| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeremy D Coplan, Srinath Gopinath, Chadi G Abdallah, Benjamin R Berr. A neurobiological hypothesis of treatment-resistant depression - mechanisms for selective serotonin reuptake inhibitor non-efficacy. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24904340. |
glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-ht1a autoreceptors by serotonin itself. |
2014-06-24 |
2023-08-13 |
Not clear |
| Paul R Albert, Faranak Vahid-Ansari, Christine Luckhar. Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24936175. |
a key component of serotonin circuitry is the 5-ht1a autoreceptor, which functions as the major somatodendritic autoreceptor to negatively regulate the "gain" of the serotonin system. |
2014-06-24 |
2023-08-13 |
mouse |
| Paul R Albert, Faranak Vahid-Ansari, Christine Luckhar. Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Frontiers in behavioral neuroscience. vol 8. 2014-06-24. PMID:24936175. |
in addition, 5-ht1a heteroreceptors are abundantly expressed post-synaptically in the prefrontal cortex (pfc), amygdala, and hippocampus to mediate serotonin actions on fear, anxiety, stress, and cognition. |
2014-06-24 |
2023-08-13 |
mouse |
| Naotaka Horiguchi, Yukio Ago, Shigeru Hasebe, Kosuke Higashino, Kazuki Asada, Yuki Kita, Kazuhiro Takuma, Toshio Matsud. Isolation rearing reduces mechanical allodynia in a mouse model of chronic inflammatory pain. Pharmacology, biochemistry, and behavior. vol 113. 2014-06-23. PMID:24161684. |
fca increased 5-ht turnover and decreased 5-ht1a receptor expression in the spinal cord of group-reared mice, while it did not have these effects in isolation-reared mice. |
2014-06-23 |
2023-08-12 |
mouse |
| Louis F Fabre, Cees J Timme. Effects of food on the bioavailability of gepirone from extended-release tablets in humans: results of two open-label crossover studies. Current therapeutic research, clinical and experimental. vol 64. issue 8. 2014-06-19. PMID:24944406. |
the new antidepressant gepirone acts preferentially on 5-hydroxytryptamine type 1a (5-ht1a) receptors and functions as a 5-ht1a agonist. |
2014-06-19 |
2023-08-13 |
Not clear |
| Kerri A Pierz, Michael E Thas. A review of vilazodone, serotonin, and major depressive disorder. The primary care companion for CNS disorders. vol 16. issue 1. 2014-06-18. PMID:24940527. |
to review the mechanism of selective serotonin reuptake inhibitor (ssri)-mediated serotonergic neurotransmission, focusing on serotonin 1a (5-ht1a) autoreceptors, which are proposed to be involved in delaying therapeutic efficacy. |
2014-06-18 |
2023-08-13 |
Not clear |
| Vladimir S Naumenko, Daria V Bazovkina, Alina A Semenova, Anton S Tsybko, Tatyana V Il'chibaeva, Elena M Kondaurova, Nina K Popov. Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:24105724. |
the expression of the gene encoding the key enzyme for 5-ht biosynthesis in the brain, tryptophan hydroxylase-2 (tph-2), and 5-ht1a receptor gene in the midbrain as well as 5-ht2a receptor gene in the frontal cortex were increased in gdnf-treated asc mice. |
2014-06-17 |
2023-08-12 |
mouse |
| Vladimir S Naumenko, Daria V Bazovkina, Alina A Semenova, Anton S Tsybko, Tatyana V Il'chibaeva, Elena M Kondaurova, Nina K Popov. Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:24105724. |
gdnf failed to change tph2, 5-ht1a , or 5-ht2a receptor mrna levels in cba mice as well as 5-ht transporter gene expression and 5-ht1a and 5-ht2a receptor functional activity in both investigated mouse strains. |
2014-06-17 |
2023-08-12 |
mouse |
| Pierre Blier, Mostafa El Mansar. The importance of serotonin and noradrenaline in anxiety. International journal of psychiatry in clinical practice. vol 11 Suppl 2. 2014-06-17. PMID:24926868. |
initially, raised 5-ht levels, resulting from serotonin (5-ht) reuptake inhibition, over-activates the cell body 5-ht1a autoreceptor, which has an inhibitory effect on the neuronal firing rate. |
2014-06-17 |
2023-08-13 |
Not clear |
| Pierre Blier, Mostafa El Mansar. The importance of serotonin and noradrenaline in anxiety. International journal of psychiatry in clinical practice. vol 11 Suppl 2. 2014-06-17. PMID:24926868. |
however, after long-term administration of ssris, these 5-ht1a autoreceptors become desensitized to the raised extracellular 5-ht levels, and increase 5-ht transmission. |
2014-06-17 |
2023-08-13 |
Not clear |
| David S Baldwi. Serotonin noradrenaline reuptake inhibitors: A new generation of treatment for anxiety disorders. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921677. |
