez Maceira, María J Mancebo, Manuel Aldegund. The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 161. 2014-10-29. PMID:24365333. |
we conclude that in rainbow trout the anorexigenic actions of 5-ht are probably mediated by activation of 5-ht1a and 5-h2c-like receptors. |
2014-10-29 |
2023-08-12 |
Not clear |
| Fernanda Chagas-Silva, Jéssica Barbosa Nascimento-Viana, Luiz Antonio S Romeiro, Luana C Barberato, François Noël, Claudia Lucia Martins Silv. Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 3. 2014-10-28. PMID:24213881. |
using the du-145 prostate cells, control experiments characterized the α1d-adrenoceptor- and 5-ht1a receptor-mediated cell growth by phenylephrine and 5-ht, respectively. |
2014-10-28 |
2023-08-12 |
rat |
| Hua-Li Wu, Si-Lin Pang, Qiong-Zhen Liu, Qian Wang, Min-Xuan Cai, Jing Shan. 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress. PloS one. vol 9. issue 2. 2014-10-28. PMID:24586946. |
when treated with 5-ht in cultured hair follicles (hfs), the increased expression of melanogenesis-related genes and the activation of 5-ht1a, 1b and 7 receptors also occurred. |
2014-10-28 |
2023-08-12 |
mouse |
| Man Luo, Xiang Simon Wang, Bryan L Roth, Alexander Golbraikh, Alexander Tropsh. Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. Journal of chemical information and modeling. vol 54. issue 2. 2014-10-23. PMID:24410373. |
the 5-hydroxytryptamine 1a (5-ht1a) serotonin receptor has been an attractive target for treating mood and anxiety disorders such as schizophrenia. |
2014-10-23 |
2023-08-12 |
Not clear |
| Abdelkareem A Ahmed, Wenqiang Ma, Yingdong Ni, Qin Zhou, Ruqian Zha. Embryonic exposure to corticosterone modifies aggressive behavior through alterations of the hypothalamic pituitary adrenal axis and the serotonergic system in the chicken. Hormones and behavior. vol 65. issue 2. 2014-10-20. PMID:24333411. |
high dose cort exposure significantly increased platelet serotonin (5-ht) uptake, decreased whole blood 5-ht concentration (p<0.05), downregulated hypothalamic tryptophan hydroxylase 1 (tph1) mrna and upregulated 5-ht receptor 1a (5-htr1a) and monoamine oxidase a (mao-a) mrna, but not monoamine oxidase b (mao-b). |
2014-10-20 |
2023-08-12 |
chicken |
| Taku Yamaguchi, Aki Tsujimatsu, Haruko Kumamoto, Tsuyoshi Izumi, Yu Omura, Takayuki Yoshida, Tsuneyuki Yamamoto, Mitsuhiro Yoshiok. [Anxiolytic effects of yokukansan and serotonin 5-HT1A receptors in rats]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 2. 2014-10-16. PMID:25314743. |
[anxiolytic effects of yokukansan and serotonin 5-ht1a receptors in rats]. |
2014-10-16 |
2023-08-13 |
rat |
| b' Zofia Rog\\xc3\\xb3\\xc5\\xb. Combined treatment with atypical antipsychotics and antidepressants in treatment-resistant depression: preclinical and clinical efficacy. Pharmacological reports : PR. vol 65. issue 6. 2014-10-14. PMID:24553002.' |
moreover, atypical antipsychotics administered in a low dose enhanced the antidepressant-like activity of antidepressants, with (among other mechanisms) the serotonin 5-ht1a, 5-ht2a and adrenergic α2 receptors likely playing an important role in their action. |
2014-10-14 |
2023-08-12 |
rat |
| Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng L. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367588. |
antidepressant-like activity of yl-0919: a novel combined selective serotonin reuptake inhibitor and 5-ht1a receptor agonist. |
2014-10-13 |
2023-08-12 |
mouse |
| Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng L. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367588. |
it has been suggested that drugs combining activities of selective serotonin reuptake inhibitor and 5-ht1a receptor agonist may form a novel strategy for higher therapeutic efficacy of antidepressant. |
2014-10-13 |
2023-08-12 |
mouse |
| Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng L. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367588. |
the present study aimed to examine the pharmacology of yl-0919, a novel synthetic compound with combined high affinity and selectivity for serotonin transporter and 5-ht1a receptors. |
2014-10-13 |
2023-08-12 |
mouse |
| Hong-xia Chen, Zeng-liang Jin, Li-ming Zhang, Rui Xue, Xiao-dan Xu, Nan Zhao, Zhi-kun Qiu, Xian-wang Wang, You-zhi Zhang, Ri-fang Yang, Yun-feng L. Antidepressant-like activity of YL-0919: a novel combined selective serotonin reuptake inhibitor and 5-HT1A receptor agonist. PloS one. vol 8. issue 12. 2014-10-13. PMID:24367588. |
yl-0919 displayed high affinity in vitro to both 5-ht1a receptor and 5-ht transporter prepared from rat cortical tissue. |
2014-10-13 |
2023-08-12 |
mouse |