| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisco Espejo-Porras, Javier Fernández-Ruiz, Roger G Pertwee, Raphael Mechoulam, Concepción Garcí. Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. Neuropharmacology. vol 75. 2014-08-19. PMID:23924692. |
however, recent evidence suggests that cbd may interact with the serotonin 5-ht1a receptor to produce some of its beneficial effects. |
2014-08-19 |
2023-08-12 |
rat |
| L Woodrow, P Sheppard, P F Gardine. Transcriptional changes in rat α-motoneurons resulting from increased physical activity. Neuroscience. vol 255. 2014-08-14. PMID:24080428. |
significant changes in mrna contents (decreases) were evident for the receptors 5-hydroxytryptamine (serotonin) receptor 1a (5ht1a), gaba a receptor, subunit alpha 2 (gabaaα2), and for the potassium conductance calcium-activated channel protein (sk2) in the motoneurons from 16-week-trained rats, and for glutamate receptor, metabotropic 1 (mglur1) in the voluntary wheel-trained rats. |
2014-08-14 |
2023-08-12 |
rat |
| Ian Mahar, Francis Rodriguez Bambico, Naguib Mechawar, José N Nobreg. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and biobehavioral reviews. vol 38. 2014-08-08. PMID:24300695. |
specifically, chronic stress significantly attenuates 5-ht neurotransmission and 5-ht1a autoreceptor sensitivity, and this effect could represent an endophenotypic hallmark for mood disorders. |
2014-08-08 |
2023-08-12 |
Not clear |
| Yosuke Nakatani, Michiyuki Suzuki, Masaki Tokunaga, Jun Maeda, Miyuki Sakai, Hiroki Ishihara, Takashi Yoshinaga, Osamu Takenaka, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuch. A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder. PloS one. vol 8. issue 9. 2014-08-07. PMID:24086433. |
serotonin 1a (5-ht1a) receptors have been mechanistically implicated in micturition control, and there has been a need for an appropriate biomarker surrogating the potency of a provisional drug acting on this receptor system for developing a new therapeutic approach to overactive bladder (oab). |
2014-08-07 |
2023-08-12 |
rat |
| Georgianna G Gould, Teresa F Burke, Miguel D Osorio, Corey M Smolik, Wynne Q Zhang, Emmanuel S Onaivi, Ting-Ting Gu, Mauris N DeSilva, Julie G Hensle. Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice. Psychoneuroendocrinology. vol 39. 2014-07-31. PMID:24126181. |
enhanced novelty-induced corticosterone spike and upregulated serotonin 5-ht1a and cannabinoid cb1 receptors in adolescent btbr mice. |
2014-07-31 |
2023-08-12 |
mouse |
| Georgianna G Gould, Teresa F Burke, Miguel D Osorio, Corey M Smolik, Wynne Q Zhang, Emmanuel S Onaivi, Ting-Ting Gu, Mauris N DeSilva, Julie G Hensle. Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice. Psychoneuroendocrinology. vol 39. 2014-07-31. PMID:24126181. |
due to their established role in hpa feedback, we hypothesized that hippocampal gαi/o-coupled serotonin 5-ht1a and cannabinoid cb1 receptor function might be upregulated in btbr mice. |
2014-07-31 |
2023-08-12 |
mouse |
| Kutralanathan Renganathan, Jiayin Gu, Mary E Rayborn, John S Crabb, Robert G Salomon, Robert J Collier, Michael A Kapin, Carmelo Romano, Joe G Hollyfield, John W Crab. CEP biomarkers as potential tools for monitoring therapeutics. PloS one. vol 8. issue 10. 2014-07-28. PMID:24098476. |
al-8309a is a serotonin 5-ht1a receptor agonist. |
2014-07-28 |
2023-08-12 |
rat |
| Patrick S Hosford, Steve W Mifflin, Andrew G Ramag. 5-hydroxytryptamine-mediated neurotransmission modulates spontaneous and vagal-evoked glutamate release in the nucleus of the solitary tract effect of uptake blockade. The Journal of pharmacology and experimental therapeutics. vol 349. issue 2. 2014-07-18. PMID:24618127. |
thus, in the nts, the spontaneous release of 5-ht is able to activate 5-ht3 receptors, but not 5-ht1a receptors, as the release in their vicinity is removed by uptake. |
2014-07-18 |
2023-08-12 |
rat |
| Pelin Tanyeri, Mehmet Emin Buyukokuroglu, Oguz Mutlu, Guner Ulak, Furuzan Yildiz Akar, Ipek Komsuoglu Celikyurt, Bekir Faruk Erde. Evidence that the anxiolytic-like effects of the beta3 receptor agonist amibegron involve serotoninergic receptor activity. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23756183. |