the probable role of disturbed serotonergic neurotransmission in anxiety is widely accepted and is the theoretical basis for the use of serotonergic agents such as the 5-ht1a receptor partial agonist, buspirone, and the selective serotonin reuptake inhibitors (ssri), such as sertraline and paroxetine, which have largely replaced the earlier antidepressants. |
2014-06-14 |
2023-08-13 |
Not clear |
| Jeffrey M Miller, Natalie Hesselgrave, R Todd Ogden, Francesca Zanderigo, Maria A Oquendo, J John Mann, Ramin V Parse. Brain serotonin 1A receptor binding as a predictor of treatment outcome in major depressive disorder. Biological psychiatry. vol 74. issue 10. 2014-06-09. PMID:23664414. |
we previously reported higher serotonin 1a receptor (5-ht1a) binding in subjects with major depressive disorder (mdd) during a major depressive episode using positron emission tomography imaging with [(11)c]way-100635. |
2014-06-09 |
2023-08-12 |
human |
| Nathalie M Goodfellow, Derya Sargin, Mark S Ansorge, Jay A Gingrich, Evelyn K Lamb. Mice with compromised 5-HTT function lack phosphotyrosine-mediated inhibitory control over prefrontal 5-HT responses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760870. |
we report that mice with compromised 5-htt, resulting from either genetic deletion or brief treatment with selective serotonin reuptake inhibitors during development, have amplified 5-ht1a receptor-mediated currents in adulthood. |
2014-06-09 |
2023-08-13 |
mouse |
| Ana P Abdala, John M Bissonnette, Adrian Newman-Tancred. Pinpointing brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists. Frontiers in physiology. vol 5. 2014-06-09. PMID:24910619. |
a promising new symptomatic strategy currently focuses on regulation of serotonergic function using highly selective serotonin type 1a (5-ht1a) "biased agonists." |
2014-06-09 |
2023-08-13 |
Not clear |
| Alan L Pehrson, Connie Sanche. Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS spectrums. vol 19. issue 2. 2014-06-03. PMID:23903233. |
based on localization and function, 5-ht can modulate glutamate neurotransmission at least through the 5-ht1a, 5-ht1b, 5-ht3, and 5-ht7 receptors, which presents a rational pharmacological opportunity for modulating glutamatergic transmission without the direct use of glutamatergic compounds. |
2014-06-03 |
2023-08-12 |
Not clear |
| Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailesc. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. vol 98. 2014-05-30. PMID:23872451. |
the inhibitory effect of nicotine upon 5-ht drn neurons was dependent on serotonin release inside the drn, since it was converted into a stimulatory response by the selective antagonist of 5-ht1a receptors n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridyl)cyclohexanecarboxamide (way100635, 25nm). |
2014-05-30 |
2023-08-12 |
rat |
| Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailesc. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. vol 98. 2014-05-30. PMID:23872451. |
adx+csr rats also presented an increased function of 5-ht1a autoreceptors, since, in these rats, serotonin (1-10μm) produced a higher increase in the potassium dependent inward rectifying current in comparison with sham-operated animals. |
2014-05-30 |
2023-08-12 |
rat |
| Carmen Frías-Domínguez, Julieta Garduño, Salvador Hernández, René Drucker-Colin, Stefan Mihailesc. Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats. Brain research bulletin. vol 98. 2014-05-30. PMID:23872451. |
these data indicate that, in the experimental model of adrenalectomised rats implanted with corticosterone pellets, nicotine increases the function of 5-ht1a receptors of 5-ht drn neurons. |
2014-05-30 |
2023-08-12 |
rat |
| Kristin A Connors, Theodore W Valenti, Kelly Lawless, James Sackerman, Emmanuel S Onaivi, Bryan W Brooks, Georgianna G Goul. Similar anxiolytic effects of agonists targeting serotonin 5-HT1A or cannabinoid CB receptors on zebrafish behavior in novel environments. Aquatic toxicology (Amsterdam, Netherlands). vol 151. 2014-05-22. PMID:24411165. |
similar anxiolytic effects of agonists targeting serotonin 5-ht1a or cannabinoid cb receptors on zebrafish behavior in novel environments. |
2014-05-22 |
2023-08-12 |
zebrafish |
| Kristin A Connors, Theodore W Valenti, Kelly Lawless, James Sackerman, Emmanuel S Onaivi, Bryan W Brooks, Georgianna G Goul. Similar anxiolytic effects of agonists targeting serotonin 5-HT1A or cannabinoid CB receptors on zebrafish behavior in novel environments. Aquatic toxicology (Amsterdam, Netherlands). vol 151. 2014-05-22. PMID:24411165. |
many ssris also act at serotonin 5-ht1a receptors. |
2014-05-22 |
2023-08-12 |
zebrafish |