we administered the serotonin 5-ht1a receptor antagonist way-100635, the serotonin 5-ht2a receptor antagonist ketanserin and the serotonin 5-ht3 receptor antagonist ondansetron in mice and evaluated their performance in the elevated plus-maze test. |
2014-07-15 |
2023-08-12 |
mouse |
| Pelin Tanyeri, Mehmet Emin Buyukokuroglu, Oguz Mutlu, Guner Ulak, Furuzan Yildiz Akar, Ipek Komsuoglu Celikyurt, Bekir Faruk Erde. Evidence that the anxiolytic-like effects of the beta3 receptor agonist amibegron involve serotoninergic receptor activity. Pharmacology, biochemistry, and behavior. vol 110. 2014-07-15. PMID:23756183. |
this effect of amibegron may be mediated by interactions with the serotonin 5-ht1a, 5-ht2a and 5-ht3 receptors. |
2014-07-15 |
2023-08-12 |
mouse |
| Songlin Wang, Yin Chen, Xinghua Liu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Guisen Zhan. Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24214603. |
a series of 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5-ht1a receptor and serotonin transporter. |
2014-07-15 |
2023-08-12 |
mouse |
| Songlin Wang, Yin Chen, Xinghua Liu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Guisen Zhan. Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24214603. |
preliminary results indicated that the target compounds exhibited high binding affinities at the 5-ht1a receptor and serotonin transporter, and produced marked antidepressant-like effects. |
2014-07-15 |
2023-08-12 |
mouse |
| Songlin Wang, Yin Chen, Xinghua Liu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Guisen Zhan. Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24214603. |
the best example from this study, compound 5, exhibited high binding affinities for the 5-ht1a receptor (ki = 96 nm) and serotonin transporter (ki = 9.8 nm). |
2014-07-15 |
2023-08-12 |
mouse |
| Songlin Wang, Yin Chen, Xinghua Liu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Guisen Zhan. Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants. Archiv der Pharmazie. vol 347. issue 1. 2014-07-15. PMID:24214603. |
the intrinsic activity of compound 5 showed agonistic property to the 5-ht1a receptor and inhibition of the 5-ht transporter. |
2014-07-15 |
2023-08-12 |
mouse |
| Toshio Matsud. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biological & pharmaceutical bulletin. vol 36. issue 12. 2014-07-14. PMID:24292048. |
the neuromodulatory effects of 5-ht are mediated through 14 receptor subtypes, and those receptors, including the 5-ht1a receptor, are considered to be potential targets for the treatment of psychiatric disorders. |
2014-07-14 |
2023-08-12 |
mouse |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
the present study demonstrated significant reductions in 5-ht1a receptor-binding density in superficial and deep layers of the pcc and fg, and in the density of 5-ht(2a) receptors in superficial layers of the pcc and fg. |
2014-07-03 |
2023-08-12 |
Not clear |
| T Billard, D Le Bars, L Zimme. PET radiotracers for molecular imaging of serotonin 5-HT1A receptors. Current medicinal chemistry. vol 21. issue 1. 2014-06-25. PMID:23992341. |
pet radiotracers for molecular imaging of serotonin 5-ht1a receptors. |
2014-06-25 |
2023-08-12 |
Not clear |
| T Billard, D Le Bars, L Zimme. PET radiotracers for molecular imaging of serotonin 5-HT1A receptors. Current medicinal chemistry. vol 21. issue 1. 2014-06-25. PMID:23992341. |
the 5-ht1a family is the best characterized subtype of the fourteen currently known 5-ht receptors. |
2014-06-25 |
2023-08-12 |
Not clear |
| Young Sup Woo, Hee Ryung Wang, Won-Myong Bah. Lurasidone as a potential therapy for bipolar disorder. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24143101. |
lurasidone has a strong antagonistic property at the d2, serotonin (5-ht)2a, and 5-ht7 receptors, and partial agonistic property at the 5-ht1a receptor. |
2014-06-24 |
2023-08-12 |
Not clear |
| Kiran Kumar Sayyaparaju, Heinz Grunze, Kostas N Fountoulaki. When to start aripiprazole therapy in patients with bipolar mania. Neuropsychiatric disease and treatment. vol 10. 2014-06-24. PMID:24648740. |
it has a unique mode of action, acting as a partial agonist at dopamine d2 and d3, and serotonin 5-ht1a; and exhibiting antagonistic action at the 5-ht2a and h1 receptors. |
2014-06-24 |
2023-08-12 |
Not clear |